Deficits in Emotional Regulation in ADHD

Transcription

1 Deficits in Emotional Regulation in ADHD Joseph Biederman, MD Professor of Psychiatry Harvard Medical School Chief, Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD Massachusetts General Hospital

2 Disclosures My spouse/partner and I have the following relevant financial relationship with a commercial interest to disclose: Research support: DOD, AACAP, Alcobra, Forest Research Institute, Ironshore, Lundbeck, Magceutics Inc., Merck, PamLab, Pfizer, Shire Pharmaceuticals Inc., SPRITES, Sunovion, Vaya Pharma/Enzymotec, and NIH. Honoraria for tuition-funded CME courses: MGH Psychiatry Academy Royalties paid to the Department of Psychiatry at MGH, for a copyrighted ADHD rating scale used for ADHD diagnoses: Ingenix, Prophase, Shire, Bracket Global, Sunovion, and Theravance US Patent Application (Provisional Number #61/233,686) through MGH corporate licensing, on a method to prevent stimulant abuse.

3 Amgydala-Prefrontal Circuitry Amygdala: Red Ventromedial prefrontal cortex: Blue Dorsomedial prefrontal cortex: Green (Kim 2011 Behavioral Brain Research)

4 Bipolar Disorder and Broader Definitions of Mood Disturbance Lewinsohn 1995 USA BPD 1 Lewinsohn 1995 USA Subsyndromal BPD 5.7 Costello 1996 USA 0 BPD Brotman 2006 USA Severe Mood Dysregulation 4 Stringaris 2009 UK 0.1 BPD Stringaris 2009 UK Mood Lability Percent with Disorder

5 Are All Forms of Irritability the Same? Heterogeneity of Irritability

6 Increasing Severity Heterogeneity of Irritability in Children ADHD ODD MDD MANIA Months Mick et al, 2007

7 Heterogeneity of Irritability Labile mood/hot temper: ODD Severe irritability: MDD Explosive/violent irritability: BPD Mick et al. Biological Psychiatry. 2005; 58:

8 Juvenile Mania The type of irritability observed in manic children is very severe, persistent, and often violent. The outbursts often include threatening or attacking behavior towards others, including family members, other children, adults, and teachers. Biederman et al. J Am Acad Child Adolesc Psychiatry. 1996; 35(8):

9 Irritability of ODD vs. Furiosity of Mania The irritable ODD child is hypersensitive to provoking stimuli from authority figures and may or may not be able to self-regulate The furious bipolar child is hypersensitive and experiences extremes of emotion that are impossible to self-regulate

10 Deficits in Emotional Regulation vs. Mood Disorders Deficits in emotional regulation are phenomenologically distinct from mood disorders, which are characterized by the experience of strong emotions, not their self-regulation Unlike deficits in emotional regulation, mood disorders require the presence of non-mood criteria including somatic and behavioral impairments Mood disorders show dysregulted mood throughout each episode, not only in response to provoking stimuli

11 Deficits in Emotional Regulation vs. Mood Disorders In contrast to mood disorders, subjects with deficits in emotional regulation do not have distinct episodes of DESR Unlike mood episodes, deficits in emotional regulation subsides relatively rapidly and does not form a distinct protracted episode of the type that would qualify for a mood disorder Thus, subjects with deficits in emotional regulation have normal moods but can become easily frustrated or angry with unexpected emotional challenges

12 Deficits in Emotional Regulation vs. Mood Disorders: Important Caveat Deficits in emotional regulation and Mood Disorders are not mutually exclusive and can co-exist

13 The MGH Study of Deficient Emotional Self Regulation in Pediatric ADHD

14 DESR in Pediatric ADHD Study Study Population 242 Youth with ADHD 224 Controls without ADHD

15 85 75 Mean 65 * CBCL Clinical Scales (Biederman et al., JAACAP, 1995) * * * * * * Bipolar ADHD Control p<0.01 Bipolar vs. ADHD Delinquent Behavior Aggressive Behavior Withdrawn Somatic Complaints Anxious Depressed Social Problems Thought Problems Attention Problems Significantly elevated in children of BPD parents (Wals et al., JAACAP, 2001)

16 CBCL Mood Dysregulation Profiles CBCL-DESR was operationalized using an aggregate score 180 and <210 in the Anxious/Depressed, Attention, and Aggression scales (AAA profile) of the CBCL CBCL-Severe Dysregulation (BP) profile was defined as 210 on the CBCL-AAA scale

17 Rates of DESR in ADHD and Control Youth (Spencer et al., Postgrad Med 2012) Controls p<.05 ADHD

18 ADHD Symptoms ADHD ADHD+DESR % No significant differences (all p>0.05)

19 Percent of subjects with ADHD-Associated Severe Impairment p< ADHD ADHD+DESR (Spencer et al., Postgrad Med 2012)

20 ADHD predicts DESR Independent of Lifetime History of Comorbidity (Spencer et al., Postgrad Med 2012) Regression model included individual comorbid disorders and ADHD as DESR predictors RED= association with DESR ADHD remained associated with DESR when covaried with each comorbidity Oppositional Defiant Disorder Conduct Disorder Multiple Anxiety Disorders Bipolar Disorder Major Depression Substance Use Disorders

21 Main Findings of Pediatric ADHD Study 44% of ADHD children had a + CBCL- DESR profile vs. 2% of controls (p<0.001) The CBCL-DESR profile was associated with elevated rates of anxiety disorders, CD and ODD but not major depression or bipolar disorder

22 Biederman et al. J Dev Behav Pediatr 2012;33(3):236-43

23 CBCL scores vs Glutamate levels Wozniak et al 2012 Solid lines represent the linear fits to the low score group data (blue) and high score group data (green). Dashed lines represent 95% confidence intervals.

24 The MGH Study of Deficient Emotional Self Regulation in Adult ADHD

25 DESR in Adults with ADHD Study Study Population 206 Adults with ADHD 123 Controls

26 Deficient Emotional Self Regulation (DESR) Methods in Adults with ADHD Barkley s Current Behavior Scale SCID / KSADS modules for Axis I disorders Quality of Life, Enjoyment, Satisfaction Scale- Short Form Social Adjustment Scale - Self Report Functional outcomes questionnaire

27 Deficient Emotional Self Regulation Inventory Items 1. Quick to get angry or become upset 2. Easily Frustrated 3. Over-react emotionally 4. Easily excited by activities going on around me 5. Lose my temper 6. Argue with others 7. Am touchy or easily annoyed by others 8. Am angry or resentful Severity: None (0), Sometimes (1) Often (2), Very Often (3) Items from Barkley s Current Behavior Scale

28 Rate of subjects endorsing DESR symptoms as Often or Very Often Not ADHD ADHD Item43 Item 1 Item 2 Item44 Item45 Item 3 Item50 Item 4 Item92 Item 5 Item93 Item 6 Item 7 Item 8 Item97 Item98 Item Item43 1 Item44 Item 2 Item45 Item 3 Item50 Item 4 Item 5 Item92 Item93 Item 6 Item97 Item 7 Item 8 Item Internal Consistency of Items (Cronbach s alpha: 0.90)

29 DESR in ADHD and Control Adults (Surman et al., American J Psychiatry, 2011) p< Controls ADHD

30 ADHD predicts DESR Independent of Lifetime and Current Comorbidity (Surman et al., American J Psychiatry, 2011) Regression model included individual comorbid disorders and ADHD as DESR predictors RED= association with DESR ADHD remained associated with DESR when covaried with each comorbidity Disruptive Behavior Disorders Major Depression Anxiety Disorders Alcohol Abuse Substance Dependence Bipolar Disorder Substance Abuse Alcohol Dependence

31 Quality of Life Enjoyment / Satisfaction in ADHD+DESR Probands ADHD/NOS n = 206; Control n =123

32 Social Adjustment Scale in ADHD+DESR Probands Correlation Functioning Domain Coefficient Z p 1. Work < Social/Leisure < Extended Famil y < Primary Relationship < Parenting Family Unit < Total SAS ScaleScore < ADHD/NOS n = 206; Control n =123

33 Rates of Divorce by Proband Diagnosis (Surman et al., American J Psychiatry, 2011) ADHD+DESR P=.001 vs. controls & ADHD ADHD Control

34 Percent of Subjects who Ever Had an Auto Accident (Surman et al., American J Psychiatry, 2011) ADHD+DESR p<.001 vs. controls p=.01 vs. ADHD ADHD p<.001 vs. controls Control

35 Intellectual Functioning and DESR (Surman et al., American J Psychiatry, 2011) ADHD+DESR ADHD Full Scale IQ WRAT Arithmetic All p s >.10 WRAT Reading

36 Rates of Executive Function Disorder in ADHD Adults With and Without DESR (Surman et al., American J Psychiatry, 2011) ADHD 33 All p s >.10 ADHD+DESR

37 Summary of DESR Findings in Adults with ADHD A Large Community Sample of Adults with and without ADHD reveals: DESR questionnaire validity Acceptable internal consistency Correlated with functional impairment A sizeable majority of ADHD Adults had DESR Comorbidity did not account for DESR in ADHD adults

38 Surman et al. Am J Psychiatry 2011

39 Percent (%) Emotional Dysregulation in ASD a***b*** Controls ADHD ASD 60 a*** 50 a**b*** 40 a*** a*** a* 10 0 Emotional Dysregulation Deficient Emotional Self-Regulation 0 Severe Emotional Dysregulation

40 Amgydala-Prefrontal Circuitry Amygdala: Red Ventromedial prefrontal cortex: Blue Dorsomedial prefrontal cortex: Green (Kim 2011 Behavioral Brain Research)

41 Resting state functional connectivity of amgydala correlation with reappraisal failure (or success) Reappraisal score: Self Report Ratings on Negative - Reappraisal

42 Tromp et al Arch Gen Psychiatry 2012;69(9):

43 What DESR is Not

44 Disruptive Mood Dysregulation Disorder (DMDD)

45 Heterogeneity of Irritability Severe recurrent temper outbursts grossly out of proportion to the situation or provocation The temper outbursts occur >3 times per week The mood between temper outbursts is persistently irritable or angry most of the day, nearly every day There has never been a distinct period lasting > 1 day during which the full symptom criteria, except duration, for a manic or hypomanic episode have been met

46 Heterogeneity of Irritability A consistent pattern of inhibited, emotionally withdrawn behavior toward adult caregivers, manifested by both : 1. The child rarely seeks comfort when distressed 2. The child rarely responds to comfort when distressed A persistent social and emotional disturbance characterized by >2 of: 1. Minimal social and emotional responsiveness to other 2. Limited positive affect 3. Episodes of unexplained irritability, sadness, or fearfulness that are evident even during nonthreatening interactions with adult caregivers

47 Percent of Subjects HIGH EPA OMEGA-3 FATTY ACIDS AND INSOSITOL IN PEDIATRIC BPD STUDY: ANTIMANIC RESPONSE OR=1.33 OR=3.75 OR=3.75 OR=21.67 OR=5.83 OR= OR=3.33 a* OR=1.07 OR= OR=6.82 OR=6.82 OR= % YMRS Improvement % YMRS Improvement YMRS<12 at Endpoint Inositol (n=7) Omega-3 FA (n=7) Omega-3 FA + Inositol (n=10) CGI Mania Improvement 2 Wozniak et al, JCP in press

48 Summary Deficits in emotional regulation are frequently associated with ADHD and ASD in both children and adults Deficits in emotional regulation increase the risk for mood disorders and associated conditions Deficits in emotional regulation are associated with functional impairment in both pediatric and adult patients with ADHD and ASD Deficits in emotional regulation are independent of psychiatric comorbidity

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