Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife; CARDIA study

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife; CARDIA study"

Transcription

1 The EPI/NPAM Spring 2014 Scientific Sessions, Hilton San Francisco Union Square, San Francisco, CA Northwestern Mar , 2014 University Feinberg School of Medicine Long-term Blood Pressure Variability throughout Young Adulthood and Cognitive Function in Midlife; CARDIA study Yuichiro Yano, MD, 1 Hongyan Ning, MD, MS, 1 Norrina Allen, PhD, 1 MPH, Jared P. Reis, PhD, 2 Lenore J. Launer, PhD, 3 Kiang Liu, PhD, 1 Kristine Yaffe, MD, 4 Philip Greenland, MD, 1 and Donald Lloyd-Jones MD, ScM 1 1. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine 2. Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute 3. Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging 4. Department of Psychiatry, University of California, San Francisco, CA, US

2 Presenter Disclosure Information Elements Yuichiro Yano, MD Department of Preventive Medicine, Northwestern University Feinberg School of Medicine FINANCIAL DISCLOSURE: Manpei Suzuki International Prize for Diabetes Research

3 BP variability (BPV) Short-term BPV (e.g., beat-to-beat and within 24-hours) Long-term BPV (e.g., day-by-day, visit-to-visit (monthly, yearly) BPV). Parati G. Nat Rev Cardiol. 2013;10(3):143.

4 Background The association of long-term (1-8 years) BPV with cognitive dysfunction has been recently reported among elderly and highrisk populations. 1-3 The association of long-term BPV with cognitive function in young adults remains uncertain 1. Sabayan et al., BMJ. 2013;347:f Alpérovitch et al.,alzheimers Dement pii: S (13) Nagai M, et al. J Hypertens. 2012;30(8):

5 Objectives We sought to determine whether: Long-term BPV throughout young adulthood (25 years) is associated with cognitive function in midlife Diverse domains of cognition (i.e., psychomotor speed, verbal memory, and executive function) are differentially associated with long-term BPV

6 Longitudinal study of lifestyle and the evolution of CVD risk factors in young adults 5,115 black and white men and women of varying educational attainment Aged at baseline ( ) Four study centers: Chicago IL, Birmingham AL, Minneapolis MN, Oakland CA Follow-up examinations at years 2, 5, 7, 10, 15, 20, 25

7 BPV measurements Average real variability (ARV) ( Δ1 + Δ2 + Δ3 + Δ4 + Δ5 + Δ6 + Δ7 ) / 7 SBP, mmhg Mean SBP across 8 visits SBP M1 Δ1 M2 M3 Δ2 Δ3 Minimum SBP M4 Δ4 M5 Δ5 Maximum SBP M6 Δ6 M7 Cumulative exposure of SBP Δ7 Standard deviation (+coefficient of variation) Y 0 Y 2 Y 5 Y 7 Y 10 Y 15 Y 20 Y 25 Cumulative exposure of BP; (M1 2year+ M2 3year + M3 2year + M4 3year + M5 5year + M6 5year + M7 5year)

8 Outcomes Cognitive function was assessed (n=2,326) at Y 25 with Digit Symbol Substitution Test (DSST, psychomotor speed test), Rey Auditory Verbal Learning Test (RAVLT, verbal memory test) Modified Stroop test (executive function test)

9 Baseline characteristics of participants (n=2,326) Age, years Men, % 43.3 Blacks, % 40.2 Education, years Body mass index, kg/m Current smoker, % 5.7 Current drinker, % 61.5 Physical activity, exercise units Antihypertensive medication, % 1.9 SBP, mmhg DBP, mmhg Fasting glucose, mg/dl Total cholesterol, mg/dl High-density lipoprotein, mg/dl Data are expressed as the means ± SD or percentage.

10 Age, sex, and race-adjusted correlation of SD BP and ARV BP with the demographics and clinical characteristics (n=2,326) SD SBP, mmhg SD DBP, mmhg ARV SBP, mmhg Demographics at Y 0 Education, years -.10 *** -.10 *** -.13 *** -.11 *** Clinical characteristics at Y 25 Body mass index, kg/m 2.17 ***.21 ***.12 ***.10 *** Physical activity, -.07 ** -.06 ** -.06 ** -.04 ARV DBP, mmhg exercise units Fasting glucose, mg/dl.11 ***.10 ***.13 ***.06 ** Total cholesterol, mg/dl High-density lipoprotein, mg/dl -.09 *** -.10 *** -.07 *** -.05 * Pearson s correlation coefficients adjusted by age, sex, and race are shown. SD and ARV were calculated by BP measures across 8 visits (Y 0-25 ). * P<.05; ** P <.01; *** P<.001.

11 Mean (95% CIs) scores of cognitive function test by deciles of ARV BP Digit Symbol Substitution Test (symbols) ARV SBP P for trend ARV DBP P=.0004 for trend Lower score means lower Psychomotor speed Rey Auditory Verbal Learning Test (words) P=.04 P=.02 Lower score means lower verbal memory Stroop test (sec + errors) P=.03 P=.41 Higher score means lower executive function Deciles of ARV SBP Deciles of ARV DBP Adjusted for age, sex, race, education, and study site.

12 Mean (95% CIs) scores of cognitive function test by deciles of SD BP Digit Symbol Substitution Test (symbols) SD SBP P=.01 for trend SD DBP P=.003 for trend Lower score means lower Psychomotor speed Rey Auditory Verbal Learning Test (words) P=.08 P=.003 Lower score means lower verbal memory Stroop test (sec + errors) P=.23 P=.18 Higher score means lower executive function Deciles of SD SBP Deciles of SD DBP Adjusted for age, sex, race, education, and study site

13 Linear regression models to examine the associations of BPV with cognitive function (n=2,326) Model 1 (Unadjusted) P β (SE) value Digit Symbol Substitution Test (symbols); Model 2 Model 3 Model 4 β (SE) P value β (SE) P value β (SE) P value Lower score means lower Psychomotor speed test SD SBP SD DBP (.005) (.007) (.004) (.006) (.006) (.008) < (.005) (.007) ARV SBP (.006) (.005) (.006) (.006) ARV DBP (.007) (.006) (.007) (.007) Rey Auditory Verbal Learning Test (words): Lower score means lower verbal memory test <.01 SD SBP SD DBP (.005) (.007) (.005) (.007) <.01 < (.007) (.008) ARV SBP (.006) (.005) (.006) ARV DBP (.007) (.007) < (.007) β means standardized regression coefficient. As adjustment factors, Model 2 includes age at baseline, sex, race, education, and study center.13 <.05 <.05 < (.005) (.007) (.006) (.007).12 <.01 <.05 <.01 Model 3 includes model 2+ clinical characteristics at Y 25 (BMI, smoking, alcohol, physical activity, fasting glucose, total cholesterol/hdl, use of antihypertensive drugs, incidence of stroke) + BP (Y 0 ) and change of BP (Y 25 -Y 0 ) Model 4 included model 2+ clinical characteristics at Y 25 + cumulative exposure of BP (Y 0-25 ).

14 Linear regression models to examine the associations of BPV with cognitive function (n=2,326) Model 1 (Unadjusted) Model 2 Model 3 Model 4 β (SE) P value β (SE) P value β (SE) P value β (SE) P value Stroop test (sec + errors): Higher score means lower executive function test SD SBP.042 (.005) SD DBP.051 (.007).013 (.005).013 (.007) < (.007).004 (.008) (.005).004 (.007) ARV SBP.045 (.006) ARV DBP.043 (.007).015 (.006).011 (.007) < (.006).004 (.007) (.006).004 (.007) β means standardized regression coefficient, and R 2 means a measure for the model prediction. As adjustment factors, Model 2 includes age at baseline, sex, race, education, and study center Model 3 includes model 2+ clinical characteristics at Y 25 (BMI, smoking, alcohol, physical activity, fasting glucose, total cholesterol/hdl, use of antihypertensive drugs, incidence of stroke) + BP (Y 0 ) and change of BP (Y 25 -Y 0 ) Model 4 included model 2+ clinical characteristics at Y 25 + cumulative exposure of BP (Y 0-25 ).

15 Strengths and Limitations Strengths CARDIA cohort, a well phenotyped longitudinal cohort with high-quality measures of BP and cognitive function Limitations We could not assess change in cognitive function over time A number of people from the original cohort were excluded in the present analysis (55%)

16 Summary and Conclusions Higher long-term BPV throughout young adulthood (25 years 50 years) is associated with lower function of psychomotor speed (i.e., DSST) and verbal memory (i.e., RAVLT) in midlife. These data suggest the testable hypothesis that reduction of BPV throughout the young adults could lead to improvement in cognitive function in midlife

17 Thank you

18 Backup

19 Correlation of SD BP with CV BP and MMD BP (n=2,326) SD SBP, mmhg SD DBP, mmhg CV SBP, mmhg.98 ***.61 *** CV DBP, mmhg.54 ***.96 *** MMD SBP, mmhg.98 ***.63 *** MMD DBP, mmhg.63 ***.97 *** Pearson s correlation coefficients are shown. SBP indicates systolic blood pressure; DBP, diastolic blood pressure; SD; standard deviation, CV; coefficient of variation, MMD; maximum and minimum BP difference. *** P<0.001.

20 Age, sex, and race-adjusted correlation of SD BP and ARV BP with the demographics and clinical characteristics (n=2,326) SD SBP, mmhg SD DBP, mmhg ARV SBP, mmhg ARV DBP, mmhg Demographics at Y 0 Education, years -.10 *** -.10 *** -.13 *** -.11 *** Demographics at Y 25 Body mass index, kg/m 2.17 ***.21 ***.12 ***.10 *** Physical activity, exercise units -.07 ** -.06 ** -.06 ** -.04 Fasting glucose, mg/dl.11 ***.10 ***.13 ***.06 ** Total cholesterol, mg/dl High-density lipoprotein, mg/dl -.09 *** -.10 *** -.07 *** -.05 * BP parameters Change of SBP (Y 25 -Y 0 ), mmhg.59 ***.36 ***.22 ***.12 *** Change of DBP (Y 25 -Y 0 ), mmhg.42 ***.47 ***.15 ***.17 *** Average SBP (Y 0-25 ), mmhg.48 ***.41 ***.43 ***.30 *** Average DBP (Y 0-25 ), mmhg.40 ***.28 ***.38 ***.19 *** Cumulative exposure of.52 ***.44 ***.44 ***.31 *** SBP (Y 0-25 ), mmhg Cumulative exposure of DBP (Y 0-25 ), mmhg.44 ***.35 ***.38 ***.22 *** Pearson s correlation coefficients adjusted by age, sex, and race are shown. SD and ARV were calculated by BP measures across 8 visits (Y 0-25 ). * P<.05; ** P <.01; *** P<.001.

21 Mean (95% CIs) scores of cognitive function test with adjustment for age, sex, race, education, and study site in deciles of ARV BP Digit Symbol Substitution Test (symbols) P for trend P=.0004 for trend Lower score means lower Psychomotor speed test Rey Auditory Verbal Learning Test (words) P=.04 P=.02 Lower score means lower verbal memory test Stroop test (sec + errors) P=.03 P=.41 Higher score means lower executive function test Deciles of ARV SBP Deciles of ARV DBP The range of ARV divided by deciles. 1 st 2 nd 3 rd 4 th 5 th 6 th 7 th 8 th 9 th 10 th Mean+SD ARV SBP, mmhg (n=232) (n=233) (n=233) (n=228) (n=235) (n=235) (n=228) (n=235) (n=234) (n=233) ARV DBP, mmhg (n=232) (n=233) (n=233) (n=235) (n=219) (n=244) (n=231) (n=233) (n=234) (n=232)

Depok-Indonesia STEPS Survey 2003

Depok-Indonesia STEPS Survey 2003 The STEPS survey of chronic disease risk factors in Indonesia/Depok was carried out from February 2003 to March 2003. Indonesia/Depok carried out Step 1, Step 2 and Step 3. Socio demographic and behavioural

More information

Risk Factors for Heart Disease

Risk Factors for Heart Disease Developmental Perspectives on Health Disparities from Conception Through Adulthood Risk Factors for Heart Disease Philip Greenland, MD Harry W. Dingman Professor Chair, Department of Preventive Medicine

More information

Northwestern University Feinberg School of Medicine Calculating the CVD Risk Score: Which Tool for Which Patient?

Northwestern University Feinberg School of Medicine Calculating the CVD Risk Score: Which Tool for Which Patient? Northwestern University Feinberg School of Medicine Calculating the CVD Risk Score: Which Tool for Which Patient? Donald M. Lloyd-Jones, MD, ScM, FACC, FAHA Senior Associate Dean Chair, Department of Preventive

More information

Randomized Design of ALLHAT BP Trial

Randomized Design of ALLHAT BP Trial Outcomes in Hypertensive Black and Nonblack Patients Treated with Chlorthalidone, Amlodipine, and Lisinopril* *Wright JT, Dunn JK, Cutler JA et al. JAMA 2005:293:1595-1608. 42,418 High-risk hypertensive

More information

Atherosclerosis 226 (2013) 214e219. Contents lists available at SciVerse ScienceDirect. Atherosclerosis

Atherosclerosis 226 (2013) 214e219. Contents lists available at SciVerse ScienceDirect. Atherosclerosis Atherosclerosis 226 (2013) 214e219 Contents lists available at SciVerse ScienceDirect Atherosclerosis journal homepage: www.elsevier.com/locate/atherosclerosis 13-year long-term associations between changes

More information

Effects of Bariatric Surgery in Obese Patients with Hypertension The GATEWAY Randomized Trial

Effects of Bariatric Surgery in Obese Patients with Hypertension The GATEWAY Randomized Trial Effects of Bariatric Surgery in Obese Patients with Hypertension The GATEWAY Randomized Trial Carlos Aurelio Schiavon, MD, FACS On behalf of the GATEWAY Executive Committee and Investigators DISCLOSURE

More information

Effects of Bariatric Surgery in Obese Patients with Hypertension The GATEWAY Randomized Trial

Effects of Bariatric Surgery in Obese Patients with Hypertension The GATEWAY Randomized Trial Effects of Bariatric Surgery in Obese Patients with Hypertension The GATEWAY Randomized Trial Carlos Aurelio Schiavon, MD, FACS On behalf of the GATEWAY Executive Committee and Investigators DISCLOSURE

More information

Alcohol consumption and blood pressure change: 5-year follow-up study of the association in normotensive workers

Alcohol consumption and blood pressure change: 5-year follow-up study of the association in normotensive workers (2001) 15, 367 372 2001 Nature Publishing Group All rights reserved 0950-9240/01 $15.00 www.nature.com/jhh ORIGINAL ARTICLE Alcohol consumption and blood pressure change: 5-year follow-up study of the

More information

Objectives. Describe results and implications of recent landmark hypertension trials

Objectives. Describe results and implications of recent landmark hypertension trials Hypertension Update Daniel Schwartz, MD Assistant Professor of Medicine Associate Medical Director of Heart Transplantation Temple University School of Medicine Disclosures I currently have no relationships

More information

ESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study

ESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study ESM1 for Glucose, blood pressure and cholesterol levels and their relationships to clinical outcomes in type 2 diabetes: a retrospective cohort study Statistical modelling details We used Cox proportional-hazards

More information

Cedars Sinai Diabetes. Michael A. Weber

Cedars Sinai Diabetes. Michael A. Weber Cedars Sinai Diabetes Michael A. Weber Speaker Disclosures I disclose that I am a Consultant for: Ablative Solutions, Boston Scientific, Boehringer Ingelheim, Eli Lilly, Forest, Medtronics, Novartis, ReCor

More information

Blood Pressure Monitoring in Chronic Kidney Disease

Blood Pressure Monitoring in Chronic Kidney Disease Blood Pressure Monitoring in Chronic Kidney Disease Aldo J. Peixoto, MD FASN FASH Associate Professor of Medicine (Nephrology), YSM Associate Chief of Medicine, VACT Director of Hypertension, VACT American

More information

Blood Pressure Measurement in SPRINT

Blood Pressure Measurement in SPRINT Blood Pressure Measurement in SPRINT Karen C. Johnson, MD, MPH, FAHA Vice Chair, SPRINT Steering Committee University of Tennessee Health Science Center, Department of Preventive Medicine For the SPRINT

More information

Supplemental Table S2: Subgroup analysis for IL-6 with BMI in 3 groups

Supplemental Table S2: Subgroup analysis for IL-6 with BMI in 3 groups Supplemental Table S1: Unadjusted and Adjusted Hazard Ratios for Diabetes Associated with Baseline Factors Considered in Model 3 SMART Participants Only Unadjusted Adjusted* Baseline p-value p-value Covariate

More information

Prevention of Heart Disease: The New Guidelines

Prevention of Heart Disease: The New Guidelines Prevention of Heart Disease: The New Guidelines Nisha I. Parikh MD MPH Assistant Professor of Medicine Division of Cardiology Department of Medicine University of California San Francisco May 18 th 2015

More information

New Hypertension Guidelines: Why the change? Neil Brummond, M.D. Avera Medical Group Internal Medicine Sioux Falls, SD

New Hypertension Guidelines: Why the change? Neil Brummond, M.D. Avera Medical Group Internal Medicine Sioux Falls, SD New Hypertension Guidelines: Why the change? Neil Brummond, M.D. Avera Medical Group Internal Medicine Sioux Falls, SD None Disclosures Objectives Understand trend in blood pressure clinical practice guidelines

More information

Talking about blood pressure

Talking about blood pressure Talking about blood pressure Mrs Khan 56 BP 158/99 BMI 32 Total cholesterol 5.4 (HDL 0.8) HbA1c 43 She has been promising to do more exercise and eat more healthily for the last 2 years but her weight

More information

Departments of Cardiology and Vascular Surgery Michaelidion Cardiac Center University of Ioannina, Greece

Departments of Cardiology and Vascular Surgery Michaelidion Cardiac Center University of Ioannina, Greece Departments of Cardiology and Vascular Surgery Michaelidion Cardiac Center University of Ioannina, Greece ARGYRIS Vassilis, PEROULIS Michalis, MATSAGKAS Miltiadis, BECHLIOULIS Aris, MICHALIS Lampros, NAKA

More information

Examining the relationship between beverage intake and cardiovascular health. Ian Macdonald University of Nottingham UK

Examining the relationship between beverage intake and cardiovascular health. Ian Macdonald University of Nottingham UK Examining the relationship between beverage intake and cardiovascular health Ian Macdonald University of Nottingham UK Outline Assessment of evidence in relation to health risks of dietary components Cardiovascular

More information

Executive Function Using Brain Research to Improve Job Search Outcomes

Executive Function Using Brain Research to Improve Job Search Outcomes Executive Function Using Brain Research to Improve Job Search Outcomes Applying research based concepts in our program and practice June 2014 www.pcghumanservices.com What is Executive Function? Air Traffic

More information

Blood Pressure Goal in Elderly Hypertensive Patients with Diabetes Mellitus: A Subanalysis of the CASE-J Trial

Blood Pressure Goal in Elderly Hypertensive Patients with Diabetes Mellitus: A Subanalysis of the CASE-J Trial Blood Pressure Goal in Elderly Hypertensive Patients with Diabetes Mellitus: A Subanalysis of the CASE-J Trial Kenji Ueshima 1, Shinji Yasuno 1, Sachiko Tanaka 1, Akira Fujimoto 1, Toshio Ogihara 2, Takao

More information

What have We Learned in Dyslipidemia Management Since the Publication of the 2013 ACC/AHA Guideline?

What have We Learned in Dyslipidemia Management Since the Publication of the 2013 ACC/AHA Guideline? What have We Learned in Dyslipidemia Management Since the Publication of the 2013 ACC/AHA Guideline? Salim S. Virani, MD, PhD, FACC, FAHA Associate Professor, Section of Cardiovascular Research Baylor

More information

Personality and physiological reactions to acute psychological stress in a large cohort of middle aged men and women

Personality and physiological reactions to acute psychological stress in a large cohort of middle aged men and women Personality and physiological reactions to acute psychological stress in a large cohort of middle aged men and women Adam Bibbey, BSc 1 Douglas Carroll 1, Tessa J. Roseboom 2, Anna C. Phillips 1, Susanne

More information

Clinical cases with Coversyl 10 mg

Clinical cases with Coversyl 10 mg Clinical cases Coversyl 10 mg For upgraded benefits in hypertension A Editorial This brochure, Clinical cases Coversyl 10 mg for upgraded benefits in hypertension, illustrates a variety of hypertensive

More information

Jieying Jiang, Ph.D. Yu Chen, Ph.D., MPH Habibul Ahsan, M.D., MMedSc

Jieying Jiang, Ph.D. Yu Chen, Ph.D., MPH Habibul Ahsan, M.D., MMedSc Jieying Jiang, Ph.D. Yu Chen, Ph.D., MPH Habibul Ahsan, M.D., MMedSc Emerging Epidemic of CVD in Developing Countries Developed countries Relative contribution of CVD deaths to total mortality in 1990

More information

2013 Report on the Assessment of Cardiovascular Risk:

2013 Report on the Assessment of Cardiovascular Risk: 2013 Report on the Assessment of Cardiovascular Risk: Full Work Group Report Supplement Based on a Systematic Review From the National Heart, Lung, and Blood Institute ACKNOWLEDGMENTS WORK GROUP MEMBERS

More information

Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk

Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk 23 Original Article Hypertens Res Vol.29 (2006) No.1 p.23-28 Ankle Brachial Index as a Marker of Atherosclerosis in Chinese Patients with High Cardiovascular Risk Buaijiaer HASIMU 1), Jue LI 1), Tomohiro

More information

Managing HTN in the Elderly: How Low to Go

Managing HTN in the Elderly: How Low to Go Managing HTN in the Elderly: How Low to Go Laxmi S. Mehta, MD, FACC The Ohio State University Medical Center Assistant Professor of Clinical Internal Medicine Clinical Director of the Women s Cardiovascular

More information

NIH Public Access Author Manuscript Clin Cardiol. Author manuscript; available in PMC 2014 March 14.

NIH Public Access Author Manuscript Clin Cardiol. Author manuscript; available in PMC 2014 March 14. NIH Public Access Author Manuscript Published in final edited form as: Clin Cardiol. 2013 January ; 36(1): 15 20. doi:10.1002/clc.22046. C-reactive protein level and the incidence of eligibility for statin

More information

Placebo-Controlled Statin Trials EXPLAINING THE DECREASE IN DEATHS FROM CHD! PREVENTION OF CARDIOVASCULAR DISEASE IN WOMEN EXPLAINING THE DECREASE IN

Placebo-Controlled Statin Trials EXPLAINING THE DECREASE IN DEATHS FROM CHD! PREVENTION OF CARDIOVASCULAR DISEASE IN WOMEN EXPLAINING THE DECREASE IN PREVENTION OF CARDIOVASCULAR DISEASE IN WOMEN Robert B. Baron MD MS Professor and Associate Dean UCSF School of Medicine Declaration of full disclosure: No conflict of interest EXPLAINING THE DECREASE

More information

ORIGINAL INVESTIGATION

ORIGINAL INVESTIGATION ORIGINAL INVESTIGATION Relationship of Blood Pressure to 25-Year Mortality Due to Coronary Heart Disease, Cardiovascular Diseases, and All Causes in Young Adult Men The Chicago Heart Association Detection

More information

/13/$ - see front matter Ó 2013 Elsevier Inc. All rights reserved.

/13/$ - see front matter Ó 2013 Elsevier Inc. All rights reserved. Prognostic Value of Frontal QRS-T Angle in Patients Without Clinical Evidence of Cardiovascular Disease (from the Multi-Ethnic Study of Atherosclerosis) Joseph A. Walsh III, MD, MS a,b, Elsayed Z. Soliman,

More information

Jared Moore, MD, FACP

Jared Moore, MD, FACP Hypertension 101 Jared Moore, MD, FACP Assistant Program Director, Internal Medicine Residency Clinical Assistant Professor of Internal Medicine Division of General Medicine The Ohio State University Wexner

More information

The role of physical activity in the prevention and management of hypertension and obesity

The role of physical activity in the prevention and management of hypertension and obesity The 1 st World Congress on Controversies in Obesity, Diabetes and Hypertension (CODHy) Berlin, October 26-29 2005 The role of physical activity in the prevention and management of hypertension and obesity

More information

Complications of Pregnancy and Lifetime Risk to Health. Brian McCulloch MD Advocate Lutheran General Hospital September 26, 2015

Complications of Pregnancy and Lifetime Risk to Health. Brian McCulloch MD Advocate Lutheran General Hospital September 26, 2015 Complications of Pregnancy and Lifetime Risk to Health Brian McCulloch MD Advocate Lutheran General Hospital September 26, 2015 Pregnancy as a window to future health In 2005 the CDC stated that almost

More information

Sugar-Loaded Beverages and the Impact on Cardiovascular Health. Christina M. Shay, PhD, MA

Sugar-Loaded Beverages and the Impact on Cardiovascular Health. Christina M. Shay, PhD, MA Sugar-Loaded Beverages and the Impact on Cardiovascular Health Christina M. Shay, PhD, MA 1 Presenter Disclosure Information Christina M. Shay, PhD, MA Sugar-Loaded Beverages and the Impact on Cardiovascular

More information

JUPITER NEJM Poll. Panel Discussion: Literature that Should Have an Impact on our Practice: The JUPITER Study

JUPITER NEJM Poll. Panel Discussion: Literature that Should Have an Impact on our Practice: The JUPITER Study Panel Discussion: Literature that Should Have an Impact on our Practice: The Study Kaiser COAST 11 th Annual Conference Maui, August 2009 Robert Blumberg, MD, FACC Ralph Brindis, MD, MPH, FACC Primary

More information

Epicardial adipose tissue in children is associated with an unfavorable cardiometabolic risk profile, but is not a stronger indicator than BMI

Epicardial adipose tissue in children is associated with an unfavorable cardiometabolic risk profile, but is not a stronger indicator than BMI Epicardial adipose tissue in children is associated with an unfavorable cardiometabolic risk profile, but is not a stronger indicator than BMI Schusterova I., Joppova E., Stromplova D., Fatulova N., Tohatyova

More information

9/18/2017 DISCLOSURES. Consultant: RubiconMD. Research: Amgen, NHLBI OUTLINE OBJECTIVES. Review current CV risk assessment tools.

9/18/2017 DISCLOSURES. Consultant: RubiconMD. Research: Amgen, NHLBI OUTLINE OBJECTIVES. Review current CV risk assessment tools. UW MEDICINE UW MEDICINE UCSF ASIAN TITLE HEALTH OR EVENT SYMPOSIUM 2017 DISCLOSURES Consultant: RubiconMD ESTIMATING CV RISK IN ASIAN AMERICANS AND PREVENTION OF CVD Research: Amgen, NHLBI EUGENE YANG,

More information

Hypertension Guidelines: Are We Pressured to Change? Oregon Cardiovascular Symposium Portland, Oregon June 6, Financial Disclosures

Hypertension Guidelines: Are We Pressured to Change? Oregon Cardiovascular Symposium Portland, Oregon June 6, Financial Disclosures Hypertension Guidelines: Are We Pressured to Change? Oregon Cardiovascular Symposium Portland, Oregon June 6, 2015 William C. Cushman, MD Professor, Preventive Medicine, Medicine, and Physiology University

More information

Effectiveness of Add-On Low-Dose Diuretics in Combination Therapy for Hypertension: Losartan/Hydrochlorothiazide vs. Candesartan/Amlodipine

Effectiveness of Add-On Low-Dose Diuretics in Combination Therapy for Hypertension: Losartan/Hydrochlorothiazide vs. Candesartan/Amlodipine 831 Original Article Hypertens Res Vol.3 (27) No.9 p.831-837 Effectiveness of Add-On Low-Dose Diuretics in Combination Therapy for Hypertension: Losartan/Hydrochlorothiazide vs. Candesartan/Amlodipine

More information

LONG-TERM EFFECTS OF SURGICAL MENAGEMENT OF PRIMARY ALDOSTERONISM ON THE CARDIOVASCULAR SISTEM

LONG-TERM EFFECTS OF SURGICAL MENAGEMENT OF PRIMARY ALDOSTERONISM ON THE CARDIOVASCULAR SISTEM LONG-TERM EFFECTS OF SURGICAL MENAGEMENT OF PRIMARY ALDOSTERONISM ON THE CARDIOVASCULAR SISTEM Riccardo Marsili, Pietro Iacconi, Massimo Chiarugi, Giampaolo Bernini*, Alessandra Bacca*, Paolo Miccoli Department

More information

sphingotest vr-hgh Risk Prediction of Incident Cardiovascular Disease

sphingotest vr-hgh Risk Prediction of Incident Cardiovascular Disease sphingotest vr-hgh Risk Prediction of Incident Cardiovascular Disease Human Growth Hormone as Vascular Risk Biomarker sphingotec offers the vascular risk human Growth Hormone biomarker (vr-hgh) for the

More information

Heart Disease and Stroke Statistics 2010 Update. 2009, American Heart Association. All rights reserved.

Heart Disease and Stroke Statistics 2010 Update. 2009, American Heart Association. All rights reserved. Heart Disease and Stroke Statistics 21 Update Questions on statistics? mailto:nancy.haase@heart.org Audio-visual questions? mailto:david.brentz@heart.org Please keep the red wave and logo attached to these

More information

Atherosclerotic Disease Risk Score

Atherosclerotic Disease Risk Score Atherosclerotic Disease Risk Score Kavita Sharma, MD, FACC Diplomate, American Board of Clinical Lipidology Director of Prevention, Cardiac Rehabilitation and the Lipid Management Clinics September 16,

More information

The impact of diabetes on cognitive decline: potential vascular, metabolic, and psychosocial risk factors

The impact of diabetes on cognitive decline: potential vascular, metabolic, and psychosocial risk factors Feinkohl et al. Alzheimer's Research & Therapy (2015) 7:46 DOI 10.1186/s13195-015-0130-5 REVIEW The impact of on cognitive decline: potential vascular, metabolic, and psychosocial risk factors Insa Feinkohl

More information

Traitements associés chez l hypertendu: Statines, Aspirine

Traitements associés chez l hypertendu: Statines, Aspirine Traitements associés chez l hypertendu: Statines, Aspirine Pr Jean-Jacques Mourad CHU Avicenne, Université Paris 13, Bobigny DU HTA, Mars 2012 jean-jacques.mourad@avc.aphp.fr Global Mortality 2000: Impact

More information

Hypertension and Diabetes Should we be SPRINTING or Reaching an ACCORD?

Hypertension and Diabetes Should we be SPRINTING or Reaching an ACCORD? Hypertension and Diabetes Should we be SPRINTING or Reaching an ACCORD? Suzanne Oparil, MD Distinguished Professor of Medicine, Professor of Cell, Developmental and Integrative Biology Director, Vascular

More information

Monitoring Cognitive Functioning: National Survey of Midlife in the United States (MIDUS)

Monitoring Cognitive Functioning: National Survey of Midlife in the United States (MIDUS) Monitoring Cognitive Functioning: National Survey of Midlife in the United States (MIDUS) IOM Committee on Public Health Dimensions of Cognitive Aging Panel 3: Epidemiology and Surveillance April 10, 2014

More information

Effectiveness of a Multidisciplinary Patient Assistance Program in Diabetes Care

Effectiveness of a Multidisciplinary Patient Assistance Program in Diabetes Care University of Rhode Island DigitalCommons@URI Senior Honors Projects Honors Program at the University of Rhode Island 2009 Effectiveness of a Multidisciplinary Patient Assistance Program in Diabetes Care

More information

CONSIDERABLE STRIDES HAVE

CONSIDERABLE STRIDES HAVE ORIGINAL INVESTIGATION Comparison of Risk Factors for Cardiovascular Mortality in Black and White Adults Mercedes R. Carnethon, PhD; Elizabeth B. Lynch, PhD; Alan R. Dyer, PhD; Donald M. Lloyd-Jones, MD,

More information

ORIGINAL INVESTIGATION. Impact of Major Cardiovascular Disease Risk Factors, Particularly in Combination, on 22-Year Mortality in Women and Men

ORIGINAL INVESTIGATION. Impact of Major Cardiovascular Disease Risk Factors, Particularly in Combination, on 22-Year Mortality in Women and Men ORIGINAL INVESTIGATION Impact of Major Cardiovascular Disease Risk Factors, Particularly in Combination, on 22-Year Mortality in and Lynn P. Lowe, PhD; Philip Greenland, MD; Karen J. Ruth, MS; Alan R.

More information

Relation between the angiotensinogen (AGT) M235T gene polymorphism and blood pressure in a large, homogeneous study population

Relation between the angiotensinogen (AGT) M235T gene polymorphism and blood pressure in a large, homogeneous study population (2003) 17, 555 559 & 2003 Nature Publishing Group All rights reserved 0950-9240/03 $25.00 www.nature.com/jhh ORIGINAL ARTICLE Relation between the angiotensinogen (AGT) M235T gene polymorphism and blood

More information

Hypertension Update Clinical Controversies Regarding Age and Race

Hypertension Update Clinical Controversies Regarding Age and Race Hypertension Update Clinical Controversies Regarding Age and Race Allison Helmer, PharmD, BCACP Assistant Clinical Professor Auburn University Harrison School of Pharmacy July 22, 2017 DISCLOSURE/CONFLICT

More information

Ischemic Heart and Cerebrovascular Disease. Harold E. Lebovitz, MD, FACE Kathmandu November 2010

Ischemic Heart and Cerebrovascular Disease. Harold E. Lebovitz, MD, FACE Kathmandu November 2010 Ischemic Heart and Cerebrovascular Disease Harold E. Lebovitz, MD, FACE Kathmandu November 2010 Relationships Between Diabetes and Ischemic Heart Disease Risk of Cardiovascular Disease in Different Categories

More information

Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes Diagnosis

Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes Diagnosis CLINICAL RESEARCH STUDY Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes Diagnosis Gregory A. Nichols, PhD, Teresa A. Hillier, MD, MS, Jonathan B. Brown, PhD, MPP Center for Health Research, Kaiser

More information

Safety of Anacetrapib in Patients with or

Safety of Anacetrapib in Patients with or Safety of Anacetrapib in Patients with or at Risk for Coronary Heart Disease Christopher P. Cannon, MD, Sukrut Shah, PhD, RPh, Hayes M. Dansky, MD, Michael Davidson, MD, Eliot A. Brinton, MD, Antonio M.

More information

THE SOUTHERN AFRICAN HYPERTENSION GUIDELINE. Brian Rayner, Division of Hypertension, University of Cape Town

THE SOUTHERN AFRICAN HYPERTENSION GUIDELINE. Brian Rayner, Division of Hypertension, University of Cape Town THE SOUTHERN AFRICAN HYPERTENSION GUIDELINE Brian Rayner, Division of Hypertension, University of Cape Town Scope of Problem Deaths attributable to high blood pressure in males, South Africa 2000 7000

More information

Validation of the SEJOY BP-1307 upper arm blood pressure monitor for home. blood pressure monitoring according to the European Society of Hypertension

Validation of the SEJOY BP-1307 upper arm blood pressure monitor for home. blood pressure monitoring according to the European Society of Hypertension Validation of the SEJOY BP-1307 upper arm blood pressure monitor for home blood pressure monitoring according to the European Society of Hypertension International Protocol revision 2010 Short title: Validation

More information

The epidemiology of subclavian artery calcification

The epidemiology of subclavian artery calcification The epidemiology of subclavian artery calcification Anand Prasad, MD, a Christina L. Wassel, PhD, b Nicole E. Jensky, PhD b and Matthew A. Allison, MD, MPH, b San Diego, Calif Objectives: The purpose of

More information

Objectives. JNC 7 Is Nice But What s Up With JNC 8? Why Do We Care? Hypertension Background: Prevalence

Objectives. JNC 7 Is Nice But What s Up With JNC 8? Why Do We Care? Hypertension Background: Prevalence JNC 7 Is Nice But What s Up With JNC 8? 37 th Annual CAPA Conference October 4 th 2013 Ignacio de Artola, Jr. M.D. Assistant Professor of Clinical Family Medicine Medical Director, Primary Care Physician

More information

Predicting failure to follow-up screened high blood pressure in Japan: a cohort study

Predicting failure to follow-up screened high blood pressure in Japan: a cohort study Journal of Public Health Vol. 37, No. 3, pp. 498 505 doi:10.1093/pubmed/fdu056 Advance Access Publication August 7, 2014 Predicting failure to follow-up screened high blood pressure in Japan: a cohort

More information

Cite this article as: BMJ, doi: /bmj (published 7 April 2006)

Cite this article as: BMJ, doi: /bmj (published 7 April 2006) Cite this article as: BMJ, doi:10.1136/bmj.38779.584028.55 (published 7 April 2006) Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA

More information

Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol

Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol Atherosclerosis 190 (2007) 306 312 Smoking and atherosclerotic cardiovascular disease in women with lower levels of serum cholesterol Sun Ha Jee a,b,c,, Jungyong Park b, Inho Jo d, Jakyoung Lee a,b, Soojin

More information

KEEP 2009 Summary Figures

KEEP 2009 Summary Figures S4 29 Summary Figures American Journal of Kidney Diseases, Vol 55, No 3, Suppl 2, 21:pp S4-S57 S41 Definitions DATA ANALYSES DIABETES Self-reported diabetes, self reported diabetic retinopathy, receiving

More information

Branko N Huisa M.D. Assistant Professor of Neurology UNM Stroke Center

Branko N Huisa M.D. Assistant Professor of Neurology UNM Stroke Center Branko N Huisa M.D. Assistant Professor of Neurology UNM Stroke Center THE END! CHANGABLE Blood pressure Diabetes Mellitus Hyperlipidemia Atrial fibrillation Nicotine Drug abuse Life style NOT CHANGABLE

More information

EuroPrevent 2010 Fatal versus total events in risk assessment models

EuroPrevent 2010 Fatal versus total events in risk assessment models EuroPrevent 2010 Fatal versus total events in risk assessment models Pekka Jousilahti, MD, PhD,Research Professor National Institute for Health and Welfare, Finland Risk assessment models Estimates the

More information

Cannabis et complications cardiovasculaires

Cannabis et complications cardiovasculaires Cannabis et complications cardiovasculaires Prof. Reto Auer, MD, MAS 16.11.2017 reto.auer@biham.unibe.ch Twitter: @retoauer Kattoor et al. http://www.acc.org/latest-in-cardiology/articles/2016/09/22/08/58/mari

More information

Association of Heart Rate With Blood Pressure Variability: Implications for Blood Pressure Measurement

Association of Heart Rate With Blood Pressure Variability: Implications for Blood Pressure Measurement nature publishing group original contributions Association of Heart Rate With Blood Pressure Variability: Implications for Blood Pressure Measurement Amos Cahan 1, Iddo Z. Ben-Dov 2 and Michael Bursztyn

More information

A factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes

A factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes A factorial randomized trial of blood pressure lowering and intensive glucose control in 11,140 patients with type 2 diabetes Hypotheses: Among individuals with type 2 diabetes, the risks of major microvascular

More information

Μη φαρµακολογική θεραπεία της υπέρτασης Μαρία Μαρκέτου Επιµ. Α Καρδιολογική Κλινική ΠΑΓΝΗ

Μη φαρµακολογική θεραπεία της υπέρτασης Μαρία Μαρκέτου Επιµ. Α Καρδιολογική Κλινική ΠΑΓΝΗ Μη φαρµακολογική θεραπεία της υπέρτασης Μαρία Μαρκέτου Επιµ. Α Καρδιολογική Κλινική ΠΑΓΝΗ Δεν υπάρχει σύγκρουση οικονοµικών συµφερόντων Θεραπευτική προσέγγιση σύµφωνα µε τις κατευθηντήριες οδηγίες Θεραπευτική

More information

Cardiovascular Health Practice Guideline Outpatient Management of Coronary Artery Disease 2003

Cardiovascular Health Practice Guideline Outpatient Management of Coronary Artery Disease 2003 Authorized By: Medical Management Guideline Committee Approval Date: 12/13/01 Revision Date: 12/11/03 Beta-Blockers Nitrates Calcium Channel Blockers MEDICATIONS Indicated in post-mi, unstable angina,

More information

Prognostic significance of blood pressure measured in the office, at home and during ambulatory monitoring in older patients in general practice

Prognostic significance of blood pressure measured in the office, at home and during ambulatory monitoring in older patients in general practice (2005) 19, 801 807 & 2005 Nature Publishing Group All rights reserved 0950-9240/05 $30.00 www.nature.com/jhh ORIGINAL ARTICLE Prognostic significance of blood pressure measured in the office, at home and

More information

Hypertension Management in Diabetic Patients

Hypertension Management in Diabetic Patients Hypertension Management in Diabetic Patients Park, Chang G, MD, PhD Cardiovascular Center, Guro Hospital, Korea University Medical School Contents (Treatment of 2 Cases) Type 2 Diabetes Mellitus Hypertension

More information

Socio-economic risk factors in the community-based PEP Family Heart Study

Socio-economic risk factors in the community-based PEP Family Heart Study Socio-economic risk factors in the community-based PEP Family Heart Study Gerda-Maria Haas 1. Evelyn Liepold 1. Peter Schwandt 1,2 1 Arteriosklerose-Praeventions-Institut. Muenchen - Nuernberg (Germany)

More information

Supplementary Information for: Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative.

Supplementary Information for: Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative. Supplementary Information for: Predictors of chronic kidney disease in type 1 diabetes: a longitudinal study from the AMD Annals initiative. Authors: Pamela Piscitelli 1, Francesca Viazzi 2 ; Paola Fioretto

More information

Disclosures. Hypertension: Nationwide Dilemma. Learning Objectives. What s Currently Recommended? Specific Concerns 3/9/2012

Disclosures. Hypertension: Nationwide Dilemma. Learning Objectives. What s Currently Recommended? Specific Concerns 3/9/2012 How Should We ACCOMPLISH Good Blood Pressure Control In Our VETS? Disclosures No conflicts of interest to disclose Updates in the Management of HypertensionIn the Elderly Antoine T. Jenkins, Pharm.D.,

More information

Management of Hypertension. M Misra MD MRCP (UK) Division of Nephrology University of Missouri School of Medicine

Management of Hypertension. M Misra MD MRCP (UK) Division of Nephrology University of Missouri School of Medicine Management of Hypertension M Misra MD MRCP (UK) Division of Nephrology University of Missouri School of Medicine Disturbing Trends in Hypertension HTN awareness, treatment and control rates are decreasing

More information

Guidelines on cardiovascular risk assessment and management

Guidelines on cardiovascular risk assessment and management European Heart Journal Supplements (2005) 7 (Supplement L), L5 L10 doi:10.1093/eurheartj/sui079 Guidelines on cardiovascular risk assessment and management David A. Wood 1,2 * 1 Cardiovascular Medicine

More information

Hypertension and Cholesterol in the Elderly

Hypertension and Cholesterol in the Elderly Hypertension and Cholesterol in the Elderly Angela Sanford, MD Assistant Professor of Geriatrics Saint Louis University School of Medicine I have no relevant financial disclosures Cushman WC. The burden

More information

Predictors of Depression Among Midlife Women in South Korea. Ham, Ok-kyung; Im, Eun-Ok. Downloaded 8-Apr :24:06

Predictors of Depression Among Midlife Women in South Korea. Ham, Ok-kyung; Im, Eun-Ok. Downloaded 8-Apr :24:06 The Henderson Repository is a free resource of the Honor Society of Nursing, Sigma Theta Tau International. It is dedicated to the dissemination of nursing research, researchrelated, and evidence-based

More information

A fixed-dose combination of bisoprolol and amlodipine in daily practice treatment of hypertension: Results of a noninvestigational

A fixed-dose combination of bisoprolol and amlodipine in daily practice treatment of hypertension: Results of a noninvestigational Hostalek U et al. Medical Research Archives, vol. 5, issue 11, November 2017 issue Page 1 of 11 RESEARCH ARTICLE A fixed-dose combination of bisoprolol and amlodipine in daily practice treatment of hypertension:

More information

ADVANCE post trial ObservatioNal Study

ADVANCE post trial ObservatioNal Study Hot Topics in Diabetes 50 th EASD, Vienna 2014 ADVANCE post trial ObservatioNal Study Sophia Zoungas The George Institute The University of Sydney Rationale and Study Design Sophia Zoungas The George Institute

More information

Impact of Hypertension Threshold and Goals on Special Populations

Impact of Hypertension Threshold and Goals on Special Populations Impact of Hypertension Threshold and Goals on Special Populations National Lipid Association 2015 Annual Scientific Sessions June 13,2015 Keith C. Ferdinand, MD, FACC,FAHA,FASH,FNLA Professor of Clinical

More information

Improved control for confounding using propensity scores and instrumental variables?

Improved control for confounding using propensity scores and instrumental variables? Improved control for confounding using propensity scores and instrumental variables? Dr. Olaf H.Klungel Dept. of Pharmacoepidemiology & Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences

More information

Coronary Artery Calcium to Predict All-Cause Mortality in Elderly Men and Women

Coronary Artery Calcium to Predict All-Cause Mortality in Elderly Men and Women Journal of the American College of Cardiology Vol. 52, No. 1, 28 28 by the American College of Cardiology Foundation ISSN 735-197/8/$34. Published by Elsevier Inc. doi:1.116/j.jacc.28.4.4 CLINICAL RESEARCH

More information

Preventing heart disease by controlling hypertension: Impact of hypertensive subtype, stage, age, and sex

Preventing heart disease by controlling hypertension: Impact of hypertensive subtype, stage, age, and sex Prevention and Rehabilitation Preventing heart disease by controlling hypertension: Impact of hypertensive subtype, stage, age, and sex Nathan D. Wong, PhD, a Gaurav Thakral, BS, a Stanley S. Franklin,

More information

Key Words: losartan, hypertension, blood pressure, cardiovascular disease, observational study

Key Words: losartan, hypertension, blood pressure, cardiovascular disease, observational study 469 Original Article Hypertens Res Vol.31 (2008) No.3 p.469-478 Impact of Blood Pressure Control on Cardiovascular Events in 26,512 Japanese Hypertensive Patients: The Japan Hypertension Evaluation with

More information

Community Based Diabetes Prevention

Community Based Diabetes Prevention Community Based Diabetes Prevention Melanie Davies Professor of Diabetes Medicine Outline NIHR Programme Grant proposal and update to progress The Vascular Check programme HbA1c debate Algorithm to detect

More information

This Protocol is applicable to Class 1, 2, and Class 3 applicants. Resting ECG shall be performed at the following intervals:

This Protocol is applicable to Class 1, 2, and Class 3 applicants. Resting ECG shall be performed at the following intervals: SCHEDULE 34: PROTOCOL ON ELECTROCARDIOGRAMS ( ECG ) 1. Applicability This Protocol is applicable to Class 1, 2, and Class 3 applicants. 2. Resting ECG Resting ECG shall be perfmed at the following intervals:

More information

HOW CONSISTENT ARE THE BLOOD PRESSURE AND PULSE RATE MEASUREMENTS OF THE ELECTRONIC BP APPARATUS AND THE MANUAL SPHYGMOMANOMETER

HOW CONSISTENT ARE THE BLOOD PRESSURE AND PULSE RATE MEASUREMENTS OF THE ELECTRONIC BP APPARATUS AND THE MANUAL SPHYGMOMANOMETER HOW CONSISTENT ARE THE BLOOD PRESSURE AND PULSE RATE MEASUREMENTS OF THE ELECTRONIC BP APPARATUS AND THE MANUAL SPHYGMOMANOMETER Naser KA. Teaching Hospital Peradeniya, Peradeniya, Sri Lanka Zawahir S

More information

Depression in Peripheral Artery Disease: An important Predictor of Outcome. Goals. Goals. Marlene Grenon, MD Assistant Professor of Surgery, UCSF

Depression in Peripheral Artery Disease: An important Predictor of Outcome. Goals. Goals. Marlene Grenon, MD Assistant Professor of Surgery, UCSF Depression in Peripheral Artery Disease: An important Predictor of Outcome There are no conflicts of interest Marlene Grenon, MD Assistant Professor of Surgery, UCSF UCSF VASCULAR SURGERY SYMPOSIUM SAN

More information

Hypertension and the SPRINT Trial: Is Lower Better

Hypertension and the SPRINT Trial: Is Lower Better Hypertension and the SPRINT Trial: Is Lower Better 8th Annual Orange County Symposium on Cardiovascular Disease Prevention Saturday, October 8, 2016 Keith C. Norris, MD, PhD, FASN Professor of Medicine,

More information

The State of Play of Diabetes Indicators

The State of Play of Diabetes Indicators The State of Play of Diabetes Indicators South Australian and National Information Catherine Chittleborough Janet Grant Anne Taylor April 2003 Diabetes Clearing House Population Research and Outcome Studies

More information

Diabetes and Cardiovascular Risk Management Denise M. Kolanczyk, PharmD, BCPS-AQ Cardiology

Diabetes and Cardiovascular Risk Management Denise M. Kolanczyk, PharmD, BCPS-AQ Cardiology Diabetes and Cardiovascular Risk Management Denise M. Kolanczyk, PharmD, BCPS-AQ Cardiology Disclosures In compliance with the accrediting board policies, the American Diabetes Association requires the

More information

The JUPITER trial: What does it tell us? Alice Y.Y. Cheng, MD, FRCPC January 24, 2009

The JUPITER trial: What does it tell us? Alice Y.Y. Cheng, MD, FRCPC January 24, 2009 The JUPITER trial: What does it tell us? Alice Y.Y. Cheng, MD, FRCPC January 24, 2009 Learning Objectives 1. Understand the role of statin therapy in the primary and secondary prevention of stroke 2. Explain

More information

Supplementary Appendix

Supplementary Appendix Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Wanner C, Inzucchi SE, Lachin JM, et al. Empagliflozin and

More information