1/27/ New Release, Quest Diagnostics Nichols Institute, Valencia

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1 NEW TESTS Please Note: Not all test codes assigned to each assay are listed in the table of contents. Please refer to the complete listing on the page numbers indicated. Test Code Test Name Effective Date Page # Drug Toxicology Amphetamines, Quantitative, Oral Fluid 2/17/ Drug Toxicology Barbiturates, Quantitative, Oral Fluid 2/17/ Drug Toxicology Benzodiazepines, Quantitative, Oral Fluid 2/17/ Drug Toxicology Cocaine, Quantitative, Oral Fluid 2/17/ Drug Toxicology Marijuana, Quantitative, Oral Fluid 2/17/ Drug Toxicology MDMA, Quantitative, Oral Fluid 2/17/ Drug Toxicology Meprobamate, Quantitative, Oral Fluid 2/17/ Drug Toxicology Methadone, Quantitative, Oral Fluid 2/17/ Drug Toxicology Monitoring 1, Quantitative, Oral Fluid 2/17/ Drug Toxicology Nicotine, Quantitative, Oral Fluid 2/17/ Drug Toxicology Opioids, Quantitative, Oral Fluid 2/17/ Drug Toxicology PCP, Quantitative, Oral Fluid 2/17/ Drug Toxicology Zolpidem, Quantitative, Oral Fluid 2/17/ New Test Offerings The following tests will be available through Quest Diagnostics on the dates indicated below. Drug Toxicology Amphetamines, Quantitative, Oral Fluid Clinical Significance Oral fluid is composed of saliva, mixed with buccal and mucosal transudates, cellular debris, bacteria, and residue of ingested products. Oral fluid as a test matrix shows promise for detection of recent drug use, and a significant body of scientific literature documents aspects such as drug disposition and detection times. Researchers comparing the effectiveness of oral fluid testing with urine drug testing found a similar pattern and frequency of positive drug test results in the general workforce over the same general period. Similarly in pain clinics, the pattern of licit and illicit drugs and metabolites observed in oral fluid paralleled results reported for urine, with some minor differences in detection rates for different drug classes. In some cases, oral fluid testing may be an acceptable alternative or the only available matrix. As an ultra-filtrate of blood, however, it shares the limitations of a decreased window of detection versus conventional urine drug testing. Test Code CPT Codes : 7 days Page 1 of 14 The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.

2 Amphetamines Class Not applicable Not applicable Amphetamine 10 ng/ml Methamphetamine 10 ng/ml Amphetamines Class Amphetamine ng/ml Methamphetamine ng/ml Drug Toxicology Barbiturates, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Barbiturates Class Not applicable Not applicable Amobarbital 10 ng/ml Butalbital 10 ng/ml Pentobarbital 10 ng/ml Phenobarbital 10 ng/ml Secobarbital 10 ng/ml Barbiturates Class Page 2 of 14

3 Amobarbital ng/ml Butalbital ng/ml Pentobarbital ng/ml Phenobarbital ng/ml Secobarbital ng/ml Drug Toxicology Benzodiazepines, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Benzodiazepines Class Not applicable Not applicable Alprazolam 0.50 ng/ml Chlordiazepoxide 0.50 ng/ml Clonazepam 0.50 ng/ml Diazepam 0.50 ng/ml Flunitrazepam 0.50 ng/ml Flurazepam 0.50 ng/ml Lorazepam 0.50 ng/ml Midazolam 0.50 ng/ml Nordiazepam 0.50 ng/ml Oxazepam 0.50 ng/ml Temazepam 0.50 ng/ml Triazolam 0.50 ng/ml Benzodiazepines Class Page 3 of 14

4 Alprazolam ng/ml Chlordiazepoxide ng/ml Clonazepam ng/ml Diazepam ng/ml Flunitrazepam ng/ml Flurazepam ng/ml Lorazepam ng/ml Midazolam ng/ml Nordiazepam ng/ml Oxazepam ng/ml Temazepam ng/ml Triazolam ng/ml Drug Toxicology Cocaine, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Cocaine Class Not applicable Not applicable Benzoylecgonine 2.5 ng/ml Cocaine 2.5 ng/ml Cocaine Class Benzoylecgonine ng/ml Cocaine ng/ml Page 4 of 14

5 Drug Toxicology Marijuana, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Marijuana Class Not applicable Not applicable THC 2.5 ng/ml Marijuana Class THC ng/ml Drug Toxicology MDMA, Quantitative, Oral Fluid Test Code CPT Codes : 7 days MDMA Class Not applicable Not applicable MDMA 10 ng/ml Page 5 of 14

6 MDMA Class MDMA ng/ml Drug Toxicology Meprobamate, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Meprobamate Class Not applicable Not applicable Carisoprodol 2.5 ng/ml Meprobamate 2.5 ng/ml Meprobamate Class Carisoprodol ng/ml Meprobamate ng/ml Drug Toxicology Methadone, Quantitative, Oral Fluid Test Code CPT Codes Page 6 of 14

7 : 7 days Methadone Class Not applicable Not applicable EDDP 5.0 ng/ml Methadone 5.0 ng/ml Methadone Class EDDP ng/ml Methadone ng/ml Drug Toxicology Monitoring 1, Quantitative, Oral Fluid Test Code CPT Codes (x2), 82520, 82205, 80154, 83887, (x2), 83925, 83840, 83992, : 7 days : Amphetamines Class Not applicable Not applicable Amphetamines 10 ng/ml Methamphetamine 10 ng/ml Barbiturates Class Not applicable Not applicable Amobarbital 10 ng/ml Butalbital 10 ng/ml Pentobarbital 10 ng/ml Page 7 of 14

8 Phenobarbital 10 ng/ml Secobarbital 10 ng/ml Benzodiazepines Class Not applicable Not applicable Alprazolam 0.50 ng/ml Chlordiazepoxide 0.50 ng/ml Clonazepam 0.50 ng/ml Diazepam 0.50 ng/ml Flunitrazepam 0.50 ng/ml Flurazepam 0.50 ng/ml Lorazepam 0.50 ng/ml Midazolam 0.50 ng/ml Nordiazepam 0.50 ng/ml Oxazepam 0.50 ng/ml Temazepam 0.50 ng/ml Triazolam 0.50 ng/ml Cocaine Class Not applicable Not applicable Benzoylecgonine 2.5 ng/ml Cocaine 2.5 ng/ml Nicotine Class Not applicable Not applicable Cotinine 5.0 ng/ml Marijuana Class Not applicable Not applicable THC 2.5 ng/ml Meprobamate Class Not applicable Not applicable Carisoprodol 2.5 ng/ml Meprobamate 2.5 ng/ml Methadone Class Not applicable Not applicable EDDP 5.0 ng/ml Methadone 5.0 ng/ml MDMA Class Not applicable Not applicable MDMA 10 ng/ml Opioids Class Not applicable ng/ml Buprenorphine ng/ml Codeine 2.5 ng/ml Dihydrocodeine 2.5 ng/ml Fentanyl 0.10 ng/ml Heroin Metabolite 1.0 ng/ml Page 8 of 14

9 Hydrocodone 2.5 ng/ml Hydromorphone 2.5 ng/ml Meperidine 5.0 ng/ml Morphine 2.5 ng/ml Norbuprenorphine 0.25 ng/ml Norhydrocodone 2.5 ng/ml Noroxycodone 2.5 ng/ml Oxycodone 2.5 ng/ml Oxymorphone 2.5 ng/ml Propoxyphene 5.0 ng/ml Tapentadol 5.0 ng/ml Tramadol 5.0 ng/ml Phencyclidine Class Not applicable Not applicable Phencyclidine 10 ng/ml Zolpidem Class Not applicable Not applicable Zolpidem 5.0 ng/ml Liquid Chromatography-Tandem Mass Spectrometry (Q-Trap) Amphetamines Class Amphetamines ng/ml Methamphetamine ng/ml Barbiturates Class Amobarbital ng/ml Butalbital ng/ml Pentobarbital ng/ml Phenobarbital ng/ml Secobarbital ng/ml Benzodiazepines Class Alprazolam ng/ml Chlordiazepoxide ng/ml Clonazepam ng/ml Diazepam ng/ml Flunitrazepam ng/ml Flurazepam ng/ml Page 9 of 14

10 Lorazepam ng/ml Midazolam ng/ml Nordiazepam ng/ml Oxazepam ng/ml Temazepam ng/ml Triazolam ng/ml Cocaine Class Benzoylecgonine ng/ml Cocaine ng/ml Marijuana Class THC ng/ml Meprobamate Class Carisoprodol ng/ml Meprobamate ng/ml Methadone Class EDDP ng/ml Methadone ng/ml MDMA Class MDMA ng/ml Nicotine Class Cotinine ng/ml Opioids Class Buprenorphine ng/ml Codeine ng/ml Dihydrocodeine ng/ml Fentanyl ng/ml Heroin Metabolite ng/ml Hydrocodone ng/ml Hydromorphone ng/ml Meperidine ng/ml Morphine ng/ml Norbuprenorphine ng/ml Norhydrocodone ng/ml Noroxycodone ng/ml Oxycodone ng/ml Oxymorphone ng/ml Page 10 of 14

11 Propoxyphene ng/ml Tapentadol ng/ml Tramadol ng/ml Phencyclidine Class Phencyclidine ng/ml Zolpidem Class Zolpidem ng/ml Drug Toxicology Nicotine, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Result Name Nicotine Class Not applicable Not applicable Cotinine 5.0 ng/ml Nicotine Class Cotinine ng/ml Drug Toxicology Opioids, Quantitative, Oral Fluid Test Code CPT Codes Page 11 of 14

12 : 7 days Opioids Class Not applicable Not applicable Buprenorphine ng/ml Codeine 2.5 ng/ml Dihydrocodeine 2.5 ng/ml Fentanyl 0.10 ng/ml Heroin Metabolite 1.0 ng/ml Hydrocodone 2.5 ng/ml Hydromorphone 2.5 ng/ml Meperidine 5.0 ng/ml Morphine 2.5 ng/ml Norbuprenorphine 0.25 ng/ml Norhydrocodone 2.5 ng/ml Noroxycodone 2.5 ng/ml Oxycodone 2.5 ng/ml Oxymorphone 2.5 ng/ml Propoxyphene 5.0 ng/ml Tapentadol 5.0 ng/ml Tramadol 5.0 ng/ml Opioids Class Buprenorphine ng/ml Codeine ng/ml Dihydrocodeine ng/ml Fentanyl ng/ml Heroin Metabolite ng/ml Hydrocodone ng/ml Hydromorphone ng/ml Page 12 of 14

13 Meperidine ng/ml Morphine ng/ml Norbuprenorphine ng/ml Norhydrocodone ng/ml Noroxycodone ng/ml Oxycodone ng/ml Oxymorphone ng/ml Propoxyphene ng/ml Tapentadol ng/ml Tramadol ng/ml Drug Toxicology PCP, Quantitative, Oral Fluid Test Code CPT Codes : 7 days Phencyclidine Class Not applicable Not applicable Phencyclidine 10 ng/ml Phencyclidine Class Phencyclidine ng/ml Drug Toxicology Zolpidem, Quantitative, Oral Fluid Test Code CPT Codes Page 13 of 14

14 : 7 days Zolpidem Class Not applicable Not applicable Zolpidem 5.0 ng/ml Zolpidem Class Zolpidem ng/ml Page 14 of 14 Quest, Quest Diagnostics, the associated logo, Nichols Institute and all associated Quest Diagnostics marks are the trademarks of Quest Diagnostics Quest Diagnostics Incorporated. All rights reserved.