4. A homozygous tall plant and a heterozygous tall plant are crossed. What is the percent probability of short offspring?

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1 LEVEL ZERO VOICE POP QUIZ (4 minutes, individual work): 1. Define gene: 2. Define phenotype: 3. A heterozygous white rabbit is crossed with a homozygous black rabbit. If they have 160 offspring, how many will be white? 4. A homozygous tall plant and a heterozygous tall plant are crossed. What is the percent probability of short offspring? Of heterozygous

2 LEVEL ZERO VOICE POP QUIZ (4 minutes, individual work): 1. In the image shown, G/g represents the gene for the protein lactase. A "G" indicates an allele that causes continual production of lactase. A "g" indicates an allele that causes lactase to be produced only infants, not adults. Lactase tolerance is a dominant inherited trait. What is the genotype of "A" (case sensitive): 2. Which of the genotypes that would be in the letters below are homozygous? Select all that apply. 3. What are the chances that an offspring will be lactose intolerant? 4. These two people who are mating decide to have a lot of babies. They have 120 babies!!! How many do you expect to be: Lactase persistent (write number here): Lactase nonpersistent (write number here):

3 Assignment #11 Genetic Counseling Case Study LO: To create a genetic disorder report for a case study. EQ: How can we use genetics to solve problems? (Cl.Ev.Re) AGENDA 12/1-12/2 1. Case Studies 2. Genetic Disorder Report HOMEWORK 1. Synthesis (till next Wed) 2. Songebob Wksht (Wed) LEVEL ZERO VOICE CATALYST (4 minutes, individual work): 1. Define gene. 2. Define phenotype. 3. In humans, the ability to roll the tongue is a dominant trait. The inability to roll the tongue is a recessive trait. If two individuals homozygous recessive for this trait have a child, what is the chance that the child will be able to roll his tongue? 4. The Punnett square above shows a genetic cross between two tall pea plants. (Phenotype is tall, Genotype is heterozygous Tt). If 75% of the offspring are tall, what type of inheritance occurred?

4 What is a case study? A case study is about a person, group, or situation that has been studied over time. [1] If the case study, for instance, is about a group it describes the behavior of the group as a whole, not the behavior of each individual in the group. Case studies can be produced by following a formal research method.

5 Sickle Cell Anemia genetic basis

6 Cystic Fibrosis genetic basis

7 Task 1 10 min Choose a disorder/case study to take on as a genetic counselor Patient Files Each group must do both families, choose who will do what family Jackson family sickle cell anemia Doherty family cystic fibrosis Take notes on your family using ¼ of your notes.

8 Close your laptops and pile them up in the corner of your desks.

9 10 min create a pedigree Focus Question: What do genetic counselors do? Create a pedigree of your family. Predict the inheritance pattern of the disorder Sex-linked, autosomal dominant, autosomal recessive, codominant, incomplete dominance, polygenic Use information from your pedigree as evidence to justify your prediction Create rough draft in NOTES side

10 Jackson A and Jackson B Doherty A and Doherty B Groups meet

11 15 min Genetic Disorder Report Individual Task: Using family history and research on a genetic disorder, write a genetic counseling report for a family. 1. Conduct research on your disorder 2. Genetics, inheritance, and pathology of the disorder Task Criteria: Your report must... Explain the genetic basis of the disease Explain the pathology and symptoms of the disease Include at least 2 figures to support explanation of the disease Explain how the trait is inherited Include and explain the family Pedigree Include and explain a Punnett Square for disease inheritance Include recommendations for the family Cite resources

12 Example Report

13 Example Report

14 Example Report

15 Example Report

16 15 min Genetic Disorder Report Individual Task: Using family history and research on a genetic disorder, write a genetic counseling report for a family. 1. Conduct research on your disorder 2. Genetics, inheritance, and pathology of the disorder Task Criteria: Your report must... Explain the genetic basis of the disease Explain the pathology and symptoms of the disease Include at least 2 figures to support explanation of the disease Explain how the trait is inherited Include and explain the family Pedigree Include and explain a Punnett Square for disease inheritance Include recommendations for the family Cite resources

17 Assignment #11 Genetic Counseling Case Study LO: To create a genetic disorder report for a case study. EQ: How can we use genetics to solve problems? (Cl.Ev.Re) AGENDA 12/1-12/2 1. Case Studies 2. Genetic Disorder Report HOMEWORK 1. Synthesis (till next Wed) 2. Songebob Wksht (Wed) LEVEL ZERO VOICE PROCESSING TASK (15 minutes, individual work): Choose your own processing task that explains what genetic counselors do in detail (use what you have learned from day 1 and your report)

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