Environmental exposure and health impacts of highly fluorinated chemicals

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1 Environmental exposure and health impacts of highly fluorinated chemicals Christopher Lau National Health and Environmental Effects Research Laboratory Andrew B. Lindstrom National Exposure Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park, North Carolina Disclaimer: Content of this presentation does not reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

2 What are Per- and Polyfluoroalkyl Substances (PFAS)? Synthetic, stable, non-reactive chemicals produced in the last 60+ years Chemical structures resemble fatty acids Their hydrophobic and oleophobic properties make them ideal surfactants (water and oil resistant) Many PFAS are extraordinarily persistent in the environment cannot be broken down by natural systems or metabolized in the body PFAS are detected in all environmental media air, water, soil, sludge These chemicals are distributed globally via air and water movement high levels detected in urban areas but also reach remote areas Many PFAS are readily detected in humans and wildlife Like other persistent organic pollutants, many PFAS bioaccumulate in animals at the top of the food chain birds, fish, livestock, and humans The most commercially useful PFAAs are the 8-carbon (C8) chemicals: Perfluorooctane Sulfonate (PFOS), Perfluorooctanoic Acid (PFOA) Recent replacement products with C4 and C6 chemicals: Perfluorobutane Sulfonate (PFBS), Perfluorohexanoic Acid (PFHxA) but many more structurally similar products (~4,000) are in the pipeline

3 PFAS are used in many consumer/industrial products Textile treatments Paints De-foaming agents Floor/Ski Denture cleaner Polymers Adhesives Lubricant additive Paper coatings Surfactants Fire-fighting foam Photographic film Mining fluids Non-stick cookware Caulks Carpets

4 Sources of PFAS exposure for humans Best documented source is contaminated drinking water near industrial production facilities or waste disposal e.g., Cottage Grove, MN; Parkersburg, WV; Dalton, GA; Decatur, AL, Paulsboro, NJ, Hooksick Fall, NY; Arnsberg, Germany; Osaka, Japan In the general population, food is considered a primary source, especially fish from contaminated waters, items contaminated by food packaging, and breast milk; followed by drinking water House dust may also be an important route of exposure especially for children who ingest relatively higher levels of dust via hand-to-mouth activity Workplace exposures are significant for some sectors: manufacturing and waste treatment, or services using PFAS

5 PFAS Health Effects Summary These chemicals not only persist in the environment, but also inside the body once ingested, particularly in humans Serum half-life PFBS (C4) PFHxS (C6) PFOS (C8) PFBA (C4) PFHxA (C4) PFOA (C6) PFNA (C9) Mouse 5 hours 30 days 40 days 12 hours 2 hours 20 days 60 days Humans 28 days 8.5 years 4-5 years 3 days 32 days 3-4 years unknown Some of these chemicals are more potent than the others, but all of them have the similar effects PFBA (C4) PFPeA (C5) PFHxA (C6) PFHpA (C7) PFOA (C8) PFNA (C9) PFDA (C10) Mouse Humans Laboratory results suggest that PFAS effects are additive

6 Profiles of PFAS Toxicity and Adverse Health Effects Liver and Metabolic toxicity Mouse: enlarged and fatty liver, decreased serum cholesterol, triglycerides Humans: increased serum cholesterol, uric acid Reproductive and Developmental Toxicity Mouse: neonatal mortality, low birth weight, growth deficits, developmental delays Humans: preeclampsia, low birth weight and small size, delayed onset of puberty Tumor Induction Mouse: liver, pancreas and testes Humans: kidney and testes Immunotoxicity Mouse: atrophy of thymus and spleen, suppressed immune responses Humans: reduced immune responses to vaccines in children Endocrine Disruption Mouse: reduced serum thyroid hormones Humans: slight elevation of serum thyroid hormones Neurotoxicity Mouse: a few reports of neuronal deficits and behavioral abnormalities Humans: some reports of learning disability

7 US EPA Regulatory Efforts Agreements with manufacturers to phase out PFOS and PFOA production in the US Health Advisory levels set for PFOA and PFOS in drinking water Unregulated contaminant monitoring rule (UCMR3) program national survey of PFAS in delivered drinking water TSCA provides authority to ban or restrict the manufacture, processing, use and importation of products containing long-chain PFAS International Regulatory Efforts European Food Safety Authority (EFSA) established provisional tolerable daily intake values for selected PFAS in food PFOS-related compounds were included in the Stockholm Convention on Persistent Organic Pollutants International Agency for Research on Cancer (IARC) classified PFOA as possibly carcinogenic to humans Long-chain PFAS listed on the REACH Candidate List of Substances of Very High Concern (SVHC)

8 Future Perspectives PFOS levels in general population dropped by ~80% in 12 years since termination of production in U.S., and PFOA by ~50% in 6 years since reduction of emission actions lead to results Demand for PFAS performance chemicals increasing with a shift in production of legacy materials elsewhere (e.g., China, Russia) New generation of replacement PFAS now being produced in the industrialized world, but their identity and health effects are relatively unknown. Environmental and health effects research on replacement PFAS now underway preliminary results suggest similarities to legacy compounds New research on human exposure of PFAS and their adverse health effects, as well as their ecological impacts will support risk assessment and regulatory decisions Risk assessment of PFAS must consider the entire class of chemicals Biomonitoring studies will inform the trends of change in the future regarding new and legacy chemicals

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