Frontal Lobe Functions. Pivotal Case: Phineas Gage. What did change? What did we learn from this? Fredric E. Rose, Ph.D. Winter /13/1848

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1 Frontal Lobe Functions Fredric E. Rose, Ph.D. Winter /13/1848 Pivotal Case: Phineas Gage 25 yo construction foreman for Rutland and Burlington RR in New England Used a tamping iron to fill holes in stones with sand over explosive powder in order to level the terrain Once forgot to put in sand What did change? What did we learn from this? Pre-accident personality Responsible, intelligent, honest, well-liked by peers and elders, the most efficient and capable man according to employers Post-accident personality Disinhibited, irreverent, capricious, disrespectful of social conventions, unable to hold a job Equipotentiality v. Localization of Function Harlow (1868): some portion of the brain that was removed by the tamping rod was responsible for the restraint and well-mannered behavior that most people possess, and that Gage lost in the accident. 1

2 Gage Revisited (Science,1994) Damasio & Damasio Computer graphics to plot trajectory Ventromedial OFC region, sparing of Broca s and other FL motor regions Region is responsible for decision-making regarding personal and social matters,as well as emotion processing Anatomy of the Frontal Lobes 3 prefrontal regions: Dorsolateral Orbitofrontal Mesial Frontal Lobe Circuitry Alexander, DeLong, & Strick (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, Oculomotor Motor Dorsolateral Orbitofrontal Anterior Cingulate 2

3 Neurotransmitters Glutamate (corticostriatal, thalamocortical) GABA (basal ganglia) Dopamine (cortical, subcortical) Modulates all 3 circuits Acetylcholine (striatal) Open circuit influence) Serotonin (cortical, subcortical) Core Frontal Circuitry Frontal Cortex Glutamate (+) Thalamus Glutamate (+) Striatum GABA (-) GABA (-) Internal External Globus Pallidus Glutamate (+) GABA (-) Subthalamic Feifel (1999) Dorsolateral Circuit Functions Subserves executive function Behavioral responses to complex problems Activation of remote memories Environmental independence Shifting/maintaining cognitive sets Generating motor programs Verbal mediation of behavior 3

4 Executive Functions Planning Decision making Self-directed goal selection Monitoring, guiding, and directing behavior to achieve a goal Dorsolateral Circuit Dysfunction Poor organizational behavior Poor memory search strategies Environmental dependency Poor set shifting (perseveration) Verbal/manual dissociations Orbitofrontal Circuit Functions 2 parallel circuits: Lateral and Medial Personality Characteristics Empathy Civility Social appropriateness Environmental independence Emotional continence 4

5 Orbitofrontal Circuit Dysfunction Personality Changes Tactlessness Impulsivity Irritability Antisocial behavior Utilization/imitation behavior Mood disorders Obsessive-Compulsive disorder Orbitofrontal Syndrome Emotional lability (mood swings) Disinhibition Criminal behavior Unusual/impulsive sexual behavior Often lack awareness Anosmia Environmental Dependency Pseudopsychopathic Anterior Cingulate Functions Motivated Behavior Drive Spontaneity Personhood Creativity 5

6 Akinetic mutism Indifference to pain Apathy Poverty of speech Psychic emptiness Anterior Cingulate Dysfunction Excessive conformity Poor response inhibition Personality Changes Impairments in social skills inappropriate or bizarre social behavior loosening" of normal social restraints Change in motivation apathy, withdrawal, lack of interest, and initiative Pseudodepression / pseudoretarded Summary of Personality/Behavioral Symptoms POSITIVE Disinhibition Impulsivity Vulgarity Irritability Emotional lability Inappropriate laughter, crying Bizarre behavior NEGATIVE Apathy uced initiative (Abulia) uced interest in daily activities/selfcare Akinetic mutism Social withdrawal 6

7 Personality/Behavioral Assessment Observation Impulsive, disinhibited, environmentally dependent Questionnaires Self-report Caregiver/family member Interviews Patient Family Secondary Motor Cortex Supplementary Motor Area Sequencing, timing, and proper initiation of voluntary movements. PET studies Specific vs random motor sequence magining this movement. Injury disorder of motor planning, organization, and initiation Secondary Motor Cortex (cont.) Premotor Area Sequencing, timing, and proper initiation of voluntary movements. BUT more in external cue readiness, such as the interval between CUE and GO. Cingulate Motor Area Emotional or motivational impetus for movement (when reward is involved) Injury lack of spontaneous motor activity, reduced speech output 7

8 Measures of SMC Functioning Written Alternating Sequences Perseveration: the inability to stop behaviors once they have started Motor Impersistence: a form of distractibility in which patients only briefly sustain a motor action in response to a command such as "Raise your arms" or "Look to the right." Measures of SMC Functioning (cont.) Luria 3-Step Fist, Edge, Palm Go-No Go (also Orbital-PFC disinhibition) Multiple Loops 8

9 Apraxia Inability to execute purposeful, complex motor acts, despite physical ability, comprehension, and willingness. Ideomotor Apraxia: Gestures to command Motor representations in Parietal Lobe, but Premotor Cortex (including SMA) translates into movements Frontal Release Signs FL lesions (nonlocalized; dementia) can produce a return of primitive reflexes: Grasp Sucking/ Snout Groping Utilization behavior 9

10 Summary of Motor Symptoms of FL Disorder Poor motor sequencing Poor initiation of movements Dysarthria Apraxia Frontal release signs Assessing Executive Functions Anatomy of the Frontal Lobes 3 prefrontal regions: Dorsolateral Orbitofrontal Mesial 10

11 Divide these 6 stimuli into 2 groups based on a shared characteristic. Now do it again based on another shared characteristic. Stroop Color-Word Test Stroop Color-Word Test 11

12 Stroop Color-Word Test Wisconsin Card Sorting Test Deck of cards with different stimuli on each Patient sorts the deck into 4 piles according to key cards Told only if right or wrong on each sort Letter Fluency Sec C F L 0 Cat F*ck! Lips Car Lever 15 Fudge Catch Fever List 30 Catching Fudge Lemon Caterpillar Fudge 45 Fever 60 Crayon Cabbage Fiddle Flower SPEED FACTORS -poor initiation -poor maintenance 12

13 C Trail Making Test A F G E B A D H A Trail Making Test B D B C Rey-Osterrieth Complex Figure copy 13

14 So, what are Executive Functions? Generate a list and identify the theme. Planning Organizing Selective attention Problem-solving Initiating Inhibiting Self-monitoring Abstract thinking Mental flexibility What s the common thread? Executive functions are complex functions that allow one to engage in effective and efficient goal-directed behavior. FL Memory Functions Working Memory Retrieval Source Memory Working Memory Serial 7 s Put this in order with letters first, then numbers: L-4-C-2-M-8. Spell WORLD backwards. What does these have in common? Define working memory. What are the 2 main components? an active system for temporarily storing and manipulating information needed in the execution of complex cognitive tasks 14

15 Working Memory (pp ) Baddeley (1986): WM has 3 components Central executive Articulatory phonological loop Visual-spatial sketch pad Goldman-Rakic (1988) Dorsolateral prefrontal cortex holds information on line while it is processed (monkey research). Confirmed by PET and fmri Paced Auditory Serial Addition Task (PASAT) TIME EXAMINER PATIENT Phonological Loop or Visual-spatial Sketchpad N-back c X Q Time q 0-Back target N A 1-Back target n C 2-Back target Phonological Loop or Visual-spatial Sketchpad 15

16 Spatial Span Task Phonological Loop or Visual-spatial Sketchpad 16

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