THREATS TO VALIDITY. Presentation by: Raul Sanchez de la Sierra
|
|
- Phoebe Boone
- 6 years ago
- Views:
Transcription
1 THREATS TO VALIDITY Presentation by: Raul Sanchez de la Sierra
2 What I want you to avoid
3 Captain, sorry, I forgot the spillovers!
4
5 Lecture Overview External Validity Attrition Spillovers Partial Compliance Fishing for results
6 Lecture Overview External Validity Attrition Spillovers Partial Compliance Fishing for results
7 Threat to External Validity: Are these results applicable in a different context?
8 Generalizability of Results Depend: Sample: is it representative? Sensitivity: would a similar, but slightly different program, have same impact?
9 Lecture Overview External Validity Attrition Spillovers Partial Compliance Fishing for results
10 Attrition: the problem Is it a problem if some of the people in the experiment vanish before you collect your data? How about if mostly the treated people disappear? Why is it a problem? Should we expect this to happen?
11 Attrition: the problem April 06/07 Tests Tests Aug 05 Pay for performance Initial Test Fixed wage Jun 05 11
12 Attrition: the problem School nutrition program What if only children > 21 Kg come to school? A. Will you underestimate the impact? B. Will you overestimate the impact? C. Neither D. Ambiguous E. Don t know
13 Before Treatment After Treament T C T C Ave Difference 0 Difference 2
14 Before Treatment After Treament T C T C [absent] [absent] 22 [absent] Ave Difference 0 Difference -0.5
15 Attrition Bias: are we hopeless? There are solutions!
16 Attrition Bias: Solutions Implementation: Track participants Analysis: Check attrition by treatment status Check attrition by observables Bound the bias Suppose that dropped participants are extremes
17 Bound the bias: example April 06/07 Tests Tests Aug 05 Pay for performance Initial Test Fixed wage Jun 05 17
18 Lecture Overview External Validity Attrition Spillovers Partial Compliance Fishing for results
19 Spillovers: the problem Not in evaluation Total Population Target Population Evaluation Sample Random Assignment Treatment Group Control Group
20 Spillovers: the problem Not in evaluation Total Population Target Population Treatment à Evaluation Sample Random Assignment Treatment Group Control Group
21 Spillovers: the problem Not in evaluation Total Population Target Population Treatment à Evaluation Sample Random Assignment Treatment Group Control Group
22 Spatial spillovers example
23 Information spillovers example
24 Spillovers: the problem Example: Suppose you randomize vaccinations within schools What problems does this create for evaluation? How can we measure total impact?
25 Vaccines in school A:
26 No vaccines in school B:
27 Spillovers: the solution Design What unit of randomization? Design the randomization to estimate spillovers
28 Spillovers: designed based solution
29 Lecture Overview External Validity Attrition Spillovers Partial Compliance Fishing for results
30 Non Compliers: the problem Not in evaluation What can you do? Can you switch them? Target Population No! Evaluation Sample Random Assignment Treatment group Control group Participants No-Shows Non- Participants Cross-overs
31 Non Compliers : the problem Not in evaluation What can you do? Can you drop them? Target Population No! Evaluation Sample Random Assignment Treatment group Control group Participants No-Shows Non- Participants Cross-overs
32 Non Compliers : the solution Target Population Not in evaluation You can compare the original groups Evaluation Sample Random Assignment Treatment group Control group Participants No-Shows Non- Participants Cross-overs
33 Intention to Treat (ITT) Intention to Treat What happened to the average child who is in a treated school in this population? What does this measure mean?
34 When is ITT Useful? Impact of a vaccination program vs. Impact of a vaccination Which one is relevant to you?
35 Non Compliers: a general problem Movement across groups Example: School feeding program. Parents could attempt to move their children from comparison school to treatment school
36 Non Compliers: a better solution Always takers Never takers Compliers Defiers
37 Never takers TREAT! NOT TREAT!
38 Always takers TREAT! NOT TREAT!
39 Compliers TREAT! NOT TREAT!
40 Defiers TREAT! NOT TREAT!
41 Non Compliers: a better solution TREAT! NOT TREAT! TAKE PILL NOT TAKE PILL
42 Non Compliers: a better solution TREAT! NOT TREAT! TAKE PILL Compliers, Always takers NOT TAKE PILL
43 Non Compliers: a better solution TAKE PILL NOT TAKE PILL TREAT! Compliers, Always takers Never takers, Defiers NOT TREAT!
44 Non Compliers: a better solution TAKE PILL NOT TAKE PILL TREAT! Compliers, Always takers Never takers, Defiers NOT TREAT! Never takers, Defiers
45 Non Compliers: a better solution TAKE PILL NOT TAKE PILL TREAT! Compliers, Always takers Never takers, Defiers NOT TREAT! Never takers, Defiers Compliers, Never takers
46 Non Compliers: a better solution If there are no defiers: We can estimate perfectly the impact of the project among the compliers.
47 From ITT to LATE Local Average Treatment Effect (LATE) Local: only for those who obey the treatment (compliers) What is the impact of the vaccine amongst people who would take it if told to, and not if not told to? Is this population relevant? 47
48 Lecture Overview External Validity Attrition Spillovers Partial Compliance Fishing for results
49 Fishing for results: the problem Let s just measure everything: something may improve Problem: The more outcomes you look at, the higher the chance you find at least one significantly affected by the program
50 Fishing for results: the solution Solution: Pre-specify outcomes of interest Report results on all measured outcomes, even null results Correct statistical tests (Bonferroni)
51 Theory of Change GOOD EVALUATIONS! Pay for performance Matatus How to randomize Spillovers Why randomize Power And if you have any doubt: Call us! Sample
Threats and Analysis. Shawn Cole. Harvard Business School
Threats and Analysis Shawn Cole Harvard Business School Course Overview 1. What is Evaluation? 2. Outcomes, Impact, and Indicators 3. Why Randomize? 4. How to Randomize? 5. Sampling and Sample Size 6.
More informationWhat can go wrong.and how to fix it!
What can go wrong.and how to fix it! Megha Pradhan Policy and Training Manager, J-PAL South Asia Kathmandu, Nepal 29 March 2017 Introduction Conception phase is important and allows to design an evaluation
More informationThreats and Analysis. Bruno Crépon J-PAL
Threats and Analysis Bruno Crépon J-PAL Course Overview 1. What is Evaluation? 2. Outcomes, Impact, and Indicators 3. Why Randomize and Common Critiques 4. How to Randomize 5. Sampling and Sample Size
More informationGlossary From Running Randomized Evaluations: A Practical Guide, by Rachel Glennerster and Kudzai Takavarasha
Glossary From Running Randomized Evaluations: A Practical Guide, by Rachel Glennerster and Kudzai Takavarasha attrition: When data are missing because we are unable to measure the outcomes of some of the
More informationGUIDE 4: COUNSELING THE UNEMPLOYED
GUIDE 4: COUNSELING THE UNEMPLOYED Addressing threats to experimental integrity This case study is based on Sample Attrition Bias in Randomized Experiments: A Tale of Two Surveys By Luc Behaghel, Bruno
More informationRandomized Experiments with Noncompliance. David Madigan
Randomized Experiments with Noncompliance David Madigan Introduction Noncompliance is an important problem in randomized experiments involving humans Includes e.g. switching subjects to standard therapy
More informationEvaluating Social Programs Course: Evaluation Glossary (Sources: 3ie and The World Bank)
Evaluating Social Programs Course: Evaluation Glossary (Sources: 3ie and The World Bank) Attribution The extent to which the observed change in outcome is the result of the intervention, having allowed
More informationTRANSLATING RESEARCH INTO ACTION
TRANSLATING RESEARCH INTO ACTION This case study is based on a current study by Esther Duflo and Tavneet Suri. J-PAL thanks the authors for allowing us to use their project 17 Key Vocabulary 1. Equivalence:
More informationWelcome to this series focused on sources of bias in epidemiologic studies. In this first module, I will provide a general overview of bias.
Welcome to this series focused on sources of bias in epidemiologic studies. In this first module, I will provide a general overview of bias. In the second module, we will focus on selection bias and in
More informationBrief introduction to instrumental variables. IV Workshop, Bristol, Miguel A. Hernán Department of Epidemiology Harvard School of Public Health
Brief introduction to instrumental variables IV Workshop, Bristol, 2008 Miguel A. Hernán Department of Epidemiology Harvard School of Public Health Goal: To consistently estimate the average causal effect
More informationMore on Experiments: Confounding and Obscuring Variables (Part 1) Dr. Stefanie Drew
1 More on Experiments: Confounding and Obscuring Variables (Part 1) Dr. Stefanie Drew stefanie.drew@csun.edu 2 Previously, On Research Methods Basic structure of an experiment Now in more detail Internal
More informationStatistical Power Sampling Design and sample Size Determination
Statistical Power Sampling Design and sample Size Determination Deo-Gracias HOUNDOLO Impact Evaluation Specialist dhoundolo@3ieimpact.org Outline 1. Sampling basics 2. What do evaluators do? 3. Statistical
More informationCritical Appraisal Istanbul 2011
Critical Appraisal Istanbul 2011 The Conviction with which many Nephrologists hold an opinion varies inversely with the Evidence Ed Lewis The Good Old Times. The Google Generation. ASN Kidney Daily LEADING
More informationBias. Zuber D. Mulla
Bias Zuber D. Mulla Explanations when you Observe or Don t Observe an Association Truth Chance Bias Confounding From Epidemiology in Medicine (Hennekens & Buring) Bias When you detect an association or
More informationComplier Average Causal Effect (CACE)
Complier Average Causal Effect (CACE) Booil Jo Stanford University Methodological Advancement Meeting Innovative Directions in Estimating Impact Office of Planning, Research & Evaluation Administration
More informationProgram Evaluations and Randomization. Lecture 5 HSE, Dagmara Celik Katreniak
Program Evaluations and Randomization Lecture 5 HSE, 10.11.2014 Dagmara Celik Katreniak Overview Treatment Effect under perfect conditions Average Treatment Effect Treatment effect under imperfect conditions
More information4/10/2018. Choosing a study design to answer a specific research question. Importance of study design. Types of study design. Types of study design
Choosing a study design to answer a specific research question Importance of study design Will determine how you collect, analyse and interpret your data Helps you decide what resources you need Impact
More informationCollecting Data Example: Does aspirin prevent heart attacks?
Collecting Data In an experiment, the researcher controls or manipulates the environment of the individuals. The intent of most experiments is to study the effect of changes in the explanatory variable
More informationCASE STUDY 4: DEWORMING IN KENYA
CASE STUDY 4: DEWORMING IN KENYA Addressing Threats to Experimental Integrity This case study is based on Edward Miguel and Michael Kremer, Worms: Identifying Impacts on Education and Health in the Presence
More informationPHP2500: Introduction to Biostatistics. Lecture III: Introduction to Probability
PHP2500: Introduction to Biostatistics Lecture III: Introduction to Probability 1 . 2 Example: 40% of adults aged 40-74 in Rhode Island have pre-diabetes, a condition that raises the risk of type 2 diabetes,
More informationSupporting children with anxiety
Supporting children with anxiety Healthy risk takers Nourishing Environment Effective Coping Strategies Effective Problem Solving Skills Healthy Thinking Habits RESILIENCE The capacity to cope and stay
More informationHYPOTHESIS TESTING 1/4/18. Hypothesis. Hypothesis. Potential hypotheses?
HYPOTHESIS TESTING Hypothesis A statement about the relationship between variables that makes a falsifiable prediction Relationship can be (as one variable changes, the other changes too) or (change in
More informationIntroduction to Program Evaluation
Introduction to Program Evaluation Nirav Mehta Assistant Professor Economics Department University of Western Ontario January 22, 2014 Mehta (UWO) Program Evaluation January 22, 2014 1 / 28 What is Program
More informationIn this chapter we discuss validity issues for quantitative research and for qualitative research.
Chapter 8 Validity of Research Results (Reminder: Don t forget to utilize the concept maps and study questions as you study this and the other chapters.) In this chapter we discuss validity issues for
More informationResearch Design. Miles Corak. Department of Economics The Graduate Center, City University of New York
Research Design The Advantages and Challenges of Randomized Controlled Trials Miles Corak Department of Economics The Graduate Center, City University of New York MilesCorak.com @MilesCorak Lecture 1 Labor
More informationBeyond the intention-to treat effect: Per-protocol effects in randomized trials
Beyond the intention-to treat effect: Per-protocol effects in randomized trials Miguel Hernán DEPARTMENTS OF EPIDEMIOLOGY AND BIOSTATISTICS Intention-to-treat analysis (estimator) estimates intention-to-treat
More informationCritical Appraisal. Dave Abbott Senior Medicines Information Pharmacist
Critical Appraisal Dave Abbott Senior Medicines Information Pharmacist Aims Identify key components of clinical trial design and apply these to a critical appraisal of the literature Be able to work out
More informationSTEP II Conceptualising a Research Design
STEP II Conceptualising a Research Design This operational step includes two chapters: Chapter 7: The research design Chapter 8: Selecting a study design CHAPTER 7 The Research Design In this chapter you
More informationVersion No. 7 Date: July Please send comments or suggestions on this glossary to
Impact Evaluation Glossary Version No. 7 Date: July 2012 Please send comments or suggestions on this glossary to 3ie@3ieimpact.org. Recommended citation: 3ie (2012) 3ie impact evaluation glossary. International
More informationResearch Questions, Variables, and Hypotheses: Part 2. Review. Hypotheses RCS /7/04. What are research questions? What are variables?
Research Questions, Variables, and Hypotheses: Part 2 RCS 6740 6/7/04 1 Review What are research questions? What are variables? Definition Function Measurement Scale 2 Hypotheses OK, now that we know how
More informationEXERCISE: HOW TO DO POWER CALCULATIONS IN OPTIMAL DESIGN SOFTWARE
...... EXERCISE: HOW TO DO POWER CALCULATIONS IN OPTIMAL DESIGN SOFTWARE TABLE OF CONTENTS 73TKey Vocabulary37T... 1 73TIntroduction37T... 73TUsing the Optimal Design Software37T... 73TEstimating Sample
More informationInstrumental Variables I (cont.)
Review Instrumental Variables Observational Studies Cross Sectional Regressions Omitted Variables, Reverse causation Randomized Control Trials Difference in Difference Time invariant omitted variables
More informationMidterm project due next Wednesday at 2 PM
Course Business Midterm project due next Wednesday at 2 PM Please submit on CourseWeb Next week s class: Discuss current use of mixed-effects models in the literature Short lecture on effect size & statistical
More informationGenetic Counselor: Hi Lisa. Hi Steve. Thanks for coming in today. The BART results came back and they are positive.
Hi, I m Kaylene Ready, a genetic counselor who specializes in the education and counseling of individuals at high-risk for hereditary breast and ovarian cancer syndrome. Women with an inherited BRCA 1
More informationChapter 9 Experimental Research (Reminder: Don t forget to utilize the concept maps and study questions as you study this and the other chapters.
Chapter 9 Experimental Research (Reminder: Don t forget to utilize the concept maps and study questions as you study this and the other chapters.) In this chapter we talk about what experiments are, we
More informationOBSERVATION METHODS: EXPERIMENTS
OBSERVATION METHODS: EXPERIMENTS Sociological Research Methods Experiments Independent variable is manipulated, and the dependent variable respond to the manipulation. e.g. Eating a chocolate bar prior
More informationRandomization as a Tool for Development Economists. Esther Duflo Sendhil Mullainathan BREAD-BIRS Summer school
Randomization as a Tool for Development Economists Esther Duflo Sendhil Mullainathan BREAD-BIRS Summer school Randomization as one solution Suppose you could do a Randomized evaluation of the microcredit
More informationHow to Randomise? (Randomisation Design)
J-PAL Africa Executive Education Course How to Randomise? (Randomisation Design) Lecture 4, January 24, 2012 Martin Abel University of Cape Town Roadmap to Randomised Evaluations 1 Environment / Context
More informationAuthor's response to reviews
Author's response to reviews Title: An open-label randomized clinical trial of prophylactic paracetamol co-administered with 7-valent pneumococcal conjugate vaccine and hexavalent diphtheria toxoid, tetanus
More informationConfounding and Bias
28 th International Conference on Pharmacoepidemiology and Therapeutic Risk Management Barcelona, Spain August 22, 2012 Confounding and Bias Tobias Gerhard, PhD Assistant Professor, Ernest Mario School
More informationLab 2: The Scientific Method. Summary
Lab 2: The Scientific Method Summary Today we will venture outside to the University pond to develop your ability to apply the scientific method to the study of animal behavior. It s not the African savannah,
More informationChapter 2. The Research Process: Coming to Terms Pearson Prentice Hall, Salkind. 1
Chapter 2 The Research Process: Coming to Terms 2009 Pearson Prentice Hall, Salkind. 1 CHAPTER OBJECTIVES - STUDENTS SHOULD BE ABLE TO: Describe the research process from formulating questions to seeking
More informationInternal Validity and Experimental Design
Internal Validity and Experimental Design February 18 1 / 24 Outline 1. Share examples from TESS 2. Talk about how to write experimental designs 3. Internal validity Why randomization works Threats to
More informationOverview of Clinical Study Design Laura Lee Johnson, Ph.D. Statistician National Center for Complementary and Alternative Medicine US National
Overview of Clinical Study Design Laura Lee Johnson, Ph.D. Statistician National Center for Complementary and Alternative Medicine US National Institutes of Health 2012 How Many Taken a similar course
More informationSession IV Practical Issues
Session IV Practical Issues Thomas J. Leeper Government Department London School of Economics and Political Science 1 Practical Issues Participant Recruitment Attention, Satisficing, and Noncompliance
More informationPLS 506 Mark T. Imperial, Ph.D. Lecture Notes: Reliability & Validity
PLS 506 Mark T. Imperial, Ph.D. Lecture Notes: Reliability & Validity Measurement & Variables - Initial step is to conceptualize and clarify the concepts embedded in a hypothesis or research question with
More informationDaily Agenda. Honors Statistics. 1. Check homework C4#9. 4. Discuss 4.3 concepts. Finish 4.2 concepts. March 28, 2017
Honors Statistics Aug 23-8:26 PM Daily Agenda 1. Check homework C4#9 Finish 4.2 concepts 4. Discuss 4.3 concepts Aug 23-8:31 PM 1 Apr 6-9:53 AM Nov 11-12:33 PM 2 Lack of BLINDING... The same person "experimenter"
More informationThe validity of inferences about the correlation (covariation) between treatment and outcome.
Threats Summary (MGS 9940, Fall, 2004-Courtesy of Amit Mehta) Statistical Conclusion Validity The validity of inferences about the correlation (covariation) between treatment and outcome. Threats to Statistical
More informationStudy design continued: intervention studies. Outline. Repetition principal approaches. Gustaf Edgren, PhD Karolinska Institutet.
Study design continued: intervention studies Gustaf Edgren, PhD Karolinska Institutet Background Outline Uncontrolled trials Non randomized, controlled trials Randomized controlled trials (with an overview
More informationThe role of Randomized Controlled Trials
The role of Randomized Controlled Trials Dr. Georgia Salanti Lecturer in Epidemiology University of Ioannina School of Medicine Outline Understanding study designs and the role of confounding Observational
More informationFahrenheit 451 Comprehension Questions
Fahrenheit 451 Comprehension Questions Part 1: The Hearth and the Salamander [Pages 3-33] 1. How are the books that are being burnt described? (3) 2. What is Montag s job? Does he like his job? (3) 3.
More informationLecture 18: Controlled experiments. April 14
Lecture 18: Controlled experiments April 14 1 Kindle vs. ipad 2 Typical steps to carry out controlled experiments in HCI Design State a lucid, testable hypothesis Identify independent and dependent variables
More informationAVOIDING BIAS AND RANDOM ERROR IN DATA ANALYSIS
AVOIDING BIAS AND RANDOM ERROR IN DATA ANALYSIS Susan S. Ellenberg, Ph.D. Perelman School of Medicine University of Pennsylvania FDA Clinical Investigator Course Silver Spring, MD November 14, 2018 OVERVIEW
More informationVALIDITY OF QUANTITATIVE RESEARCH
Validity 1 VALIDITY OF QUANTITATIVE RESEARCH Recall the basic aim of science is to explain natural phenomena. Such explanations are called theories (Kerlinger, 1986, p. 8). Theories have varying degrees
More informationFahrenheit 451 Comprehension Questions
Name: Fahrenheit 451 Comprehension Questions Directions: Use the following questions to help check your understanding while reading. If you don t know an answer, look back at the book, ask a friend, or
More informationExperiments in the Real World
Experiments in the Real World Goal of a randomized comparative experiment: Subjects should be treated the same in all ways except for the treatments we are trying to compare. Example: Rats in cages given
More informationGeneralizing the right question, which is?
Generalizing RCT results to broader populations IOM Workshop Washington, DC, April 25, 2013 Generalizing the right question, which is? Miguel A. Hernán Harvard School of Public Health Observational studies
More informationDenial and Unawareness in Huntington s Disease
Denial and Unawareness in Huntington s Disease Arik Johnson, PsyD HDSA Center of Excellence at UCLA June 21, 2014 30 th Annual HDSA Convention Dallas, TX Disclaimer The information provided by speakers
More informationSTA 291 Lecture 4 Jan 26, 2010
STA 291 Lecture 4 Jan 26, 2010 Methods of Collecting Data Survey Experiment STA 291 - Lecture 4 1 Review: Methods of Collecting Data Observational Study vs. Experiment An observational study (survey) passively
More informationDichotomizing partial compliance and increased participant burden in factorial designs: the performance of four noncompliance methods
Merrill and McClure Trials (2015) 16:523 DOI 1186/s13063-015-1044-z TRIALS RESEARCH Open Access Dichotomizing partial compliance and increased participant burden in factorial designs: the performance of
More informationVery Short Notes. Short Notes. 1 placebo definition 2 placebo effect definition
Chapter 5 The Placebo Effect Notes and Transcript When you make a speech or presentation, you want to know the material very well, even if you have notes and a transcript to look at. You can learn the
More informationIncorporating Clinical Information into the Label
ECC Population Health Group LLC expertise-driven consulting in global maternal-child health & pharmacoepidemiology Incorporating Clinical Information into the Label Labels without Categories: A Workshop
More informationRegression Discontinuity Design
Regression Discontinuity Design Regression Discontinuity Design Units are assigned to conditions based on a cutoff score on a measured covariate, For example, employees who exceed a cutoff for absenteeism
More informationSo You Want to do a Survey?
Institute of Nuclear Power Operations So You Want to do a Survey? G. Kenneth Koves Ph.D. NAECP Conference, Austin TX 2015 September 29 1 Who am I? Ph.D. in Industrial/Organizational Psychology from Georgia
More informationSession 14: Take Charge of Your Lifestyle
Session 14: Take Charge of Your Lifestyle In GLB, you have learned: 1. Many facts about healthy eating and being more physically active. 2. What makes it hard to change long-standing lifestyle behaviors.
More informationNeural codes PSY 310 Greg Francis. Lecture 12. COC illusion
Neural codes PSY 310 Greg Francis Lecture 12 Is 100 billion neurons enough? COC illusion The COC illusion looks like real squares because the neural responses are similar True squares COC squares Ganglion
More informationEvidence Based Practice
Evidence Based Practice RCS 6740 7/26/04 Evidence Based Practice: Definitions Evidence based practice is the integration of the best available external clinical evidence from systematic research with individual
More informationThreats to validity in intervention studies. Potential problems Issues to consider in planning
Threats to validity in intervention studies Potential problems Issues to consider in planning An important distinction Credited to Campbell & Stanley (1963) Threats to Internal validity Threats to External
More informationLecture II: Difference in Difference. Causality is difficult to Show from cross
Review Lecture II: Regression Discontinuity and Difference in Difference From Lecture I Causality is difficult to Show from cross sectional observational studies What caused what? X caused Y, Y caused
More informationNon-inferiority trials and switch from non-inferiority to superiority. D Costagliola U 943 INSERM and UPMC Paris 06
Non-inferiority trials and switch from non-inferiority to superiority D Costagliola U 943 INSERM and UPMC Paris 06 References l ICH E 9 et E10 l Points to consider on biostatistical methodological issues
More informationStat 13, Intro. to Statistical Methods for the Life and Health Sciences.
Stat 13, Intro. to Statistical Methods for the Life and Health Sciences. 1. Hand in HW. 2. Causation and prediction. 3. Multiple testing and publication bias. 3. Relationship between CIs and tests. 4.
More informationLecture 3. Previous lecture. Learning outcomes of lecture 3. Today. Trustworthiness in Fixed Design Research. Class question - Causality
Lecture 3 Empirical Research Methods IN4304 design (fixed design) Previous lecture A research plan Consider: purpose, theory, research question, mode inquiry, sampling method Research question Descriptive/
More information50% reduction in strokes
Now, let's look at some health messages. The next three questions are about the following advertisement for an imaginary drug called Gritagrel. Gritagrel 50% reduction in strokes Gritagrel is a new pill
More informationTitle:Bounding the Per-Protocol Effect in Randomized Trials: An Application to Colorectal Cancer Screening
Author's response to reviews Title:Bounding the Per-Protocol Effect in Randomized Trials: An Application to Colorectal Cancer Screening Authors: Sonja A Swanson (sswanson@hsph.harvard.edu) Oyvind Holme
More informationCommon Statistical Issues in Biomedical Research
Common Statistical Issues in Biomedical Research Howard Cabral, Ph.D., M.P.H. Boston University CTSI Boston University School of Public Health Department of Biostatistics May 15, 2013 1 Overview of Basic
More informationBe patient centered, ask the proper questions:
Teaching Tool description. Title For whom? (pregrad, postgrad, residents, ) Goals/ Educational objectives Methods (small group, lecture, ) Short description Practical Implementation advice Tips for success
More informationChecklist for appraisal of study relevance (child sex offenses)
Appendix 3 Evaluation protocols. [posted as supplied by author] Checklist for appraisal of study relevance (child sex offenses) First author, year, reference number Relevance Yes No Cannot answer Not applicable
More informationPhase III Clinical Trial. Randomization, Blinding and Baseline Assessment. Chi-hong Tseng, PhD Statistics Core, Department of Medicine
Phase III Clinical Trial Randomization, Blinding and Baseline Assessment Chi-hong Tseng, PhD Statistics Core, Department of Medicine Reference Clinical Trials: A Practical Approach. Pocock SJ. Wiley, Chichester,
More informationClinical Trials Lecture 4: Data analysis
Clinical Trials Lecture 4: Data analysis Dick Menzies, MD Respiratory Epidemiology and Clinical Research Unit Montreal Chest Institute TB Research methods course July 17, 2014 Lecture 4: Data analysis
More informationExperimental Methods. Policy Track
Experimental Methods Policy Track East Asia Regional Impact Evaluation Workshop Seoul, South Korea Nazmul Chaudhury, World Bank Reference Spanish Version & French Version also available, Portuguese soon.
More informationInfluencing Mountain Biker behaviour
Influencing Mountain Biker behaviour Attitude sampling to improve compliance with temporary access restrictions Glentress Forest, Scotland - 2011 Phil Whitfield Design & Interpretation Forestry Commission
More informationWorkshop on Experiments in Political Economy May Columbia Center for the Study of Development Strategies & the Harriman Institute
Workshop on Experiments in Political Economy 18-20 May 2011 Columbia Center for the Study of Development Strategies & the Harriman Institute Contents Preface v 1 Causal Inference I: The Fundamental Problem
More informationGLOSSARY OF GENERAL TERMS
GLOSSARY OF GENERAL TERMS Absolute risk reduction Absolute risk reduction (ARR) is the difference between the event rate in the control group (CER) and the event rate in the treated group (EER). ARR =
More informationMAT Mathematics in Today's World
MAT 1000 Mathematics in Today's World Last Time 1. What does a sample tell us about the population? 2. Practical problems in sample surveys. Last Time Parameter: Number that describes a population Statistic:
More informationAMS 5 EXPERIMENTAL DESIGN
AMS 5 EXPERIMENTAL DESIGN Controlled Experiment Suppose a new drug is introduced, how do we gather evidence that it is effective to treat a given disease? The key idea is comparison. A group of patients
More informationPsychology 2015 Scoring Guidelines
AP Psychology 2015 Scoring Guidelines College Board, Advanced Placement Program, AP, AP Central, and the acorn logo are registered trademarks of the College Board. AP Central is the official online home
More informationMEDITATION AND MINDFULNESS & GUT HEALTH
MEDITATION AND MINDFULNESS & GUT HEALTH Meditation Issues of the gut and the connection of gut microbes to stress and emotional issues brings some interesting questions So far we know that meditation can
More informationResearch Process. the Research Loop. Now might be a good time to review the decisions made when conducting any research project.
Research Process Choices & Combinations of research attributes Research Loop and its Applications Research Process and what portions of the process give us what aspects of validity Data Integrity Experimenter
More informationUNC Family Health Study
Health Cognition & Behavior Lab Person County Pilot Study on HPV Vaccination (2006) Updated 04/30/2010 This study was conducted with women (n=146) in two healthcare facilities in Person County (a rural
More informationDoing Quantitative Research 26E02900, 6 ECTS Lecture 6: Structural Equations Modeling. Olli-Pekka Kauppila Daria Kautto
Doing Quantitative Research 26E02900, 6 ECTS Lecture 6: Structural Equations Modeling Olli-Pekka Kauppila Daria Kautto Session VI, September 20 2017 Learning objectives 1. Get familiar with the basic idea
More informationThe Practice of Statistics 1 Week 2: Relationships and Data Collection
The Practice of Statistics 1 Week 2: Relationships and Data Collection Video 12: Data Collection - Experiments Experiments are the gold standard since they allow us to make causal conclusions. example,
More informationORIENTATION SAN FRANCISCO STOP SMOKING PROGRAM
ORIENTATION SAN FRANCISCO STOP SMOKING PROGRAM PURPOSE To introduce the program, tell the participants what to expect, and set an overall positive tone for the series. AGENDA Item Time 0.1 Acknowledgement
More informationCritical Appraisal of RCT
Critical Appraisal of RCT What is critical appraisal? Definition Process of systematically examining research evidence to assess its reliability (validity/internal validity), results and relevance (external
More informationContinuous or Intermittent Calorie Deficits: Which is Better for Fat Loss?
Continuous or Intermittent Calorie Deficits: Which is Better for Fat Loss? Byrne et al., Int J Obes, September, 2017 [Epub ahead of print] James Krieger, M.S. Background As you lose weight, your body tries
More informationDesigned Experiments have developed their own terminology. The individuals in an experiment are often called subjects.
When we wish to show a causal relationship between our explanatory variable and the response variable, a well designed experiment provides the best option. Here, we will discuss a few basic concepts and
More informationThe RoB 2.0 tool (individually randomized, cross-over trials)
The RoB 2.0 tool (individually randomized, cross-over trials) Study design Randomized parallel group trial Cluster-randomized trial Randomized cross-over or other matched design Specify which outcome is
More informationThe comparison or control group may be allocated a placebo intervention, an alternative real intervention or no intervention at all.
1. RANDOMISED CONTROLLED TRIALS (Treatment studies) (Relevant JAMA User s Guides, Numbers IIA & B: references (3,4) Introduction: The most valid study design for assessing the effectiveness (both the benefits
More informationCHAPTER 9: Producing Data: Experiments
CHAPTER 9: Producing Data: Experiments The Basic Practice of Statistics 6 th Edition Moore / Notz / Fligner Lecture PowerPoint Slides Chapter 9 Concepts 2 Observation vs. Experiment Subjects, Factors,
More informationFunctional Analytic Group Therapy: In-Vivo Healing in Community Context (18)
Functional Analytic Group Therapy: In-Vivo Healing in Community Context (18) Disclosure (no support): Luc Vandenberghe and Renee Hoekstra: We have not received and will not receive any commercial support
More information20. Experiments. November 7,
20. Experiments November 7, 2015 1 Experiments are motivated by our desire to know causation combined with the fact that we typically only have correlations. The cause of a correlation may be the two variables
More information