Lecture: Introduction to nervous system development
|
|
|
- Millicent Hall
- 5 years ago
- Views:
Transcription
1 Lecture: Introduction to nervous system development Prof. Ilan Davis, Department of Biochemistry. Wellcome Senior Research Fellow Senior Research Fellow, Jesus College
2 References Molecular Biology of the Cell, Sixth Edition Authors: Alberts et al. Chapter 21: Development of Multicellular Organisms Principles of Neurobiology, 1st Edition Author: Liqun Luo ISBN: For movies: (click on student and register for resources)
3 Content of lectures 3 1. How does the human brain develop? 2. Janelia Research Campus 3. The brain initiative 4. The human brain and MRI 5. The mouse brain 6. The steps of brain development in a nutshell 7. The anatomy of neurons 8. Axon pathfinding 9. Memory and learning 10. Synaptic plasticity and localised translation 11. Optogenetics
4 How does the human brain develop and function in health and disease? neurons connections
5
6 The Brain initiative
7 The human brain
8 Using MRI scanning to record brain activity in humans Major drawbacks: Poor resolution - single cell imaging not possible Poor specificity - imaging specific molecules not possible
9 The mouse brain
10 Regions of the mammalian brain are organised into layers Camillo Golgi Ramon Y Cajal Brainbow Silver Nitride stain Randomly expressed red, green and blue fluorescent proteins
11 Brain development and function? Specify the correct neurons in the right place Create appropriate circuits - axon path finding Modulate the connections Synaptic plasticity Human brain: ~10 10 neurons ~10 14 synapses
12 Brain development in a nutshell
13 Typical mammalian neutron and glia
14 There are many types of neurons
15 Axon pathfinding in Xenopus
16 Cytoskeleton and molecular motors in neurons
17 Memory What is the molecular mechanism of memory formation? Known Unknown
18 The organisation of the human central nervous system (CNS)
19 Long term potentiation (LTP) Figure Legend: (A) Experimental setup. The stimulating electrode was placed at the perforant path, which consists of axons that innervate dentate gyrus granule cells. A second electrode was placed near the granule cell bodies to record the field excitatory postsynaptic potential (fepsp), which represents the collective EPSPs from the population of granule cells near the recording electrode. Axons of dentate gyrus granule cells form the mossy fibers. (B) High-frequency stimulations (downward arrows, each representing 10 s of 15-Hz stimulation) caused an increase in the amplitude of fepsps produced afterward by single stimuli (green dots) compared to controls (yellow dots, no highfrequency stimulation). (Adapted from Bliss TVP & Lomo T [1973] J Physiol 232: With permission from The Physiological Society.)
20 Synaptic plasticity Dendrite Inhibitory input Axon Axons Excitatory input Dendrite Dendrite New connection Strengthen or weaken existing connection
21 Live cell imaging of the NMJ during chemical activation (assay for synaptic plasticity) Ataman et.al 2006 Lu Yang and mcd8-gfp Ilan Davis in (unpublished) motorneurons Richard Parton Ataman et al Neuron
22 Much is known about LTP and synaptic plasticity at the molecular level Dlg CamKII Scaffolding Vesicles Membranes Neurotransmitters Ion receptors Calcium channels Calcium binding Signalling Actin Microtubules Translation machinery Calabrese et al DOI: /physiol
23 The big unknowns Dendrites Axon 1) Synapses in different parts of cell are modulated independently 2) Distance from cell body to synapses too large for transcriptional regulation
24 Hypothesis: local translation Dendrites Axon 1) mrnas present at dendrite and axon termini 2) Local translation of pre-synaptic mrna
25 Arc mrna moves into dendrites in response to neuronal activation Sections of mouse brains O Steward (2001) PNAS Colloquium. A cellular mechanism for targeting newly synthesized mrnas to synaptic sites on dendrites
26 More support for the hypothesis Wang et al and Kelsey C. Martin. (2009) Synapse- and stimulus-specific local translation during long-term neuronal plasticity, Science, 324, , Susanne tom Dieck, Cyril Hanus, and Erin M. Schuman (2014) Neuron 81: e1 SnapShot: Local Protein Translation in Dendrites Toshiaki Shigeoka et al, and Christine E. Holt (2016) Cell 166: 181. Dynamic Axonal Translation in Developing and Mature Visual Circuits.
27 How does optogenetics work? A light sensitive ion channel cloned from algae into transgenic flies The channel rhodopsin is expressed in a specific set of neurones using the GAL4/UAS system ion channel opens when exposed to blue light A flash of blue light causes the neurones to fire
28 Optogenetics - channel rhodopsin Wild type control Thomas Germe and Ilan Davis
29 Thanks Any questions?
30 Copyright Notice Staff and students of this university are reminded that copyright subsists in a number of diagrams in this presentation, and the work from which it was taken. This Digital Copy has been made under the terms of a CLA licence which allows you to: - access and download a copy; - print out a copy. The Digital Copy and any digital or printed copy supplied to or made by you under the terms of this Licence are for use in connection with this Course of Study. You may retain such copies after the end of the course, but strictly for your own use. All copies (including electronic ones) shall include this Copyright Notice and shall be destroyed and/or deleted if and when required by the University. Except as provided for by copyright law, no further copying, storage or distribution (including by ) is permitted without the consent of the copyright holder. The author (which term includes artists and other visual creators) has moral rights in the work and neither staff nor students may cause, or permit, the distortion, mutilation or other modification of the work, or any other derogatory treatment of it, which would be prejudicial to the honour or reputation of the author. Course of Study: Molecular and Cellular Biochemistry, Year 3 Name of Designated Person authorising scanning: Prof. Ilan Davis All textbooks and individual references to primary or review papers in this lecture 30
Synaptic plasticityhippocampus. Neur 8790 Topics in Neuroscience: Neuroplasticity. Outline. Synaptic plasticity hypothesis
Synaptic plasticityhippocampus Neur 8790 Topics in Neuroscience: Neuroplasticity Outline Synaptic plasticity hypothesis Long term potentiation in the hippocampus How it s measured What it looks like Mechanisms
Synaptic plasticity. Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses.
Synaptic plasticity Activity-dependent changes in synaptic strength. Changes in innervation patterns. New synapses or deterioration of synapses. Repair/changes in the nervous system after damage. MRC Centre
Memory Systems II How Stored: Engram and LTP. Reading: BCP Chapter 25
Memory Systems II How Stored: Engram and LTP Reading: BCP Chapter 25 Memory Systems Learning is the acquisition of new knowledge or skills. Memory is the retention of learned information. Many different
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) Hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
BIPN 140 Problem Set 6
BIPN 140 Problem Set 6 1) The hippocampus is a cortical structure in the medial portion of the temporal lobe (medial temporal lobe in primates. a) What is the main function of the hippocampus? The hippocampus
11/2/2011. Basic circuit anatomy (the circuit is the same in all parts of the cerebellum)
11/2/2011 Neuroscientists have been attracted to the puzzle of the Cerebellum ever since Cajal. The orderly structure, the size of the cerebellum and the regularity of the neural elements demands explanation.
Lecture 22: A little Neurobiology
BIO 5099: Molecular Biology for Computer Scientists (et al) Lecture 22: A little Neurobiology http://compbio.uchsc.edu/hunter/bio5099 Larry.Hunter@uchsc.edu Nervous system development Part of the ectoderm
Anatomy Review. Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (
Anatomy Review Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction Neurons communicate with other cells at junctions
Synaptic Plasticity and the NMDA Receptor
Synaptic Plasticity and the NMDA Receptor Lecture 4.2 David S. Touretzky November, 2015 Long Term Synaptic Plasticity Long Term Potentiation (LTP) Reversal of LTP Long Term Depression (LTD) Reversal of
Part 11: Mechanisms of Learning
Neurophysiology and Information: Theory of Brain Function Christopher Fiorillo BiS 527, Spring 2012 042 350 4326, fiorillo@kaist.ac.kr Part 11: Mechanisms of Learning Reading: Bear, Connors, and Paradiso,
What Cell Make Up the Brain and Spinal Cord
What Cell Make Up the Brain and Spinal Cord Jennifer LaVail, Ph.D. (http://anatomy.ucsf.edu/pages/lavaillab/index.html) What kinds of cells are these?" Neuron?" Epithelial cell?" Glial cell?" What makes
Neuronal Plasticity, Learning and Memory. David Keays Institute of Molecular Pathology
Neuronal Plasticity, Learning and Memory David Keays Institute of Molecular Pathology http://keayslab.org Structure 1. What is learning and memory? 2. Anatomical basis 3. Cellular basis 4. Molecular
Synaptic plasticity and hippocampal memory
Synaptic plasticity and hippocampal memory Tobias Bast School of Psychology, University of Nottingham tobias.bast@nottingham.ac.uk Synaptic plasticity as the neurophysiological substrate of learning Hebb
CHAPTER 44: Neurons and Nervous Systems
CHAPTER 44: Neurons and Nervous Systems 1. What are the three different types of neurons and what are their functions? a. b. c. 2. Label and list the function of each part of the neuron. 3. How does the
Action potential. Definition: an all-or-none change in voltage that propagates itself down the axon
Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Action potential Definition: an all-or-none change in voltage that propagates itself down the axon Naturally
Introduction to Neurobiology
Biology 240 General Zoology Introduction to Neurobiology Nervous System functions: communication of information via nerve signals integration and processing of information control of physiological and
Neurobiology. Cells of the nervous system
Neurobiology Cells of the nervous system Anthony Heape 2010 1 The nervous system Central nervous system (CNS) Peripheral nervous system (PNS) 2 Enteric nervous system (digestive tract, gall bladder and
Neuroscience 201A (2016) - Problems in Synaptic Physiology
Question 1: The record below in A shows an EPSC recorded from a cerebellar granule cell following stimulation (at the gap in the record) of a mossy fiber input. These responses are, then, evoked by stimulation.
Feedback Education and Neuroscience. Pankaj Sah
Feedback Education and Neuroscience Pankaj Sah Science of Learning Learning The process of acquiring a skill or knowledge that leads to a change in behaviour Memory The ability to retain and recover information
Title: Plasticity of intrinsic excitability in mature granule cells of the dentate gyrus
Title: Plasticity of intrinsic excitability in mature granule cells of the dentate gyrus Authors: Jeffrey Lopez-Rojas a1, Martin Heine b1 and Michael R. Kreutz ac1 a Research Group Neuroplasticity, b Research
Hole s Human Anatomy and Physiology Tenth Edition. Chapter 10
PowerPoint Lecture Outlines to accompany Hole s Human Anatomy and Physiology Tenth Edition Shier Butler Lewis Chapter 10 Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or
NERVOUS SYSTEM 1 CHAPTER 10 BIO 211: ANATOMY & PHYSIOLOGY I
BIO 211: ANATOMY & PHYSIOLOGY I 1 Ch 10 A Ch 10 B This set CHAPTER 10 NERVOUS SYSTEM 1 BASIC STRUCTURE and FUNCTION Dr. Lawrence G. Altman www.lawrencegaltman.com Some illustrations are courtesy of McGraw-Hill.
Neurons, Synapses, and Signaling
Chapter 48 Neurons, Synapses, and Signaling PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions
5-Nervous system II: Physiology of Neurons
5-Nervous system II: Physiology of Neurons AXON ION GRADIENTS ACTION POTENTIAL (axon conduction) GRADED POTENTIAL (cell-cell communication at synapse) SYNAPSE STRUCTURE & FUNCTION NEURAL INTEGRATION CNS
συν together απτειν to clasp 2h Neuroscience with Pharmacology Functions and Mechanisms of Reflexes Cogito, ergo sum ( I think therefore I am ) Down
2h Neuroscience with Pharmacology Functions and Mechanisms of Reflexes Neuroscience is studied at many different levels: from brain, to system, network, neurone, synapse, and molecule... Top Up Down René
Principles of Anatomy and Physiology
Principles of Anatomy and Physiology 14 th Edition CHAPTER 12 Nervous Tissue Introduction The purpose of the chapter is to: 1. Understand how the nervous system helps to keep controlled conditions within
2Lesson. Outline 3.2. Lesson Plan. The OVERVIEW. Lesson 3.2: How do our neurons communicate with each other? LESSON. Unit1.2
Outline OVERVIEW Rationale: This lesson is intended to introduce students to the process of synaptic transmission, which is how one neuron communicates with another neuron. Using the pain pathway as a
Neuroscience with Pharmacology 2 Functions and Mechanisms of Reflexes. Prof Richard Ribchester
Neuroscience with Pharmacology 2 Functions and Mechanisms of Reflexes Prof Richard Ribchester René Descartes Cogito, ergo sum The 21st century still holds many challenges to Neuroscience and Pharmacology
SUPPLEMENTARY INFORMATION
SUPPLEMENTARY INFORMATION doi:10.1038/nature11306 Supplementary Figures Supplementary Figure 1. Basic characterization of GFP+ RGLs in the dentate gyrus of adult nestin-gfp mice. a, Sample confocal images
2Lesson. Outline 3.3. Lesson Plan. The OVERVIEW. Lesson 3.3 Why does applying pressure relieve pain? LESSON. Unit1.2
Outline 2Lesson Unit1.2 OVERVIEW Rationale: This lesson introduces students to inhibitory synapses. To review synaptic transmission, the class involves a student model pathway to act out synaptic transmission.
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 http://neuroscience.uth.tmc.edu/s1/chapter06.html http://neuroscience.uth.tmc.edu/s1/chapter07.html Chris Cohan, Ph.D. Dept. of
1) Drop off in the Bi 150 box outside Baxter 331 or to the head TA (jcolas).
Bi/CNS/NB 150 Problem Set 3 Due: Tuesday, Oct. 27, at 4:30 pm Instructions: 1) Drop off in the Bi 150 box outside Baxter 331 or e-mail to the head TA (jcolas). 2) Submit with this cover page. 3) Use a
Chapter 2: Cellular Mechanisms and Cognition
Chapter 2: Cellular Mechanisms and Cognition MULTIPLE CHOICE 1. Two principles about neurons were defined by Ramón y Cajal. The principle of connectional specificity states that, whereas the principle
Chapter 2--Introduction to the Physiology of Perception
Chapter 2--Introduction to the Physiology of Perception Student: 1. Our perception of the environment depends on A. the properties of the objects in the environment. B. the properties of the electrical
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3
NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES 34.3 NEURONS COMMUNICATE WITH OTHER CELLS AT SYNAPSES Neurons communicate with other neurons or target cells at synapses. Chemical synapse: a very narrow
SYNAPTIC COMMUNICATION
BASICS OF NEUROBIOLOGY SYNAPTIC COMMUNICATION ZSOLT LIPOSITS 1 NERVE ENDINGS II. Interneuronal communication 2 INTERNEURONAL COMMUNICATION I. ELECTRONIC SYNAPSE GAP JUNCTION II. CHEMICAL SYNAPSE SYNAPSES
Activity Dependent Changes At the Developing Neuromuscular Junction
Activity Dependent Changes At the Developing Neuromuscular Junction (slides 16, 17 and 18 have been slightly modified for clarity) MCP Lecture 2-3 9.013/7.68 04 Neuromuscular Junction Development 1. Muscle
BIOLOGY 12 NERVOUS SYSTEM PRACTICE
1 Name: BIOLOGY 12 NERVOUS SYSTEM PRACTICE Date: 1) Identify structures X, Y and Z and give one function of each. 2) Which processes are involved in the movement of molecule Y from point X to point Z?
Anatomy of a Neuron. Copyright 2000 by BSCS and Videodiscovery, Inc. Permission granted for classroom use. Master 2.1
Anatomy of a Neuron Master 2.1 Neurons Interact With Other Neurons Through Synapses Master 2.2 How Do Neurons Communicate? 1 2 3 4 5 6 Master 2.3 Neurons Communicate by Neurotransmission Neurons communicate
Hole s Human Anatomy and Physiology Eleventh Edition. Chapter 10
PowerPoint Lecture Outlines to accompany Hole s Human Anatomy and Physiology Eleventh Edition Shier Butler Lewis Chapter 10 Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction
Cell Neurobiology Course
Cell Neurobiology Course 2017-18 Textbooks - this course is not based on a specific textbook. However for basic or additional information you can refer to the following books (DBIOS library): Neuroscience
Nervous System. 2. Receives information from the environment from CNS to organs and glands. 1. Relays messages, processes info, analyzes data
Nervous System 1. Relays messages, processes info, analyzes data 2. Receives information from the environment from CNS to organs and glands 3. Transmits impulses from CNS to muscles and glands 4. Transmits
Anatomy of a Neuron. Copyright 2000 by BSCS and Videodiscovery, Inc. Permission granted for classroom use. Updated Master 2.
Anatomy of a Neuron Master 2.1 Neurons Interact with Other Neurons through Synapses Master 2.2 Name Date Due Cells of the Nervous System Learning Target: Identify and state the function of the components
Chapter 45: Synapses Transmission of Nerve Impulses Between Neurons. Chad Smurthwaite & Jordan Shellmire
Chapter 45: Synapses Transmission of Nerve Impulses Between Neurons Chad Smurthwaite & Jordan Shellmire The Chemical Synapse The most common type of synapse used for signal transmission in the central
CHAPTER 48: NERVOUS SYSTEMS
CHAPTER 48: NERVOUS SYSTEMS Name I. AN OVERVIEW OF NERVOUS SYSTEMS A. Nervous systems perform the three overlapping functions of sensory input, integration, and motor output B. Networks of neurons with
Modeling Excitatory and Inhibitory Chemical Synapses
In review, a synapse is the place where signals are transmitted from a neuron, the presynaptic neuron, to another cell. This second cell may be another neuron, muscle cell or glandular cell. If the second
Cellular Neurobiology BIPN140
Cellular Neurobiology BIPN140 1st Midterm Exam Ready for Pickup By the elevator on the 3 rd Floor of Pacific Hall (waiver) Exam Depot Window at the north entrance to Pacific Hall (no waiver) Mon-Fri, 10:00
All questions below pertain to mandatory material: all slides, and mandatory homework (if any).
ECOL 182 Spring 2008 Dr. Ferriere s lectures Lecture 6: Nervous system and brain Quiz Book reference: LIFE-The Science of Biology, 8 th Edition. http://bcs.whfreeman.com/thelifewire8e/ All questions below
Jan 10: Neurons and the Brain
Geometry of Neuroscience Matilde Marcolli & Doris Tsao Jan 10: Neurons and the Brain Material largely from Principles of Neurobiology by Liqun Luo Outline Brains of different animals Neurons: structure
CYTOARCHITECTURE OF CEREBRAL CORTEX
BASICS OF NEUROBIOLOGY CYTOARCHITECTURE OF CEREBRAL CORTEX ZSOLT LIPOSITS 1 CELLULAR COMPOSITION OF THE CEREBRAL CORTEX THE CEREBRAL CORTEX CONSISTS OF THE ARCHICORTEX (HIPPOCAMPAL FORMA- TION), PALEOCORTEX
Chapter 11: Functional Organization of Nervous Tissue
Chapter 11: Functional Organization of Nervous Tissue I. Functions of the Nervous System A. List and describe the five major nervous system functions: 1. 2. 3. 4. 5. II. Divisions of the Nervous System
LESSON 3.3 WORKBOOK. Why does applying pressure relieve pain? Workbook. Postsynaptic potentials
Depolarize to decrease the resting membrane potential. Decreasing membrane potential means that the membrane potential is becoming more positive. Excitatory postsynaptic potentials (EPSP) graded postsynaptic
Synapse Formation. Steven McLoon Department of Neuroscience University of Minnesota
Synapse Formation Steven McLoon Department of Neuroscience University of Minnesota 1 Course News Midterm Exam Monday, Nov 13 9:30-11:30am Bring a #2 pencil!! 2 Course News Lecture schedule: Mon (Oct 31)
Concept 48.1 Neuron organization and structure reflect function in information transfer
Name Chapter 48: Neurons, Synapses, and Signaling Period Chapter 48: Neurons, Synapses, and Signaling Concept 48.1 Neuron organization and structure reflect function in information transfer 1. What is
Chapter 4 Neuronal Physiology
Chapter 4 Neuronal Physiology V edit. Pg. 99-131 VI edit. Pg. 85-113 VII edit. Pg. 87-113 Input Zone Dendrites and Cell body Nucleus Trigger Zone Axon hillock Conducting Zone Axon (may be from 1mm to more
ANSWERS TO PRE- LAB ASSIGNMENTS
Lab 14 Introduction to Nervous System Hamilton ANSWERS TO PRE- LAB ASSIGNMENTS Pre-Lab Activity 1: 1. a. orbicularis oculi b. sternocleidomastoid c. deltoid d. pectoralis major e. biceps brachii f. rectus
Outline. Neuron Structure. Week 4 - Nervous System. The Nervous System: Neurons and Synapses
Outline Week 4 - The Nervous System: Neurons and Synapses Neurons Neuron structures Types of neurons Electrical activity of neurons Depolarization, repolarization, hyperpolarization Synapses Release of
Ion Channels Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com)
Ion Channels Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction At synapses, ions move across cell membranes through
Serotonergic Control of the Developing Cerebellum M. Oostland
Serotonergic Control of the Developing Cerebellum M. Oostland Summary Brain development is a precise and crucial process, dependent on many factors. The neurotransmitter serotonin is one of the factors
BIPN100 F15 Human Physiology 1 Lecture 3. Synaptic Transmission p. 1
BIPN100 F15 Human Physiology 1 Lecture 3. Synaptic Transmission p. 1 Terms you should know: synapse, neuromuscular junction (NMJ), pre-synaptic, post-synaptic, synaptic cleft, acetylcholine (ACh), acetylcholine
1) Drop off in the Bi 150 box outside Baxter 331 or to the head TA (jcolas).
Bi/CNS/NB 150 Problem Set 3 Due: Tuesday, Oct. 27, at 4:30 pm Instructions: 1) Drop off in the Bi 150 box outside Baxter 331 or e-mail to the head TA (jcolas). 2) Submit with this cover page. 3) Use a
How Synapses Integrate Information and Change
How Synapses Integrate Information and Change Rachel Stewart class of 2016 https://nba.uth.tmc.edu/neuroscience/s1/chapter06.html https://nba.uth.tmc.edu/neuroscience/s1/chapter07.html Chris Cohan, Ph.D.
Modeling of Hippocampal Behavior
Modeling of Hippocampal Behavior Diana Ponce-Morado, Venmathi Gunasekaran and Varsha Vijayan Abstract The hippocampus is identified as an important structure in the cerebral cortex of mammals for forming
B C. i) At what region(s) on the drawing above would you expect a high density of voltage-gated sodium channels?
MIT Department of Biology 7.013: Introductory Biology - Spring 2005 Instructors: Professor Hazel Sive, Professor Tyler Jacks, Dr. Claudette Gardel 7.013 SECTION NEUROBIOLOGY 2 Part A ligand-gated sodium
PSY 215 Lecture 3 (1/19/2011) (Synapses & Neurotransmitters) Dr. Achtman PSY 215
Corrections: None needed. PSY 215 Lecture 3 Topic: Synapses & Neurotransmitters Chapters 2 & 3, pages 40-57 Lecture Notes: SYNAPSES & NEUROTRANSMITTERS, CHAPTER 3 Action Potential (above diagram found
Functions of Nervous System Neuron Structure
Chapter 10 Nervous System I Divisions of the Nervous System Cell Types of Neural Tissue neurons neuroglial cells Central Nervous System brain spinal cord Peripheral Nervous System nerves cranial nerves
Neurons! John A. White Dept. of Bioengineering
Neurons! John A. White Dept. of Bioengineering john.white@utah.edu What makes neurons different from cardiomyocytes? Morphological polarity Transport systems Shape and function of action potentials Neuronal
LESSON 3.3 WORKBOOK. Why does applying pressure relieve pain?
Postsynaptic potentials small changes in voltage (membrane potential) due to the binding of neurotransmitter. Receptor-gated ion channels ion channels that open or close in response to the binding of a
Cellular Neurobiology BIPN140
Cellular Neurobiology BIPN140 1st Midterm Exam Ready for Pickup By the elevator on the 3 rd Floor of Pacific Hall (waiver) Exam Depot Window at the north entrance to Pacific Hall (no waiver) Mon-Fri, 10:00
Cellular Neurobiology / BIPN 140
SECOND MIDTERM EXAMINATION Fall, 2015 GENERAL INSTRUCTIONS 1. Please write your name on ALL 6 pages. 2. Please answer each question IN THE SPACE ALLOTTED. 1) /10 pts 2) /10 pts 3) /15 pts 4) /15 pts 5)
STRUCTURAL ELEMENTS OF THE NERVOUS SYSTEM
STRUCTURAL ELEMENTS OF THE NERVOUS SYSTEM STRUCTURE AND MAINTENANCE OF NEURONS (a) (b) Dendrites Cell body Initial segment collateral terminals (a) Diagrammatic representation of a neuron. The break in
Ameen Alsaras. Ameen Alsaras. Mohd.Khatatbeh
9 Ameen Alsaras Ameen Alsaras Mohd.Khatatbeh Nerve Cells (Neurons) *Remember: The neural cell consists of: 1-Cell body 2-Dendrites 3-Axon which ends as axon terminals. The conduction of impulse through
Chapter Nervous Systems
The Nervous System Chapter Nervous Systems Which animals have nervous systems? (Which do not) What are the basic components of a NS? What kind of fish performs brain operations? What differentiates one
Brain and Cognition. Cognitive Neuroscience. If the brain were simple enough to understand, we would be too stupid to understand it
Brain and Cognition Cognitive Neuroscience If the brain were simple enough to understand, we would be too stupid to understand it 1 The Chemical Synapse 2 Chemical Neurotransmission At rest, the synapse
Electrical Properties of Neurons. Steven McLoon Department of Neuroscience University of Minnesota
Electrical Properties of Neurons Steven McLoon Department of Neuroscience University of Minnesota 1 Neuronal Communication Neurons communicate with other cells, often over long distances. The electrical
10.1: Introduction. Cell types in neural tissue: Neurons Neuroglial cells (also known as neuroglia, glia, and glial cells) Dendrites.
10.1: Introduction Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display. Cell types in neural tissue: Neurons Neuroglial cells (also known as neuroglia, glia, and glial
Why am I working in a Drosophila lab? Dr. Stefan Pulver, Brandeis University
Why am I working in a Drosophila lab? Dr. Stefan Pulver, Brandeis University !Short life span The advantages of Drosophila as a model organism in neurocience!genetic manipulations are relatively easy!forward
What is Anatomy and Physiology?
Introduction BI 212 BI 213 BI 211 Ecosystems Organs / organ systems Cells Organelles Communities Tissues Molecules Populations Organisms Campbell et al. Figure 1.4 Introduction What is Anatomy and Physiology?
Sincerely, Ms. Paoloni and Mrs. Whitney
Dear Students, Welcome to AP Psychology! We will begin our course of study focusing on the nervous system with a particular emphasis on how the brain and neurotransmitters influence our behaviors. In preparation
Neurons: Structure and communication
Neurons: Structure and communication http://faculty.washington.edu/chudler/gall1.html Common Components of a Neuron Dendrites Input, receives neurotransmitters Soma Processing, decision Axon Transmits
BIPN140 Lecture 12: Synaptic Plasticity (II)
BIPN140 Lecture 12: Synaptic Plasticity (II) 1. Early v.s. Late LTP 2. Long-Term Depression 3. Molecular Mechanisms of Long-Term Depression: NMDA-R dependent 4. Molecular Mechanisms of Long-Term Depression:
Ch. 45 Continues (Have You Read Ch. 45 yet?) u Central Nervous System Synapses - Synaptic functions of neurons - Information transmission via nerve
Ch. 45 Continues (Have You Read Ch. 45 yet?) u Central Nervous System Synapses - Synaptic functions of neurons - Information transmission via nerve impulses - Impulse may be blocked in its transmission
Function of the Nervous System
Nervous System Function of the Nervous System Receive sensory information, interpret it, and send out appropriate commands to form a response Composed of neurons (functional unit of the nervous system)
Chapter 9 Refinement of Synaptic Connections
Chapter 9 Refinement of Synaptic Connections Afferent Projection Error during Development During development there is a constant rearrangement of synaptic connections, new synapses are formed and old synapses
Cellular and Molecular Mechanisms of Learning and Memory
Cellular/Molecular Mechanisms of Learning and Memory 27 Cellular and Molecular Mechanisms of Learning and Memory 2 Matthew Lattal and Ted Abel The nature of the cellular basis of learning and memory remains
ANATOMY AND PHYSIOLOGY OF NEURONS. AP Biology Chapter 48
ANATOMY AND PHYSIOLOGY OF NEURONS AP Biology Chapter 48 Objectives Describe the different types of neurons Describe the structure and function of dendrites, axons, a synapse, types of ion channels, and
How we study the brain: a survey of methods used in neuroscience
How we study the brain: a survey of methods used in neuroscience Preparing living neurons for recording Large identifiable neurons in a leech Rohon-Beard neurons in a frog spinal cord Living slice of a
Organization of the nervous system. [See Fig. 48.1]
![Organization of the nervous system. [See Fig. 48.1]](/thumbs/90/103926552.jpg "Organization of the nervous system. [See Fig. 48.1]")
Nervous System [Note: This is the text version of this lecture file. To make the lecture notes downloadable over a slow connection (e.g. modem) the figures have been replaced with figure numbers as found
Neurons, Synapses, and Signaling
Neurons, Synapses, and Signaling The Neuron is the functional unit of the nervous system. Neurons are composed of a cell body, which contains the nucleus and organelles; Dendrites which are extensions
Bioscience in the 21st century
Bioscience in the 21st century Neurons, Synapses, and Signaling Dr. Michael Burger Outline: 1. Why neuroscience? 2. The neuron 3. Action potentials 4. Synapses 5. Organization of the nervous system 6.
SUPPLEMENTARY INFORMATION
Supplementary Figure 1. Normal AMPAR-mediated fepsp input-output curve in CA3-Psen cdko mice. Input-output curves, which are plotted initial slopes of the evoked fepsp as function of the amplitude of the
Thalamo-Cortical Relationships Ultrastructure of Thalamic Synaptic Glomerulus
Central Visual Pathways V1/2 NEUR 3001 dvanced Visual Neuroscience The Lateral Geniculate Nucleus () is more than a relay station LP SC Professor Tom Salt UCL Institute of Ophthalmology Retina t.salt@ucl.ac.uk
The Brain & Homeostasis. The Brain & Technology. CAT, PET, and MRI Scans
The Brain & Homeostasis Today, scientists have a lot of information about what happens in the different parts of the brain; however they are still trying to understand how the brain functions. We know
Neurons, Synapses and Signaling. Chapter 48
Neurons, Synapses and Signaling Chapter 48 Warm Up Exercise What types of cells can receive a nerve signal? Nervous Organization Neurons- nerve cells. Brain- organized into clusters of neurons, called
Bio 3411 Midterm Review:
Midterm Review: Structure/Development/Systems/ Plastics/Talents/Diseases/Genes Structure General Overview Wednesday 1( 2( THE BRAIN ATLAS 3 rd ed, p. 8! THE BRAIN ATLAS 3 rd ed, p. 9! Mid-line (sagittal)
MCB MIDTERM EXAM #1 MONDAY MARCH 3, 2008 ANSWER KEY
MCB 160 - MIDTERM EXAM #1 MONDAY MARCH 3, 2008 ANSWER KEY Name ID# Instructions: -Only tests written in pen will be regarded -Please submit a written request indicating where and why you deserve more points
MOLECULAR AND CELLULAR NEUROSCIENCE
MOLECULAR AND CELLULAR NEUROSCIENCE BMP-218 November 4, 2014 DIVISIONS OF THE NERVOUS SYSTEM The nervous system is composed of two primary divisions: 1. CNS - Central Nervous System (Brain + Spinal Cord)