AREAS OF CONCENTRATION

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1 Dr. Shruti Mehta, Director The development of antibiotics, improved access to safe food, clean water, sewage disposal and vaccines has led to dramatic progress in controlling infectious diseases. Despite these remarkable achievements, infectious diseases remain the leading causes of death in many parts of the world. Emerging diseases, such as antibiotic-resistant bacteria, SARS coronavirus, and avian and swine influenza viruses have been identified and some have become established in both the developed and developing world. The aim of the infectious disease area of concentration is to build upon the core epidemiology curriculum to provide students with the requisite knowledge of the epidemiology, analytical and laboratory methodology, immunology and pathogen biology necessary to understand the dynamic interactions of infectious agents and their hosts, vectors and environment. Capitalizing on the wide range of infectious disease interests at the school, students in this area of concentration take a range of courses offered in the Department of Epidemiology and other departments to obtain a broad and thorough understanding of infectious disease epidemiology. A strength of the Infectious Disease Epidemiology concentration is the substantial involvement of faculty with preeminent national and international studies of infectious diseases. The Department is particularly strong in the area of HIV/AIDS, where faculty established vanguard studies, including the Multicenter AIDS Cohort Study (MACS) and AIDS Linked to the Intravenous Experience (ALIVE) that have made fundamental contributions to the epidemiology of HIV/AIDS in the United States. Other areas of focus include other chronic infections such as hepatitis infections and tuberculosis as well as acute infections including dengue, cholera, malaria, influenza. Research studies within the program range from the molecular to behavioral, from population-based surveys to long-term observational studies to large scale cluster-randomized trials to test behavioral and pharmacologic interventions. Through seminars and discussions with faculty, students become familiar with ongoing projects within the Infectious Disease Epidemiology concentration. These projects afford unique opportunities to gain research experience not obtained through coursework, as well as valuable settings for masters and doctoral thesis projects. In the Infectious Disease Epidemiology area of concentration, masters and doctoral students are required to complete a minimum number of credit hours in required and elective courses in four broad categories as listed below. These four categories are 1) required core courses in infectious disease epidemiology; 2) biology and pathogenesis of infectious diseases; 3) advanced analytical and statistical methods (for PhD and ScD students); and 4) electives in infectious disease epidemiology. Students should meet with their academic advisors to plan an enriching program that will meet their individual academic goals. Required and elective courses may be revised periodically.

2 Required Core Courses in Infectious Disease Epidemiology All students are required to take the courses listed below: (term) Epidemiology of Infectious Diseases (4)* (2 nd ) Concepts and Methods in Infectious Disease Epidemiology (3) (3 rd ) Epidemiologic Inference in Outbreak Investigation (3) (4 th ) Principles of Immunology I (4) (1 st )(suggested 2 nd year) AND Principles of Immunology II (4) (2 nd ) Immunology, Infection and Disease (3) (2 nd )(suggested 2 nd year) Practical Skills in Conducting Research in Clinical Epidemiology & Investigation (3) (1 st ) (suggested 2 nd year) Health Survey Research Methods (4) (2 nd ) (suggested 2 nd year) Fundamentals of Human Physiology (for non-md doctoral students) (4) (2 nd ) (suggested 2 nd year) Biology and Pathogenesis of Infectious Diseases All students are required to take at least one of the courses listed below: (term) Epidemiology and Natural History of Human Viral Infections (6) (3 rd in class, 1 st online) Principles of Bacterial Infection (3) (4 th ) Fundamental Virology (4) (1 st, suggested 2 nd year) Pathogenesis of Bacterial Infection (4) (2 nd ) Evolution of Infectious Disease (3) (1 st ) Vector Biology and Vector Borne Diseases (3) (3 rd ) Advanced Analytical and Statistical Methods for PhD and ScD Students in Infectious Disease Epidemiology PhD and ScD students are required to take at least one of the courses listed below: (term) Infectious Disease Dynamics: Theoretical and Computational Approaches (3) (4 th ) Advanced Methods in the Design and Analysis of Cohort Studies (4) (1 st ) Survival Analysis (3) (1 st ) Analysis of Longitudinal Data (4) (3 rd ) Multilevel Statistical Models in Public Health (4) (4 th ) Statistics for Psycho-social Research: Structural Models (4) (2 nd ) Spatial Analysis and GIS I (3) (3 rd ) Spatial Analysis and GIS II (4) (4 th )

3 General Electives in Infectious Disease Epidemiology All students are required to take one of the courses listed below: (term) Epidemiology and Public Health Impact of HIV and AIDS (4) (1 st, in class; 2 nd online) Emerging Infections (2) (4 th ) Epidemiologic Basis for Tuberculosis Control (2) (3 rd ) Healthcare Epidemiology (4) (2 nd ) Advanced Topics on Control and Prevention of HIV/AIDS (4) (2 nd ) Professional Epidemiology Methods (4) (3 rd ) Public Health Surveillance (3) (4 th ) Food and Water-Borne Diseases (4) (3 rd ) Vaccine Development and Application (4) (2 nd ) Infectious Diseases and Child Survival (3) (3 rd ) Infection, Immunity and Undernutrition: Interactions and Effects (4) (3 rd ) Clinical and Epidemiological Aspects of Tropical Diseases (3) (4 th ) Vaccine Policy Issues (3) (3 rd ) Biologic Basis of Vaccine Development (3) (4 th ) Principles of Public Health Ecology (4) (2 nd ) Malariology (4) (4 th ) Sexually Transmitted Infections in Public Health Practice (4) (4 th ) HIV Infection in Women, Children, and Adolescents (4) (4 th )

4 Required Courses by Term First Term: Epidemiologic Methods 1 (5) Statistical Methods in Public Health I (4)* Methods in Biostatistics 1 (4) Doctoral Seminars Epidemiology (3) (2nd yr doctoral students only) Advanced Methods for Design and Analysis of Cohort Studies (4) Health Survey Research Methods (4) (2nd yr doctoral students) (offered 2nd term) Practical Skills in Conducting Research in Clinical Epidemiology & Investigation (3) Principles of Immunology I (4) Fundamental Virology (4) Evolution of Infectious Disease (3) Advanced Methods for Design and Analysis of Cohort Studies (4) Statistics for Psycho-social Research: Measurement (4) Survival Analysis (3) Epidemiology and Public Health Impact of HIV and AIDS (4) (also offered online in 2nd term) Applied Aspects of Cohort Studies (4) Second Term: Epidemiologic Methods 2 (5) Statistical Methods in Public Health II (4) Methods in Biostatistics II (4) Statistics for Psycho-social Research: Structural Models (4) Doctoral Seminars in Epidemiology (3) (2nd year doctoral students only) Public Health Perspectives on Research (2) Epidemiology of Infectious Diseases (4) Immunology, Infection and Disease (3) Principles of Immunology II (4)

5 Fundamentals of Human Physiology (4) (non-md, 2 nd year doctoral students) Pathogenesis of Bacterial Infections (4) Advanced Topics on Control and Prevention of HIV/AIDS (4) Vaccine Development and Application (4) Third Term: Epidemiologic Methods 3 (5) Statistical Methods in Public Health III (4) Methods in Biostatistics III (4) Doctoral Seminars (3) (2nd yr doctoral students only) Concepts and Methods in Infectious Disease Epidemiology (3) Epidemiology and Natural History of Human Viral Infections (6) (also offered online 1st term) Vector Biology and Vector-Borne Diseases (3) Spatial Analysis and GIS I (3) Analysis of Longitudinal Data (4) Epidemiology Basis of Tuberculosis Control (2) Professional Epidemiology Methods (4) Food and Water-Borne Diseases (3) Infectious Diseases and Child Survival (3) Infection, Immunity and Undernutrition (4) Vaccine Policy Issues (3) Vector Biology and Vector-Borne Diseases (3)

6 Fourth Term: ** Methodologic Challenges in Epidemiologic Research (5) Statistical Methods in Public Health IV (4) Methods in Biostatistics IV* (4) Problems in the Design of Epidemiologic Studies (4) (2nd year doctoral students) Epidemiologic Inference in Outbreak Investigations (3) Infectious Disease Dynamics (3) Spatial Analysis and GIS II (4) Multilevel Models in Public Health (4) Principles of Bacterial Infection (3) Emerging Infections (2) Public Health Surveillance (3) Clinical and Epidemiological Aspects of Tropical Diseases (3) Biologic Basis of Vaccine Development (3) Malariology (4) Sexually Transmitted Infections in Public Health Practice (4) HIV in Women, Children, and Adolescents (4) Research Ethics (1 )++ course is offered each term. This course meets the School requirements. Students may also take or to satisfy the ethics requirement. ** Required for doctoral students only Black=department/school wide requirements Red=ID EPI required courses Blue=ID EPI requirement one biology and one advanced analytical course Purple=ID EPI electives