Cytokines, adhesion molecules and apoptosis markers. A comprehensive product line for human and veterinary ELISAs

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1 Cytokines, adhesion molecules and apoptosis markers A comprehensive product line for human and veterinary ELISAs

2 IBL International s cytokine product line... is extremely comprehensive. The assays are intended for the detection of a variety of immuno-modulators, including human and animal cytokines, and offers highly sensitive versions. Immunoassays are available for measuring a variety of molecules, including: Cytokines incl. chemokines, growth factors Soluble cytokine receptors Apoptosis markers Cell adhesion molecules Hematopoietic cytokines Hematopoiesis is a complex and dynamic developmental process in the formation of new blood cells. The proliferation and differentiation of hematopoietic progenitor cells, their survival, and all functional activities of the mature circulating forms are subject to regulation by a cascade of proteins that are generally known as hematopoietic cytokines. common myeloid progenitor multipotential hematopoetic stem cell (hemocytoblast) mast cell common lymphoid progenitor natural killer cell small lymphocyte Many of these proteins are multifunctional. They act at very early differentiation stages and also at later stages. Hematopoietic cytokines are at the forefront of pharmacological achievement in clinical settings. They augment established therapy forms, as well as the prophylaxis of immune defects (such as in the substitution of immunoglobulins, and in bone marrow transplantation). megakaryocyte thrombocytes erythrocyte myeloblast basophil neutrophil eosinophil monocyte macrophage T lymphocyte B lymphocyte plasma cell Development of various blood cells from hematopoietic stem cells, to mature cells.

3 Human ELISA line for colony stimulating factors (CSF s) SCF G-CSF GM-CSF Stem cell factor Granulocyte colony stimulating factor Granulocyte macrophage colony stimulating factor other species available The hematopoietic cytokine ELISA product line includes Interleukins Colony stimulating factors (CSF s) Human ELISA line for interleukins IL- * IL- * IL- hs IL-ra IL-2 * IL-2 hs IL-3 IL-4 * IL-5 IL-6 * IL-6 hs IL-7 IL-2 (p70) * Interleukin- Interleukin- Interleukin- (high sensitivity) Interleukin- (receptor antagonist) Interleukin-2 Interleukin-2 (high sensitivity) Interleukin-3 Interleukin-4 Interleukin-5 Interleukin-6 Interleukin-6 (high sensitivity) Interleukin-7 Interleukin-2 (p70)

4 Cell Adhesion Molecules (CAMs) Communication between cells is maintained by soluble factors, such as cytokines. A second mechanism is interaction via direct cell-to-cell contact, facilitated by an array of cell surface molecules (adhesion molecules), which interact via ligand-receptor binding. Adhesion molecules are essential for leukocyte migration, and also seem to play a role in T-cell activation. Soluble cell adhesion molecules (scams) may represent important biomarkers for inflammatory processes involving activation or damage to cells, such as platelets and the endothelium. They are formed as the result of shedding due to cell stimulation and by de novo synthesis of truncated soluble forms. There are four major families of proteins that mediate cell-to-cell interactions: Immunoglobulin superfamily (IgSF) cell adhesion molecules Integrins Cadherins Selectins Our CAM ELISA product line includes: Immunoglobulin superfamily (IgSF) cell adhesion molecules Cadherins Selectins / Ligands Human ELISA line for cell adhesion molecules se-selectin * sl-selectin * sp-selectin sicam- * sicam- hs sicam-2 sicam-3 sve-cadherin specam- svcam- * Endothelial cell adhesion molecule (soluble) Leukocyte cell adhesion molecule (soluble) Platelet endothelial cell adhesion molecule (soluble) Intercellular adhesion molecule- (soluble) Intercellular adhesion molecule- (soluble, high sensitivity) Intercellular adhesion molecule-2 (soluble) Intercellular adhesion molecule-3 (soluble) Vascular endothelial cadherin (soluble) Platelet endothelial cell adhesion molecule- (soluble) Vascular cell adhesion molecule- (soluble)

5 Apoptosis Markers Apoptosis is a physiological form of programmed cell death, and continues to be one of the hottest topics in biomedical research today. Apoptosis is an integral part of the natural life cycle and plays a pathogenic role in diseases such as cancer, viral infections, and autoimmunity, among others. Apoptosis can be initiated in two alternative modes: the death-receptor (extrinsic) pathway, or the mitochondrial (intrinsic) pathway. The apoptosis ELISA product line includes: Specialized cell-surface receptors called death receptors Death-inducing ligands Caspases (the executioners of apoptosis) Granzymes Human ELISA line for apoptosis markers Caspase 8 / Caspase 9 APO- / FAS * scd30 * scd40 scd34 (OX40) scd37 (4-BB) DcR3 DR5 Bcl-2 Cu / Zn SOD Cytochrome c APRIL scd40l * scd40l hs sfasl * TNF- * TNF- hs TNFsTNF-R (60 kda) * stnf-r2 (80 kda) * TRAIL Granzyme A / Granzyme B Cysteinyl aspartate-specific protease 8 / 9 APO- cell surface antigen / Fas receptor Cluster of differentiation 30 (soluble) Cluster of differentiation 40 (soluble) Cluster of differentiation 34 (soluble) Cluster of differentiation 37 (soluble) Decoy receptor 3 Death receptor 5 B cell lymphoma 2 Copper / Zinc superoxide dismutases A proliferation-inducing ligand CD 40 ligand (soluble) CD 40 ligand (soluble, high sensitivity) Fas ligand (soluble) Tumor necrosis factor Tumor necrosis factor (high sensitivity) Tumor necrosis factor TNF receptor (soluble) TNF receptor 2 (soluble) TNF-related apoptosis-inducing ligand

6 Chemokines Chemokines are a super-family of small, secreted proteins involved in leukocyte traffic, recruitment, and recirculation. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; as such, they are chemotactic cytokines. Their main functions are to attract leukocytes to sites of infection and inflammation, and to contribute to the homeostatic circulation of leukocytes within tissue. Thus, they play a critical role in many patho-physiological processes, such as infectious and autoimmune diseases, inflammation, and neurodegenerative diseases. Structure of interleukin-8, a chemokine of the C-X-C sub-family. The chemokine ELISA product line includes: C-C motif chemokines C-X-C motif chemokines Human ELISA line for chemokines CCL2 / MCP- CCL5 / RANTES CCL8 / MCP-2 CCL / Eotaxin CXCL / GRO- CXCL2 / GRO- CXCL8 / IL-8 * CXCL8 / IL-8 hs C-C motif chemokine 2 / Monocyte chemoattractant protein C-C motif chemokine 5 / Regulated upon activation, normal T- cell expressed and secreted C-C motif chemokine 8 / Monocyte chemoattractant protein 2 C-C motif chemokine C-X-C motif chemokine / Growth-regulated protein C-X-C motif chemokine 2 / Growth-regulated protein C-X-C motif chemokine 8 / Interleukin-8 C-X-C motif chemokine 8 / Interleukin-8 (high sensitivity)

7 Miscellaneous Human ELISA line Miscellaneous I IFN- * IFN- IFN- IFN- hs IFN- * sil-2r * sil-6r Interferon- Interferon- Interferon- Interferon- (high sensitivity) Interferon- Interleukin-2 receptor (soluble) Interleukin-6 receptor (soluble) Human ELISA line Miscellaneous II IL-0 * IL-0 hs IL-3 * IL-5 IL-6 IL-23 MMP- MMP-9 * MMP-3 TIMP- VEGF-A VEGF-C svegf-r TGF- * TGF- 2 bfgf EGF LIF LIF-R (gp90) Interleukin-0 Interleukin-0 (high sensitivity) Interleukin-3 Interleukin-5 Interleukin-6 Interleukin-23 Matrix metalloproteinase- Matrix metalloproteinase-9 Matrix metalloproteinase-3 Tissue inhibitor of metalloproteinase- Vascular endothelial cell growth factor A Vascular endothelial cell growth factor C Vascular endothelial cell growth factor receptor (soluble) Transforming growth factor- Transforming growth factor- 2 Fibroblast growth factor basic Epidermal growth factor Leukemia inhibitor factor Leukemia inhibitory factor receptor / gp90

8 IBL International GmbH Flughafenstrasse 52 a D Hamburg Germany Phone: +49 (0) Fax: +49 (0) IBL@IBL-International.com w w w. I B L - I n t e r n a t i o n a l. c o m Cytokine 0/09

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