Viruses. Poxviridae. DNA viruses: 6 families. Herpesviridae Adenoviridae. Hepadnaviridae Papovaviridae Parvoviridae

Size: px
Start display at page:

Download "Viruses. Poxviridae. DNA viruses: 6 families. Herpesviridae Adenoviridae. Hepadnaviridae Papovaviridae Parvoviridae"

Transcription

1 Viruses DNA viruses: 6 families Poxviridae Herpesviridae Adenoviridae Hepadnaviridae Papovaviridae Parvoviridae

2 Human herpesviruses Three subfamilies (genome structure, tissue tropism, cytopathologic effect, site of latent infection) Alphaherpesvirinae: Human herpesvirus 1 Herpes simplex type 1 HSV-1 Human herpesvirus 2 Herpes simplex type 2 HSV-2 Human herpesvirus 3 Varicella-zoster virus VZV Gammaherpesvirinae Human herpesvirus 4 Epstein-Barr virus EBV Human herpesvirus 8 Kaposi s sarcoma related virus HHV-8 Betaherpesvirinae Human herpesvirus 5 Cytomegalovirus CMV Human herpesvirus 6Herpes lymphotropic virus HHV-6 Human herpesvirus 7 Human herpesvirus 7 HHV-7

3 Human herpesviruses Three subfamilies (genome structure, tissue tropism, cytopathologic effect, site of latent infection) Alphaherpesvirinae: Human herpesvirus 1 Herpes simplex type 1 HSV-1 Human herpesvirus 2 Herpes simplex type 2 HSV-2 Human herpesvirus 3 Varicella-zoster virus VZV Gammaherpesvirinae Human herpesvirus 4 Epstein-Barr virus EBV oncogenic Human herpesvirus 8 Kaposi s sarcoma related virus HHV-8 oncogenic Betaherpesvirinae Human herpesvirus 5 Cytomegalovirus CMV: congenital infection Human herpesvirus 6Herpes lymphotropic virus HHV-6 Human herpesvirus 7 Human herpesvirus 7 HHV-7

4 Human herpesviruses

5 Human herpesviruses Large, enveloped double stranded DNA viruses Sensitive to acid, solvents, detergents and drying

6 Human herpesviruses They have common: Virion morphology Basic mode of replication Capacity to establish latent and recurrent infections, in case of EBV immortalizing infections Ubiquitous Usually cause benign disease especially in children In immunosuppressed people they cause significant morbidity and mortality

7 Human herpesviruses -DNA polymerase: -viral DNA replication -good target for antiviral drugs. -lytic,persistant, latent, for EBV immortalizing infections

8 Herpes simplex virus Two types: HSV-1 and HSV-2 HSV can infect most types of human cells and even cells of other species. Lytic infection of fibroblasts and epitelial cells but latent infection of neurons The primary target cell: mucoepitelial cells Site of latency: neurons

9 Herpes simplex virus Means of spread: HSV-1 close contact, HSV-2 close contact+sexual transmission! Generally cause infection at the site of infection HSV-1: infections above the waist HSV-2: infections below the waist

10 Herpes simplex virus

11 Herpes simplex virus

12 Herpes simplex virus

13 Herpes simplex virus

14 Herpes simplex virus Recurrence: stress, trauma, fever, sunlight) The virus travels back down the nerve causing lessions at the dermatome Recurrences are less severe and more localized

15 HSV-1 is common 90% have antibody by 2 years of age HSV-2 occurs later in life with sexual activity Physicians,nurses,dentists at risk for infection of fingers (herpetic whitlow) Immunocompromised people and neonates at risk of disseminated, life-threateneing disease.

16 Laboratory diagnosis Direct antigen detection DNA :PCR in tissue or vesicle fluid

17 Laboratory diagnosis Serology:primary infection, type specific antibody by ELISA (differentiates HSV-1 and HSV-2)

18 Varicella-Zoster Chickenpox(varicella) With recurrence :herpes zostershingles:zona Primary target cell: mucoepitelial cell Site of latency: neuron Means of spread: respiratory and close contact

19 Chickenpox(varicella)

20 Shingles

21 Varicella-Zoster Extremely communicable Rates of infection exceeds 90% among household contact Contagious before and during symptoms Vaccine.

22 Epstein-Barr Virus Heterophile antibody-positive infectious mononucleosis Chronic disease Associated with endemic Burkitt s lymphoma, Hodgkin s disease, nasopharyngeal carcinoma, B-cell lymphomas in patients with acquired or congenital immunodeficiencies. Hairy oral leukoplakia Mitogen for B cells and immortalizes them

23 Epstein-Barr Virus Gammaherpesvirinae: Primary target cell: B cells and epitelial cells Site of latency: B cell Means of spread: saliva (kissing disease).

24 EBV-associated neoplasms Geographic distribution Co-factor? Endemic Burkett s lymphoma: Africa:malaria Nasopharyngeal carcinoma: China

25 Cytomegalovirus(CMV) Betaherpesvirnae: lymphotropic Primary target cell: monocyte, lymphocte, epitelial cell Site of latency: monocyte, lymphocyte and? Means of spread: close contact, transfusions, tissue transplant and congenital

26 Congenital infection

27 Congenital infection An important cause of congenital disease Serious birth defects is high if primary infection occurs during pregnancy Microcephaly, intracerebral calcification,hepatosplenomegaly,rash(cytomega lic inclusion disease), unilateral or bilateral hearing loss, mental retardation CMV in the urine in the first week (culture,pcr)

28 Laboratory tests Antigen in peripheral leucocytes DNA by PCR Cell culture: Human diploid fibroblasts Serology: primary infection

29 Human herpesvirus 8 Kaposi s sarcoma related virus HHV-8 (especially in HIV /AIDS)

30

Human Herpes Viruses (HHV) Mazin Barry, MD, FRCPC, FACP, DTM&H Assistant Professor and Consultant Infectious Diseases KSU

Human Herpes Viruses (HHV) Mazin Barry, MD, FRCPC, FACP, DTM&H Assistant Professor and Consultant Infectious Diseases KSU Human Herpes Viruses (HHV) Mazin Barry, MD, FRCPC, FACP, DTM&H Assistant Professor and Consultant Infectious Diseases KSU HERPES VIRUS INFECTIONS objectives: ØTo know the clinically important HHVs. ØTo

More information

VZV, EBV, and HHV-6-8

VZV, EBV, and HHV-6-8 VZV, EBV, and HHV-6-8 Anne Gershon Common Features of Herpesviruses Morphology Basic mode of replication Primary infection followed by latency Ubiquitous Ability to cause recurrent infections (reactivation

More information

Human Herpesviruses. VZV, EBV, and HHV-6-8. The rash of VZV is vesicular. MID 34

Human Herpesviruses. VZV, EBV, and HHV-6-8. The rash of VZV is vesicular. MID 34 VZV, EBV, and HHV-6-8 Anne Gershon Human Herpesviruses Replication (lytic infection) occurs in a cascade Latency occurs when the cascade is interrupted Transcription of viral genome and protein synthesis

More information

Properties of Herpesviruses

Properties of Herpesviruses Herpesviruses Properties of Herpesviruses Structure and Composition Spherical icosahedron, 150-200 nm Double-stranded DNA, linear More than 35 proteins Enveloped Replication from nucleus (budding) Features

More information

Herpesviruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics

Herpesviruses. Virion. Genome. Genes and proteins. Viruses and hosts. Diseases. Distinctive characteristics Herpesviruses Virion Genome Genes and proteins Viruses and hosts Diseases Distinctive characteristics Virion Enveloped icosahedral capsid (T=16), diameter 125 nm Diameter of enveloped virion 200 nm Capsid

More information

MedChem401 Herpesviridae. Herpesviridae

MedChem401 Herpesviridae. Herpesviridae MedChem401 Herpesviridae Members of the herpesvirus family have been identified in more than 80 different animal species Eight have been identified as human pathogens Herpes viruses are a leading cause

More information

Human Herpesviruses. Medical Virology, 27 Nov 2015.

Human Herpesviruses. Medical Virology, 27 Nov 2015. Human Herpesviruses Assoc.Prof. Murat Sayan Kocaeli Üniversitesi, Rutin PCR Lab. Sorumlu Öğt.Üyesi Yakın Doğu Üniversitesi, DESAM Kurucu Öğrt. Üyesi sayanmurat@hotmail.com 0533 6479020 Medical Virology,

More information

Herpes viruses. Dr.farah hazem. Classification:

Herpes viruses. Dr.farah hazem. Classification: Dr.farah hazem Herpes viruses Herpesviridae are a large family of viruses contains several of the most important human viral pathogens. Clinically, the herpesviruses exhibit a spectrum of diseases. Some

More information

Multiple Choice Questions - Paper 1

Multiple Choice Questions - Paper 1 Multiple Choice Questions - Paper 1 Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could

More information

Lab 3: Pathogenesis of Virus Infections & Pattern 450 MIC PRACTICAL PART SECTION (30397) MIC AMAL ALGHAMDI 1

Lab 3: Pathogenesis of Virus Infections & Pattern 450 MIC PRACTICAL PART SECTION (30397) MIC AMAL ALGHAMDI 1 Lab 3: Pathogenesis of Virus Infections & Pattern 450 MIC PRACTICAL PART SECTION (30397) 2018 450 MIC AMAL ALGHAMDI 1 Learning Outcomes The pathogenesis of viral infection The viral disease pattern Specific

More information

Persistent Infections

Persistent Infections Persistent Infections Lecture 17 Biology 3310/4310 Virology Spring 2017 Paralyze resistance with persistence WOODY HAYES Acute vs persistent infections Acute infection - rapid and self-limiting Persistent

More information

Hepatitis and Herpes Viruses. These two virus groups are very diverse, but cause much human morbidity and mortality

Hepatitis and Herpes Viruses. These two virus groups are very diverse, but cause much human morbidity and mortality Hepatitis and Herpes Viruses These two virus groups are very diverse, but cause much human morbidity and mortality Liver Functions Performs 3 major functions: Regulation: of blood composition glucose levels,

More information

For more information about how to cite these materials visit

For more information about how to cite these materials visit Author(s): David Miller, M.D., Ph.D., 2009 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 License: http://creativecommons.org/licenses/by-nc-sa/3.0/

More information

DNA viruses. complex. enveloped. linear. enveloped. Non-enveloped. circular. Papovaviridae Adenoviridae Parvoviridae Poxviridae.

DNA viruses. complex. enveloped. linear. enveloped. Non-enveloped. circular. Papovaviridae Adenoviridae Parvoviridae Poxviridae. DNA VIRUSES DNA viruses Double stranded Single stranded complex enveloped Non-enveloped Non-enveloped enveloped circular linear Herpesviridae Hepadnaviridae Papovaviridae Adenoviridae Parvoviridae Poxviridae

More information

INFECTION WITH CYTOMEGALOVIRUS

INFECTION WITH CYTOMEGALOVIRUS Analele Universităţii din Oradea, Fascicula:Protecţia Mediului Vol. XIV, 009 INFECTION WITH CYTOMEGALOVIRUS 854 Negruţ Nicoleta University of Oradea, Faculty of Medicine and Pharmacy, Department of Public

More information

Common Features of Herpesviruses

Common Features of Herpesviruses Common Features of Herpesviruses Morphology Basic mode of replication Primary infection followed by latency Ubiquitous Ability to cause recurrent infections (reactivation of latent virus), reinfections

More information

Human Herpesviruses. Varicella-zoster virus. Human Herpesvirus (VZV) phospholipid envelope, tegument, icosahedral capsid, DNA core

Human Herpesviruses. Varicella-zoster virus. Human Herpesvirus (VZV) phospholipid envelope, tegument, icosahedral capsid, DNA core Common Features of Herpesviruses Morphology Basic mode of replication Primary infection followed by latency Ubiquitous Human Herpesvirus (VZV) phospholipid envelope, tegument, icosahedral capsid, DNA core

More information

Large DNA viruses: Herpesviruses, Poxviruses, Baculoviruses and Giant viruses

Large DNA viruses: Herpesviruses, Poxviruses, Baculoviruses and Giant viruses Large DNA viruses: Herpesviruses, Poxviruses, Baculoviruses and Giant viruses Viruses are the only obstacles to the domination of the Earth by mankind. -Joshua Lederberg Recommended reading: Field s Virology

More information

Human Herpesviruses. Varicella-zoster virus. Human Herpesvirus (VZV) phospholipid envelope, tegument, icosahedral capsid, DNA core

Human Herpesviruses. Varicella-zoster virus. Human Herpesvirus (VZV) phospholipid envelope, tegument, icosahedral capsid, DNA core Common Features of Herpesviruses Morphology Basic mode of replication Primary infection followed by latency Ubiquitous Ability to cause recurrent infections (reactivation of latent virus), reinfections

More information

Medical Virology. Herpesviruses, Orthomyxoviruses, and Retro virus. - Herpesviruses Structure & Composition: Herpesviruses

Medical Virology. Herpesviruses, Orthomyxoviruses, and Retro virus. - Herpesviruses Structure & Composition: Herpesviruses Medical Virology Lecture 2 Asst. Prof. Dr. Dalya Basil Herpesviruses, Orthomyxoviruses, and Retro virus - Herpesviruses Structure & Composition: Herpesviruses Enveloped DNA viruses. All herpesviruses have

More information

Herpesviruses: The Tired, the Rashy, and the Ubiquitous

Herpesviruses: The Tired, the Rashy, and the Ubiquitous Herpesviruses: The Tired, the Rashy, and the Ubiquitous M. Anthony Moody, MD Associate Professor Pediatric Infectious Diseases Chief Medical Officer Duke Human Vaccine Institute Duke University Medical

More information

Human Immunodeficiency Virus. Acquired Immune Deficiency Syndrome AIDS

Human Immunodeficiency Virus. Acquired Immune Deficiency Syndrome AIDS Human Immunodeficiency Virus Acquired Immune Deficiency Syndrome AIDS Sudden outbreak in USA of opportunistic infections and cancers in young men in 1981 Pneumocystis carinii pneumonia (PCP), Kaposi s

More information

Chapters 21-26: Selected Viral Pathogens

Chapters 21-26: Selected Viral Pathogens Chapters 21-26: Selected Viral Pathogens 1. DNA Viral Pathogens 2. RNA Viral Pathogens 1. DNA Viral Pathogens Smallpox (pp. 623-4) Caused by variola virus (dsdna, enveloped): portal of entry is the respiratory

More information

Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection. Masoud Mardani M.D,FIDSA

Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection. Masoud Mardani M.D,FIDSA Clinical Aspect and Application of Laboratory Test in Herpes Virus Infection Masoud Mardani M.D,FIDSA Shahidhid Bh BeheshtiMdi Medical lui Universityit Cytomegalovirus (CMV), Epstein Barr Virus(EBV), Herpes

More information

Viral Diseases in the Hematolymphatics. By:Ass. Prof. Nader Alaridah

Viral Diseases in the Hematolymphatics. By:Ass. Prof. Nader Alaridah Viral Diseases in the Hematolymphatics By:Ass. Prof. Nader Alaridah Parvoviruses Members of the family Parvoviridae, are small (diameter, ~22 nm), nonenveloped, icosahedral viruses with a linear single-strand

More information

Repetitorium of selected human viruses HIV

Repetitorium of selected human viruses HIV Repetitorium of selected human viruses HIV Chair and Department of Medical Microbiology Poznan University of Medical Sciences Chairman: prof. dr hab. Andrzej Szkaradkiewicz Wieniawskiego Street 3, 61-712

More information

Alphaherpesvirinae. Simplexvirus (HHV1&2/ HSV1&2) Varicellovirus (HHV3/VZV)

Alphaherpesvirinae. Simplexvirus (HHV1&2/ HSV1&2) Varicellovirus (HHV3/VZV) Alphaherpesvirinae Simplexvirus (HHV1&2/ HSV1&2) Varicellovirus (HHV3/VZV) HERPES SIMPLEX VIRUS First human herpesvirus discovered (1922) Two serotypes recognised HSV-1 & HSV-2 (1962) HSV polymorphism

More information

Virus. Landmarks in Virology. Introduction to Virology. Landmarks in Virology. Definitions. Definitions. Latin for slimy liquid or poison

Virus. Landmarks in Virology. Introduction to Virology. Landmarks in Virology. Definitions. Definitions. Latin for slimy liquid or poison Landmarks in Virology Introduction to Virology Scott M. Hammer, M.D. Introduction of concept of filterable agents for plant pathogens (Mayer, Ivanofsky, Beijerinck in late 1880 s) First filterable agent

More information

Introduction to Viruses That Infect Humans: The DNA Viruses

Introduction to Viruses That Infect Humans: The DNA Viruses Chapter 24 Introduction to Viruses That Infect Humans: The DNA Viruses Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display. 24.1 Viruses in Human Infections and Diseases

More information

Epstein-Barr Virus 1

Epstein-Barr Virus 1 Epstein-Barr Virus 1 Herpesviruses dsdna, linear, enveloped, 180-200 nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV HSV-2 virus particle. Note that

More information

The Clinical Spectrum of Herpesvirus Infections

The Clinical Spectrum of Herpesvirus Infections The Clinical Spectrum of Herpesvirus Infections Rebecca G. Wallihan, MD Assistant Professor of Clinical Medicine Department of Pediatrics Nationwide Children s Hospital The Ohio State University Wexner

More information

Note: Syllabus notes refer to the slides for Dr. Gershon s lecture, which may be downloaded from the course website.

Note: Syllabus notes refer to the slides for Dr. Gershon s lecture, which may be downloaded from the course website. Anne Gershon Herpesviruses Note: Syllabus notes refer to the slides for Dr. Gershon s lecture, which may be downloaded from the course website. Slide 1 Common features of the herpesviruses are: 1. similar

More information

Herpesviruses. -Recurrence: clinically obvious disease due to reactivation. **Reactivation and recurrence are used interchangeably.

Herpesviruses. -Recurrence: clinically obvious disease due to reactivation. **Reactivation and recurrence are used interchangeably. *Herpesviruses: A large group of viruses (100 strains), but we are concerned with only 8 strains as they are the only ones to infect human beings *herpesviruses groups: HSV-1 HSV-2 VZV CMV EBV HHV-6 HHV-7

More information

+ Intermittent shedding in urine, + Urinary tract

+ Intermittent shedding in urine, + Urinary tract Table 16.3 Examples of s in humans Microorganism Site of persistence Infectiousness of microorganism Viruses Consequence Herpes simplex Dorsal root ganglia Activation, cold sore + Salivary glands + Not

More information

Laboratory Diagnosis of Viral Congenital Infections. M Parsania, Ph.D. Tehran Medical Branch, Islamic Azad University

Laboratory Diagnosis of Viral Congenital Infections. M Parsania, Ph.D. Tehran Medical Branch, Islamic Azad University Laboratory Diagnosis of Viral Congenital Infections M Parsania, Ph.D. Tehran Medical Branch, Islamic Azad University HERPES VIRUSES VIRAL STRUCTURE Core: Consists of a single linear molecul of dsdna in

More information

MONTGOMERY COUNTY COMMUNITY COLLEGE CHAPTER 13: VIRUSES. 1. Obligate intracellular parasites that multiply in living host cells

MONTGOMERY COUNTY COMMUNITY COLLEGE CHAPTER 13: VIRUSES. 1. Obligate intracellular parasites that multiply in living host cells MONTGOMERY COUNTY COMMUNITY COLLEGE CHAPTER 13: VIRUSES I. CHARACTERISTICS OF VIRUSES A. General Characteristics 1. Obligate intracellular parasites that multiply in living host cells 2. Contain a single

More information

Herpes viruse. Dr. Hala Al Daghistani. HHV-1 Herpes simplex virus-1 Oral (fever blisters), ocular lesions, encephalitis

Herpes viruse. Dr. Hala Al Daghistani. HHV-1 Herpes simplex virus-1 Oral (fever blisters), ocular lesions, encephalitis Herpes viruse Dr. Hala Al Daghistani HHV-1 Herpes simplex virus-1 Oral (fever blisters), ocular lesions, encephalitis HHV-2 Herpes simplex virus-2 Genital, anal lesions Severe neonatal infections, meningitis

More information

Chronic Viral Infections vs. Our Immune System: Revisiting our view of viruses as pathogens

Chronic Viral Infections vs. Our Immune System: Revisiting our view of viruses as pathogens Chronic Viral Infections vs. Our Immune System: Revisiting our view of viruses as pathogens Tiffany A. Reese Assistant Professor Departments of Immunology and Microbiology Challenge your idea of classic

More information

Introduction to Virology. Landmarks in Virology

Introduction to Virology. Landmarks in Virology Introduction to Virology Scott M. Hammer, M.D. Landmarks in Virology Introduction of concept of filterable agents for plant pathogens (Mayer, Ivanofsky, Beijerinck in late 1880 s) First filterable agent

More information

Common Characteristics and Distinct Features of Human Pathogenic Herpesviruses

Common Characteristics and Distinct Features of Human Pathogenic Herpesviruses Common Characteristics and Distinct Features of Human Pathogenic Herpesviruses Hartmut Hengel Chapter 1 1.1 Hallmarks of Herpesvirus Infections The members of the family of the herpesviridae are phylogenetically

More information

herpesviruses dsdna, linear, enveloped, nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV

herpesviruses dsdna, linear, enveloped, nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV Herpesviridae herpesviruses dsdna, linear, enveloped, 180-200 nm Large genome, codes for 75 viral proteins 50-70% similarity Cross reactivity between HSV and VZV HSV-2 virus particle. Note that all herpesviruses

More information

Foundations in Microbiology Seventh Edition

Foundations in Microbiology Seventh Edition Lecture PowerPoint to accompany Foundations in Microbiology Seventh Edition Talaro Chapter 24 To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn

More information

BLOCK 12 Viruses of the ENT

BLOCK 12 Viruses of the ENT BLOCK 12 Viruses of the ENT Acute infections Introduction Pharyngitis, Common cold, Sinusitis, Otitis media Recurrent infections Herpes zoster oticus Chronic infections HIV and ENT manifestations Neoplasms

More information

A summary of guidance related to viral rash in pregnancy

A summary of guidance related to viral rash in pregnancy A summary of guidance related to viral rash in pregnancy Wednesday 12 th July 2017 Dr Rukhsana Hussain Introduction Viral exanthema can cause rash in pregnant women and should be considered even in countries

More information

VIRUSES AND CANCER Michael Lea

VIRUSES AND CANCER Michael Lea VIRUSES AND CANCER 2010 Michael Lea VIRAL ONCOLOGY - LECTURE OUTLINE 1. Historical Review 2. Viruses Associated with Cancer 3. RNA Tumor Viruses 4. DNA Tumor Viruses HISTORICAL REVIEW Historical Review

More information

Section 1 Individual viruses. Introduction to virology. History of viruses. Viral taxonomy

Section 1 Individual viruses. Introduction to virology. History of viruses. Viral taxonomy Section 1 Individual viruses Introduction to virology History of viruses The existence of viruses was first suspected in the nineteenth century when it was shown that filtered extract of infective material

More information

Immunodeficiencies HIV/AIDS

Immunodeficiencies HIV/AIDS Immunodeficiencies HIV/AIDS Immunodeficiencies Due to impaired function of one or more components of the immune or inflammatory responses. Problem may be with: B cells T cells phagocytes or complement

More information

Viruses. CLS 212: Medical Microbiology Miss Zeina Alkudmani

Viruses. CLS 212: Medical Microbiology Miss Zeina Alkudmani Viruses CLS 212: Medical Microbiology Miss Zeina Alkudmani History Through the 1800s, many scientists discovered that something smaller than bacteria could cause disease and they called it virion (Latin

More information

Herpes Simplex Virus 1-2

Herpes Simplex Virus 1-2 Yamilet Melendez Microbiology 1 Presentation Herpes Simplex Virus 1-2 Introduction Herpes viruses are a leading cause of human viral diseases, second only to influenza and cold viruses Are capable of causing

More information

The Study of Congenital Infections. A/Prof. William Rawlinson Dr. Sian Munro

The Study of Congenital Infections. A/Prof. William Rawlinson Dr. Sian Munro The Study of Congenital Infections A/Prof. William Rawlinson Dr. Sian Munro Current Studies SCIP Study of Cytomegalovirus (CMV) Infection in Pregnancy ASCI Amniotic Fluid Study of Congenital Infections

More information

19/06/2013. Viruses are not organisms (do not belong to any kingdom). Viruses are not made of cells, have no cytoplasm, and no membranes.

19/06/2013. Viruses are not organisms (do not belong to any kingdom). Viruses are not made of cells, have no cytoplasm, and no membranes. VIRUSES Many diseases of plants and animals are caused by bacteria or viruses that invade the body. Bacteria and viruses are NOT similar kinds of micro-organisms. Bacteria are classified as living organisms,

More information

COMMON VIRAL INFECTIONS. Dr D. Tenea Department of Dermatology University of Pretoria

COMMON VIRAL INFECTIONS. Dr D. Tenea Department of Dermatology University of Pretoria COMMON VIRAL INFECTIONS Dr D. Tenea Department of Dermatology University of Pretoria GENERAL Viral infections of the skin important in immunocompromised Pts. Infection: direct inoculation ( warts ) or

More information

Cytomegalovirus (CMV) End-Point PCR Kit Product# EP36300

Cytomegalovirus (CMV) End-Point PCR Kit Product# EP36300 3430 Schmon Parkway Thorold, ON, Canada L2V 4Y6 Phone: 866-667-4362 (905) 227-8848 Fax: (905) 227-1061 Email: techsupport@norgenbiotek.com Cytomegalovirus (CMV) End-Point PCR Kit Product# EP36300 Product

More information

الحترمونا من خري الدعاء

الحترمونا من خري الدعاء الحترمونا من خري الدعاء Instructions for candidates The examination consists of 30 multiple choice questions, each divided into 5 different parts. Each part contains a statement which could be true or

More information

Infections in immunocompromised host

Infections in immunocompromised host Infections in immunocompromised host Immunodeficiencies Primary immunodeficiencies Neutrophil defect Humoral: B cell defect Humoral: Complement Cellular: T cells Combined severe immunodeficiency Secondary

More information

Viral hepatitis. Supervised by: Dr.Gaith. presented by: Shaima a & Anas & Ala a

Viral hepatitis. Supervised by: Dr.Gaith. presented by: Shaima a & Anas & Ala a Viral hepatitis Supervised by: Dr.Gaith presented by: Shaima a & Anas & Ala a Etiology Common: Hepatitis A Hepatitis B Hepatitis C Hepatitis D Hepatitis E Less common: Cytomegalovirus EBV Rare: Herpes

More information

Persistent Infections

Persistent Infections Persistent Infections Lecture 16 Virology W3310/4310 Spring 2013 1 Breaking Up Is Hard To Do Neil Sedaka 1962 2 Acute vs. Persistent Infections Acute - a natural infection that usually is rapid and self

More information

Welcome to Pathogen Group 6

Welcome to Pathogen Group 6 Welcome to Pathogen Group 6 Human herpesviruses 1 (HHV-1) and 2 (HHV-2 or HSV-2) Varicella-zoster virus (chickenpox and shingles) Neisseria gonorrhoeae Treponema pallidum Human papillomaviruses (HPV) Human

More information

To provide guidance on prevention and control of illness caused by varicella-zoster virus (VZV).

To provide guidance on prevention and control of illness caused by varicella-zoster virus (VZV). Effective Date: 04/18 Replaces: 0 4 / 1 3 / 1 7 Page 1 of 4 POLICY: To provide guidance on prevention and control of illness caused by varicella-zoster virus (VZV). DEFINITIONS Two syndromes occur from

More information

Chapter 25. 바이러스 (The Viruses)

Chapter 25. 바이러스 (The Viruses) Chapter 25 바이러스 (The Viruses) Generalized Structure of Viruses 2 2 Virus Classification Classification based on numerous characteristics Nucleic acid type Presence or absence of envelope Capsid symmetry

More information

Nucleic acid Strands Family Example Accession Base pairs

Nucleic acid Strands Family Example Accession Base pairs Table 16.1 Classification of viruses based on nucleic acid composition. Note that NCBI BioProject accessions begin PRJNA and typically encompass several segments. Adapted from Schaechter et al. (1999)

More information

Viruses. Properties. Some viruses contain other ingredients (e.g., lipids, carbohydrates), but these are derived from their host cells.

Viruses. Properties. Some viruses contain other ingredients (e.g., lipids, carbohydrates), but these are derived from their host cells. Viruses Properties They are obligate intracellular parasites. Probably there are no cells in nature that escape infection by one or more kinds of viruses. (Viruses that infect bacteria are called bacteriophages.)

More information

laboratory methods in diagnosis of viral infections in

laboratory methods in diagnosis of viral infections in laboratory methods in diagnosis of viral infections in immunocompromised patients Masoud Parsania, Ph.D. Masoud Parsania, Ph.D. Department of Microbiology, Tehran Medical Sciences Branch, Islamic Azad

More information

California Association for Medical Laboratory Technology

California Association for Medical Laboratory Technology California Association for Medical Laboratory Technology Distance Learning Program The Bug Everyone Has Epstein-Barr Virus: A Case Study Course # DL- Jane Bruner, CLS(ASCP), Ph.D. Associate Dean, College

More information

Potential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections.

Potential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections. In the name of God Principles of post Tx infections 1: Potential etiologies of infection in these patients are diverse, including common and uncommon opportunistic infections. Infection processes can progress

More information

Prof Dr Najlaa Fawzi

Prof Dr Najlaa Fawzi 1 Prof Dr Najlaa Fawzi is an acute highly infectious disease, characterized by vesicular rash, mild fever and mild constitutional symptoms. is a local manifestation of reactivation of latent varicella

More information

Basheq Jehad. Mohammed Khraisat. Ashraf Al-Khasawneh

Basheq Jehad. Mohammed Khraisat. Ashraf Al-Khasawneh 2 Basheq Jehad Mohammed Khraisat Ashraf Al-Khasawneh 0 Note: information in boxes are copied from the slides, the doctor have read them. In this lecture we will talk about three viruses (parvovirus,hhv8

More information

History electron microscopes

History electron microscopes Viruses History Through the 1800s, many scientists discovered that something smaller than bacteria could cause disease and they called it virion (Latin word- poison) In the 1930s, after the invention of

More information

Viruses. Rotavirus (causes stomach flu) HIV virus

Viruses. Rotavirus (causes stomach flu) HIV virus Viruses Rotavirus (causes stomach flu) HIV virus What is a virus? A virus is a microscopic, infectious agent that may infect any type of living cell. Viruses must infect living cells in order to make more

More information

Virology Introduction. Definitions. Introduction. Structure of virus. Virus transmission. Classification of virus. DNA Virus. RNA Virus. Treatment.

Virology Introduction. Definitions. Introduction. Structure of virus. Virus transmission. Classification of virus. DNA Virus. RNA Virus. Treatment. DEVH Virology Introduction Definitions. Introduction. Structure of virus. Virus transmission. Classification of virus. DNA Virus. RNA Virus. Treatment. Definitions Virology: The science which study the

More information

virology MCQs 2- A virus commonly transmitted by use of contaminated surgical tools & needles produces a disease called serum hepatitis.

virology MCQs 2- A virus commonly transmitted by use of contaminated surgical tools & needles produces a disease called serum hepatitis. virology MCQs 1- A virus which causes AIDS is: a- Small pox virus. b- Coxsackie B virus. c- Mumps virus. d- Rubella virus. e- HIV-III virus. 2- A virus commonly transmitted by use of contaminated surgical

More information

Disease and Contemporary Society

Disease and Contemporary Society Disease and Contemporary Society Alan Mortimer PhD Lecture 1 The notes to accompany this lecture series are provided for the educational use of the course participants. It is believed that images may be

More information

EBV and Infectious Mononucleosis. Infectious Disease Definitions. Infectious Diseases

EBV and Infectious Mononucleosis. Infectious Disease Definitions. Infectious Diseases Infectious Disease Definitions Infection when a microorganism invades a host and multiplies enough to disrupt normal function by causing signs and symptoms Pathogencity ability of an organism to cause

More information

Lecture 10 VIROLOGY Assistant prof.dr. Baheeja A. alkhalidi

Lecture 10 VIROLOGY Assistant prof.dr. Baheeja A. alkhalidi Lecture 10 VIROLOGY Assistant prof.dr. Baheeja A. alkhalidi Viruses are microbes that REQUIRE a host cell to replicate. By themselves they cannot replicate. They border on the edge of living and non-living.

More information

Virology - Lecture 2

Virology - Lecture 2 Virology - Lecture 2 Last lecture we discussed Measles, Rubella and Mumps as childhood viral exanthems. Today's lecture is based on topics from the previous semester. We will be talking about: 1- Parvovirus

More information

Herpesviridae Papillomaviridae. Herpesviridae Papillomaviridae Adenoviridae. Adenoviridae. Anelloviridae Circoviridae Hepadnaviridae

Herpesviridae Papillomaviridae. Herpesviridae Papillomaviridae Adenoviridae. Adenoviridae. Anelloviridae Circoviridae Hepadnaviridae Human DNA viruses Herpesviridae Papillomaviridae Adenoviridae Maciej Przybylski Chair and Department of Medical Microbiology DNA viruses infecting human Adenoviridae Anelloviridae Circoviridae Hepadnaviridae

More information

1. Selected Viral Pathogens

1. Selected Viral Pathogens Chapters 19-24: Selected Pathogens 1. Selected Viral Pathogens 2. Selected Bacterial Pathogens 1. Selected Viral Pathogens Influenza (flu) (pp. 678-682) Caused by various strains of Influenzavirus (RNA,

More information

HERPES VIRUSES. Large DNA viruses, replication is intranuclear and produce typical intranuclear inclusions.

HERPES VIRUSES. Large DNA viruses, replication is intranuclear and produce typical intranuclear inclusions. Viral infections HERPES VIRUSES Large DNA viruses, replication is intranuclear and produce typical intranuclear inclusions. Typical feature: absence of viral elimination after infection, clinical latency

More information

HSV DNA replication. Herpesvirus Latency. Latency and Chemotherapy. Human Herpesviruses - subtypes. Acyclovir (acycloguanosine) {Zovirax}

HSV DNA replication. Herpesvirus Latency. Latency and Chemotherapy. Human Herpesviruses - subtypes. Acyclovir (acycloguanosine) {Zovirax} Human Herpesviruses - subtypes Herpes Simplex I (HSVI) - herpes labialis (cold sores) herpes keratitis (eye infections) HSVII - herpes genitalis (genital herpes) Varicella Zoster virus (VZV) Chicken pox

More information

How could the small size of viruses have helped researchers detect viruses before the invention of the electron microscope? 13-1

How could the small size of viruses have helped researchers detect viruses before the invention of the electron microscope? 13-1 3 4 5 6 7 8 9 0 3 4 5 6 Chapter 3 Viruses, Viroids, and Prions General Characteristics of Viruses General Characteristics of Viruses Obligatory intracellular parasites Contain DNA or RNA Contain a protein

More information

Medical Virology Pathogenesis of viral infection

Medical Virology Pathogenesis of viral infection Medical Virology Pathogenesis of viral infection Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Pathogenesis of viral infection Viral

More information

Herpesviruses. Tools of diagnosis : what to use and when. Corinne Liesnard Laboratory of Virology Erasme Hospital - ULB

Herpesviruses. Tools of diagnosis : what to use and when. Corinne Liesnard Laboratory of Virology Erasme Hospital - ULB Herpesviruses Tools of diagnosis : what to use and when Corinne Liesnard Laboratory of Virology Erasme Hospital - ULB Evolution of the techniques in the virology lab Techniques : "Classic" methods Ag detection

More information

General Properties of Viruses

General Properties of Viruses 1 I. Viruses as Agents of Disease. V. F. Righthand, Ph.D. August 15, 2001 General Properties of Viruses Viruses can infect every form of life. There are hundreds of different viruses that can produce diseases

More information

Cytomegalovirus in critically ill patients

Cytomegalovirus in critically ill patients ! Cytomegalovirus in critically ill patients Frédéric Pène Medical ICU, Hôpital Cochin, AP-HP, Paris, France Université Paris Descartes, Sorbonne Paris Cité Institut Cochin, Inserm U1016, CNRS UMR-8104

More information

Introduction to Microbiology for M.D. Students. University of Jordan. School of Medicine. Section of Microbiology and Immunology

Introduction to Microbiology for M.D. Students. University of Jordan. School of Medicine. Section of Microbiology and Immunology Introduction to Microbiology for M.D. Students University of Jordan School of Medicine Department of Pathology, Microbiology and Forensic Medicine Section of Microbiology and Immunology Malik Sallam, MD,

More information

OCCUPATIONAL HEALTH DISEASE SPECIFIC RECOMMENDATIONS

OCCUPATIONAL HEALTH DISEASE SPECIFIC RECOMMENDATIONS Herpes simplex virus (HSV) Cold sores Genital herpes Herpetic whitlow OCCUPATIONAL HEALTH DISEASE SPECIFIC RECOMMENDATIONS contact with primary or recurrent lesions, infectious saliva or genital secretions

More information

Prokaryotic Biology. VIRAL STDs, HIV-1 AND AIDS

Prokaryotic Biology. VIRAL STDs, HIV-1 AND AIDS Prokaryotic Biology VIRAL STDs, HIV-1 AND AIDS Prokaryotic Biology FROM THE CDC VIRAL STDs, HIV-1 AND AIDS VIRAL STDs & CONTACT VIRAL DISEASES A. GENITAL HERPES & COLD SORES 1. HERPES SIMPLEX VIRUS-2 (HHV-2)

More information

Bio-Rad Laboratories. The Best Protection Whoever You Are. Congenital and Pediatric Disease Testing

Bio-Rad Laboratories. The Best Protection Whoever You Are. Congenital and Pediatric Disease Testing Bio-Rad Laboratories I N F E C T I O U S D I S E A S E T E S T I N G The Best Protection Whoever You Are Congenital and Pediatric Disease Testing Bio-Rad Laboratories I N F E C T I O U S D I S E A S E

More information

EBV infection B cells and lymphomagenesis. Sridhar Chaganti

EBV infection B cells and lymphomagenesis. Sridhar Chaganti EBV infection B cells and lymphomagenesis Sridhar Chaganti How EBV infects B-cells How viral genes influence the infected B cell Differences and similarities between in vitro and in vivo infection How

More information

Viruses and cancer: Should we be more afraid?

Viruses and cancer: Should we be more afraid? Viruses and cancer: Should we be more afraid? Viruses and cancer: Should we be more afraid? During the past 30 years it has become exceedingly clear that several viruses play significant roles in the development

More information

Antiviral Drugs Lecture 5

Antiviral Drugs Lecture 5 Antiviral Drugs Lecture 5 Antimicrobial Chemotherapy (MLAB 366) 1 Dr. Mohamed A. El-Sakhawy 2 Introduction Viruses are microscopic organisms that can infect all living cells. They are parasitic and multiply

More information

History of Virology. Russian Bacteriologist Dimitri Iwanowski TMD tobacco mosaic disease TMV isolated and purified

History of Virology. Russian Bacteriologist Dimitri Iwanowski TMD tobacco mosaic disease TMV isolated and purified Viruses & Prions Viruses Virus miniscule, acellular, infectious agent having one or several pieces of either DNA or RNA No cytoplasmic membrane, cytosol, organelles Cannot carry out any metabolic pathway

More information

http://www.savinglivesuk.com/ HIV Awareness Study Morning 24 th November 2017 Agenda HIV Basics & Stages of HIV HIV Testing, Health Advising & Sexual Health Saving Lives Antiretroviral Medication Antenatal/Postnatal

More information

Chair of Medical Biology, Microbiology, Virology, and Immunology STRUCTURE, CLASSIFICATION AND PHYSIOLOGY OF VIRUSES

Chair of Medical Biology, Microbiology, Virology, and Immunology STRUCTURE, CLASSIFICATION AND PHYSIOLOGY OF VIRUSES Chair of Medical Biology, Microbiology, Virology, and Immunology STRUCTURE, CLASSIFICATION AND PHYSIOLOGY OF VIRUSES Viruses are small obligate intracellular parasites, which by definition contain either

More information

Infectious Mononucleosis The Virus Pathophysiology: Age: History: Fever. Lymphadenopathy

Infectious Mononucleosis The Virus Pathophysiology: Age: History: Fever. Lymphadenopathy Infectious Mononucleosis The Virus A member of the Herpesvirus family Infects human B lymphocytes Herpes viruses contain double-stranded DNA, and they have an icosahedral capsid and a glycoprotein-containing

More information

Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS

Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS APRIL 2017 Infectious viruses are a global health threat Since the approval of the first antiviral drug

More information

Human Herpes Viruses

Human Herpes Viruses Human Herpes Viruses Objectives: To know the clinically important HHVs. To know the common characteristics of HHVs. To know the common modes of transmission of different HHVs To know the clinical features

More information

Congenital/Neonatal Herpes Simplex Infections

Congenital/Neonatal Herpes Simplex Infections Congenital/Neonatal Herpes Simplex Infections Infectious and Tropical Pediatric Division Department of Child Health Medical Faculty University of Sumatera Utara Herpes Infections Herpes from the Greek

More information

Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS

Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS Image of Ebola viruses exiting host cells HUMAN VIRUSES & THE LIMITATION OF ANTIVIRAL DRUG AGENTS MAY 2017 1 Infectious viral pathogens are a significant global health threat to mankind 2 Since the approval

More information