Advanced HIV Disease / AIDS
|
|
- Lorena Barker
- 5 years ago
- Views:
Transcription
1 Advanced HIV Disease / AIDS Technical Summary for Activists Gilles Van Cutsem, SAMU, MSF
2 Objectives Why is increased investment in Advanced HIV Disease (AHD) / AIDS critical? What are the issues? What are we asking for?
3 Definition of advanced disease Adults, adolescents and children 5 years with: CD4 cell count < 200 or WHO stage 3 or 4 event All children <5 years old with HIV infection
4 Why we need to invest in AHD/AIDS HIV deaths in 2017 (WHO GHO, 2018) Decline in HIV deaths is slowing down (WHO, 2018) 1/3 PLHIV present to care with AHD (WHO, 2017) Majority of PLHIV admitted to hospital have AHD (Ousley 2018, CID) Inpatient mortality is extremely high (Ousley 2018, CID) HIV response has focused on Test & Treat Neglect of mortality reduction (e.g. PEPFAR only introduced an indicator on mortality in 2018)
5 Role of ART experienced underestimated Historical focus on T&T of late presenters Shift of AHD towards ART experienced: Re-entry into care after treatment interruption Undetected or untreated treatment failure Most important factor for future adult HIV incidence: viral suppression on ART (Johnson 2016, GHA)
6 Late presentation & ART discontinuation 2016 South Africa 33% started ART at CD4 <200 17% started ART at CD4 <100 Men twice as likely to start late Carmona et al Clin Inf Dis 2018; Osler et al; Clin Inf Dis 2018 Continuing Burden of Advanced HIV Disease Over 10 Years of Increasing Antiretroviral Therapy Coverage in South Africa,Meg Osler & all, CID 2018;66,suppl 2)
7 Factors influencing future HIV incidence (Johnson 2016)
8 ART failure & ART interruption Opportunistic infections: 1. TB 2. Cryptococcal Meningitis 3. Severe Bacterial Infections 4. Pneumocystis Pneumonia (PCP) 5. Toxoplasmosis 6. Kaposi Sarcoma (Ford 2015, Lancet) Main causes of death
9 What do we need AHD in national policies Diagnostic & screening tests: CD4 VL CrAg TB-LAM GeneXpert Prevention: TB: CTX/INH/B6; 3(1)HP; IPT Crypto: fluconazole Toxo, PCP & SBI: cotrimoxazole (CTX) Treatment: Crypto: flucytosine, amphotericin B, fluconazole Toxo/PCP: CTX, clindamycin, primaquine SBI: broad-spectrum antibiotics (ceftriaxone ) Kaposi: chemotherapy (PLD, ABV, paclitaxel) Models of care: Adherence strategies Early Tracing of lost to follow-up Welcome back services Post-discharge follow-up
10 Policies: preliminary results from the dashboard Kenya, Lesotho, Zambia have AHD policies Other 29 countries surveyed don t
11 CD4 The entry door to the AHD package of care NOT for monitoring (unless there is no VL): targeted or diagnostic CD4 For diagnosis of AHD: At initiation or re-initiation of ART If VL is high If clinically indicated (e.g. new OI) To help with diagnosis of Ois (frequency differs at different CD4) In Emergency Wards POC is preferable Gap: Often not funded by PEPFAR, GF, MoH Stockouts of reagents and cartridges Maintenance of machines
12 Viral load At 6 months after start ART and then annually Essential to detect poor adherence or treatment failure Needs to lead to re-suppression Number switched to 2 nd line Gaps: Often only # of 1 st VL reported Useless without # 2 nd VL and # switched to 2 nd line Report on % on ART who are suppressed Commodities often not present Laboratory capacity
13 TB-LAM Greatly increases detection of TB Decreases mortality in hospital (STAMP trial) Shortens time to TB treatment (Huerga 2018) For all PLHIV admitted to hospital + at PHC all with TB symptoms or severely ill Role for screening unclear Gaps: Hardly used outside of research (except South Africa) Very limited provision by PEPFAR and GF Often no policy
14 CrAg For all CD4<100 Positivity should lead to lumbar puncture At hospital and PHC Gaps: Policy Funding Supply
15 Treatment TB: - CTX/INH/B6-3HP Crypto: - Fluconazole: funding, supply - Flucytosine: registration, policy, funding - Ampho B: funding, adverse events - Liposomal Ampho B: policy, cost
16 Treatment Severe bacterial infections: Antibiotics: ceftriaxone Kaposi sarcoma: The key is to have some chemotherapy options: PLD (pegylated liposomal doxorubicin): best but expensive and production issues Paclitaxel: cheaper but slightly more complex ABV (doxorubicin/bleomycin/vincristine): inferior to options above but cheaper; definitely better than nothing. Mono- and bitherapy are last resort, inferior options
17 Models of care Adherence support & differentiated models of care to help patients stay on ART Early tracing of lost to follow up: to bring patients with AHD back into care Welcome back services: to ensure people with prior ART exposure feel comfortable and access adequate treatment Post-discharge follow-up: to prevent high mortality after hospitalisation
Challenge - Advanced HIV in Antiretroviral- Experienced Patients. Esther C. Casas South African Medical Unit Medecins Sans Frontieres
Challenge - Advanced HIV in Antiretroviral- Experienced Patients Esther C. Casas South African Medical Unit Medecins Sans Frontieres The forgotten 4 th 90: HIV related mortality plateauing % of Advance
More informationCD4 WORKSHOP REPORT JULY 22, 2017
CD4 WORKSHOP REPORT JULY 22, 2017 TABLE OF CONTENTS Contents Introduction 1 Strengthening the interface between diagnostics and care treatment monitoring 2 Findings from the first regional CD4 workshop
More informationDifferentiated Care Improving Engagement and Retention in HIV Care. Meg Doherty, MD PhD MPH World Health Organization
Differentiated Care Improving Engagement and Retention in HIV Care Meg Doherty, MD PhD MPH World Health Organization Why differentiated care and how can it facilitate epidemic control Effects on linkage,
More informationWho Is Dying and Why? AIDS Mortality as a Progress Metric
Who Is Dying and Why? AIDS Mortality as a Progress Metric Sharonann Lynch HIV & TB Policy Advisor MSF Access Campaign 1 OUTLINE 1. Trends in mortality 2. Finding the RIPs among the LTFU 3. Who is dying
More informationAdvanced HIV and seriously ill: challenges in low resource settings Rosie Burton, Southern African Medical Unit, MSF
Advanced HIV and seriously ill: challenges in low resource settings Rosie Burton, Southern African Medical Unit, MSF Mozambique Mozambique Mozambique Mozambique Preventing mortality MSF hospital, Kinshasa,
More informationEast Africa Regional CD4 Workshop: The Role of CD4 Testing During Viral Load Scale-Up
East Africa Regional Workshop: The Role of Testing During Viral Load Scale-Up 18-19 May 2017 Nairobi, Kenya 1 Background... 3 Strengthening the Interface between Diagnostics and Care... 3 Country Needs
More informationFrom to zero new infections, zero deaths, reduced stigma
From 95-95-95 to zero new infections, zero deaths, reduced stigma Ambassador Deborah Birx IAS July 2018 #PEPFAR15 Moving from generic to specific Moving from words to action Holding ourselves accountable
More informationOPPORTUNISTIC INFECTIONS. Institute of Infectious Diseases, Pune India
OPPORTUNISTIC INFECTIONS Institute of Infectious Diseases, Pune India DISCLOSURES Nothing to declare Outline The problem Bacterial Fungal Protozoal Viral Decline in OI prevalence in HAART era: USA CROI
More informationOpportunities for improvement
Are there opportunities to manage cryptococcal meningitis better? Signals High-quality evidence Nelesh Govender National Institute for Communicable Diseases Inclusion in guidelines Translation into clinical
More informationStopping Senseless Deaths
MSF Access Campaign Technical Briefing Document JULY 2018 Stopping Senseless Deaths Overcoming access barriers to affordable, lifesaving diagnostics and treatments for HIV and opportunistic infections
More informationThe CQUIN Learning Network Patients at High Risk: Innovations and Experience
The CQUIN Learning Network Patients at High Risk: Innovations and Experience Lucas Molfino Medecins Sans Frontieres MSF Mozambique July 17-19, 2017 Harare, Zimbabwe Chamanculo Project Background CRAM-
More informationHIV Viral Load Testing Market Analysis. September 2012 Laboratory Services Team Clinton Health Access Initiative
HIV Viral Load Testing Market Analysis September 2012 Laboratory Services Team Clinton Health Access Initiative Agenda Background on Viral Load Testing Growth of Global Viral Load Market Factors Impacting
More informationPatients at High Risk Experience, Guidelines, and Best Practices. Mozambique. José Tique, MD MPH MoH July 17-19, 2017 Harare, Zimbabwe
Patients at High Risk Experience, Guidelines, and Best Practices Mozambique José Tique, MD MPH MoH July 17-19, 2017 Harare, Zimbabwe Content Scope of the Problem Treatment Guidelines Best Prac9ces Differen9a9ng
More informationNatural History of Untreated HIV-1 Infection
Opportunistic infections Dr. Guido van den Berk December 2009 HIV [e] EDUCATION Natural History of Untreated HIV-1 Infection 1000 + CD4 Cells 800 600 400 Constitutional Symptoms Early Opportunistic Infections
More informationThe Financial Implications of Reaching Global Treatment and Prevention Goals CHAI slide warehouse
The Financial Implications of Reaching Global Treatment and Prevention Goals CHAI slide warehouse Clinton Health Access Initiative (CHAI) October 2, 2015 As we near global consensus toward test and offer
More informationOpportunistic Infections BHIVA Guidelines
Opportunistic Infections BHIVA Guidelines Mark Nelson David Dockrell Simon Edwards I have.. 1. Read all of the BHIVA guidelines 12% 2. Read some of the BHIVA guidelines in their entirety 3. Browsed some
More informationThe CQUIN Learning Network Lighthouse ALUP and POC VL: Innovations and Experience
The CQUIN Learning Network Lighthouse ALUP and POC VL: Innovations and Experience Eric Auben Mtemang ombe Lighthouse Trust - Malawi July 17-19, 2017 Harare, Zimbabwe THE LIGHTHOUSE WHO recognized Centre
More informationMeningi&s in HIV NORTHWEST AIDS EDUCATION AND TRAINING CENTER
NORTHWEST AIDS EDUCATION AND TRAINING CENTER Meningi&s in HIV Christina M. Marra, MD Neurology and Medicine University of Washington School of Medicine Susceptibility to CNS Opportunistic Infections CD4+
More informationLEFT BEHIND BY THE HIV RESPONSE
LEFT BEHIND BY THE HIV RESPONSE Advanced HIV in the Democratic Republic of Congo: Free care, adapted to patient needs, is essential for survival. Kinshasa, Democratic Republic of Congo December 2017 ADVANCED
More informationAWACC-2011 ART in the Inpatient Setting
AWACC-2011 ART in the Inpatient Setting Why no ART preparation for inpatients? 1.No link between inpatient and outpatient programmes HIV and AIDS services are delivered by well-funded but separate vertical
More informationOI prophylaxis When to start, when to stop. Eva Raphael, MD MPH Family and community medicine, pgy-2 University of California, San Francisco
OI prophylaxis When to start, when to stop Eva Raphael, MD MPH Family and community medicine, pgy-2 University of California, San Francisco Learning Objectives o Recognize when to start OI prophylaxis
More informationA Call to Action. Differentiated Service Delivery for Adults at High Risk of HIV Disease Progression
Differentiated Service Delivery for Adults at High Risk of HIV Disease Progression A Call to Action HIV LEARNING NETWORK The CQUIN Project for Differentiated Service Delivery Table of Contents Acknowledgements...
More informationDiagnostics product development projects
Page 0 Diagnostics product development projects Smiljka de Lussigny Technical Officer, HIV UNITAID Copenhagen, 23 September 2013 Page 1 1 2 3 About UNITAID HIV diagnostics market UNITAID s current investment
More informationINH Prophylaxis Therapy (IPT) should NOT be implemented for all HIV patients in the Asia Pacific
INH Prophylaxis Therapy (IPT) should NOT be implemented for all HIV patients in the Asia Pacific Thuy Le, MD DPhil Duke University School of Medicine, USA Oxford University Clinical Research Unit Hospital
More informationCryptococcal Meningitis
Cryptococcal Meningitis Dr N Thumbiran Infectious Diseases Department UKZN Index patient 27 year old female Presented to King Edward Hospital on 17/07/2005 with: Severe headaches Vomiting Photophobia X
More informationTB and HIV co-infection including IRIS
TB and HIV co-infection including IRIS Richard Lessells SAHCS Conference 2018 Clinical scenario 1 36-year-old male Presents with cough, fever & weight loss HIV test positive (new diagnosis) Sputum Xpert
More informationApproach to the critically ill patient with advanced HIV in low resource settings. Sebastian Albus, MD MSF, Operational Center Bruxelles
Approach to the critically ill patient with advanced HIV in low resource settings Sebastian Albus, MD MSF, Operational Center Bruxelles why You should be this guy. instead of that guy ME USFR, Guinea-Conakry
More informationSummary of PEPFAR State of Program Area (SOPA): Care & Support
Summary of PEPFAR State of Program Area (SOPA): Care & Support Prepared by E. Michael Reyes, MD, MPH (Original SOPA is a 45 page document) Introduction: Care and Support refers to the broad array of non-art
More informationInvesting for Impact
Global Fund Strategic Framework: Investing for Impact M&E: Capturing data to improve services Workshop to Scale Up the Implementation of Collaborative TB/HIV Activities in Africa 10-11 April, 2013; Maputo,
More informationAccelerating Children s HIV Treatment (ACT): Rationale, Progress & Challenges
Accelerating Children s HIV Treatment (ACT): Rationale, Progress & Challenges George Siberry, MD, MPH OGAC Senior Technical Advisor for Pediatrics March, 2016 Compared to Adults, Children (
More informationHIV DIAGNOSTIC TESTS IN LOW- AND MIDDLE-INCOME COUNTRIES: FORECASTS OF GLOBAL DEMAND FOR
HIV DIAGNOSTIC TESTS IN LOW- AND MIDDLE-INCOME COUNTRIES: FORECASTS OF GLOBAL DEMAND FOR 2015 2020 Presented by Vincent Habiyambere (WHO), Biyi Adesina (Avenir Health) and Meghan Wareham (CHAI) on behalf
More informationCLINICAL GUIDELINES: MANAGING COMMON COINFECTIONS AND COMORBIDITIES
CLINICAL GUIDELINES: MANAGING COMMON COINFECTIONS AND COMORBIDITIES 5 5.1 Introduction.... 192 5.2 Prevention, screening and management of common coinfections.... 192 5.3 Prevention, screening and management
More informationversus CD4. PoC - Messaging - Specificity and - Ethics sensitivity of HIV - Feedback from diagnostic tests demonstration projects
PRE-CONFERENCE WORKSHOPS WEDNESDAY, 24 OCTOBER 2018 10h00 14h00 Pre-Conference Workshop Pre-Conference Workshop Pre-Conference Workshop Pre-Conference Workshop ITREMA trial feedback PrEP for the private
More informationOutline. Cryptococcosis Pneumocystosis Diarrhea. Case Histories: HIV Related- Opportunistic Infections in 2015
AU Edited: 05/06/15 Case Histories: HIV Related- Opportunistic Infections in 2015 Henry Masur, MD Clinical Professor of Medicine George Washington University School of Medicine Bethesda, Maryland Washington,
More informationMDR TB/HIV INTEGRATION MDR TB WORKSHOP 18 SEPTEMBER 2015
MDR TB/HIV INTEGRATION MDR TB WORKSHOP 18 SEPTEMBER 2015 HIV & MDR :Impact of early ART initiation Adjusted HR: 0.14; p = 0.042 86% reduction in mortality with ART Initiation during MDR-TB treatment 2015
More informationPresented by: Melissa Egan, Regional Health Education Coordinator, CATIE Date: Tuesday October 8th, 2013, 1 2pm EST
Presented by: Melissa Egan, Regional Health Education Coordinator, CATIE Date: Tuesday October 8th, 2013, 1 2pm EST Agenda 1. HIV and the immune system 2. The progression of untreated HIV 3. Monitoring
More informationManagement of HIV Infected Children and Adolescents: Public Sector Approach in Kenya
Management of HIV Infected Children and Adolescents: Public Sector Approach in Kenya KPA 2018 24-04-2018 Dr. Margaret Wainaina- Wafula Outline Introduction Evaluation of a child living with HIV. Standard
More informationJOINT WHO/UNAIDS/UNICEF STATEMENT ON USE OF COTRIMOXAZOLE AS PROPHYLAXIS IN HIV EXPOSED AND HIV INFECTED CHILDREN
JOINT WHO/UNAIDS/UNICEF STATEMENT ON USE OF COTRIMOXAZOLE AS PROPHYLAXIS IN HIV EXPOSED AND HIV INFECTED CHILDREN WHO, UNAIDS and UNICEF, guided by recent evidence, have agreed to modify as an interim
More informationStrengthening Laboratory Systems for HIV Differentiated Service Delivery
ADVANCING THE LABORATORY PROFESSION AND NETWORKS IN AFRICA Strengthening Laboratory Systems for HIV Differentiated Service Delivery Anafi Mataka African Society for Laboratory Medicine AIDS 2018 Outline
More informationWhen to start: guidelines comparison
The editorial staff When to start: guidelines comparison The optimal time to begin antiretroviral therapy remains a critical question for the HIV field, and consensus about the appropriate CD4+ cell count
More informationOpportunistic infections. Sanjay Pujari, MD, FIDSA Institute of Infectious Diseases, Pune, India
Opportunistic infections Sanjay Pujari, MD, FIDSA Institute of Infectious Diseases, Pune, India Disclosures Advisory board, Speaker fees: Mylan, Hetero, Cipla ltd Outline Why OI s still occur? Mycobacterial
More informationOpportunistic Infection Updates, Richard A. Murphy, MD, MPH Harbor-UCLA Medical Center Geffen School of Medicine at UCLA
Opportunistic Infection Updates, 2018 Richard A. Murphy, MD, MPH Harbor-UCLA Medical Center Geffen School of Medicine at UCLA Objectives 1. Describe context for persistence of OIs globally 2. Provide updates
More informationRecurring and Emerging Questions Related to Management of HIV-Related Opportunistic Infections. Objectives. Henry Masur MD
Recurring and Emerging Questions Related to Management of HIV-Related Opportunistic Infections Henry Masur MD Clinical Professor of Medicine George Washington University School of Medicine Objectives To
More informationHIV Update For the Internist
HIV Update For the Internist Disclosures I declare that I have received no incentives, financial or otherwise, from pharmaceutical or biomedical companies relevant to the content of this talk. As an Infectious
More informationRapid Diagnostics CHAI Experience. 6 th Moving Forward in Diagnostics Forum Les Pensieres November 7, 2012
Rapid Diagnostics CHAI Experience 6 th Moving Forward in Diagnostics Forum Les Pensieres November 7, 2012 CHAI is working in 12 countries on HIV POC test implementation Kenya Tanzania Ethiopia Malawi Mozambique
More informationAnnex 3: draft list of potential PICO questions on care packages for PLHIV
Annex 3: draft list of potential PICO questions on care packages for PLHIV 1. Frequency of clinic visits Comments What is the most effective and acceptable frequency of clinic visit for adults, adolescents
More informationThe New WHO guidelines on intensified TB case finding and Isoniazid preventive therapy and operational considerations
Workshop to accelerate the implementation of the Three Is for HIV/TB and earlier initiation of ART in Southern Africa, March 14-18, 2011, Johannesburg, South Africa. The New WHO guidelines on intensified
More informationINTERNAL QUESTIONS AND ANSWERS DRAFT
WHO CONSOLIDATED GUIDELINES ON THE USE OF ANTIRETROVIRAL DRUGS FOR TREATING AND PREVENTING HIV INFECTION Background: INTERNAL QUESTIONS AND ANSWERS DRAFT At the end of 2012, 9.7 million people were receiving
More informationImmediate Offer of HIV Treatment: How To Deliver on the Second 90 (including Supply Chain Management and Drug Stockouts)
Immediate Offer of HIV Treatment: How To Deliver on the Second 90 (including Supply Chain Management and Drug Stockouts) Roselyne TOBY,MD, ID specialist Infectious Disease Unit/Yaounde Central Hospital
More information90% 90% 90% 30% 10% 5% 70% 90% 95% WHY HIV SELF-TESTING? PLHIV diagnosed PLHIV undiagnosed
WHY HIV SELF-TESTING? In 2014, the United Nations set bold new targets, calling on the global community to ensure that by 2020, 90% of all people living with HIV will know their HIV status, 90% of all
More informationKAP conference 19 th March 2008: Dr Mohamed Hussein Jin.
SENSITIVITY PATTERNS, SEROTYPES OF CRYPTOCOCCUS NEOFORMANS AND DIAGNOSTIC VALUE OF INDIA INK IN PATIENTS WITH CRYPTOCOCCAL MENINGITIS AT KENYATTA NATIONAL HOSPITAL. KAP conference 19 th March 2008: Dr
More informationAIDS at 25. Epidemiology and Clinical Management MID 37
AIDS at 25 Epidemiology and Clinical Management Blood HIV Transmission transfusion injection drug use Sexual Intercourse heterosexual male to male Perinatal intrapartum breast feeding Regional HIV and
More informationA Case of Cryptococcal Meningitis
A Case of Cryptococcal Meningitis DOUGLAS FISH ALBANY MEDICAL COLLEGE JUNE 4, 2013 History Patient transferred from Columbia Memorial Hospital with lethargy, shortness of breath, chest pains and failure
More informationTAG-ICW TB/HIV UNGASS Report 2009.
TAG-ICW TB/HIV UNGASS Report 2009. Mechanism to engage the civil society in TB/HIV M&E Francis G. Apina (NETMA+) and J. Syed (TAG) 16 th TB/HIV WG Core Group Meeting Almaty Kazakhstan 26-28 th May 2010.
More informationSession 1B - Auditorium Adult cases - Adherence - Mental health - STIs - Opportunistic Infections - TB - Drug Interactions Panel discussion
CONFERENCE PROGRAMME WEDNESDAY, 24 OCTOBER 2018 08h00 18h00 Registration OFFICIAL MEETING COMMENCES 14h00 15h30 Session 1A Adolescent cases - Teen pregnancy and breast feeding - Previously on PrEP, now
More informationDidactic Series. Fungal Infections: small bother to big mortality
Didactic Series Fungal Infections: small bother to big mortality Christian B. Ramers, MD, MPH Family Health Centers of San Diego Ciaccio Memorial Clinic 8/8/13 ACCREDITATION STATEMENT: University of California,
More informationCare of HIV Infected People
Care of HIV Infected People Patrick Ndase, MD, MPH MTN Annual Meeting Marriott Key Bridge, Arlington, VA April 21-23, 2008 Why Care for HIV infected in such a meeting? Site Core Community Why Care for
More informationDo you think Universal Test and Treat should be implemented in all clinics and hospitals in South Africa?
UTT SDI and other TLA s Dr Julia Turner Right to Care NGO Acknowledgements to Dr Francois Venter, Dr Giordano, Dr Leon Levin, Dr Louise Gilbert, Dr Rachel Wake, Dr Mhairi Maskew and many others Do you
More informationGoal of this chapter. 6.1 Introduction Good practices for linkage to care General care for people living with HIV 84
Clinical guidelines across THE CONTINuUM OF CARE: LINKING PEOPLE DIAGNOSEd WiTH hiv infection to hiv care and treatment 06 6.1 Introduction 84 6.2 Good practices for linkage to care 84 6.3 General care
More informationCan we treat our way out of the HIV epidemic?
Can we treat our way out of the HIV epidemic? Richard E. Chaisson, MD Center for AIDS Research Center for TB Research Johns Hopkins University Schoolboy s (and politician s) tricks for evading the question
More informationThe CQUIN Learning Network
The CQUIN Learning Network Adolescents Living with HIV: National Guidelines, Minimum Package, Challenges and Priorities Swaziland Ms Nobuhle Mthethwa MOH- SWAZILAND October 24-27, 2017 Johannesburg, South
More informationIsoniazid preventive therapy for HIV+:
Isoniazid preventive therapy for HIV+: Controversial topics Gary Maartens Division of Clinical Pharmacology UNIVERSITY OF CAPE TOWN IYUNIVESITHI YASEKAPA UNIVERSITEIT VAN KAAPSTAD Risk of TB disease after
More informationHIV Management in Resource-Poor Settings
HIV Management in Resource-Poor Settings Research in Progress Eran Bendavid, MD Infectious Diseases Center for Health Policy Outline Context Methods Results Conclusions Discussion Context The number of
More informationPrevention and Treatment of Selected Opportunistic Infections: A Guidelines Update
Prevention and Treatment of Selected Opportunistic Infections: A Guidelines Update Constance A. Benson, MD Professor of Medicine Division of Infectious Diseases University of California, San Diego Disclosures
More informationUNITAID investments to innovate and scale up access to HIV diagnostics
UNITAID investments to innovate and scale up access to HIV diagnostics WHO Annual meeting with Diagnostic Manufacturers and Stakeholders 10 March 2016 Smiljka de Lussigny (HIV Diagnostics Programme Manager,
More informationManaging Advanced HIV Disease in a Public Health Approach
Clinical Infectious Diseases SUPPLEMENT ARTICLE Managing Advanced HIV Disease in a Public Health Approach Nathan Ford, 1 Graeme Meintjes, 2,3 Alexandra Calmy, 4 Helen Bygrave, 5 Chantal Migone, 1 Marco
More informationPDF of Trial CTRI Website URL -
Clinical Trial Details (PDF Generation Date :- Sun, 30 Dec 2018 00:34:16 GMT) CTRI Number CTRI/2009/091/000652 [Registered on: 27/10/2009] - Last Modified On 11/03/2014 Post Graduate Thesis Type of Trial
More informationImproving quality of services and retention in HIV care and treatment: Severely immunosuppressed package of care (SIPOC)
Improving quality of services and retention in HIV care and treatment: Severely immunosuppressed package of care (SIPOC) Dr. Maureen Syowai Kathuku-Kaati December 2015 Objectives 1. To understand the mechanism
More informationMedical Challenges of HIV/AIDS pandemic: The WHO perspective. SOLTHIS HIV Forum
Medical Challenges of HIV/AIDS pandemic: The WHO perspective SOLTHIS HIV Forum Marco Vitoria HIV/AIDS Department World Health Organization September 2013 Topic 2002 2003 2006 2010 2013 When to start 1
More informationPrinciples and Structure of a Research Protocol. Anthony D Harries The Union, Paris, France MSF, Brussels, Belgium
Principles and Structure of a Research Protocol Anthony D Harries The Union, Paris, France MSF, Brussels, Belgium BASIC STRUCTURE Background and rationale to study Aim and objectives (the research question)
More informationICASA SATELLITE SYMPOSIUM Tuesday, 1 December 18:30 20:30 Prof. Soudre Room Rainbow Towers Conference Centre. Twitter Hash Tag: #EIDInnovation
Optimizing Testing and Treatment of HIV-Exposed Infants: Creating Sustainable Markets for Point-of-Care Technologies within National Diagnostic Networks ICASA SATELLITE SYMPOSIUM Tuesday, 1 December 18:30
More informationPART II! IMMUNE SENESCENCE!
PART II! IMMUNE SENESCENCE! IMMUNE SENESCENCE! RESEARCH IN HIV Background Senescence: the state of being old or the process or aging Immune senescence: the immune system profile seen in the elderly Does
More informationand the Working Group from the EMBO-AIDS Related Mycoses Workshop Institute of Infectious Disease and Molecular Medicine, University of Cape Town,
1 AIDS-related mycoses: the way forward Gordon D. Brown 1,2*, Graeme Meintjes 1, Jay K. Kolls 3, Clive Gray 1, William Horsnell 1 and the Working Group from the EMBO-AIDS Related Mycoses Workshop 1 Institute
More informationThe Nexus Between 90/90/90 and Epidemic Control. Ambassador Deborah Birx IAS July 2018
The Nexus Between 90/90/90 and Epidemic Control Ambassador Deborah Birx IAS July 2018 What is the Global Goal for HIV? The HIV/AIDS SDG Goal: Control the HIV Pandemic by 2030 90/90/90 by 2020 and 95/95/95
More informationMENINGITIS CRYPTOCOCCAL. learn about the symptoms, diagnosing and treating this disease
CRYPTOCOCCAL MENINGITIS learn about the symptoms, diagnosing and treating this disease A PUBLICATION FROM Information, Inspiration and Advocacy for People Living With HIV/AIDS JANAURY 2007 Cryptococcal
More informationThe global plan to eliminate mother to child transmission (emtct) of HIV: challenges in integration and of therapeutic strategies
Training Course in Sexual and Reproductive Health Research 2014 Module: Principles and Practice of Sexually Transmitted Infections Prevention and Care The global plan to eliminate mother to child transmission
More information20 Years of Tears and Triumphs
20 Years of Tears and Triumphs A Clinical Research Nurse s Perspective on HIV/AIDS Bobi Keenan, RN, ACRN Clinical Research Nurse UC Irvine Dept. of Medicine/Infectious Diseases Objectives 1. Understand
More informationAidspan Review of a Study on the Costs and Health Impact of Continued Global Fund Support for Antiretroviral Therapy
An independent watchdog of the Global Fund, and publisher of Global Fund Observer P.O. Box 66869-00800, Nairobi, Kenya Web: www.aidspan.org Email: info@aidspan.org Phone: +254-20-418-0149 Fax: +254-20-418-0156
More informationCryptococcosis of the Central Nervous System: Classical and Immune-Reconstitution Disease
Cryptococcosis of the Central Nervous System: Classical and Immune-Reconstitution Disease Assist Prof. Somnuek Sungkanuparph Division of Infectious Diseases Faculty of Medicine Ramathibodi Hospital Mahidol
More informationtargets for HIV-positive children
Accessing antiretroviral therapy (ART) is a matter of life and death for HIV-infected children. Without ART, half of children born with HIV die by the age of two years, and 80 percent die by the age of
More informationSurveillance of Recent HIV Infections: Using a Pointof-Care Recency Test to Rapidly Detect and Respond to Recent Infections
Surveillance of Recent HIV Infections: Using a Pointof-Care Recency Test to Rapidly Detect and Respond to Recent Infections WHAT WAS THE PROBLEM? As countries make progress towards universal coverage of
More informationART Resource Requirements and Potential Efficiency Gains in Tanzania
ART Resource Requirements and Potential Efficiency Gains in Tanzania July 15, 2016 Steven Forsythe, Bryant Lee, Arin Dutta and Catherine Barker Executive Summary The weighted average site-level cost of
More informationRegional program of the East Europe and Central Asia Union of PLWH within the framework of the Global Fund New Funding Model
Regional program of the East Europe and Central Asia Union of PLWH within the framework of the Global Fund New Funding Model Background for the program development Problem areas Access to the whole HIV-care
More informationA Randomized Clinical Trial Comparing 6 EH vs 36H for TB Prevention in HIV-infected Adults in south India: Impact on Mortality
A Randomized Clinical Trial Comparing 6 EH vs 36H for TB Prevention in HIV-infected Adults in south India: Impact on Mortality Soumya Swaminathan,, PA Menon,, P Venkatesan et al Indian Council of Medical
More informationFrom Africa to Georgia: What We Have Learned From the Treatment for All Initiative
From Africa to Georgia: What We Have Learned From the 90-90-90 Treatment for All Initiative Carlos del Rio, MD Professor of Global Health Rollins School of Public Health Professor of Medicine Emory University
More informationUnified Xpert MTB/RIF Forecasting Initiative
Photo: Riccardo Venturi Unified Xpert MTB/RIF Forecasting Initiative Wayne van Gemert WHO Global TB Programme, Geneva WHO ANNUAL MEETING WITH HIV DIAGNOSTIC MANUFACTURERS AND STAKEHOLDERS 11 March 2016
More informationCD4 Assays Are No Longer Needed for Care of Children in Low-resource Countries. The case against Di Gibb
CD4 Assays Are No Longer Needed for Care of Children in Low-resource Countries The case against Di Gibb The value of CD4 Pre-ART CD4 CD4 monitoring on ART Pre-ART CD4 for linkage to care & clinical management
More informationHIV AND LUNG HEALTH. Stephen Aston Infectious Diseases SpR Royal Liverpool University Hospital
HIV AND LUNG HEALTH Stephen Aston Infectious Diseases SpR Royal Liverpool University Hospital Introduction HIV infection exerts multiple effects on pulmonary immune responses: Generalised state of immune
More informationPneumocystis Pneumonia (PCP): Part 2
NORTHWEST AIDS EDUCATION AND TRAINING CENTER Pneumocystis Pneumonia (PCP): Part 2 Brian R. Wood, MD Medical Director, NW AETC ECHO Assistant Professor of Medicine, University of Washington Presentation
More informationGUIDELINE FOR THE MANAGEMENT OF CRYPTOCOCCAL MENINGITIS
GUIDELINE FOR THE MANAGEMENT OF CRYPTOCOCCAL MENINGITIS Full title of guideline Guideline for the management of cryptococcal meningitis Author Dr P Venkatesan (ID consultant) Division and specialty Medicine,
More informationHIV/AIDS and Nutrition Programming in ACF International Network
HIV/AIDS and Nutrition Programming in ACF International Network Main Aim of ACF-International (ACFIN) To combat malnutrition through assistance in: Nutrition Health Water and Sanitation Food Security Advocacy
More informationCosts and Consequences of HIV Linkage-to-Care Strategies Implemented in Urban and Rural South African Settings Kristen Little, MPH PhD
Costs and Consequences of HIV Linkage-to-Care Strategies Implemented in Urban and Rural South African Settings Kristen Little, MPH PhD Co-Authors: Tonderai Mobuto, Griffiths Kubeka, Salome Charalambous,
More informationThe Child with HIV and a Fever 1
The Child with HIV and a Fever 1 Author: Andrew Riordan Amanda Williams Date of preparation: August 2003 Date reviewed: February 2012 Next review date: February 2014 Contents 1. Introduction 2. HIV disease
More informationANNEXURE A: EXPLANATORY NOTES ON THE DMR 164 REPORTING ON HIV AND TB FORM
ANNEXURE A: EXPLANATORY NOTES ON THE DMR 164 REPORTING ON HIV AND TB FORM The form and content of the explanatory note is to: Inform those responsible for completing the DMR 164 Reporting Form - as to
More informationReview of the Democratic Republic of the Congo (DRC) by the Committee on the Elimination of Discrimination Against Women (CEDAW)
Review of the Democratic Republic of the Congo (DRC) by the Committee on the Elimination of Discrimination Against Women (CEDAW) Submission: Elizabeth Glaser Pediatric AIDS Foundation June 2013 Introduction:
More informationINITIATING ART IN CHILDREN: Follow the six steps
INITIATING ART IN CHILDREN: Follow the six steps STEP 1: DECIDE IF THE CHILD HAS CONFIRMED HIV INFECTION Child < 18 months: HIV infection is confirmed if the PCR is positive and the VL is more than 10,000
More informationPEPFAR Malawi Baobab Health Trust EMRS
PEPFAR Malawi Baobab Health Trust EMRS Leveraging Patient-level Systems for Surveillance & Monitoring September 13, 2017 Johannesburg, South Africa What is the Baobab EMRS System? Modular Point of care
More informationAIDS at 30 Epidemiology and Clinical Epidemiology and Management MID 37
AIDS at 30 Epidemiology and Clinical Management Blood HIV Transmission transfusion injection drug use Sexual Intercourse heterosexual male to male Perinatal intrapartum breast feeding Adults and children
More informationClinical presentation Opportunistic infections
Clinical presentation Opportunistic infections Assoc Prof. Thanyawee Puthanakit Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University,Bangkok, Thailand
More informationHIV Clinicians Society Conference TB/HIV Treatment Cascade
HIV Clinicians Society Conference-2012 TB/HIV Treatment Cascade Dr Judith Mwansa-Kambafwile Wits Reproductive Health & HIV Institute University of Witwatersrand TB/HIV Treatment Cascade Overview TB stats
More information