5 Infections. To be used in conjunction with NICE guidance, The British National Formulary for adults and/or children and

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1 5 Infections To be used in conjunction with NICE guidance, The British National Formulary for adults and/or children and Southend University Hospital, Antibiotic Guidelines Index 5.1 Antibacterial drugs 5.2 Antifungal drugs 5.3 Antiviral drugs 5.4 Antiprotozoal drugs 5.5 Anthelmintic drugs

2 5.1 Antibacterial drugs See MMGs on staffnet for local guidance on prescribing antibiotics (020, 026 & 030) DRUG BRAND / FORMULATION NOTES Penicillins Benzyl penicillin Procaine Benzyl penicillin 600mg & 1.2g injection vial 600mg injection x 2 vial GP pack Benzyl penicillin Benzathine 2.4million units injection vial + diluent Benzyl penicillin 100mg 250mg injection single dose vial 1.2million units injection vial 600,000 units injection 4ml vial + diluent Prepared in SPU on request Phenoxymethylpenicillin 250mg tablets x mg/5ml & 250mg/5ml sugar free suspension 100ml Penicillinase resistant penicillin Flucloxacillin 250mg & 500mg injection vial 250mg & 500mg capsules x 28 Broad Spectrum penicillins

3 Amoxicillin Co-amoxiclav 250mg, 500mg & 1g injection vial 250mg & 500mg capsules x 21 3g powder sachet x 2 125mg/5ml & 250mg/5ml sugar free suspension100ml 600mg & 1.2g injection vial 1.2g injection in 0.9% normal saline 50ml 375mg & 625mg tablets x /31mg/5ml & 250/62.5mg/5ml sugar free suspension 100ml 400/57mg/5ml sugar free suspension 70ml Bags are prepared in SPU Antipseudomonal Penicillins Piperacillin 4g + Tazobactam 500mg (Tazocin ) Piperacillin 4g + Tazobactam 500mg injection vial Piperacillin 2g + Tazobactam 250mg injection vial Restricted antibiotics See MMG030 Cephalosporins - All cephalosporins are restricted in the Trust Cefaclor Cefotaxime Ceftazidime Ceftriaxone 375mg SR tablets x14 125mg/5ml & 250mg/5ml suspension 100ml 500mg, 1g & 2g injection vial 500mg, 1g & 2g injection vial 250mg, 1g & 2g injection vial

4 Cefuroxime 250mg, 750mg & 1.5g injection vial 750mg injection in 0.9% normal saline 50ml bag 750mg in Metronidazole 500mg injection 100ml bag Bags are prepared in SPU Carbapenems - All Carbapenems are restricted in the Trust (see MMG030) Ertapenem Meropenem 1g injection vial 500mg & 1g injection vial Tetracyclines Demeclocycline 150mg capsules x 28 Doxycycline 100mg capsules x 8 / 14 50mg capsules x mg dispersible tablets x 8 Lymecycline 408mg capsules x 28 Minocycline Minocycline MR 100mg capsules x 56 Minocycline 50mg tablets x 28 Oxytetracycline 250mg tablets x 28 Tigecycline 50mg injection vial Restricted Antibiotic see MMG030

5 Aminoglycosides Amikacin 100mg/2ml & 500mg/2ml injection ampoule Restricted Antibiotic see MMG030 Gentamicin Tobramycin Macrolides 20mg/2ml & 80mg/2ml injection ampoule 4.5mg/ bead x 30 bead chain sachet Collagen fleece 5x8cm x 1 dressing pack Gentamicin in collagen 1.3mg gentamicin base per sq cm (10cmx10cmx0.5cm)sponge x 1pack 80mg/2ml & 240mg/6ml injection ampoule 300mg/5ml nebuliser solution vials x 56 Azithromycin 500mg tablets x 3 250mg tablets x 4 200mg/5ml suspension 15ml Clarithromycin 500mg injection vial 250mg & 500mg tablets x mg/5ml & 250mg/5ml suspension 70ml Erythromycin 1g injection vial 250mg tablets x 14 Erythromycin stearate 250mg tablets x mg/5ml, 250mg/5ml & 500mg/5ml suspension 100ml See MMG017 for dosing guidance

6 Clindamycin Clindamycin 300mg/2ml & 600mg/4ml injection ampoule 150mg capsules x 24 / mg capsules x24 75mg/5ml suspension 80ml / 100ml Restricted Antibiotic see MMG030 Some Other Antibacterials Chloramphenicol 1g injection ampoule 250mg capsules x 60 Colistin Sulphomethate(Colomycin) 1million units & 2 million units injection vial Colistin (Promaxin) 1 million units powder for nebuliser solution x 30 Daptomycin 350mg & 500mg injection vial Restricted Antibiotic see Sodium Fusidate 500mg injection vial 250mg tablets x 100 Fusidic acid 250mg/5ml suspension 50ml MMG030 Vancomycin 500mg & 1g injection vial 125mg capsules x 28 Vancomycin 1g injection in 250ml Sodium chloride 0.9% Vancomycin 501mg to 1g injection dose unit See MMG016 for dosing guidance Prepared in SPU

7 Teicoplanin Linezolid 200mg & 400mg injection vial 2mg/ml injection bags 300ml 600mg tablets x 10 Restricted Antibiotic see MMG030 Sulfonamides and Trimethoprim Co-trimoxazole 480mg/5ml injection ampoule 480mg & 960mg tablets x mg tablets x mg/5ml & 480mg/5ml suspension 100ml Sulfadiazine 500mg tablets x 56 Trimethoprim 100mg & 200mg tablets x 14 10mg/ml suspension 100ml Antituberculosis drugs Ethambutol Isoniazid 100mg & 400mg tablets x56 100mg tablets x28 300mg/5ml suspension 200ml 50mg/5ml suspension 500ml Rifabutin 150mg capsules x 30 Rifampicin 600mg injection vial

8 150mg & 300mg capsules x mg/5ml suspension 120ml Combined preparations Rifampicin 120mg + Isoniazid 50mg + Pyrazinamide 300mg tablets(rifater ) x 100 Rifampicin 300mg + Isoniazid 150mg tablets 300/150) x 56 Rifampicin 150mg + Isoniazid 100mg tablets 150/100) x 84 (Rifinah (Rifinah Antileprotic drugs Dapsone 50mg & 100mg tablets x 28 50mg/5ml suspension 50ml Metronidazole and Tinidazole Metronidazole 500mg/100ml injection 100ml bag 200mg & 400mg tablets x mg/5ml suspension 100ml 500mg & 1g suppositories x 10 Tinidazole 500mg tablets x 16

9 Quinolones - All Quinolones are restricted in the Trust (see MMG030) Ciprofloxacin 200mg & 400mg injection 100ml vial 500mg tablets x mg tablets x 10 / mg/5ml suspension 100ml Levofloxacin 500mg injection 100ml vial 500mg tablets x 5 / 10 Nitrofurantoin Nitrofurantoin 50mg & 100mg capsules x 30 MR 100mg capsules x 14 50mg tablets x mg/5ml suspension 100ml Return to index

10 5.2 Antifungal drugs Triazole Antifungals Fluconazole Itraconazole Voriconazole 200mg injection 100ml vial 50mg injection 25ml vial 50mg & 200mg capsules x 7 150mg capsules x 1 50mg/5ml suspension 35ml 100mg capsules x15 50mg/5ml suspension 150ml 200mg injection vial 200mg tablets x 28 50mg tablets x 28 Polyene Antifungals Amphotericin Amphotericin (Ambisome ) 50mg injection vial See MMG014 for dosing guidance Nystatin 100,000 units /ml suspension 30ml Echinocandin Antifungals Caspofungin 50mg & 70mg injection vial

11 Other Antifungals Terbinafine 250mg tablets x 28 Return to index

12 5.3 Antiviral drugs DRUG BRAND / FORMULATION NOTES HIV Infections follow BHIVA guidance Nucleoside reverse transcriptase inhibitors Abacavir (Ziagen ) 300mg tablets x mg/5ml oral solution 240ml Didanosine (Videx ) 25mg tablets x mg capsules x 30 Emtricitabine (Emtriva ) 200mg capsules x 30 Lamivudine Lamivudine (Epivir ) 300mg tablets x 30 Lamivudine (Epivir ) 150mg tablets x 60 Lamivudine (Epivir ) 50mg/5ml oral solution 240ml Lamivudine (Zeffix ) 100mg tablets x28 Tenofovir Disoproxil (Viread ) Zidovudine(AZT)(Retrovir ) 245mg tablets x30 10mg/ml injection 20ml vial 250mg capsules x mg/10ml syrup 200ml

13 Protease inhibitors Atazanavir (Reyataz ) 300mg capsules x mg capsules x 60 Darunavir (Prevista ) 400mg & 600mg tablets x 60 Ritonavir (Norvir ) 100mg tablets x 30 Non-nucleoside reverse transcriptase inhibitors Efavirenz (Sustiva ) 600mg tablets x mg tablets x 90 30mg/ml oral solution 180ml Etravirine (Intelence ) 100mg tablets x120 Nevirapine (Viramune ) 200mg tablets x 60 50mg/5ml suspension 240ml Other Antiretrovirals Maraviroc (celsentri ) 150mg tablets x 60 Raltegravir (Isentress ) 400mg tablets x 60 Combination Products Atripla Efavirenz 600mg, Emtricitabine 200mg, Tenofovir

14 245mg tablets x 30 Combivir Lamivudine 150mg, Zidovudine 300mg tablets x 60 Eviplera Emtricitabine 200mg, Rilpivirine 25mg, Tenofovir 245mg tablets x 30 Kelatra Lopinavir 200mg, Ritonavir 50mg tablets x 120 Lopinavir 80mg, Ritonavir 20mg/ml oral solution 60ml Kivexa Abacavir 600mg, Lamivudine 300mg tablets x 30 Trizivir Abacavir 300mg, Lamivudine150mg, Zidovudine 300mg tablets x 60 Truvada Emtricitabine 200mg, Tenofovir 245mg tablets x 30 Post exposure prophylaxis(pep) Truvada & Kelatra x 5 day unit pack + Loperamide & Domperidone x 28 tablets unit pack Herpesvirus Infections Aciclovir 250mg & 500mg injection vial 800mg dispersible tablets x mg dispersible tablets x mg dispersible tablets x mg/5ml suspension 125ml Famciclovir 250mg tablets x 21 Valaciclovir 500mg tablets x mg tablets x mg tablets x 60 Cytomegalovirus infection

15 Cidofovir Ganciclovir Foscarnet Valganciclovir 375mg/5ml injection vial 500mg injection vial 24mg/ml injection 250ml vial 450mg tablets x60 Influenza Oseltamivir 30mg & 75mg capsules x 10 Oseltamivir 6mg/ml suspension 75ml / 100ml Zanamivir 5mg/dose inhalation disks 20 doses Respiratory syncytial virus Palivizumab 50mg & 100mg injection vial Ribavirin (copegus ) 200mg tablets x 168 Return to index

16 5.4 Antiprotozoal drugs Antimalarials Quinine Quinine bisulphate 300mg tablets x 28 Quinine sulphate 300mg tablets x 28 Quinine sulphate 200mg tablets x28 Drugs for pneumocystis pneumonia Pentamidine isetionate 300mg injection vial Return to index 5.6 Anthelmintics Drugs for threadworms Mebendazole 100mg tablets x 6 100mg/5ml suspension 30ml Return to index

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