Curriculum Vitae. Personal Details. Scientific Education. Awards. Scholarships. Rademacher, Christoph. December 2011 ongoing

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1 Curriculum Vitae Personal Details Name Nationality Rademacher, Christoph German Scientific Education December 2011 ongoing March 2009 October 2011 January 2009 March 2009 October 2006 January 2009 October 2004 October 2006 October 2001 October 2004 Awards Group Leader (Prof. Dr. Peter H. Seeberger, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany) Research Associate (Prof. Dr. James C. Paulson, The Scripps Research Institute, La Jolla, USA) Postdoctoral Fellow, bridging (Prof. Dr. Thomas Peters, Institute of Chemistry, University of Lübeck, Germany) PhD Thesis: Investigations into Viral Entry Mechanisms and Carbohydrate-Protein Interactions using NMR (summa cum laude, Prof. Dr. Thomas Peters, Institute of Chemistry, University of Lübeck, Germany) Master Studies in Molecular Life Science at the University of Lübeck (grade 1.0, with honours) Bachelor Studies in Molecular Biotechnology at the University of Lübeck (grade 1.1, with honours) 2012 Best oral communication presented at the 26 th International Carbohydrate Symposium by Young Investigators 2010 Professor-Otto-Roth-Preis from the University of Lübeck 2009 Glycoaward from the Verein zur Foerderung der Glycowissenschaften e.v., Hamburg 2006 Best Masters degree in Molecular Life Science 2004 Best Bachelors degree in Molecular Biotechnology Scholarships Sachkostenzuschuss from the Fonds der chemischen Industrie Associated member of the Sonderforschungsbereich 765 Multivalency Emmy-Noether Research Group Leader Liebig-Stipendium from the Fonds der chemischen Industrie EMBO Long-Term Fellowship PhD stipend from the Fonds der chemischen Industrie

2 Publication List (full) Hanske J, Aleksić S, Ballaschk M, Jurk M, Shanina E, Beerbaum M, Schmieder P, Keller BG*, Rademacher C*. An intra-domain allosteric network modulates the calcium affinity of the C-type lectin receptor Langerin. J Am Chem Soc, accepted. 29. Wamhoff EC, Hanske J, Schnirch L, Aretz J, Grube M, Varon Silva D, Rademacher C* (2016) 19 F NMR-guided design of glycomimetic Langerin ligands. ACS Chem Biol, accepted 28. Aretz J, Kondo Y, Honda K, Anumala UR, Nazaré M, Watanabe N, Osada H, Rademacher C* (2016) Chemical fragment arrays for rapid druggability assessment. Chem Comm, Aretz J, Wratil PR, Wamhoff EC, Nguyen HG, Reutter W, Rademacher C* (2016) Fragment-screening of N-acetylmannosamine kinase reveals noncarbohydrate inhibitors. Can J Chem, accepted 26. Broecker F, Hanske J, Martin CE, Baek JY, Wahlbrink A, Wojcik F, Hartmann L, Rademacher C, Anish C., and Seeberger PH (2016). Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Commun, 7, Mallagaray A, Rademacher C, Parra F, Hansman G, Peters T. (2016) STD NMR titrations reveal complex multistep-binding of L-fucose to norovirus particles. Glycobiology, accepted Lee CU, Hahne G, Hanske J, Bange T, Bier D, Rademacher C, Hennig S, Grossmann TN (2015) Reox modulation of PTEN phosphatase activity by reactive oxygen species and bisperoxovanadium complexes. Angew Chem Int Ed, 54, Aretz J, Wamhoff EC, Hanske J, Heymann D and Rademacher C* (2014) Computational and experimental prediction of human C-type lectin receptor druggability. Front. Immunol. 5: Broecker F, Aretz J, Yang Y, Hanske H, Guo X, Reinhardt A, Wahlbrink A, Rademacher C, Anish C, Seeberger PH. (2014) Epitope Recognition of Antibodies against a Yersinia pestis Lipopolysaccharide Trisaccharide Component. ACS Chem Biol, Glas A, Bier D, Hahn G, Rademacher C, Ottmann C, Grossmann TN. (2014) Constrained Peptides with Target-Adapted Crosslinks as Inhibitors of a Pathogenic Protein-Protein Interaction. Angew Chem Int Ed, 53, Ponader D, Maffre P, Aretz J, Pussak D, Ninnemann NM, Schmidt S, Seeberger PH, Rademacher C, Nienhaus GU, Hartmann L (2014) Carbohydrate-Lectin Recognition of Sequence-defined Heteromultivalent Glycooligomers. J Am Chem Soc., 136, Macauley MS, Pfrengle F, Rademacher C, Nycholat CM, Gale AJ, von Drygalski A, Paulson JC (2013) Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. J Clin Invest, 123, Highlighted: Nitschke L (2013) N Engl J Med, 369, Kawasaki N, Vela JL, Nycholat CM, Rademacher C, Khurana A, van Rooijen N, Crocker PR, Kronenberg M, Paulson JC (2013) Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation. Proc Natl Acad Sci USA, 110, Rillahan CD, Schwartz E, Rademacher C, McBride R, Rangarajan J, Fokin VV, Paulson JC (2013) On-Chip Synthesis and Screening of a Sialoside Library Yields a High Affinity Ligand for Siglec-7. ACS Chem Biol, 8,

3 Nycholat C*, Rademacher C*, Kawasaki N, Paulson JC (2012) In silico aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages. J Am Chem Soc, 134, (*equal contribution) 15. Landström J, Persson K, Rademacher C, Lundborg M, Wakarchuk W, Peters T., Widmalm G. (2012) Small molecules containing hetero-bicyclic ring systems compete with UDP-Glc for binding to WaaG glycosyltransferase. Glycoconj J, 29, Rademacher, C, Bru, T, McBride, R, Robison, E, Nycholat, CM, Kremer, EJ, and Paulson, JC (2012) A Siglec-like sialic acid binding motif revealed in an adenovirus capsid protein. Glycobiology, 22, Rademacher C*, Paulson JC (2012) Glycan Fingerprints: Calculating Diversity in Glycan Libraries. ACS Chem Biol, 7, (*corresponding author) Yu B, van Ingen H, Vivekanandan S, Rademacher C, Norris SE, and Freedberg DI. (2011) More Accurate 1 J CH Coupling Measurement in the Presence of 3 J HH Strong Coupling in Natural Abundance. J Magn Reson, 215, Fiege B, Rademacher C, Cartmell J, Kitov PI, Parra F,and Peters T (2011) Molecular Details of the Recognition of Blood Group Antigens by a Human Norovirus as studied by STD NMR Spectroscopy. Angew Chem Int Ed, 51, Zeng Y, Rademacher C, Nycholat CM, Futakawa S, Lemme K, Ernst B, and Paulson JC (2011) High affinity sialoside ligands of myelin associated glycoprotein. Bioorg Med Chem Lett. 21, Rademacher C, Guiard J, Kitov PI, Fiege B, Dalton KP, Parra F, Bundle DR, Peters T (2011) Targeting Norovirus Infection - Multivalent Entry Inhibitor Design Based on NMR Experiments. Chemistry, 17, Kawasaki N, Rademacher C, Paulson JC (2010) CD22 Regulates Adaptive and Innate Immune Responses of B Cells. J Innate Immun., 3, Rademacher C, Landström J, Sindhuwinata N, Palcic MM, Widmalm G, Peters T (2010) NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments. Glycoconj J. 27, Paulson JC and Rademacher C (2009) Glycan terminator. Nat Struc Mol Biol, 16, Rademacher C, Krishna, NR, Parra F, Palcic MM, Peters T (2008) NMR Experiments Reveal the Molecular Basis of Receptor Recognition by a Calicivirus, J Am Chem Soc, 130, Highlighted: Frank AO, Kessler H (2008) The sweetest candy for the virus. Nature. 452, Rademacher C and Peters T (2008) Molecular Recognition of Ligands by Native Viruses and Virus like Particles as Studied by NMR, Topics in Current Chemistry, Bioactive Conformation II, 273, Rademacher C, Shoemaker GK, Kim HS, Zheng RB, Taha H, Liu C, Nacario RC, Schriemer DC, Klassen JS, Peters T, Lowary TL (2007) Ligand specificity of CS-35, a monoclonal antibody that recognizes mycobacterial lipoarabinomannan: a model system for oligofuranoside-protein recognition. J Am Chem Soc., 129, Angulo J, Rademacher C, Biet T, Benie AJ, Blume A, Peters H, Palcic M, Parra F and Peters T (2006) NMR Analysis of Carbohydrate-Protein Interactions, Methods Enzymol, 416,

4 Peters H, Kusov YY, Meyer S, Benie AJ, Bäuml E, Wolff M, Rademacher C, Peters T and Gauss-Müller V (2005) Hepatitis A virus proteinase 3C binding to viral RNA: correlation with substrate binding and enzyme dimerization, Biochem J, 385, (online available at google scholar: Other articles and books 2015 Rademacher C., Seeberger PH. (2015) High-Throughput Synthesis of Diverse Compound Collections for Lead Discovery and Optimization. Handb Exp Pharmacol. Aretz J, Rademacher C (2015) Fragmentbasierte Wirkstoffentwicklung. Nachr Chem Seeberger PH and Rademacher C (Eds.) (2014) Carbohydrates as Drugs. Top Med Chem 12. ISBN Invited Lectures at Conferences 2016 Rademacher C. Ligand-based targeted delivery to C-type lectin receptors on immune cells. Cells-in-Motion Cluster of Excellence, University of Münster Rademacher C. NMR-based fragment screening against C-type lectin receptors. Inauguration symposium of the new high field NMR spectrometer. University of Stuttgart. Rademacher C. Carbohydrates as drugs. Molecular Modeling in drug discovery symposium, Riga. Rademacher C. Applications of 19 F NMR fragment-based screening and chemical arrays for druggability assessment. RIKEN Max Planck Joint Research Center, Kobe Rademacher C. Druggability of Human C-type Lectin Receptors. RIKEN Max Planck Joint Research Center, Castle Ringberg Rademacher C. Modulating carbohydrate binding proteins in immune cell regulation. Closing Symposium DFG Research Group 806, Berlin. Rademacher C. Modulating carbohydrate binding proteins in immune cell regulation. 3rd Transatlantic Frontiers of Chemistry Symposium, Kloster Seeon. Rademacher C. Kohlenhydrat-bindende Proteine als Zielrezeptoren zur Modulation der Immunantwort. 16. Steinheimer Gespräche des Fonds für den Hochschullehrer Nachwuchs, Bad Homburg Rademacher C, Guiard J, Kitov PI, Fiege B, Dalton KP, Parra F, Bundle DR, Peters T. Development of multivalent entry inhibitors of Norovirus infections from fragment-based screening. ACS Meeting, San Diego, USA. Rademacher C and Paulson JC. Glycan Fingerprints: Calculating Diversity in Glycan Libraries. Glycan Forum, Berlin, Germany Rademacher, C. NMR Experiments Guiding the Design of Multivalent Inhibitors Against Norovirus Cell Entry. Gordon Research Conference - Carbohydrates, Waterville, USA. Rademacher C, Guiard J, Kitov PI, Fiege B, Dalton KP, Parra F, Bundle DR, Peters T. Characterizing Virus/Carbohydrate interaction using NMR. ACS Meeting, Anaheim, USA. Lectures at conferences and research institutions 2015 Rademacher C, Ca 2+ recognition of the C-type lectin receptor Langerin reveals

5 an intradomain allosteric network, Glyco23, Split, Croatia. Rademacher C, Fragment-based ligand design of C-type lectin ligands. Helmholtz Institute for Pharmaceutical Research Saarland, Germany 2014 Rademacher C, Fragment-based ligand design of C-type lectin ligands. Seminars on Drug Discovery and Development, Pharmazentrum Basel, Switzerland Rademacher C, Druggability of Mammalian C-type Lectin Receptors. ACS Meeting San Francisco, USA. Rademacher C, Druggability of Carbohydrate Binding Proteins. Chemical Genomic Center Seminar, Dortmund, Germany 2013 Rademacher C, Targeting immune cell receptors using carbohydrate derivatives. Heinrich-Pette Institut, Hamburg, Germany Rademacher C and Paulson JC, Glycan Fingerprints: Principles and Applications. Beilstein Symposium, Potsdam, Germany 2012 Rademacher C, Targeting immune cell receptors using carbohydrate derivatives. Montagskolloqium des Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen, Germany 2012 Rademacher C, Nycholat CM, Kawasaki N, Chen WC, Paulson JC, In vivo targeting of macrophages using sialoside analogs. 26 th International Carbohydrate Symposium, Madrid, Spain Rademacher C, Kawasaki N, Nycholat C, Paulson JC, Glycan-based targeting of Siglec-1 to modulate macrophage biology. EMBO US fellow Meeting. La Jolla. USA Rademacher C, Carbohydrate-Virus Interactions as Studied by NMR. SFB 470 Closing Symposium, Hamburg, Germany Rademacher C, Krishna NR, Tan M, Jiang X, Parra F, Peters T, Binding of carbohydrate ligands to Caliciviruses as studied by NMR. NMR group seminar, NIH, Bethesda, Maryland, USA Rademacher C, Peters T, Critical Aspects of STD NMR. Group Seminar (Prof. Dr. Göran Widmalm), Department of Organic Chemistry, University of Stockholm, Sweden. Rademacher C, Krishna NR, Parra F, Peters T, Insights into the Molecular Recognition of Histo-Blood Group Antigens by Rabbit Hemorrhagic Disease Virus from NMR. 14 th Eurocarb, Lübeck, Germany. Rademacher C, Krishna NR, Parra F, Palcic MM, Peters T, Histo-Blood Group Antigen Recognition by Caliciviruses as studied by STD NMR. 2 nd Joint Japanese/German Meeting, Lübeck, Germany.