JPEMS Nantes, Basic Immunology Introduction to the immune system Definitions Structure and General Organization

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "JPEMS Nantes, Basic Immunology Introduction to the immune system Definitions Structure and General Organization"

Transcription

1 JPEMS Nantes, Basic Immunology Introduction to the immune system Definitions Structure and General Organization Teacher: Pr. Régis Josien, Laboratoire Immunologie and INSERM U1064, CHU Nantes 1

2 Immunology and immunity: definitions Immunology: science of the immune system Immune system: a collection of tissues, cells and molecules which mediates the defense and protection of host against pathogens Immune response: coordinated reactions of the immune system to infectious microbes Immunity: state of protection or resistance against infections The physiological function of the immune system is to prevent or eradicate infections

3 Immune responses are diverse Diversity and complexity of the immune responses are mostly related to the diversity of pathogens (i.e. extra or intracellular bacteria, virus, etc..) and their adapta<on during evolu<on together with the fact that the immune system should not a>ack host <ssues (no<on of self- non self discrimina<on). 3

4 The importance of immunology in medicine Products of the immune system are rou5nely used in clinical laboratory and treatments: - monoclonal an<bodies - cytokines

5 Effec5veness of vaccina5ons for some common infec5ous diseases

6 Important dates in the history of immunology 1796 E. Jenner: vaccine protects against small pox 1886 L. Pasteur: vaccine against rabies 1885 E. Metchnikoff: phagocytosis/macrophages (Nobel 1908) 1890 R. Koch: hypersensitivity reaction (BK) (Nobel 1905) 1891 E. von Berhing: antitoxins (anticorps) (Nobel 1901) 1897 J. Bordet: complement (Nobel 1919) 1897 P Ehrlich: antibodies - side chain theory (Nobel 1908) vaccina5on 6

7 The 1908 Nobel prize in Medicine and Physiology Ilya Ilyich METCHNIKOV Paul EHRLICH

8 Important dates in the history of immunology 1796 E. Jenner: vaccine protects against small pox 1886 L. Pasteur: vaccine against rabies 1885 E. Metchnikoff: phagocytosis (Nobel 1908) 1890 R. Koch: hypersensitivity reaction (BK) (Nobel 1905) 1891 E. von Berhing: antitoxins (anticorps) (Nobel 1901) 1897 J. Bordet: complement (Nobel 1919) 1897 P Ehrlich: antibodies - side chain theory (Nobel 1908) vaccina5on Cell- mediated immunity Humoral immunity 8

9 Important dates in the history of immunology 1796 E. Jenner: vaccine protects against small pox 1886 L. Pasteur: vaccine against rabies vaccina5on 1885 E. Metchnikoff: phagocytosis (Nobel 1908) Cell- mediated immunity 1890 R. Koch: hypersensitivity reaction (BK) (Nobel 1905) 1891 E. von Berhing: antitoxins (anticorps) (Nobel 1901) 1897 J. Bordet: complement (Nobel 1919) Humoral immunity 1900 P Ehrlich: antibodies - side chain theory (Nobel 1908) 1921 K. Landsteiner: haptens (Nobel 1930) 1963 F. MacFarlane Burnet: Clonal selection theory (Nobel 1960) 1958 J. Dausset: HLA (Nobel 1980) 1959 G. Edelman: Ig sequence(nobel 1972) 1963 J. Miller: fonctions of thymus T lymphocyte 1973 R. Steinman: dendritic cells (Nobel 2011) 1975 R. Zinkernagel et P. Doherty: allogeneic restriction (Nobel 1996) 1976 S. Tonegawa: organization of Ig genes (Nobel 1987) 1979 OMS: small pox eradication 1984 M. Davis et T. Mak: organization of TCR genes 1988 P. Marrack et H. van Boehmer: mechanisms of thymic selection 1991 T. Mossman: Th1 and Th2 cells 1997 C. Janeway, B. Beutler: Toll-like réceptors (TLR) (Nobel 2011) 9

10 BASIC CONCEPTS in IMMUNOLOGY 1. Components of the immune system 2. Principles of innate and adapative immunity 3. Recognition and effector mechanisms of adaptive immunity 10

11 BASIC CONCEPTS in IMMUNOLOGY 1. Components of the immune system 2. Principles of innate and adapative immunity 3. Recognition and effector mechanisms of adaptive immunity 11

12 Cells of the immune system Lymphoid progenitor HSC Myeloid progenitor GM precursor Gran. Prec. Monocytes- DC precursor Blood and lymph nodes Eosinophil Basophil Neutrophil Monocyte PreDC Blood Polymorphonuclear cells 12 Tissues Mastocyte Macrophage Dendritic cell

13 Myeloid cells of the immune system Polymorphonuclears Mastocyte 13

14 Cells of the immune system Hemogram: Leuk: /mm3 Neutr: 52-75% Lympho: 20-45% Lymphoid progenitor HSC Myeloid progenitor GM precursor Mono: 3-9 % Eosino: 0-5% Baso: 0-1,5 % DC: 0,1-0,5% Gran. Prec. Monocytes- DC precursor Blood and lymph nodes B T Lymphocytes NK ILCs Innate lymphoid cells Eosinophil Basophil Neutrophil Polymorphonuclear cells Monocyte PreDC Blood plasmocytes 14 Tissues antibodies Mastocyte Macrophage Dendritic cell

15 Principal cells of the immune system and their func5ons

16 More definitions ü Antigen (Ag): a molecule that binds to an antibody or a T cell receptor expressed by lymphocytes. Antigens that bind to antibodies include all classes of molecules. Most TCR bind only peptide fragments of proteins complexed with MHC molecules. ü Antigen receptor: membrane glycoprotein expressed by lymphocytes (T = T cell receptor (TCR); B = BCR) which can recognize antigens. ü Antibody (Ab): a type of soluble glycoprotein molecules, also called immunoglobulin (Ig), produced by B lymphocytes, that bind antigen, often with a high degree of specificity and high affinity. ü Effectors: cells or their products directly involved in the elimination of infectious microbes or antigens 16

17 Lymphoid organs and tissues Primary lymphoid organs sites of lymphocyte development Secondary lymphoid organs site of antigen capture and initiation of the adaptive immune response 17

18 Morphology of lymph nodes

19 Morphology of the spleen

20 Segrega5on of T and B lymphocytes secondary lymphoid organs

21 Naive lymphocytes trafic between blood and secondary lymphoid organs in which they meet antigens

22 BASIC CONCEPTS in IMMUNOLOGY 1. Components of the immune system 2. Principles of innate and adapative immunity 3. Recognition and effector mechanisms of adaptive immunity 22

23 The 3 phases of an immune response to infection Innate immune response Adap5ve immune response 23

24 The immune response 24

25 Innate and adaptive immunity 25

26 Principles of innate and adaptive immune responses Innate or natural immunity Poorly specific response Innate and therefore immediate Due to phagocytes (PMN, MØ), DC, NK cells, complement Use poorly specific and conserved receptors (PRR) recognizing pathogen associated molecular patterns (PAMPs) Constitute the first lign of defense against pathogens No memory (stereotyped response) 26

27 Recognition of microbes by the innate immune system: pattern recognition receptors (PRR) 27

28 Bacterial infection initiates inflammation 28

29 Principles of innate and adaptive immune responses Innate or natural immunity Poorly specific response Innate and therefore immediate Due to phagocytes (PMN, MØ), DC, NK cells, complement Use poorly specific and conserved receptors (PRR) recognizing pathogen associated molecular patterns (PAMPs) Constitute the first lign of defense against pathogens No memory (stereotyped response) Adaptive or specific mmunity Highly specific response Inducible and therefore delayed (>4d) Due to lymphocytes (T and B) and antibodies produced by B cells Use highly specific and diverse receptors (T cell receptor, TCR; B cell receptor, BCR) that recognize antigens Induce protection against reinfection (immune memory) with the same pathogen 29

30 Dendritic cells initiate adaptive immune responses 30

31 Principles of innate and adaptive immune responses Innate or natural immunity Poorly specific response Innate and therefore immediate Due to phagocytes (PMN, MØ), DC, NK cells, complement Use poorly specific and conserved receptors (PRR) recognizing pathogen associated molecular patterns (PAMPs) Constitute the first lign of defense against pathogens No memory (stereotyped response) Adaptive or specific mmunity Highly specific response Inducible and therefore delayed (>4d) Due to lymphocytes (T and B) and antibodies produced by B cells Use highly specific and diverse receptors (T cell receptor, TCR; B cell receptor, BCR) that recognize antigens Induce protection against reinfection (immune memory) with the same pathogen 31

32 Types of adap5ve immunity 2 classes of T lymphocytes: - Helper / CD4+: produce cytokines that help other immune cells to eliminate microbes - Cytotoxic /CD8+: kill virus infected cells

33 Clonal selec5on of lymphocytes

34 Origin of the diversity of lymphocyte antigen receptors TCR: T cell receptor (lympho T) BCR: B cell receptor (lympho B) 34

35 Development of lymphocytes Bone marrow CLP prob Elimination of autoreactive B cells B mature Blood Thymus prot Elimination of autoreactive T lymphocytes T mature Homeostasis of lymphocyte populations Secondary lymphoid organs (LN, spleen..) 35

36 Matura5on of lymphocytes

37 Steps in the activation of T lymphocytes Ag recognition Naive T cells APC (dendritic cell) Activation Clonal expansion/ proliferation IL-2 Differentiation cytokines Effectors Apoptosis Memory T cells Apoptosis 37

38 Migra5on of T lymphocytes

39 Stages in the life history of lymphocytes

40 Primary and secondary immune responses

41 Proper5es of adap5ve immune responses

42 Lymphocyte activation requires two signals T lymphocyte B lymphocyte 42

43 BASIC CONCEPTS in IMMUNOLOGY 1. Components of the immune system 2. Principles of innate and adapative immunity 3. Recognition and effector mechanisms of adaptive immunity 43

44 The different classes of pathogens will be cleared by different types of effector cells 44

45 Types of adaptive immunity 45

46 Antibodies eliminate extracellular pathogens and their toxins: mechanism of action as anti-infectious effectors 46

47 Cytotoxic T lymphocytes (CD8 T cells) eliminate virus-infected cells

48 Helper T cells eliminate intracellular bacteria 48

49 Classes of lymphocytes and their functions Helper T lymphocytes play a central role in the organisa5on of adap5ve immune responses 49

50 Effector Th cells and classes of pathogens Autoimmunity Inflammatory diseases Autoimmunity Allergy 50

51 Antigen recognition by lymphocytes B Lymphocyte BCR (surface Ig) recognize antigenic determinants (epitopes) in a native molecule (antigen) T Lymphocyte TCR regognize a protein fragment (peptide) presented by a molecule of the major histocompatibility complex (MHC)) requirement for an antigen-presenting cell (APC) 51

52 Class I MHC molecules present peptides to CD8 + T cells Class II MHC molecules present peptides do CD4 + T lymphocytes 52

JPEMS Nantes, Basic Immunology INNATE IMMUNITY

JPEMS Nantes, Basic Immunology INNATE IMMUNITY JPEMS Nantes, 2014- Basic Immunology INNATE IMMUNITY Teacher: Pr. Régis Josien, Laboratoire d Immunologie and INSERM U1064, CHU Nantes Regis.Josien@univ-nantes.fr 1 Contents 1. General features and specificity

More information

Chapter 1. Chapter 1 Concepts. MCMP422 Immunology and Biologics Immunology is important personally and professionally!

Chapter 1. Chapter 1 Concepts. MCMP422 Immunology and Biologics Immunology is important personally and professionally! MCMP422 Immunology and Biologics Immunology is important personally and professionally! Learn the language - use the glossary and index RNR - Reading, Note taking, Reviewing All materials in Chapters 1-3

More information

Adaptive Immunity: Specific Defenses of the Host

Adaptive Immunity: Specific Defenses of the Host 17 Adaptive Immunity: Specific Defenses of the Host SLOs Differentiate between innate and adaptive immunity, and humoral and cellular immunity. Define antigen, epitope, and hapten. Explain the function

More information

Defensive mechanisms include :

Defensive mechanisms include : Acquired Immunity Defensive mechanisms include : 1) Innate immunity (Natural or Non specific) 2) Acquired immunity (Adaptive or Specific) Cell-mediated immunity Humoral immunity Two mechanisms 1) Humoral

More information

Introduction to Immune System

Introduction to Immune System Introduction to Immune System Learning outcome You will be able to understand, at a fundamental level, the STRUCTURES and FUNCTIONS of cell surface and soluble molecules involved in recognition of foreign

More information

11/25/2017. THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS BARRIER DEFENSES INNATE IMMUNITY OF VERTEBRATES

11/25/2017. THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS BARRIER DEFENSES INNATE IMMUNITY OF VERTEBRATES THE IMMUNE SYSTEM Chapter 43 IMMUNITY INNATE IMMUNITY EXAMPLE IN INSECTS Exoskeleton made of chitin forms the first barrier to pathogens Digestive system is protected by a chitin-based barrier and lysozyme,

More information

Introduction to Immunology Lectures 1-3 by Bellur S. Prabhakar. March 13-14, 2007

Introduction to Immunology Lectures 1-3 by Bellur S. Prabhakar. March 13-14, 2007 Introduction to Immunology Lectures 1-3 by Bellur S. Prabhakar. March 13-14, 2007 TheComponents Of The Immune System and Innate Immunity: Ref: Immunobiology-5 th edition. Janeway et al. Chapters-1 & 2.

More information

Medical Virology Immunology. Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University

Medical Virology Immunology. Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Medical Virology Immunology Dr. Sameer Naji, MB, BCh, PhD (UK) Head of Basic Medical Sciences Dept. Faculty of Medicine The Hashemite University Human blood cells Phases of immune responses Microbe Naïve

More information

There are 2 major lines of defense: Non-specific (Innate Immunity) and. Specific. (Adaptive Immunity) Photo of macrophage cell

There are 2 major lines of defense: Non-specific (Innate Immunity) and. Specific. (Adaptive Immunity) Photo of macrophage cell There are 2 major lines of defense: Non-specific (Innate Immunity) and Specific (Adaptive Immunity) Photo of macrophage cell Development of the Immune System ery pl neu mφ nk CD8 + CTL CD4 + thy TH1 mye

More information

General Overview of Immunology. Kimberly S. Schluns, Ph.D. Associate Professor Department of Immunology UT MD Anderson Cancer Center

General Overview of Immunology. Kimberly S. Schluns, Ph.D. Associate Professor Department of Immunology UT MD Anderson Cancer Center General Overview of Immunology Kimberly S. Schluns, Ph.D. Associate Professor Department of Immunology UT MD Anderson Cancer Center Objectives Describe differences between innate and adaptive immune responses

More information

White Blood Cells (WBCs)

White Blood Cells (WBCs) YOUR ACTIVE IMMUNE DEFENSES 1 ADAPTIVE IMMUNE RESPONSE 2! Innate Immunity - invariant (generalized) - early, limited specificity - the first line of defense 1. Barriers - skin, tears 2. Phagocytes - neutrophils,

More information

Physiology Unit 3. ADAPTIVE IMMUNITY The Specific Immune Response

Physiology Unit 3. ADAPTIVE IMMUNITY The Specific Immune Response Physiology Unit 3 ADAPTIVE IMMUNITY The Specific Immune Response In Physiology Today The Adaptive Arm of the Immune System Specific Immune Response Internal defense against a specific pathogen Acquired

More information

immunity defenses invertebrates chapter 49

immunity defenses invertebrates chapter 49 immunity chapter 49 defenses Animal defenses -- thinking about immunity two main types innate immunity acquired immunity mechanism of action non-specific defenses specific defenses invertebrates phagocytosis

More information

Chapter 24 The Immune System

Chapter 24 The Immune System Chapter 24 The Immune System The Immune System Layered defense system The skin and chemical barriers The innate and adaptive immune systems Immunity The body s ability to recognize and destroy specific

More information

Immunology Lecture 4. Clinical Relevance of the Immune System

Immunology Lecture 4. Clinical Relevance of the Immune System Immunology Lecture 4 The Well Patient: How innate and adaptive immune responses maintain health - 13, pg 169-181, 191-195. Immune Deficiency - 15 Autoimmunity - 16 Transplantation - 17, pg 260-270 Tumor

More information

The Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep

The Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep The Immune System: Innate and Adaptive Body Defenses Outline PART 1: INNATE DEFENSES 21.1 Surface barriers act as the first line of defense to keep invaders out of the body (pp. 772 773; Fig. 21.1; Table

More information

All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity

All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity 1 2 3 4 5 6 7 8 9 The Immune System All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity Figure 43.2 In innate immunity, recognition and

More information

Clinical Basis of the Immune Response and the Complement Cascade

Clinical Basis of the Immune Response and the Complement Cascade Clinical Basis of the Immune Response and the Complement Cascade Bryan L. Martin, DO, MMAS, FACAAI, FAAAAI, FACOI, FACP Emeritus Professor of Medicine and Pediatrics President, American College of Allergy,

More information

Chapter 35 Active Reading Guide The Immune System

Chapter 35 Active Reading Guide The Immune System Name: AP Biology Mr. Croft Chapter 35 Active Reading Guide The Immune System Section 1 Phagocytosis plays an important role in the immune systems of both invertebrates and vertebrates. Review the process

More information

Introduction to Immunology Part 2 September 30, Dan Stetson

Introduction to Immunology Part 2 September 30, Dan Stetson Introduction to Immunology Part 2 September 30, 2016 Dan Stetson stetson@uw.edu 441 Lecture #2 Slide 1 of 26 CLASS ANNOUNCEMENT PLEASE NO TREE NUTS IN CLASS!!! (Peanuts, walnuts, almonds, cashews, etc)

More information

The Immune System. These are classified as the Innate and Adaptive Immune Responses. Innate Immunity

The Immune System. These are classified as the Innate and Adaptive Immune Responses. Innate Immunity The Immune System Biological mechanisms that defend an organism must be 1. triggered by a stimulus upon injury or pathogen attack 2. able to counteract the injury or invasion 3. able to recognise foreign

More information

Unit 5 The Human Immune Response to Infection

Unit 5 The Human Immune Response to Infection Unit 5 The Human Immune Response to Infection Unit 5-page 1 FOM Chapter 21 Resistance and the Immune System: Innate Immunity Preview: In Chapter 21, we will learn about the branch of the immune system

More information

all of the above the ability to impart long term memory adaptive immunity all of the above bone marrow none of the above

all of the above the ability to impart long term memory adaptive immunity all of the above bone marrow none of the above 1. (3 points) Immediately after a pathogen enters the body, it faces the cells and soluble proteins of the innate immune system. Which of the following are characteristics of innate immunity? a. inflammation

More information

Nonspecific External Barriers skin, mucous membranes

Nonspecific External Barriers skin, mucous membranes Immune system Chapter 36 BI 103 Plant-Animal A&P Levels of Defense Against Disease Nonspecific External Barriers skin, mucous membranes Physical barriers? Brainstorm with a partner If these barriers are

More information

Nonspecific External Barriers skin, mucous membranes

Nonspecific External Barriers skin, mucous membranes Immune system Chapter 36 BI 103 Plant-Animal A&P Levels of Defense Against Disease Nonspecific External Barriers skin, mucous membranes Physical barriers? Brainstorm with a partner If these barriers are

More information

Immunology. Overview. Kris.ne Kra1s, M.D.

Immunology. Overview. Kris.ne Kra1s, M.D. Immunology Overview Kris.ne Kra1s, M.D. Immunology Overview Defini.ons Cells Lymphocytes An.gen-presen.ng cells Effector cells Responses The innate immune response Capturing and displaying an.gens Cell-mediated

More information

Defense mechanism against pathogens

Defense mechanism against pathogens Defense mechanism against pathogens Immune System What is immune system? Cells and organs within an animal s body that contribute to immune defenses against pathogens ( ) Bacteria -Major entry points ;open

More information

Chapter 13 Lymphatic and Immune Systems

Chapter 13 Lymphatic and Immune Systems The Chapter 13 Lymphatic and Immune Systems 1 The Lymphatic Vessels Lymphoid Organs Three functions contribute to homeostasis 1. Return excess tissue fluid to the bloodstream 2. Help defend the body against

More information

Physiology Unit 3 THE SPECIFIC IMMUNE RESPONSE

Physiology Unit 3 THE SPECIFIC IMMUNE RESPONSE Physiology Unit 3 THE SPECIFIC IMMUNE RESPONSE The Adap4ve Arm of the Immune System Specific Immune Response Internal defense against a specific pathogen Acquired as you are exposed to diseases The immune

More information

Chapter 23 Immunity Exam Study Questions

Chapter 23 Immunity Exam Study Questions Chapter 23 Immunity Exam Study Questions 1. Define 1) Immunity 2) Neutrophils 3) Macrophage 4) Epitopes 5) Interferon 6) Complement system 7) Histamine 8) Mast cells 9) Antigen 10) Antigens receptors 11)

More information

Properties & Overview of IRs Dr. Nasser M. Kaplan JUST, Jordan. 10-Jul-16 NM Kaplan 1

Properties & Overview of IRs Dr. Nasser M. Kaplan JUST, Jordan. 10-Jul-16 NM Kaplan 1 Properties & Overview of IRs Dr. Nasser M. Kaplan JUST, Jordan 10-Jul-16 NM Kaplan 1 Major components of IS & their properties Definitions IS = cells & molecules responsible for: 1- Physiologic; protective

More information

ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY

ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY ACTIVATION OF T LYMPHOCYTES AND CELL MEDIATED IMMUNITY The recognition of specific antigen by naïve T cell induces its own activation and effector phases. T helper cells recognize peptide antigens through

More information

WHY IS THIS IMPORTANT?

WHY IS THIS IMPORTANT? CHAPTER 16 THE ADAPTIVE IMMUNE RESPONSE WHY IS THIS IMPORTANT? The adaptive immune system protects us from many infections The adaptive immune system has memory so we are not infected by the same pathogen

More information

The Immune System All animals have innate immunity, a defense active immediately

The Immune System All animals have innate immunity, a defense active immediately The Immune System All animals have innate immunity, a defense active immediately upon infection Vertebrates also have adaptive immunity Figure 43.2 INNATE IMMUNITY (all animals) Recognition of traits shared

More information

Immunology. T-Lymphocytes. 16. Oktober 2014, Ruhr-Universität Bochum Karin Peters,

Immunology. T-Lymphocytes. 16. Oktober 2014, Ruhr-Universität Bochum Karin Peters, Immunology T-Lymphocytes 16. Oktober 2014, Ruhr-Universität Bochum Karin Peters, karin.peters@rub.de The role of T-effector cells in the immune response against microbes cellular immunity humoral immunity

More information

Chapter 22: The Lymphatic System and Immunity

Chapter 22: The Lymphatic System and Immunity Bio40C schedule Lecture Immune system Lab Quiz 2 this week; bring a scantron! Study guide on my website (see lab assignments) Extra credit Critical thinking questions at end of chapters 5 pts/chapter Due

More information

number Done by Corrected by Doctor Sameer

number Done by Corrected by Doctor Sameer number Immunology Done by Tamara and Hiba Corrected by Rana Ghassan Doctor Sameer Immunology In the development of cells, we have certain stages that take place: 1) Multi potential 1 hematopoietic stem

More information

Structure and Function of Antigen Recognition Molecules

Structure and Function of Antigen Recognition Molecules MICR2209 Structure and Function of Antigen Recognition Molecules Dr Allison Imrie allison.imrie@uwa.edu.au 1 Synopsis: In this lecture we will examine the major receptors used by cells of the innate and

More information

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 13 Effector Responses: Cell- and Antibody-Mediated Immunity Copyright 2013 by W. H.

More information

The Adaptive Immune Responses

The Adaptive Immune Responses The Adaptive Immune Responses The two arms of the immune responses are; 1) the cell mediated, and 2) the humoral responses. In this chapter we will discuss the two responses in detail and we will start

More information

In other words. how to prevent David from killing Goliath. Tammy Rickabaugh, Ph.D. January 14, 2014

In other words. how to prevent David from killing Goliath. Tammy Rickabaugh, Ph.D. January 14, 2014 In other words. how to prevent David from killing Goliath Tammy Rickabaugh, Ph.D. January 14, 2014 2011 Nobel Prize in Medicine IMMUNOLOGISTS!!!!!!! Bruce A. Beutler Jules A. Hoffman Ralph M. Steinman

More information

The Immune System is the Third Line of Defense Against Infection. Components of Human Immune System

The Immune System is the Third Line of Defense Against Infection. Components of Human Immune System Chapter 17: Specific Host Defenses: The Immune Response The Immune Response Immunity: Free from burden. Ability of an organism to recognize and defend itself against specific pathogens or antigens. Immune

More information

Microbiology 204: Cellular and Molecular Immunology

Microbiology 204: Cellular and Molecular Immunology Microbiology 204: Cellular and Molecular Immunology Class meets MWF 1:00-2:30PM (*exceptions: no class Fri Sept 23, Fri Oct 14, Nov 11, or Wed Nov 23) Lectures are open to auditors and will be live-streamed

More information

T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes:

T-cell activation T cells migrate to secondary lymphoid tissues where they interact with antigen, antigen-presenting cells, and other lymphocytes: Interactions between innate immunity & adaptive immunity What happens to T cells after they leave the thymus? Naïve T cells exit the thymus and enter the bloodstream. If they remain in the bloodstream,

More information

Effector T Cells and

Effector T Cells and 1 Effector T Cells and Cytokines Andrew Lichtman, MD PhD Brigham and Women's Hospital Harvard Medical School 2 Lecture outline Cytokines Subsets of CD4+ T cells: definitions, functions, development New

More information

Acquired Immunity Cells are initially and require before they can work Responds to individual microbes

Acquired Immunity Cells are initially and require before they can work Responds to individual microbes 1 of 10 THE IMMUNE SYSTEM CHAPTER 43; PAGES 898 921 WHY DO WE NEED AN IMMUNE SYSTEM? It s a dirty, dirty world out there and we are vastly outnumbered Bacteria and parasites are everywhere The body has

More information

Immunology Basics Relevant to Cancer Immunotherapy: T Cell Activation, Costimulation, and Effector T Cells

Immunology Basics Relevant to Cancer Immunotherapy: T Cell Activation, Costimulation, and Effector T Cells Immunology Basics Relevant to Cancer Immunotherapy: T Cell Activation, Costimulation, and Effector T Cells Andrew H. Lichtman, M.D. Ph.D. Department of Pathology Brigham and Women s Hospital and Harvard

More information

1. The scavenger receptor, CD36, functions as a coreceptor for which TLR? a. TLR ½ b. TLR 3 c. TLR 4 d. TLR 2/6

1. The scavenger receptor, CD36, functions as a coreceptor for which TLR? a. TLR ½ b. TLR 3 c. TLR 4 d. TLR 2/6 Allergy and Immunology Review Corner: Cellular and Molecular Immunology, 8th Edition By Abul K. Abbas, MBBS, Andrew H. H. Lichtman, MD, PhD and Shiv Pillai, MBBS, PhD. Chapter 4 (pages 62-74): Innate Immunity

More information

NOTES: CH 43, part 1 The Immune System - Nonspecific & Specific Defenses ( )

NOTES: CH 43, part 1 The Immune System - Nonspecific & Specific Defenses ( ) NOTES: CH 43, part 1 The Immune System - Nonspecific & Specific Defenses (43.1-43.2) The lymphatic system is closely associated with the cardiovascular system. LYMPHATIC PATHWAYS Lymphatic capillaries

More information

I. Lines of Defense Pathogen: Table 1: Types of Immune Mechanisms. Table 2: Innate Immunity: First Lines of Defense

I. Lines of Defense Pathogen: Table 1: Types of Immune Mechanisms. Table 2: Innate Immunity: First Lines of Defense I. Lines of Defense Pathogen: Table 1: Types of Immune Mechanisms Table 2: Innate Immunity: First Lines of Defense Innate Immunity involves nonspecific physical & chemical barriers that are adapted for

More information

Immunology - Lecture 2 Adaptive Immune System 1

Immunology - Lecture 2 Adaptive Immune System 1 Immunology - Lecture 2 Adaptive Immune System 1 Book chapters: Molecules of the Adaptive Immunity 6 Adaptive Cells and Organs 7 Generation of Immune Diversity Lymphocyte Antigen Receptors - 8 CD markers

More information

Immunology Molecular regulation of the immune system

Immunology Molecular regulation of the immune system Immunology Molecular regulation of the immune system - Introduction - Monika Raulf Lecture 19.04.2017 Molecular medicine - Immunology Date Topic Lecturer 19.04.17 Introduction Raulf 26.04.17 Innate Immunity

More information

CHAPTER 18: Immune System

CHAPTER 18: Immune System CHAPTER 18: Immune System 1. What are four characteristics of the specific immune system? a. b. c. d. 2. List the two main types of defense mechanisms and briefly describe features of each. 3. Give examples

More information

Lymphatic System. Where s your immunity idol?

Lymphatic System. Where s your immunity idol? Lymphatic System Where s your immunity idol? Functions of the Lymphatic System Fluid Balance Drains excess fluid from tissues Lymph contains solutes from plasma Fat Absorption Lymphatic system absorbs

More information

Title: NATURAL KILLER CELL FUNCTIONS AND SURFACE RECEPTORS

Title: NATURAL KILLER CELL FUNCTIONS AND SURFACE RECEPTORS LECTURE: 14 Title: NATURAL KILLER CELL FUNCTIONS AND SURFACE RECEPTORS LEARNING OBJECTIVES: The student should be able to: Describe the general morphology of the NK-cells. Enumerate the different functions

More information

Chapter 21 The Immune System: Innate and Adaptive Body Defenses

Chapter 21 The Immune System: Innate and Adaptive Body Defenses Chapter 21 The Immune System: Innate and Adaptive Body Defenses 1/25/2016 1 Annie Leibovitz/Contact Press Images The Immune System Immune system provides resistance to disease Made up of two intrinsic

More information

The Major Histocompatibility Complex (MHC)

The Major Histocompatibility Complex (MHC) The Major Histocompatibility Complex (MHC) An introduction to adaptive immune system before we discuss MHC B cells The main cells of adaptive immune system are: -B cells -T cells B cells: Recognize antigens

More information

Chapter 07 Lecture Outline

Chapter 07 Lecture Outline Chapter 07 Lecture Outline See separate PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright 2016 McGraw-Hill Education. Permission required for reproduction

More information

Fluid movement in capillaries. Not all fluid is reclaimed at the venous end of the capillaries; that is the job of the lymphatic system

Fluid movement in capillaries. Not all fluid is reclaimed at the venous end of the capillaries; that is the job of the lymphatic system Capillary exchange Fluid movement in capillaries Not all fluid is reclaimed at the venous end of the capillaries; that is the job of the lymphatic system Lymphatic vessels Lymphatic capillaries permeate

More information

Antigen Presentation to Lymphocytes

Antigen Presentation to Lymphocytes Antigen Presentation to Lymphocytes Jiyang O Wang, Chiba Cancer Center Research Institute, Chiba, Japan Takeshi Watanabe, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan Antigen presentation

More information

Basic immunology. Lecture 9. Innate immunity: inflammation, leukocyte migration. Péter Engelmann

Basic immunology. Lecture 9. Innate immunity: inflammation, leukocyte migration. Péter Engelmann Basic immunology Lecture 9. Innate immunity: inflammation, leukocyte migration Péter Engelmann Different levels of the immune response Recognition molecules of innate immunity Initiation of local and systemic

More information

Microbiology 204: Cellular and Molecular Immunology

Microbiology 204: Cellular and Molecular Immunology Microbiology 204: Cellular and Molecular Immunology Class meets MWF 1:00-2:30PM (*exceptions: no class Fri Oct 11; Wed Nov 27 will be moved to 11/25) Lectures are open to auditors Discussions are restricted

More information

Lines of Defense. Immunology, Immune Response, and Immunological Testing. Immunology Terminology

Lines of Defense. Immunology, Immune Response, and Immunological Testing. Immunology Terminology Immunology, Immune Response, and Immunological Testing Lines of Defense If the First and Second lines of defense fail, then the Third line of defense is activated. B and T lymphocytes undergo a selective

More information

Immunology 2011 Lecture 2 Immune Reactions, Ag/Ab 20 September

Immunology 2011 Lecture 2 Immune Reactions, Ag/Ab 20 September Immunology 2011 Lecture 2 Immune Reactions, Ag/Ab 20 September HANDOUTS #1 Roadmap TODAY Immune Reactions, Antigen/Antibody, Core Notes Chapters 1 & 2 and Appendix 1,2 (Precipitin Curve, Ab Labeling) Ag/Ab

More information

Innate immunity (rapid response) Dendritic cell. Macrophage. Natural killer cell. Complement protein. Neutrophil

Innate immunity (rapid response) Dendritic cell. Macrophage. Natural killer cell. Complement protein. Neutrophil 1 The immune system The immune response The immune system comprises two arms functioning cooperatively to provide a comprehensive protective response: the innate and the adaptive immune system. The innate

More information

Chapter 1. Full file at

Chapter 1. Full file at Chapter 1 1. Which is the best definition of immunity? Answer: B A. The state of having been exposed to a pathogen repeatedly B. The state of being resistant to reinfection with a pathogen C. When an individual

More information

Chapters 20, 21. Lymphatic and Immune System. Overview. Specific Defenses 22/10/12. Part II. Specific Immunity BIOL242

Chapters 20, 21. Lymphatic and Immune System. Overview. Specific Defenses 22/10/12. Part II. Specific Immunity BIOL242 Chapters 20, 21. Lymphatic and Immune System Part II. Specific Immunity BIOL242 Overview Properties of specific immunity Antigen presentation and the MHC complexes T cell activation B cell activation Antibodies

More information

Diseases-causing agents, pathogens, can produce infections within the body.

Diseases-causing agents, pathogens, can produce infections within the body. BIO 212: ANATOMY & PHYSIOLOGY II 1 CHAPTER 16 Lecture: Dr. Lawrence G. Altman www.lawrencegaltman.com Some illustrations are courtesy of McGraw-Hill. LYMPHATIC and IMMUNE Systems Body Defenses Against

More information

1. Lymphatic vessels recover about of the fluid filtered by capillaries. A. ~1% C. ~25% E. ~85% B. ~10% D. ~50%

1. Lymphatic vessels recover about of the fluid filtered by capillaries. A. ~1% C. ~25% E. ~85% B. ~10% D. ~50% BIOL2030 Huaman A&P II -- Exam 3 -- XXXX -- Form A Name: 1. Lymphatic vessels recover about of the fluid filtered by capillaries. A. ~1% C. ~25% E. ~85% B. ~10% D. ~50% 2. Special lymphatic vessels called

More information

Allergy and Immunology Review Corner: Chapter 1 of Immunology IV: Clinical Applications in Health and Disease, by Joseph A. Bellanti.

Allergy and Immunology Review Corner: Chapter 1 of Immunology IV: Clinical Applications in Health and Disease, by Joseph A. Bellanti. Allergy and Immunology Review Corner: Chapter 1 of Immunology IV: Clinical Applications in Health and Disease, by Joseph A. Bellanti. Chapter 1: Overview of Immunology Prepared by David Scott, MD, Scripps

More information

Unit 6: Adaptive Immunity. Adaptive Immunity (Humoral Immunity; Cell-Mediated Immunity; Immunodeficiency; Hypersensitivity)

Unit 6: Adaptive Immunity. Adaptive Immunity (Humoral Immunity; Cell-Mediated Immunity; Immunodeficiency; Hypersensitivity) Unit 6: Adaptive Immunity Adaptive Immunity (Humoral Immunity; Cell-Mediated Immunity; Immunodeficiency; Hypersensitivity) : ADAPTIVE IMMUNITY: AN OVERVIEW OF INNATE AND ADAPTIVE IMMUNITY Adaptive Immunity

More information

SPECIFIC DEFENSE: THE IMMUNE SYSTEM

SPECIFIC DEFENSE: THE IMMUNE SYSTEM SPECIFIC DEFENSE: THE IMMUNE SYSTEM Lymphocytes: are white blood cells that exists in two primary forms B cells: made in the bone marrow and complete their development there or in the spleen. B cells make

More information

Introduction to the Immune System

Introduction to the Immune System Introduction to the Immune System Stephen Canfield, MD, PhD Division of Pulmonary, Allergy, and Critical Care Medicine The Immune System in Health Defense against invading organisms Surveillance against

More information

IMMUNITY AND DISEASE II

IMMUNITY AND DISEASE II IMMUNITY AND DISEASE II A. Evolution of the immune system. 1. Figure 1--57.25, p. 1167 from Raven and Johnson Biology 6 th ed. shows how the immune system evolved. Figure 1. How the immune system evolved.

More information

Immune system - introduction. Radek Spisek Institute of Immunology, 2nd Medical School, Charles University

Immune system - introduction. Radek Spisek Institute of Immunology, 2nd Medical School, Charles University Immune system - introduction Radek Spisek Institute of Immunology, 2nd Medical School, Charles University Edward JENNER 1749-1823 Eradication of variola (smallpox) Know The Enemy The immune system exists

More information

The Adaptive Immune Response. T-cells

The Adaptive Immune Response. T-cells The Adaptive Immune Response T-cells T Lymphocytes T lymphocytes develop from precursors in the thymus. Mature T cells are found in the blood, where they constitute 60% to 70% of lymphocytes, and in T-cell

More information

42 THE IMMUNE SYSTEM

42 THE IMMUNE SYSTEM Chapter 42 The Immune System 1213 42 THE IMMUNE SYSTEM Figure 42.1 In this compound light micrograph purple-stained neutrophil (upper left) and eosinophil (lower right) are white blood cells that float

More information

The Immune System. Chapter 43. Biology Eighth Edition Neil Campbell and Jane Reece. PowerPoint Lecture Presentations for

The Immune System. Chapter 43. Biology Eighth Edition Neil Campbell and Jane Reece. PowerPoint Lecture Presentations for Chapter 43 The Immune System PowerPoint Lecture Presentations for Biology Eighth Edition Neil Campbell and Jane Reece Lectures by Chris Romero, updated by Erin Barley with contributions from Joan Sharp

More information

Question 1. Kupffer cells, microglial cells and osteoclasts are all examples of what type of immune system cell?

Question 1. Kupffer cells, microglial cells and osteoclasts are all examples of what type of immune system cell? Abbas Chapter 2: Sarah Spriet February 8, 2015 Question 1. Kupffer cells, microglial cells and osteoclasts are all examples of what type of immune system cell? a. Dendritic cells b. Macrophages c. Monocytes

More information

AP Biology Campbell - Chapter 43 - The Immune System

AP Biology Campbell - Chapter 43 - The Immune System AP Biology Campbell - Chapter 43 - The Immune System Name What?...Read?...The Overview? Name the three general categories of pathogens: 1. 2. 3. Our immune system is designed to protect us against p Dedicated

More information

The development of T cells in the thymus

The development of T cells in the thymus T cells rearrange their receptors in the thymus whereas B cells do so in the bone marrow. The development of T cells in the thymus The lobular/cellular organization of the thymus Immature cells are called

More information

Pathogens and the immune system

Pathogens and the immune system Pathogens and the immune system Veronica Leautaud, Ph.D. vl2@ rice.edu Keck Hall 224 / 232-lab Lecture 8 BIOE 301-Bioengineering and World Health Review of lecture 7 Science Science is the human activity

More information

LYMPHATIC AND IMMUNE SYSTEMS. Chapter 33

LYMPHATIC AND IMMUNE SYSTEMS. Chapter 33 LYMPHATIC AND IMMUNE SYSTEMS Chapter 33 THE LYMPHATIC SYSTEM The lymphatic system has three main functions Take up excess tissue fluid and return it to the bloodstream Receive fats called lipoproteins

More information

Chapter 21: Innate and Adaptive Body Defenses

Chapter 21: Innate and Adaptive Body Defenses Chapter 21: Innate and Adaptive Body Defenses I. 2 main types of body defenses A. Innate (nonspecific) defense: not to a specific microorganism or substance B. Adaptive (specific) defense: immunity to

More information

Cell Mediated Immunity CELL MEDIATED IMMUNITY. Basic Elements of Cell Mediated Immunity (CMI) Antibody-dependent cell-mediated cytotoxicity (ADCC)

Cell Mediated Immunity CELL MEDIATED IMMUNITY. Basic Elements of Cell Mediated Immunity (CMI) Antibody-dependent cell-mediated cytotoxicity (ADCC) Chapter 16 CELL MEDIATED IMMUNITY Cell Mediated Immunity Also known as Cellular Immunity or CMI The effector phase T cells Specificity for immune recognition reactions TH provide cytokines CTLs do the

More information

Antigen Presentation and T Lymphocyte Activation. Shiv Pillai MD, PhD Massachusetts General Hospital Harvard Medical School. FOCiS

Antigen Presentation and T Lymphocyte Activation. Shiv Pillai MD, PhD Massachusetts General Hospital Harvard Medical School. FOCiS 1 Antigen Presentation and T Lymphocyte Activation Shiv Pillai MD, PhD Massachusetts General Hospital Harvard Medical School FOCiS 2 Lecture outline Overview of T cell activation and the rules of adaptive

More information

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 11 T-Cell Activation, Differentiation, and Memory Copyright 2013 by W. H. Freeman and

More information

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION

Scott Abrams, Ph.D. Professor of Oncology, x4375 Kuby Immunology SEVENTH EDITION Scott Abrams, Ph.D. Professor of Oncology, x4375 scott.abrams@roswellpark.org Kuby Immunology SEVENTH EDITION CHAPTER 11 T-Cell Activation, Differentiation, and Memory Copyright 2013 by W. H. Freeman and

More information

Innate Immunity. Natural or native immunity

Innate Immunity. Natural or native immunity Innate Immunity 1 Innate Immunity Natural or native immunity 2 When microbes enter in the body 3 Secondly, it also stimulates the adaptive immune system 4 Immunologic memory 5 Components of Innate Immunity

More information

Immune Surveillance. Immune Surveillance. Immune Surveillance. Neutrophil granulocytes Macrophages. M-cells

Immune Surveillance. Immune Surveillance. Immune Surveillance. Neutrophil granulocytes Macrophages. M-cells he immune system is everywhere Some organs have developed strategies towards the immune system to keep it out or to put it under control Immune privileged organs: Brain Eye estis hyroid gland Humoral immunity

More information

Immunity and Infection. Chapter 17

Immunity and Infection. Chapter 17 Immunity and Infection Chapter 17 The Chain of Infection Transmitted through a chain of infection (six links) Pathogen: Disease causing microorganism Reservoir: Natural environment of the pathogen Portal

More information

Lecture 9: T-cell Mediated Immunity

Lecture 9: T-cell Mediated Immunity Lecture 9: T-cell Mediated Immunity Questions to Consider How do T cells know where to go? Questions to Consider How do T cells know where to go? How does antigen get targeted to a T cell expressing the

More information

Campbell's Biology: Concepts and Connections, 7e (Reece et al.) Chapter 24 The Immune System Multiple-Choice Questions

Campbell's Biology: Concepts and Connections, 7e (Reece et al.) Chapter 24 The Immune System Multiple-Choice Questions Campbell's Biology: Concepts and Connections, 7e (Reece et al.) Chapter 24 The Immune System 24.1 Multiple-Choice Questions 1) The body's innate defenses against infection include A) several nonspecific

More information

Cell-mediated Immunity

Cell-mediated Immunity Cellular & Molecular Immunology Cell-mediated Immunity Nicholas M. Ponzio, Ph.D. Department of Pathology & Laboratory Medicine April 6, 2009 Today s Presentation: Overview Cellular Interactions In Humoral

More information