Mary-Ann Davies and Matthias Egger on behalf of the IeDEA-SA Collaboration
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1 Mary-Ann Davies and Matthias Egger on behalf of the IeDEA-SA Collaboration National Institute of Allergy and Infectious Diseases (NIAID) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
2 Session Overview 1. Introduction and overview of IeDEA-Southern Africa - Mary-Ann Davies 2. Life expectancy in ART-treated adult patients - Leigh Johnson 3. Studies at the Centre for Infectious Diseases Research in Zambia (CIDRZ) - Carolyn Bolton 4. Modeling for Clinical Decision Making: two examples - Nello Blaser 5. Virological response in children treated with ABC-based compared to d4t-based ART - Karl Technau 6. Cancer studies within the IeDEA-SA cohort - Mazvita Sengayi
3 What is IeDEA-Southern Africa International epidemiologic databases to evaluate AIDS Regional collaboration of HIV cohorts that identifies and pursues research relevant to the region that can t be addressed in a single cohort Data centres - University of Cape Town, South Africa - University of Bern, Switzerland Together with 6 other regions contribute to the global IeDEA collaboration (
4 Global IeDEA collaboration IeDEAfunded by NIAID since 2006 to establish regional data centers in order to: collect and harmonize data and createan international consortium to address unique and evolving research questions in HIV/AIDS clinical care and epidemiology that are currently unanswerable by single cohorts. establish and implement methodology to effectively pool the high quality data collected during clinical care.
5 Region 1: North America Canada United States Region 5: Asia and Australia Region 2: Latin America & Caribbean Argentina Brazil Chile Haiti Honduras Mexico Peru Australia Cambodia China India Indonesia Japan Malaysia Philippines Singapore South Korea Taiwan Thailand Vietnam Region 9: Central Africa Region 8: West Africa Benin Burkina Fuaso Cote d'ivoire Gambia Ghana Guinea-Bissau Mali Nigeria Senegal Togo Burundi Cameroon Central African Republic Congo, Dem. Rep. of (Zaire) Rwanda Region 11: Southern Africa Lesotho Malawi Mozambique South Africa Zambia Zimbabwe Region 10: East Africa Kenya Tanzania Uganda
6 Urban ART site Rural ART site 18 sites in 6 countries >300,000 adults >30,000 children Figure: Map of IeDEA sites Lesotho SolidarMed, Lesotho Malawi Lighthouse clinic, Lilongwe Queen Elizabeth Central Hospital, Blantyre Mozambique SolidarMed, Mozambique CISM, Manhica South Africa Aurum Institute, Johannesburg Thambalethu Clinic Cohort, Johannesburg Khayelitsha ART program, Cape Town Red Cross Children s Hospital, Cape Town Tygerberg Hospital, Stellenbosch Gugulethu ART program, Cape Town McCord Hospital, Durban Harriet Shezi, Soweto Rahima Moosa, Johannesburg Hlabisa HIV Treatment Program, Hlabisa Zimbabwe Newlands Clinic, Harare SolidarMed, Zimbabwe Zambia CIDRZ, clinics countrywide
7 Affiliated Investigators Benjamin Chi: Centre for Infectious Disease Research in Zambia; Sam Phiri: Lighthouse Trust Clinic; Joep van Oosterhout: Queen Elizabeth Hospital; Cleophas Chimbetete: Newlands Clinic; Christiane Fritz: SolidarMed Zimbabwe; Sabrina Pestilli: SolidarMed Mozambique; Denise Naniche: Centro de Investigaçao em Saude de Manhiça; James Ndirangu: Africa Centre for Health & Population Studies; Christopher Hoffmann: Aurum Institute for Health Research; Robin Wood: Gugulethu & Masiphumelele clinics; Kathryn Stinson: Khayelitsha ART Programme/Médecins sans Frontières; Janet Giddy: McCord Hospital; Brian Eley: Red Cross Children s Hospital; Matt Fox: Themba Lethu Clinic; Hans Prozesky: Tygerberg Academic Hospital; Karl Technau: Rahima Moosa Mother and Child Hospital; Harry Moultrie: Harriet Shezi Clinic; SolidarMed Lesotho Data Centres Marie Baliff, Julia Bohlius, Nello Blaser, Andrew Boulle, Lucy Campbell, Morna Cornell, Janne Estill, Béatrice Fatzer, Lukas Fenner, Claire Graber, Andreas Haas, Leigh Johnson, Fritz Kaeser, Leatitia Kampiire, Olivia Keiser, Nicola Maxwell, Erna Morden, Landon Myer, Luisa Salazar, Franziska Schoeni-Affolter, Michael Schomaker, Gilles Wandeler
8 Specific Aims for IeDEA Southern Africa 1. To collate and analyse data related to the delivery of ART in children and adults, with a focus on long-term program effectiveness and outcomes. 2. To describe the long-term and temporal trends in regimen durability and tolerability and examine ART monitoring strategies. 3. To describe important co-morbidities and co-infections of HIV infection, with a focus on tuberculosis and cancer. 4. To explore the interface between ART and pregnancy, focusing on pregnant women on ART and cohorts of exposed infants.
9 With many thanks to Patients, caregivers, staff and site investigators from all IeDEA-SA sites. NIAID, NICHD and NCI
10 Session Overview 1. Introduction and overview of IeDEA-Southern Africa - Mary-Ann Davies 2. Life expectancy in ART-treated adult patients - Leigh Johnson 3. Studies at the Centre for Infectious Diseases Research in Zambia (CIDRZ) - Carolyn Bolton 4. Modeling for Clinical Decision Making: two examples - Nello Blaser 5. Virological response in children treated with ABC-based compared to d4t-based ART - Karl Technau 6. Cancer studies within the IeDEA-SA cohort - Mazvita Sengayi
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HIBA ABDALRAHIM Capsca Focal Point Public Health Authority Introduction Definition Symptom Transmission Global situation Local situation Control Content Introduction Yellow fever (YF) is a mosquito-borne