Basic Immunology Concepts

Transcription

1 Western Technical College Basic Immunology Concepts Course Outcome Summary Course Information Description Career Cluster Instructional Level Total Credits 2.00 Total Hours This course provides an overview of the immune system including laboratory testing methods for diagnosis of immune system disorders, viral and bacterial infections. Health Science Associate Degree Courses Types of Instruction Instruction Type Lecture Lab Credits/Hours 1 CR / 18 HR 1 CR / 36 HR Course History Purpose/Goals Apply knowledge of the immune system including lab testing methods for diagnosis of immune system disorders, bacterial and viral infections. Target Population This course is designed for students enrolled in the MLT/CLT program. Pre/Corequisites Prerequisite Urinalysis Textbooks Clinical Immunology and Serology. 3rd Edition. Copyright Stevens, Edwared. Publisher: F.A. Davis Company. ISBN-13: Required Basic Immunology Concepts Lab Manual. Western. Publisher: Western. Required. Learner Supplies Course Outcome Summary - Page 1 of 7

2 Lab Coat - $20. Vendor: Campus Shop. Required. Safety Glasses. Vendor: Campus Shop. Required. Core Abilities 1. Apply mathematical concepts. Status Active 2. Status Active 3. Transfer social and natural science theories into practical applications. Status Active Program Outcomes 1. Practice laboratory safety and regulatory compliance. Summative 1.1. Student Exhibition of Proficiency, Performance Tasks 1.2. Clinical Evaluation 1.1. Practice standard precautions 1.2. Locate emergency equipment 1.3. Demonstrate appropriate handling and disposal of biohazardous waste 1.4. Follow HIPAA regulations 2. Collect and process biological specimens for analysis Identify patient and specimens accurately 2.2. Process lab specimens per CLSI standards 2.3. Perform blood and other specimen collection procedures per CLSI standards 3. Monitor and evaluate quality control in the laboratory Take appropriate action 3.2. Assess acceptability of QC results 3.3. Use appropriate quality control protocol 4. Apply modern clinical methodologies including problem solving and troubleshooting according to predetermined 4.1. Perform procedures following laboratory guidelines 4.2. Recognize normal, abnormal and critical values 4.3. Operate laboratory instruments efficiently 4.4. Perform routine maintenance on laboratory instruments 4.5. Assist with troubleshooting 4.6. Determine reportability of results 5. Correlate laboratory results to diagnosis of clinical conditions and/or diseases. Course Outcome Summary - Page 2 of 7

3 5.1. Recognize and correlate lab test results to hematology/coagulation findings 5.2. Recognize and correlate lab test results to chemistry findings 5.3. Recognize and correlate lab test results to blood bank findings 5.4. Recognize and correlate lab test results to microbiology findings 5.5. Recognize and correlate lab test results to immunology findings 5.6. Recognize and correlate lab test results to urinalysis findings 5.7. Correlate test results from multiple lab areas to diagnose patient clinical condition/disease External Standards Title Association Status NAACLS Active Target Standards 1. Methodologies for all major areas currently practiced by a modern clinical laboratory, including problem solving and troubleshooting techniques 2. Collecting, processing, and analyzing biological specimens and other substances 3. Laboratory result use in diagnosis and treatment 5. The required competencies to participate in the orientation of new employees Course Competencies 1. Summarize the functions of the immune system Domain Cognitive Level Synthesis Status Active Transfer social and natural science theories into practical applications by writing a summary of the functions of the immune system 1.2. by developing a flowchart of the functions of the immune system 1.1. summary identifies the key functions of the immune system 1.2. summary includes only relevant and necessary details 1.3. summary is concise without being sketchy 1.4. summary evidences correct grammar, punctuation and spelling 1.5. flowchart depicts all of the functions in the immune system 1.6. flowchart shows the relationship of one system to another 1.7. flowchart shows a clear understanding of the immune systems 1.8. flowchart is neat and well organized 1.a. Define immunologic terms. 1.b. Breakdown the components of immune response: nonspecific and specific immunity 1.c. Identify what constitutes a foreign substance (antigen) within the body Course Outcome Summary - Page 3 of 7

4 1.d. 1.e. 1.f. 1.g. 1.h. 1.i. 1.j. 1.k. 1.l. Characterize the cells involved in both nonspecific and specific immunity Characterize the compounds produced by the various cells involved in immunity Identify complement activity involved in both innate and specific immunity Label the component parts of immunoglobulins and the binding areas of antigens, complement and macrophages Differentiate between the five types of immunoglobulins structurally and functionally Diagram the interaction between cells and compounds involved in the immune response Distinguish the types of immunity produced by different antigens Summarize how immunity develops in the fetus to old age Summarize the destruction of antigens during immune response 2. Characterize the types of reactions used in immuno-diagnostic testing Domain Cognitive Level Analysis Status Active Apply mathematical concepts. 5. The required competencies to participate in the orientation of new employees 2.1. by comparing types of reactions used in immuno-diagnostic testing and reporting your findings in a chart 2.2. or by creating a concept map/web of types of reactions used in immuno-diagnostic testing 2.1. comparison is based on important features or attributes of types of reactions used in immuno-diagnostic testing 2.2. comparison includes the similarities between the types of reactions used in immuno-diagnostic testing 2.3. comparison includes the differences between the types of reactions used in immuno-diagnostic testing 2.4. comparison is neat and presentable 2.5. comparison evidences correct grammar, punctuation and spelling 2.6. map/web main types of reactions used in immuno-diagnostic testing is at the center and important related themes branch out from the core 2.7. map/web uses circles or ovals to enclose an important term or concept within the topic 2.8. map/web uses straight lines with arrows (single or double-headed) to link terms that are related 2.9. map/web includes at least 4 items map/web concepts are arranged in a pattern that best represents the information map/web concepts build on one another and show the relationship between items map/web is neatly presented 2.a. Define key terms relating to antigen-antibody reactions 2.b. Identify factors essential for antigen-antibody reactions 2.c. Describe events occuring during the primary and secondary antigen 2.d. Differentiate between prozone, zone of equivalence, and post-zone in antigen-antibody reactions 2.e. Describe structural characteristics affecting antigen-antibody binding 2.f. Describe the impact and importance environmental factors (temperature, ionic strength, hydrogen ion concentrations etc.) 2.g. Distinguish between monoclonal and polyclonal antibodies in antigen-antibody reactions 2.h. Distinguish what antigen-antibody reactions are more sensitive due to whether it is a primary or secondary manifestation 2.i. Distinguish between the types of antigen-antibody reactions (precipitation, agglutination, solid-phase immunoassay, complement-fixation, or neutralization reactions 2.j. Identify laboratory tests that use specific antigen-antibody reactions 3. Perform immuno-diagnostic testing for bacteria Course Outcome Summary - Page 4 of 7

5 Domain Psychomotor Level Practice Status Active Practice laboratory safety and regulatory compliance. Collect and process biological specimens for analysis. Monitor and evaluate quality control in the laboratory. 2. Collecting, processing, and analyzing biological specimens and other substances 3.1. by completing a lab report on immuno-diagnostic testing for viral diseases 3.1. lab report includes a title page with the title of the experiment, the date it was performed, and the individual who conducted the experiment 3.2. lab report includes an overview of the procedure used for the lab 3.3. lab report includes a list of the materials, equipment, and steps used to conduct the experiment 3.4. lab report includes a summary of the results 3.5. lab results are presented in standard laboratory reporting and by manufacturer directions 3.6. lab report includes a description of the conclusions you drew and why 3.7. lab report is word processed or neatly handwritten 3.8. lab report is well organized; sections are clearly marked with appropriate headings 3.9. lab report uses appropriate scientific vocabulary 3.a. Name the causative agent of syphilis 3.b. Describe the epidemiology of syphilis 3.c. Describe the signs/symptoms of primary, secondary, latent, and tertiary syphilis 3.d. Differentiate between treponemal and nontreponemal methods of diagnosing syphilis and when is each used 3.e. List five causes of biologic false positives when testing for syphilis 3.f. Name the causative agent of Lyme disease 3.g. Describe the signs/symptoms/epidemiology of Lyme disease 3.h. Discuss the diagnostic evaluation of Lyme disease 3.i. Explain what is meant by non-suppurative, post-streptococcal disease. 3.j. Describe the signs/symptoms/epidemiology of rheumatic fever 3.k. Describe the signs/symptoms/epidemiology of acute glomerulonephritis 3.l. Describe the methods used to diagnose streptococcal infections 3.m. Explain the principle of the ASO test 3.n. Describe the clinical condition associated with Mycoplasma pneumonia infection 3.o. Explain the interpretation of the cold agglutinin titer 4. Perform immuno-diagnostic testing for viral diseases Domain Psychomotor Level Practice Status Active Course Outcome Summary - Page 5 of 7

6 Practice laboratory safety and regulatory compliance. Collect and process biological specimens for analysis. Monitor and evaluate quality control in the laboratory. 2. Collecting, processing, and analyzing biological specimens and other substances 5. The required competencies to participate in the orientation of new employees 4.1. by completing a lab report on immuno-diagnostic testing for bacteria 4.1. lab report includes a title page with the title of the experiment, the date it was performed, and the individual who conducted the experiment 4.2. lab report includes an overview of the procedure used for the lab 4.3. lab report includes a list of the materials, equipment, and steps used to conduct the experiment 4.4. lab report includes a summary of the results 4.5. lab results are presented in standard laboratory reporting and by manufacturer directions 4.6. lab report includes a description of the conclusions you drew and why 4.7. lab report is word processed or neatly handwritten 4.8. lab report is well organized; sections are clearly marked with appropriate headings 4.9. lab report uses appropriate scientific vocabulary 4.a. Name the causative agent of AIDS 4.b. Describe the signs/symptoms/epidemiology of HIV infection 4.c. Explain the diagnostic evaluation of HIV infection 4.d. Give the common name of the diseases associated with each of the Herpes viruses 4.e. Describe the signs/symptoms/epidemiology of cytomegalovirus infection 4.f. Describe the signs/symptoms/epidemiology of Epstein-Barr virus infection 4.g. Define heterophile antibody and explain how it is used to diagnose infectious mononucleosis 4.h. List the EBV specific antibodies, what their presence indicates and the clinical situations when they may be measured 4.i. Describe the signs/symptoms/epidemiology of rubella infection 4.j. Explain the diagnostic evaluation of rubella infection 4.k. Describe the signs/symptoms/epidemiology of viral hepatitis 4.l. Explain the diagnostic evaluation of viral hepatitis 4.m. Distinguish between evaluation of immune status and current infection for viral diseases 5. Perform immuno-diagnostic testing for various immune system disorders Domain Psychomotor Level Practice Status Active Practice laboratory safety and regulatory compliance. Collect and process biological specimens for analysis. Monitor and evaluate quality control in the laboratory. Course Outcome Summary - Page 6 of 7

7 2. Collecting, processing, and analyzing biological specimens and other substances 5.1. by completing a lab report on immuno-diagnostic testing for various immune system disorders 5.1. lab report includes a title page with the title of the experiment, the date it was performed, and the individual who conducted the experiment 5.2. lab report includes an overview of the procedure used for the lab 5.3. lab report includes a list of the materials, equipment, and steps used to conduct the experiment 5.4. lab report includes a summary of the results 5.5. lab results are presented in standard laboratory reporting and by manufacturer directions 5.6. lab report includes a description of the conclusions you drew and why 5.7. lab report is word processed or neatly handwritten 5.8. lab report is well organized; sections are clearly marked with appropriate headings 5.9. lab report uses appropriate scientific vocabulary 5.a. Define terms related to abnormal immune response: hypersensitivity, autoimmunity, immunodeficiency, immunoproliferative disorders 5.b. Contrast the four types of hypersensitivity reaction mechanisms 5.c. Summarize disease processes for hypersensitivity reactions 5.d. Survey diagnostic tests in the diagnosis of hypersensitivity conditions 5.e. Describe skin test administration technique and localized tissue response 5.f. Differentiate between organ-specific and nonorgan-specific autoimmune diseases 5.g. Contrast disease symptoms and local and systemic disease processes related to various autoimmune diseases 5.h. Relate antinuclear antibodies and immunofluorescent patterns to autoimmune diseases 5.i. Describe laboratory methodologies used in the diagnosis of autoimmune system disorders 5.j. Contrast immunoproliferative disorders (monoclonal and polyclonal) 5.k. Contrast laboratory tests to evaluate immune dysfunction 5.l. Relate protein electrophoresis patterns with various immunoproliferative and immunodeficient disorders 5.m. Distinguish between inherited and acquired immunodeficiency conditions 5.n. Summarize disease characteristics/diagnostic methods of immunodeficiency diseases: agammaglobulinemias, deficiencies of cellular immunity, combined deficiency disease Course Outcome Summary - Page 7 of 7