Lecture 2 The Darwinian Revolution
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1 Lecture 2 The Darwinian Revolution
2 Theories of evolution first developed by the Greek philosophers.
3 Theories of evolution first developed by the Greek philosophers. Anaximander ( BC) wrote about the sudden appearance of humans from fishlike creatures.
4 Is this evolution?
5 Is this evolution? NO! It is spontaneous generation!
6 Two characteristics of spontaneous generation were common to early Greek philosophers:
7 Two characteristics of spontaneous generation were common to early Greek philosophers: 1. Resulted from the generative powers of nature (i.e., not actions of a God).
8 Two characteristics of spontaneous generation were common to early Greek philosophers: 1. Resulted from the generative powers of nature (i.e., not actions of a God). 2. Were nonteleological (i.e., without an underlying design or goal).
9 The influence of Aristotle ( BC) Plato and Aristotle
10 The influence of Aristotle ( BC) 1. All species are fixed and eternal
11 The influence of Aristotle ( BC) 1. All species are fixed and eternal evolution not possible!
12 The influence of Aristotle ( BC) 2. The philosophy of essentialism
13 The influence of Aristotle ( BC) 2. The philosophy of essentialism each species represented by its eidos
14 The influence of Aristotle ( BC) 2. The philosophy of essentialism each species represented by its eidos variation among individuals of a species is not real, nor important.
15 The influence of Aristotle ( BC) 3. The scala naturae or great chain of being
16 The influence of Aristotle ( BC) 3. The scala naturae or great chain of being refers to a linear progression of organisms from most simple to most complex.
17 The influence of Aristotle ( BC) 3. The scala naturae or great chain of being refers to a linear progression of organisms from most simple to most complex. over time, believed to reflect the actions of a creator.
18 A 1579 drawing of the scala naturae
19 How did evolutionary thinking develop?
20 How did evolutionary thinking develop? 1. The scientific revolution
21 How did evolutionary thinking develop? 1. The scientific revolution Astronomy earth not the center of the universe!
22 How did evolutionary thinking develop? 1. The scientific revolution Astronomy earth not the center of the universe! Geology evidence for great age of earth, study of fossils
23 How did evolutionary thinking develop? 1. The scientific revolution Astronomy earth not the center of the universe! Geology evidence for great age of earth, study of fossils 2. The discovery of new faunas
24 How did evolutionary thinking develop? 1. The scientific revolution Astronomy earth not the center of the universe! Geology evidence for great age of earth, study of fossils 2. The discovery of new faunas 3. Extinction
25 How did evolutionary thinking develop? 4. The microscope
26 How did evolutionary thinking develop? 4. The microscope provided support for spontaneous generation.
27 How did evolutionary thinking develop? 4. The microscope provided support for spontaneous generation. 5. Development of the science of systematics
28 How did evolutionary thinking develop? 4. The microscope provided support for spontaneous generation. 5. Development of the science of systematics undermined the scala naturae.
29 Evolution according to Lamarck ( )
30 Evolution according to Lamarck ( ) Recognized two causes of evolutionary change:
31 Evolution according to Lamarck ( ) Recognized two causes of evolutionary change: 1. Life has an innate potential to acquire greater and greater complexity.
32 Evolution according to Lamarck ( ) Recognized two causes of evolutionary change: 1. Life has an innate potential to acquire greater and greater complexity. - now called orthogenesis.
33 Recognized two causes of evolutionary change: 2. Organisms reacted to their environments and changed form.
34 Recognized two causes of evolutionary change: 2. Organisms reacted to their environments and changed form. changes were then transmitted to subsequent generations.
35 Recognized two causes of evolutionary change: 2. Organisms reacted to their environments and changed form. changes were then transmitted to subsequent generations. now called the inheritance of acquired characteristics or soft inheritance.
36 The science of epigenetics
37 Lamarck s theory of organic progression
38 Charles Darwin Alfred Russel Wallace
39 Thomas Robert Malthus ( )
40
41 Evolution according to Charles Darwin ( )
42 Evolution according to Charles Darwin ( ) - publication of On the origin of species by means of natural selection or the preservation of favored races in the struggle for life ( The origin ) occurred in 1859.
43 Darwin had two main objectives in writing this book
44 Darwin s objectives: 1. To make the case that evolution had occurred.
45 Darwin s objectives: 1. To make the case that evolution had occurred. 2. To provide a mechanism for how evolutionary change occurs.
46 Alfred Russel Wallace and the Ternate paper
47 Darwin s Five Theories
48 Darwin s Five Theories 1. Evolution per se
49 Darwin s Five Theories 1. Evolution per se the world is steadily changing and populations of organisms are transformed over time.
50 Darwin s Five Theories 1. Evolution per se the world is steadily changing and populations of organisms are transformed over time. 2. Common descent
51 Darwin s Five Theories 1. Evolution per se the world is steadily changing and populations of organisms are transformed over time. 2. Common descent every group of organisms has descended from a common ancestor.
52 Darwin s Five Theories 1. Evolution per se the world is steadily changing and populations of organisms are transformed over time. 2. Common descent every group of organisms has descended from a common ancestor. all species can ultimately be traced to a single origin of life on earth.
53 Darwin s Five Theories 3. Multiplication of species
54 Darwin s Five Theories 3. Multiplication of species this process is now called speciation.
55 Darwin s Five Theories 3. Multiplication of species this process is now called speciation. Darwin s view similar to what is now called allopatric speciation.
56 Darwin s Five Theories 3. Multiplication of species this process is now called speciation. Darwin s view similar to what is now called allopatric speciation. 4. Gradualism
57 Darwin s Five Theories 3. Multiplication of species this process is now called speciation. Darwin s view similar to what is now called allopatric speciation. 4. Gradualism most evolutionary change occurs slowly.
58 Darwin s Five Theories 3. Multiplication of species this process is now called speciation. Darwin s view similar to what is now called allopatric speciation. 4. Gradualism most evolutionary change occurs slowly. 5. Natural selection
59 Darwin s Five Theories 3. Multiplication of species this process is now called speciation. Darwin s view similar to what is now called allopatric speciation. 4. Gradualism most evolutionary change occurs slowly. 5. Natural selection this was Darwin s mechanism for how evolutionary change occurred.
60 Similarities between Lamarck s and Darwin s theories
61 Similarities between Lamarck s and Darwin s theories 1. Lineages change over time - evolution occurs.
62 Similarities between Lamarck s and Darwin s theories 1. Lineages change over time - evolution occurs. 2. A continually changing world drives evolutionary change.
63 Similarities between Lamarck s and Darwin s theories 1. Lineages change over time - evolution occurs. 2. A continually changing world drives evolutionary change. 3. The rate of change is slow (gradualism).
64 Differences between Lamarck s and Darwin s Theories
65 Differences between Lamarck s and Darwin s Theories Lamarck Darwin Inheritance soft hard
66 Differences between Lamarck s and Darwin s Theories Lamarck Darwin Inheritance soft hard Extinction no yes
67 Differences between Lamarck s and Darwin s Theories Lamarck Darwin Inheritance soft hard Extinction no yes Orthogenesis yes no
68 Differences between Lamarck s and Darwin s Theories Lamarck Darwin Inheritance soft hard Extinction no yes Orthogenesis yes no Common descent no yes
69 Differences between Lamarck s and Darwin s Theories Lamarck Darwin Inheritance soft hard Extinction no yes Orthogenesis yes no Common descent no yes Speciation no yes
70 Differences between Lamarck s and Darwin s Theories Lamarck Darwin Inheritance soft hard Extinction no yes Orthogenesis yes no Common descent no yes Speciation no yes Role of environment creates sorts variation variation
71 The Darwinian Revolution
72 The Darwinian Revolution Darwin s theory challenged the prevailing beliefs of his day:
73 The Darwinian Revolution Darwin s theory challenged the prevailing beliefs of his day: 1. The belief in a constant world of limited age.
74 The Darwinian Revolution Darwin s theory challenged the prevailing beliefs of his day: 1. The belief in a constant world of limited age. 2. The belief in a world designed by a wise and benign creator.
75 The Darwinian Revolution Darwin s theory challenged the prevailing beliefs of his day: 1. The belief in a constant world of limited age. 2. The belief in a world designed by a wise and benign creator. 3. The belief in the immutability of species.
76 The Darwinian Revolution Darwin s theory challenged the prevailing beliefs of his day: 1. The belief in a constant world of limited age. 2. The belief in a world designed by a wise and benign creator. 3. The belief in the immutability of species. 4. The belief in the unique position of man in creation.
77 The Darwinian Revolution Darwin s theory challenged the prevailing beliefs of his day: 1. The belief in a constant world of limited age. 2. The belief in a world designed by a wise and benign creator. 3. The belief in the immutability of species. 4. The belief in the unique position of man in creation. 5. The belief in the philosophy of essentialism.
78
79 Evolution in action: the HIV virus
80 Peter and Rosemary Grant Barry Sinervo
81 The HIV/AIDS pandemic
82 Life expectancy in Botswana
83 What is HIV?
84 What is HIV? HIV is a retrovirus (i.e., RNA-based) with 9 genes
85 What is HIV? HIV is a retrovirus (i.e., RNA-based) with 9 genes is diploid (i.e., has 2 copies of each RNA strand)
86 The life cycle of HIV
87 Q: How does HIV cause AIDS?
88 Q: How does HIV cause AIDS? A: By attacking a key player in our immune system CD4 helper T cells.
89 The role of helper T cells in the immune response
90 The progression of an HIV infection
91 Changes in CD4 T-cell count during HIV infection
92 The life cycle of HIV
93 Natural selection, AZT, and the What is AZT? HIV virus
94 Natural selection, AZT, and the What is AZT? HIV virus AZT (azidothymidine) is a base analogue.
95 Structure of azidothymidine
96 Natural selection, AZT, and the What is AZT? HIV virus AZT (azidothymidine) is a base analogue. Incorporation of AZT (instead of T) by reverse transcriptase halts replication.
97 How AZT blocks reverse transcriptase
98 Evolution of AZT resistance
99 Resistance evolves in the polymerase s active site
100 Evolution of the HIV virus
101 Resistance to AZT has evolved in all patients taking the drug (usually in ~6 months)! This is an example of parallel evolution.
102 How does HIV evolve so rapidly?
103 How does HIV evolve so rapidly? 1. High mutation rate HIV s mutation rate is 10 6 higher than ours!
104 How does HIV evolve so rapidly? 1. High mutation rate HIV s mutation rate is 10 6 higher than ours! 2. Short generation time 1 year 300 viral generations.
105 How does HIV evolve so rapidly? 1. High mutation rate HIV s mutation rate is 10 6 higher than ours! 2. Short generation time 1 year 300 viral generations. 10 years of viral 2-3 x 10 6 years of evolution human evolution!
106 Evolution of HIV within an individual patient
107 Where did HIV come from?
108 Phylogeny of HIV-1 and related viruses
109 Where did HIV come from? HIV jumped to humans multiple times from different primate hosts.
110 Where did HIV come from? HIV jumped to humans multiple times from different primate hosts. Inter-species transfers of infectious diseases are called zoonoses.
111 Other examples of zoonoses Malaria (P. falciparum) Marburg fever Cholera Leishmaniasis Plague Hantavirus Dengue fever Toxoplasmosis H1N1 swine flu Rabies Ebola Ringworms SARS Cowpox West Nile virus Lyme disease Creutzfeldt-Jakob disease Yellow fever
112 Human Plasmodium falciparum Chimpanzee Plasmodium spp. see Rich et al. Proc. Natl. Acad. Sci. U.S.A. 106: 14902
113 Dating the origin of HIV-1 in humans
114 Dating the origin of HIV-1 in humans
115 Dating the origin of HIV-1 in humans
116 Q: Why is HIV infection usually fatal?
117 Q: How do viruses achieve reproductive success?
118 Q: How do viruses achieve reproductive success? à 1. Infect host
119 Q: How do viruses achieve reproductive success? à 1. Infect host 2. Reproduce within host
120 Q: How do viruses achieve reproductive success? à à 1. Infect host 2. Reproduce within host 3. Infect new host
121 Q: How do viruses achieve reproductive success? à à 1. Infect host 2. Reproduce within host 3. Infect new host
122 Strategy 1: Reproduce rapidly within host
123 Strategy 1: Reproduce rapidly within host Chance of infecting new host Host viability
124 Strategy 1: Reproduce rapidly within host Chance of infecting new host Host viability Strategy 2: Reproduce slowly within host
125 Strategy 1: Reproduce rapidly within host Chance of infecting new host Host viability Strategy 2: Reproduce slowly within host Chance of infecting new host Host viability
126 Q: Why is HIV infection usually fatal?
127 Q: Why is HIV infection usually fatal? A: Because the virus is short- sighted
128 Q: Why is HIV infection usually fatal? A: Because the virus is short- sighted - lethal strains predominate because of a shortterm advantage in survival and reproduction.
129 Q: Why has a vaccine for HIV-1 not been successfully developed?
130 Q: Why has a vaccine for HIV-1 not been successfully developed? A1: Because the virus evolves very rapidly.
131 Q: Why has a vaccine for HIV-1 not been successfully developed? A1: Because the virus evolves very rapidly. A2: Because of HIV-1 strain diversity.
132 Distribution of HIV-1 major clades
133 The CCR5-Δ32 allele confers resistance to HIV infection
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