Exploring risks for MRSA infection A tale of two studies
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1 CATIE-News CATIE s bite-sized HIV and hepatitis C news bulletins. Exploring risks for MRSA infection A tale of two studies 2 March 2012 A group of bacteria called S. aureus (Staphylococcus aureus ) are commonly found on the skin of animals and people. Specifically, these bacteria can be found in 25% to 50% of healthy people in at least one of these places: inside the nostrils the skin between the anus and genitals genitals armpits mouth and throat For most people, exposure to S. aureus arises because of touching an infected surface or object. As people frequently touch parts of their body, especially the face, it is easy to imagine how S. aureus can spread from a contaminated surface to a person. Good hygiene and hand washing are important to help restrict the spread of S. aureus because attempts at creating a potent vaccine against this germ have not been successful. Further information on preventing S. aureus infections appears later in this CATIE News bulletin. In otherwise-healthy humans, S. aureus lives on the skin and does not cause disease. When bacteria are resident on or inside the body and not causing harm, researchers say that the person has been colonized by these bacteria. However, because of cuts, punctures, wounds and abrasions, S. aureus can sometimes penetrate the skin. Once inside the skin, S. aureus can cause inflammation, boils and abscesses. In severe cases, the infection can affect and damage large areas of skin and other organs, causing serious complications. Some strains of S. aureus have become resistant to an antibiotic called methicillin and these strains are called MRSA methicillin-resistant S. aureus. Two kinds of MRSA MRSA was originally a problem restricted to hospitalized patients. However, well-recognized cases of communityacquired MRSA have occurred. It is not just the location (health-care facility vs. community) that distinguishes these two types of MRSA. Health-care-associated MRSA has been associated with the following: surgery living in a nursing home having a catheter Health-care-associated MRSA can cause pneumonia. In contrast, community-acquired MRSA is mostly associated with skin and soft tissue infections, infection of the lining of the heart, and, in some cases, a rapidly worsening form of pneumonia. The rest of this report focuses on community-acquired MRSA. Who is at risk? Some outbreaks of community-acquired MRSA have affected people who may have been exposed to MRSA by close personal contact with other people in the following facilities:
2 military barracks prisons athletic facilities Based on years of research, scientists have found that the following groups are at increased risk for S. aureus infection: men infants and young children elderly people people with severely damaged kidneys who need artificial blood filtration (dialysis) diabetics people receiving chemotherapy for cancer people with rheumatoid arthritis people who use street drugs people who abuse alcohol In most of the above cases, there is the issue of a weakened immune system from several potential causes. For instance, in both the very young and the elderly, the immune system is not at its prime and both populations are at increased risk for infections. Excess intake of alcohol and exposure to street drugs can also weaken the immune system. As weakened immunity plays a role in a person s susceptibility to infections, it should not be surprising that there have been reports of MRSA causing complications in HIV-positive people, whose immune systems are also weakened because of HIV infection. In separate studies in different American cities (Chicago and San Diego) two teams of researchers have investigated MRSA in the community and possible risk factors among HIV-positive people. In the Chicago study, researchers found that factors such as a history of being imprisoned and living in a neighbourhood with a relatively high proportion of former prison inmates seemed to confer a far greater risk for MRSA than being HIV positive. In the second study, researchers in San Diego analysed data from many studies of MRSA among HIV-positive people. Their analysis suggests that engagement in high-risk behaviours seems to put some HIV-positive people at increased risk for MRSA. Chicago Prisons, shelter and geography Researchers in Chicago recently investigated MRSA among 601 participants (76% were HIV positive). Participants were recruited from a clinic that provided care for HIV-positive women and from a clinic that provided care for people recently released from prison. Analysis of swabs taken from the nostrils of participants revealed that HIV-positive people were nearly three times as likely to have MRSA as HIV-negative people. However, when researchers took many factors into account such as whether participants were homeless or lived in a hostel for homeless people or in a shelter for people undergoing drug withdrawal or in public housing or a mental health facility HIV infection was no longer a significant factor for having MRSA. According to the team, this finding suggests that community exposures may be more important for predicting MRSA colonization than HIV status in certain populations. Participants who lived in neighbourhoods where there were relatively many former prison inmates seemed to be at increased risk for having been colonized by MRSA. Indeed, the Chicago team found that 71% of people in its study who had been colonized by MRSA had formerly been imprisoned. The team theorized that HIV status may be a [signifier] for exposure to high-risk social networks rather than being the major factor contributing to the high colonization and infection burden. The specific factors that occur in prison that could place people at risk for MRSA colonization were not explored in the Chicago study. San Diego Links to behaviour
3 A research team in San Diego conducted a review of scientific literature published between 1996 and January 2011 on MRSA and HIV. The review found that HIV-positive people are at increased risk for colonization by MRSA. It is important to note that while many people are colonized by S. aureus (some of which is MRSA), most people, including HIV-positive people, will not develop infections unless they have risk factors for MRSA. To gain an understanding of possible risk factors, the San Diego researchers scoured the scientific literature for MRSA risk factors among HIV-positive people. They found that studies linked a heightened risk for MRSA colonization to known risk factors such as weakened immunity (low CD4+ cell counts), recent hospitalization, recent use of antibiotics and having chronic skin disease. When the researchers focused on recent research, they found that MRSA colonization was linked to certain highrisk behaviours, particularly among HIV-positive men who have sex with men (MSM) regardless of age who engaged in the following: unprotected anal intercourse multiple sexual partners recent diagnosis of a sexually transmitted infection (including syphilis) visiting a public bathhouse or sauna substance use (including crystal meth) Exactly how unprotected sex can help spread MRSA deserves further study, but here is one possibility: MRSA can live in the intestine and anything inserted into the anus penises, fingers, sex toys may become contaminated with these bacteria. The widespread availability of potent combination therapy for HIV, commonly called ART or HAART, has meant that there are now less people with HIV who have severely weakened immune systems compared to the time before ART was available. Therefore, behavioural factors (rather than low CD4+ cell counts) likely play a more prominent role in the spread of and risk for MRSA infections today. Types of MRSA infections among HIV-positive people The literature review revealed that abscesses were the most common type of skin and soft tissue infection caused by MRSA among HIV-positive people. According to the research team, such infections were usually mild and associated with low rates of complications. Most of these infections were in the lower extremities arms and hands, feet and legs. However, infections could occur elsewhere and recent reports suggest that MRSA in the anogenital area is increasing. The researchers suggest that this is associated with high-risk behaviours (as previously described). More serious MRSA infections such as those that had spread to the bloodstream tended to occur among people who had one or more of the following risk factors: injected street drugs severe kidney dysfunction low CD4+ cell counts (less than 200 cells) The research team also found that MRSA could cause other complications, such as infecting the lining of the brain and the heart, bones, the sinuses and vital organs (liver, lungs and kidneys). However, such serious infections were uncommon particularly among people using ART. Trends in MRSA Among HIV-negative people, MRSA infections now seem to be less common both in health-care settings and in the community than they were several years ago. A similar general trend appears to be occurring among HIV-positive people. Preventing MRSA
4 Several steps can be taken to reduce the risk of exposure to MRSA: Practice good hygiene wash hands regularly with warm water and soap or use an alcohol-based hand sanitizer. Shower with soap after sexual contact. Avoid sharing personal items such as towels, washcloths, razors, clothes (including uniforms) and sex toys. Cover wounds and avoid contact with other people s wounds or bandages. Reduce illicit substance use and seek professional help for quitting. See a physician for accurate advice about treating skin infections. The San Diego teams calls for further research to evaluate the impact of high-risk behaviours on MRSA colonization and infection. High-risk behaviour is a relatively broad term but can include the following: engaging in unprotected intercourse with or without multiple partners engaging in substance use (not only injecting drugs but inhaling or otherwise ingesting street drugs, as these weaken the immune system) Future research on MRSA risk will hopefully also explore the following issues: clinical trials with antibiotics to decolonize large groups of people in a community studies that take swabs not only from inside the nostrils but from other body parts such as the ano-genital region the impact of ART on MRSA colonization risk in HIV-positive people Although reports of MRSA infections among HIV-positive people in high-income countries appear to be waning, overall, the risk of MRSA colonization and infection is still greater for HIV-positive people than it is for HIV-negative people. Therefore, further research focusing on the immune system, use of antibiotics and behaviour is necessary to understand why this is the case. Until the results of such research become available, the San Diego researchers urge HIV-positive people to reduce their risk of acquiring MRSA by engaging in good hygiene practices, taking ART and minimizing episodes of unprotected sex and substance use. Resources MRSA Fact Sheets from the Public Health Agency of Canada MRSA facts from ministère de la Santé et des Services sociaux Québec Personal MRSA prevention tips from the American Centers for Disease Control and Prevention New York City Department of Health and Mental Hygiene REFERENCES: Sean R Hosein 1. Lowy FD. Staphylococcal Infections. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison s Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; Chapter Que Y-A and Moreillo P. Staphylococcus aureus (including Staphylococcal toxic shock). In: Mandell GL, Bennett JE and Dolin R, editors. Principles and Practice of Infectious Diseases. Seventh ed. Philadelphia: Elsevier; p Ellis MW, Hospenthal DR, Dooley DP, et al. Natural history of community-acquired methicillin-resistant Staphylococcus aureus colonization and infection in soldiers. Clinical Infectious Diseases Oct 1;39(7): Popovich KJ, Smith KY, Khawcharoenporn T, et al. Community-associated methicillin-resistant Staphylococcus aureus colonization in high-risk groups of HIV-infected patients. Clinical Infectious Diseases. 2012; in press. 5. Proctor RA. Challenges for a universal Staphylococcus aureus vaccine. Clinical Infectious Diseases. 2012; in press. 6. Shadyab A, Crum-Cianflone N. Methicillin-resistant Staphylococcus aureus (MRSA) infections among HIV-
5 infected persons in the era of highly active antiretroviral therapy: a review of the literature. HIV Medicine. 2012; in press. 7. Crum-Cianflone NF, Shadyab AH, Weintrob A, et al. Association of methicillin-resistant Staphylococcus aureus (MRSA) colonization with high-risk sexual behaviors in persons infected with human immunodeficiency virus (HIV). Medicine (Baltimore) Nov;90(6): Szumowski JD, Wener KM, Gold HS, et al. Methicillin-resistant Staphylococcus aureus colonization, behavioral risk factors, and skin and soft-tissue infection at an ambulatory clinic serving a large population of HIV-infected men who have sex with men. Clinical Infectious Diseases Jul 1;49(1): Lee NE, Taylor MM, Bancroft E, et al. Risk factors for community-associated methicillin-resistant Staphylococcus aureus skin infections among HIV-positive men who have sex with men. Clinical Infectious Diseases May 15;40(10): Cohen AL, Shuler C, McAllister S, et al. Methamphetamine use and methicillin-resistant Staphylococcus aureus skin infections. Emerging Infectious Diseases Nov;13(11): Antoniou T, Devlin R, Gough K, et al. Prevalence of community-associated methicillin-resistant Staphylococcus aureus colonization in men who have sex with men. International Journal of STD & AIDS Mar;20(3):180-3.
6 Produced By: 555 Richmond Street West, Suite 505, Box 1104 Toronto, Ontario M5V 3B1 Canada Phone: Toll-free: Fax: Charitable registration number: RR Disclaimer Decisions about particular medical treatments should always be made in consultation with a qualified medical practitioner knowledgeable about HIV- and hepatitis C-related illness and the treatments in question. CATIE provides information resources to help people living with HIV and/or hepatitis C who wish to manage their own health care in partnership with their care providers. Information accessed through or published or provided by CATIE, however, is not to be considered medical advice. We do not recommend or advocate particular treatments and we urge users to consult as broad a range of sources as possible. We strongly urge users to consult with a qualified medical practitioner prior to undertaking any decision, use or action of a medical nature. CATIE endeavours to provide the most up-to-date and accurate information at the time of publication. However, information changes and users are encouraged to ensure they have the most current information. Users relying solely on this information do so entirely at their own risk. Neither CATIE nor any of its partners or funders, nor any of their employees, directors, officers or volunteers may be held liable for damages of any kind that may result from the use or misuse of any such information. Any opinions expressed herein or in any article or publication accessed or published or provided by CATIE may not reflect the policies or opinions of CATIE or any partners or funders. Information on safer drug use is presented as a public health service to help people make healthier choices to reduce the spread of HIV, viral hepatitis and other infections. It is not intended to encourage or promote the use or possession of illegal drugs. Permission to Reproduce This document is copyrighted. It may be reprinted and distributed in its entirety for non-commercial purposes without prior permission, but permission must be obtained to edit its content. The following credit must appear on any reprint: This information was provided by CATIE (the Canadian AIDS Treatment Information Exchange). For more information, contact CATIE at CATIE Production of this content has been made possible through a financial contribution from the Public Health Agency of Canada. Available online at:
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