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1 12 TH INTERNATIONAL WORKSHOP ON CO-INFECTION HIV & HEPATITIS BERLIN, GERMANY JUNE 2016 MEETING PROSPECTUS

2 CONTENT Introduction... 3 Workshop description... 4 Background... 4 Meeting Objectives... 4 Learning Objectives... 4 Format... 4 Unique Meeting Features... 5 Target audience... 5 Demographics... 5 Geographical Distribution... 5 Organizing Committee... 6 Scientific Committee... 8 Participants Feedback Learning Objectives... 9 Impact... 9 General Conference Experience... 9 Organization Lectures Metrics Publicity Motivation Quotes...16 Summarys

3 INTRODUCTION The HIV/Hepatitis Co-infection workshop was initiated 12 years ago to address the rising need among clinicians and researchers for a workshop specifically focusing on these very challenging patients. With the success of antiretroviral therapy, HIV infected patients were seeing improvement in longevity, only to be challenged with the dangers and complications of their additional viral infection. Depending on the country - this was either a majority, or a significant minority of the HIV patients under care. Although HIV/Hepatitis co-infection was a small part of some major HIV conferences, the field lacked a dedicated meeting on this topic. Over the years more and more educational components were added given the growing needs of clinicians to keep up with the rapid developments. The HIV/Hepatitis Co-infection workshop still remains the only focused co-infection meeting in the field. The 2016-edition will continue to focus on developments in basic science, emerging therapies and clinical management. It will emphasize translational research and best practices in the clinical management of Hepatitis and HIV co-infection. We hope this information is of interest. Please contact us if specific information is missing and we will gladly provide you with additional documentation. Kind regards, MARION PETERS, MD University of California San Francisco, CA, USA JÜRGEN ROCKSTROH, MD University of Bonn Bonn, Germany STEFAN MAUSS, MD Center for HIV and Hepatogastroenterology, Düsseldorf, Germany Chairs

4 WORKSHOP DESCRIPTION BACKGROUND Initiated 12 years ago, this annual workshop is the leading medical gathering for those involved in the clinical care of co-infected individuals. The program provides an excellent platform to exchange the medical information and new treatment results, and to discuss them with the experts active in the different disciplines (including Virology, Hepatology, Immunology, Infectious Disease and Primary Care). MEETING OBJECTIVES To gather clinicians involved in the treatment HIV and Hepatitis Co-infection in an interactive workshop setting To improve the basic knowledge of antiviral therapy and give basic guidance to healthcare professionals involved in treatment of co-infected patients To provide a platform for presentation and discussion of the latest developments in the field To map current studies and results To translate new data to treatment guidelines To educate clinicians on how to best implement current and new drugs LEARNING OBJECTIVES After participating in this activity, the participants will demonstrate the ability to optimally manage their patients with HIV/HCV co-infection and HIV/HBV co-infection, including strategies for avoiding drug-drug interactions and improving patient adherence to therapy. Strategies for avoiding drug-drug interactions so as to optimally manage patients with HIV/HDV co-infections and HIV/HBV co-infections. Strategies to improve patient adherence to therapy. Strategies to manage co-infected patients with cirrhosis and end stage liver disease. FORMAT The format of the workshop includes plenary expert presentations, discussion sessions on areas currently lacking consensus, and abstract-driven presentations. Experts in the area are invited to give state-of-the-art lectures and controversial patient cases are be discussed by expert panels. Although originally this meeting is abstract-driven, starting 2013 it was decided to emphasize the educational character of this meeting, limiting oral abstract presentations. Poster sessions remain a very important part of this workshop. To ensure the quality of accepted abstracts, all submitted abstracts go through a blind, peer-reviewed process conducted by the members of the Organizing and Scientific Committees. The below table shows the abstract submission statistics from the past four years: Total number accepted abstracts Oral presentations Poster presentations

5 UNIQUE MEETING FEATURES The International Co-infection workshop is a clinically focused workshop in which all world experts are present to share their experience and discuss their data. The cross-disciplinary sharing of information between hepatologists and infectious disease experts creates a unique opportunity to further improve the daily management of HIV and Hepatitis co-infected patients. TARGET AUDIENCE The primary target audience for the International Co-infection workshop are clinicians involved in daily care for coinfected patients. DEMOGRAPHICS Clinicians 78% 72% 72% 81% 67% Researchers 11% 9% 11% 11% 19% Post-graduate students 5% 4% 5% 3% Regulatory / Industry 4% 9% 4% 5% Nurses 7% Other 7% TOTAL number of participants GEOGRAPHICAL DISTRIBUTION Australia 2 Austria 2 Canada 13 Czech Republic 1 Finland 4 Germany 2 Greece 7 Hungary 2 India 1 Israel 1 Italy 1 Poland 1 Portugal 19 Romania 1 Saudi Arabia 1 Spain 119 Switzerland 5 Tanzania 1 The Netherlands 2 United Kingdom 59 USA 6 5

6 ORGANIZING COMMITTEE CHARLES BOUCHER, MD, PHD Erasmus Medical Center Rotterdam, the Netherlands DOUGLAS DIETERICH, MD Mount Sinai Medical Center New York, NY, USA KARINE LACOMBE, MD, PHD Hôpital Saint Antoine Paris, France MARK NELSON, MD Chelsea and Westminster Hospital London, UK MARION PETERS, MD University of California San Francisco, CA, USA MASSIMO PUOTI, MD Niguarda Cà Granda Hospital Milan, Italy 6

7 ORGANIZING COMMITTEE JÜRGEN ROCKSTROH, MD University of Bonn Bonn, Germany RUI SARMENTO E CASTRO, MD Hospital Joaquin Urbano Porto, Portugal VICENTE SORIANO, MD, PHD Hospital Carlos III Madrid, Spain JONATHAN SCHAPIRO, MD Sheba Medical Center Tel Aviv, Israel KENNETH SHERMAN, MD, PHD University of Cincinnati Cincinnati, OH, USA MARK SULKOWSKI, MD Johns Hopkins University Baltimore, MD, USA 7

8 SCIENTIFIC COMMITTEE Sanjay Bhagani...Royal Free Hospital London, United Kingdom Raffaele Bruno...University of Pavia, Italy Giampiero Carosi...University of Brescia, Italy Andy Hoepelman...UMC Utrecht, the Netherlands Andrzej Horban...Hospital for Infectious Diseases, Poland Patrick Ingiliz...Medical Center for Infectious Diseases, Germany Arthur Kim...Massachusetts General Hospital, USA Marina Klein...McGill University Health Centre, Canada Sharon Lewin...Monash University Alfred Hospital, Australia Stefan Mauss...Center for HIV and Hepatogastroenterology, Germany Marina Nuñez...Wake Forest University Health Sciences, USA Juan A. Pineda...Hospital de Valme, Spain Stanislas Pol...Hôpital Cochin, France Giuliano Rizzardini...University of Milan, Italy Dominique Salmon...Hopital Cochin, France Ulrich Spengler...University of Bonn, Germany Cristina Tural...Hospital Germans Trias i Pujol, Spain 8

9 PARTICIPANTS FEEDBACK 2015 LEARNING OBJECTIVES The following objectives have been met: Agree Neutral Disagree Not applicable Insight in optimal management of co-infected patients 95% 0% 5% 0% Knowledge on the complications of liver disease 96% 0% 4% 0% IMPACT Attendance to the meetings has changed my Agree Neutral Disagree Not applicable Thinking 81% 9% 10% 0% Behaviour 71% 19% 10% 0% Prescribing 34% 43% 9% 14% GENERAL CONFERENCE EXPERIENCE Good Average Poor Not applicable Overall event experience 96% 0% 4% 0% Opportunity of networking 78% 18% 4% 0% Content of the conference 96% 0% 4% 0% Time allocation for discussion 96% 0% 4% 0% Time allocation per presentation 96% 0% 4% 0% Agree Neutral Disagree Not applicable No commercial bias (product selling) perceived 91% 0% 9% 0% I would recommend this conference to my peers 91% 5% 4% 0% I plan to attend this conference next year 73% 18% 9% 0% 9

10 PARTICIPANTS FEEDBACK 2015 ORGANIZATION Good Average Poor Not applicable Content of electronic announcements 80% 12% 0% 8% Frequency of electronic announcements 84% 8% 0% 8% Information of conference website 88% 4% 4% 4% Online registration process 67% 8% 0% 25% Online abstract submission process 39% 0% 4% 57% Meeting venue 79% 21% 0% 0% Food & beverage 75% 25% 0% 0% Audiovisuals 96% 4% 0% 0% Onsite logistics 96% 4% 0% 0% Service level of Conference Secretariat 92% 0% 0% 8% 10

11 PARTICIPANTS FEEDBACK 2015 LECTURES THURSDAY 11 JUNE Pre-workshop Educational Course HCV - the virus G. Dusheiko, Royal Free Hospital, UK Acute hepatitis C C. Boesecke, MD, Bonn University Hospital, Germany Chronic hepatitis and HIV: implications for care J. Rockstroh, MD, University of Bonn, Germany Non hepatic complications K. Sherman, MD, PhD, University of Cincinnati, USA Treatment of HCV in HIV M. Sulkowski, MD, John Hopkins University, USA ESLD a guide for HIV physicians M. Peters, MD, University of California, USA Topic 91% 2% 1% 6% Content 89% 5% 0% 6% Performance 92% 2% 0% 6% Topic 88% 5% 2% 5% Content 92% 2% 0% 6% Performance 89% 5% 0% 6% Topic 94% 5% 1% 0% Content 97% 2% 1% 0% Performance 95% 3% 2% 0% Topic 94% 3% 3% 0% Content 95% 2% 3% 0% Performance 95% 2% 3% 0% Topic 94% 3% 3% 0% Content 95% 2% 3% 0% Performance 95% 2% 3% 0% Topic 92% 5% 3% 0% Content 93% 5% 2% 0% Performance 95% 3% 2% 0% 11

12 PARTICIPANTS FEEDBACK 2015 Session 1: The changing world of hepatitis What s new in HCV/HIV coinfection therapy M.Sulkowski, MD, John Hopkins University, USA Will DAA drugdrug interactions matter in the future D. Back, PhD, University of Liverpool, UK Viral hepatitis and pregnancy E. Nastouli, FRCPH, FRCPath, University College London Hospitals NHS Trust, UK Topic 100% 0% 0% 0% Content 100% 0% 0% 0% Performance 100% 0% 0% 0% Topic 100% 0% 0% 0% Content 100% 0% 0% 0% Performance 100% 0% 0% 0% Topic 93% 0% 0% 7% Content 65% 12% 11% 12% Performance 85% 4% 4% 7% Session 2: Money makes the world go around Cost per cure - is it worth it? D. Dieterich, MD, Mount Sinai Medical Centre, USA Towards more affordable HCV therapy A. Hill, MD, University of Liverpool, UK Topic 100% 0% 0% 0% Content 88% 4% 4% 4% Performance 96% 0% 4% 0% Topic 100% 0% 0% 0% Content 86% 0% 9% 5% Performance 100% 0% 0% 0% 12

13 PARTICIPANTS FEEDBACK 2015 FRIDAY 12 JUNE Session 3: Cost-effectiveness in hepatitis care and management ESLD and its complications M. Puoti, MD, Niguarda Ca Granda Hospital, Italy Management of HCV: pre / post transplant K. Agarwal, MD, Kings College Hospital, UK Immunology and the pathophysiology of liver disease in coinfection R. Chung, MD, Massachusetts General Hospital, USA NASH, what is it, who gets it and what are the implications for the HIV patient E. Tsotchatzis, MD, MSc, FEBTM, PhD, Health Royal Free Hospital, UK Topic 94% 0% 0% 6% Content 94% 0% 0% 6% Performance 94% 0% 0% 6% Topic 92% 0% 3% 6% Content 91% 3% 0% 6% Performance 94% 0% 0% 6% Topic 88% 0% 6% 6% Content 74% 15% 5% 6% Performance 88% 3% 3% 6% Topic 94% 0% 3% 3% Content 90% 7% 0% 3% Performance 88% 7% 2% 3% Session 4: Management of other viral hepatitis HBV - current and future treatment paradigms P. Kennedy, MD, Royal Free Hospital, UK Viral hepatitis and malignancy D. Pinato, MD, MRCP (UK) MRes, PhD, Imperial College London - Hammersmith Hospital, UK Topic 89% 4% 7% 0% Content 90% 7% 4% 0% Performance 89% 7% 4% 0% Topic 92% 0% 8% 0% Content 92% 0% 8% 0% Performance 84% 8% 8% 0% 13

14 PARTICIPANTS FEEDBACK 2015 Delta hepatitis - new approaches to therapy V. Soriano, MD, PhD, La Paz University Hospital, Spain Recreational drug use in the HIV population D. Stuart, 56 Dean Street s GUM/HIV Clinic, UK Topic 96% 0% 4% 0% Content 96% 0% 4% 0% Performance 88% 8% 4% 0% Topic 96% 0% 0% 4% Content 96% 0% 0% 4% Performance 91% 5% 0% 5% Session 5: Abstract driven presentations The impact of HIV and hepatitis B virus on hepatic stellate cell activation using a novel in vitro system K.P. Singh, Monash University, Australia European mitochondrial DNA haplogroups impact on liver fibrosis progression among HCV and HIV/HCV coinfected patients from Northwest Spain E. Poveda, Instituto de Investigación Biomédica de A Coruña (INIBIC), Spain Hepatitis C virus co-infection independently increases the risk of cardiovascular disease in HIV-positive patients V. Soriano, La Paz University Hospital, Madrid, Spain NS3 resistance-associated mutations occurring as highfrequency and low-frequency variants among treatmentnaïve patients infected with hepatitis C virus (HCV) genotype 1a A.M. Geretti, University of Liverpool, UK Real-World Data on HIV positive patients with Hepatitis C on Simeprevir and/or Sofosbuvir D. Del Bello, Mount Sinai Medical Center, USA Topic 78% 0% 14% 7% Content 85% 0% 0% 15% Topic 83% 0% 17% 0% Content 75% 0% 17% 8% Topic 92% 0% 8% 0% Content 85% 0% 15% 0% Topic 77% 8% 7% 8% Content 77% 8% 8% 7% Topic 93% 0% 0% 7% Content 93% 0% 0% 7% 14

15 METRICS 2015 ATTENTION TO THIS MEETING WAS DRAWN BY Virology Education announcement 9% Virology Education website 15% Flyer at other meetings 3% Industry invite 18% Word of mouth 23% Previous workshop: I attend every year 26% INFLUENCED TO ATTEND THIS MEETING BY Meeting objectives 24% Scientific program 49% Experience from precious edition 20% Opportunity to meet with colleagues 7% 15

16 QUOTES Good and effective interaction with experts, clinical oriented information. The invited talks on treatments and outcomes Panel discussions, talks by experts - fantastic opportunity Pre workshop - very educational, a good start Summary of EASL (update) Overall good meeting. Enjoyed the general reviews and updates on pathogenesis of liver and extrahepatic complications Always very useful contents, clinically oriented. See you next year! Excellent! 16

17 SUMMARY Since its initiation 12 years ago, the HIV/Hepatitis Co-infection workshop remains the only focused co-infection meeting in the field. The program provides an excellent platform to exchange the medical information and new treatment results, and to discuss them with the experts active in the different disciplines (including Virology, Hepatology, Immunology, Infectious Disease and Primary Care). The cross-disciplinary sharing of information between hepatologists and infectious disease experts creates a unique opportunity to further improve the daily management of HIV and Hepatitis co-infected patients. The Organizing Committee is pleased with the results of the 10 th International workshop on HIV and Hepatitis Co-infection. The workshop clearly meets a need for international interchange on this important topic. The Organizing Committee therefore looks forward to organizing the 12 th edition of the workshop and to welcoming returning and new participants in June 2016 in Berlin. 17

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