1 st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases. Monday and Tuesday November 28-29, 2016

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1 colitis big data 1 st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases Monday and Tuesday November 28-29, 2016 New Residence Hall Ballroom A & B 3625 Park Avenue, Montreal inflammatory autoimmune virus multiple sclerosis genetic statistical infection genotyping bioinformatics ulcerative complex traits gwas genomics Crohn s disease mouse immune variants malaria transcriptomic analysis model McGill University Research Center on Complex Traits Bridging the research community

2 Welcome remarks from Dr Silvia Vidal Co-director of the McGill Research Center on Complex Traits Professor, Dept. of Human Genetics, McGill University Dear Friends and Colleagues, Welcome to the 1 st International Symposium on Immunogenetics of Infectious and Inflammatory Diseases in Montreal! The Symposium marks the inauguration of the McGill University Research Center on Complex Traits (MRCCT). Our international Center networks 35 basic and clinical investigators from academia and private sector using a multidisciplinary approach to study human diseases with a complex genetic etiology. The MRCCT central theme is immune-mediated diseases, from severe infections to chronic inflammatory disorders such as multiple sclerosis, rheumatoid arthritis and Inflammatory bowel disease. Our mission is to establish a Center of excellence in basic and translational research, education, and entrepreneurship to accelerate new scientific discoveries enabling personalized medicine approaches to cure immune-mediated disorders. For our first Symposium, we are delighted to feature an exceptional program showcasing the breadth of research, and its applications to human health, undertaken by MRCCT members. They will present their latest discoveries about the role of host genetic factors, the immune system and the microbiota on the development and outcome of immune-mediated diseases, using mouse and human models. Others will discuss how this new knowledge is informing new clinical approaches and successful treatments. A number of talks will tackle the new trends in computational medicine to unlock epigenetic regulators and characterize their role in cell homeostasis and their contribution to disease states. Finally, other presentations will focus on new technologies including intra-vital imaging to understand immune responses in live animals as well as gene editing methods to validate new drug targets. Canada has the highest rate of multiple sclerosis in the world. So to further stimulate discussion, our keynote speaker, Dr Marco Prinz, Director of the Institute of Neuropathology University Medical Center, University of Freiburg, and a specialist in the study of brain-specific immune functions, will be presenting new work on the function of the innate immune system in autoimmune and neurodegenerative CNS disorders. This Symposium places great importance on the involvement of students and post doctoral fellows. Fortyseven posters will be presented during the event, and we thank in advance our panel of judges who will have to make tough decisions to identify the winners of the poster competition! By presenting the various aspects of fundamental, clinical and translational research related to various infectious and inflammatory diseases, we hope that the Symposium will provide a platform that promotes interdisciplinary thinking, generates new ideas and fosters scientific advancement. The Symposium has attracted 215 participants from universities, hospitals and biotech companies that will have an opportunity to join the conversation, network and discuss with our experts. We sincerely thank all those involved in the organization of the symposium, in particular all of our speakers. We acknowledge the team of volunteers, lead by Ms Marianne Provost, for their diligence and enthusiasm in the preparation of this event. We are also very grateful to our sponsors and partners for their generous support that has permitted to organize a Symposium free of charge. We look forward to an exciting meeting that promises great scientific debates and enjoyable social interactions. Let s make together an unforgettable event in snowy Montreal! Silvia Vidal On behalf of the organizing committee

3 MRCCT Members 35 experts in immune-mediated disease 6 Depa Human Genetic Variation Biochemical Function Cellular Functions Basic Clinical Translational Research Microbiome E ects Creation of Mouse Models Preclinical Mouse Models Martin Olivier 4 Canad 3 Intern 3 Privat 4 x Canadian Institutions McGill University University of Toronto Université de Montréal University of British Columbia 3 x International Institutions Université de Liège Institut Pasteur University of Cambridge 6 x McGill Departments Microbiology and Immunology Human Genetics Medicine Biochemistry Physiology Computer Science 2 x Private Sector Partners Janssen Lallemand

4 agenda Monday Nov 28 th, :30 am Registration (Coffee is provided) 9:00 am Opening remarks by MRCCT Director, Dr Silvia Vidal 9:10 10:10 am Session I - Mechanisms of inflammatory disorders: Mouse Models Chair: Dr Sidong Huang, Dept of Biochemistry, McGill University 9:10 am Dr. Jörg Fritz, Dept. Microbiology and Immunology, McGill University Roles of Group 2 Innate Lymphoid Cells in Health and Disease 9:40 am Dr. Maya Saleh, Dept. of Medicine, McGill Inflammasome control of inflammatory diseases and cancer 10:10 10:45 am Coffee break 10:45 am 12:30 pm Session II - Mechanisms of Infectious and inflammatory disorders: Human Models Chair: Dr Salman Qureshi, MUHC 10:45 am Dr. Luis Barreiro, Université de Montréal Genetic and epigenetic regulation of immune responses to infection 11:15 am Dr. Donald Vinh, Dept of Medicine, MUHC Human Genetic Susceptibility to Infectious Diseases: When the Rubber of Immunology Hits the Road of Life 11:45 am Dr. Kevin Kain, SAR Laboratories, Rotman Centre for Global Health, UHN Preventing death and disability from Life-threatening infections 12:15 pm Dr. Amit Bar-Or, Montreal Neurological Institute (MNI) Antibody-independent roles of B cells in autoimmune regulation and infection control 12:30 2:00 pm Lunch break (*provided) Poster session I 2:00 3:00 pm Session III - Genetic determinants of neuroinflammation and malignancy Chair: Dr Sylvie Lesage, Centre de recherche Hôpital Maisonneuve-Rosemont 2:00 pm Dr. Stephen Sawcer, Cambridge University, UK MS genetics: Pitfalls and Prospects 2:30 pm Dr. Nada Jabado, Dept of Medicine, MUHC Oncohistones: a tale of histone tail 3:00 3:45 pm Coffee break Poster session II 3:45 4:00 pm MRCCT: Opening of the new Center Dr. Philippe Gros, Co-Director, MRCCT Dr. Rose Goldstein, VP Research & International Relations Dr. David Eidelman, Vice-Principal & Dean, Faculty of Medicine 4:00 5:00 pm Keynote session I Dr. Marco Prinz, Dir. Institute of Neuropathology, University of Freiburg, Germany Myeloid cells in the brain 5:00 5:05 pm Closing Remarks by Dr Samantha Gruenheid 5:05 7:00 pm WINE & CHEESE mixer Poster session III

5 agenda Tuesday Nov 29 th, :30 am Arrival (Coffee is provided) 9:00 9:40 am Session I New Technologies Chair: Caitlin Schneider, Laboratory of Dr Mandl, McGill University 9:00 am Dr. Judith Mandl, Dept. of Physiology, McGill University Visualizing the spatio-temporal dynamics of T cells in homeostasis and immunodeficiency 9:15 am Dr. Jerry Pelletier, Dept. of Biochemistry, McGill University Drug-Target Validation using CRISPR/Cas9 9:30 am Christopher Kenny, Eve Technologies Immune Biomarker Array To Enable Precision Medicine 9:40 10:20 am Session II - Computational Medicine Chair: Dr David Langlais, Laboratory of Dr Gros, McGill University 9:40 am Dr. Mathieu Blanchette, School of Computer Sciences, McGill University Know thy Ancestors to Know Thyself: Improving our understanding of the human genome using paleogenomics 9:55 am Dr. Guillaume Bourque, McGill University and Genome Quebec Innovation Center Epigenomic resources to better understand human non-coding DNA 10:10 am Dr. Michael G. Smith, Executive Sales Specialist, Sequencing & Data Analysis, Illumina Analyzing the Microbiome using BaseSpace Sequence Hub 10:20 am Coffee break 10:50 11:15 am Session III Stem Cells Chair: Barbara Mindt, Laboratory of Dr Fritz, McGill University 10:50 am Dr. Ana Nijnik, Dept of Physiology, McGill University Hematopoietic stem cells: transcriptional regulation and genomic stability 11:05 am Dr. Roger Bossé, Sr. Market Segment Leader, Perkin Elmer Functional Stem Cell Characterization 11:15 11:45 am Session IV Infection Chair: Todd Douglas, Laboratory of Dr Saleh, McGill University 11:15 am Dr. Erwin Schurr, Dept. of Medicine, Human Genetics, RI-MUHC Leprosy as human model for inflammatory disease susceptibility 11:30 am Dr. Martin Olivier, Dept. Microbiology and Immunology, McGill Vector-Transmitted Pathogen Exosomes: Impact on Innate Immune Response and Infection 11:45 am 12:15 pm Session V Inflammatory Diseases Chair: Mathieu Mancini, Laboratory of Dr Vidal, McGill University 11:45 am Dr. Ciro Piccirillo, Dept. Microbiology and Immunology, McGill Development and functional dynamics of immunoregulatory mechanisms in human health and disease 12:00 pm Dr. Jack Antel, Montreal Neurological Institute, McGill Dynamic properties of human microglia 12:15 1:30 pm Lunch break (*provided)

6 agenda Tuesday Nov 29 th, 2016 (CONt d) 1:30 2:00 pm Keynote session II (Chair: Dr Judith Mandl) Dr. Jayne Danska, University of Toronto - Hospital for Sick Children The complex causes of autoimmunity: genes, sex and microbes 2:00 4:00 pm Round Table * Scientific Board Members (SAB) and Clinical Advisory Committee (CAC) meeting Moderators: Drs Vidal & Gros 2:00 4:00 pm 3 min Talks * Students and PDF session Moderator: Mathieu Mancini 4:00 pm Award Ceremony for winners of poster competition in PDF, Ph.D. and M.Sc. categories 4:15 pm Closing Remarks by Dr Silvia Vidal 4:30 7:00 pm Mixer * 1 free beverage included Location: Thomson House, 3650 McTavish St, Montreal

7 KEYNOTE SPEAKERS Dr Marco Prinz Director of the Institute of Neuropathology University of Freiburg, Germany Marco Prinz is Professor of Neuropathology and Chair of the Institute of Neuropathology at the University of Freiburg, Germany. Dr. Prinz obtained his MD at the Charité, Humboldt-University Berlin in During his MD thesis he investigated the pathology of cortical interneurons in humans at the Institute of Neuroanatomy at the Charitè Berlin. He did a postdoc at the Max-Delbrück-Centre (MDC) of Molecular Medicine dedicated to the function of glial cells in the central nervous system (CNS), especially microglia. He performed his residency in Neuropathology at the University Hospital Zurich, Switzerland and studied there the role of the peripheral and CNS-restricted immune system for the pathogenesis of neurodegenerative diseases such as prion diseases. In 2003 he became a group leader at the University Hospital in Göttingen, Germany and in 2007 lecturer of Neuropathology there. He was recruited to the University of Freiburg, Germany, in 2008 and was promoted to the rank of Full Professor and Chair of the Institute of Neuropathology. Dr. Prinz laboratory studies the mechanisms that regulate the development and function of the mononuclear phagocyte lineage in the central nervous system including microglia, perivascular and meningeal macrophages. His laboratory has made seminal discoveries in CNS macrophage biology revealing their embryonic origin and their local maintenance in situ. Dr. Prinz belongs to several German Research Foundation (DFG)- and EU-funded scientific consortia to decipher the transcriptional regulation of the macrophage lineage in the CNS. Currently, his research group aims to understand myeloid cell biology in the CNS during health and disease and studies the impact of the immune system on the pathogenesis of neurological disorders such as neurodegenerative diseases, ultimately aimed at recognizing novel therapeutic strategies and targets to treat these central nervous system diseases. Dr. Prinz has authored more than 170 primary papers and reviews in high profile journals and has obtained extensive DFG and EU funding for his studies on macrophage biology in the CNS in mice and humans.

8 KEYNOTE SPEAKERS Dr JAYNE DANSKA Hospital for Sick Children University of Toronto, Canada Dr. Danska was raised in New York City, and educated in the United States at Kenyon College, Cornell University, Cold Spring Harbor Labs and Stanford University. She holds The Anne and Max Tanenbaum Chair in Molecular Medicine, is a Senior Scientist at the Hospital for Sick Children and a Professor in the Faculty of Medicine at University of Toronto with appointments in the Departments of Immunology, and Medical Biophysics. Her research is focused on defining the mechanisms underlying immune system diseases and application of this knowledge to improve their diagnosis, prevention and treatment. Her lab works on the genetic and environmental causes of autoimmune disease, particularly Type 1 diabetes (T1D), the molecular mechanisms of acute lymphoid leukemia (ALL), and innate immune surveillance of leukemia and leukemia stem cells. She has led multi-disciplinary projects applying genetic, genomic and immunological analysis to identify T1D-risk genes and to determine how these variants control autoimmune pathogenesis. An evolving focus is the roles of environmental factors in the rising rates of autoimmune and inflammatory diseases, specifically the role of the intestinal microbiome in modifying inherited risk of autoimmunity in rodent models and in longitudinal studies in children with high genetic risk for type 1 and type 2 diabetes. This work is also investigating the impact of sex as a key determinant of autoimmune diseases, many of which are far more prevalent in females. In addition, Dr. Danska and her collaborators discovered a signaling pathway in macrophages pivotal to the survival of human normal hematopoietic stem cells and acute leukemia stem cells that sustain leukemic growth. They have developed a biologic therapy to manipulate this immune checkpoint to impair the survival of leukemia and other blood cell cancers that is now in clinical trials. Dr. Danska has an active training program of post-doctoral fellows, graduate students and technologists. She is a Chair of the College of Reviewers, Canadian Institutes of Health Research, and serves as a panel member and Chair in the Canadian Diabetes Association, the Juvenile Diabetes Research Foundation, the Canadian Cancer Society and the National Institutes of Health (U.S). She is actively engaged in knowledge translation beyond the medical community to patients, their advocates and government policy makers.

9 List of posters presented on Nov 28 th, POSTER PRESENTATIONS # Presenter Status Inst. Lab Title 1 Anupam Adhikari Postdoc MUHC M. Olivier 2 Fernando Alvarez PhD student McGill C. Piccirillo 3 Patricio Artusa PhD student McGill J. Mandl 4 Vanessa Diniz Atayde RA MUHC M. Olivier Leishmania-induced SHP-1 Activation in Hepatocytes Inhibits NO Production IL-3 modulates the functional plasticity of Foxp3+ T cells in infections The role of T cell repertoire diversity in CD4+ T cell responses Multifaceted roles of Leishmania exosomes in the exacerbation of the infection 5 Audiger Cindy PhD student CR-HMR S. Lesage Bim regulates merocytic dendritic cell proportion 6 Giselle Boukhaled PhD student McGill C. Krawczyk 7 Christopher J.F. Cameron Polycomb group factor 6, PCGF6, controls dendritic cell responses to inflammatory microenvironments PhD student McGill M. Blanchette Improved Hi-C Contact Maps by Adaptive Density Estimation 8 Tyler Cannon MSc student McGill S. Gruenheid 9 Julien Chambon Undergrad McGill J. Zhang 10 Anastasia Cheng MSc student McGill I. Colmegna 11 Roxanne Collin PhD student CR-HMR S. Lesage 12 Alanna Crouse MSc student McGill D. Malo 13 Todd Douglas PhD student McGill M. Saleh 14 Megan Eva Postdoc McGill D. Malo 15 Nassima Fodil RA McGill P. Gros 16 Benjamin P Forestell Undergrad McGill J. Mandl 17 Michael Forster Postdoc McGill A. Nijnik 18 Natalia Giannakopoulou PhD student McGill S. Gruendheid, H. Le Moual Investigating the Impact of EPEC Infection on Mitochondrial Antigen Presentation Characterization of gut macrophages and CD8 T cells in mice developing autoimmune peripheral neuropathy Mesenchymal Stromal Cell Derived Extracellular Vesicles: Role on T-cell Suppression Genetic interaction between two insulin-dependant diabetes susceptibility loci in determining immunoregulatory CD4- CD8- T cell proportion A Syst-OMICS Approach to Ensuring Food Safety and Reducing the Economic Burden of Salmonellosis Cross-regulation between the inflammasome and linear ubiquitination machinery Identifying the transcriptional coactivator NCOA7 as an immune regulator of the host response to Salmonella infection by genome-wide mutagenesis Ccdc88b is required for pathogenesis of inflammatory bowel disease Distinct regulatory subsets differ in their recirculation dynamics through secondary lymphoid organs Mysm1 as a potential drug target for p53 activation in B cell malignancies Two-component systems and altered virulence of Citrobacter rodentium 19 Hannah Guak PhD student McGill C. Krawczyk Induction of glycolysis is required for dendritic cell migration 20 Boram Ham Postdoc McGill J. Mogil 21 Saloua Jeidane PhD student IRCM C. Deschepper 22 Thiviya Jeyakumar MSc student McGill P. Gros 23 Eugene Kang PhD student McGill S. Gruenheid 24 James Kennedy PhD student McGill P. Gros 25 Vijay Kumar Postdoc Panjab University S. Chhibber Cytotoxic T cells may induce pain hypersensitivity in female but not male mice after nerve injury in an interferon-greceptor-dependent manner Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1 Themis and IRF1-deficient Mice Show Increased Susceptibility to Colitis-Associated Colorectal Cancer Establishing a primary mouse intestinal epithelial cell monolayer culture system to study Citrobacter rodentium infection Ccdc88b is a Novel Regulator of Maturation and Effector Functions of T Cells During Pathological Inflammation A Comparison of inflammatory innate immune response during Klebsiella pneumoniae B5055 induced pneumonia and sepsis in BALB/c mice

10 POSTER PRESENTATIONS (CONT D) # Presenter Status Inst. Lab Title 26 Edward Kwarteng PhD student INRS K. Heinonen 27 David Langlais Postdoc McGill P. Gros 28 Gabriel André Leiva- Torres PhD student McGill S. Vidal 29 Vicki Leung PhD student McGill P. Gros 30 Alonso Lira PhD student McGill M. Olivier 31 Mathieu Mancini PhD student McGill S. Vidal 32 Diana Matheoud Postdoc U. Montreal M. Desjardins 33 Barbara Mindt PhD student McGill J. Fritz 34 Victor Mullins- Dansereau MSc student CR-HMR S. Lesage 35 Oladayo Oladiran PhD student McGill J. Zhang 36 Jean-Frédéric Olivier PhD student McGill P. Gros 37 Sakina Orkhis PhD student CR-CHUS S. Ramanathan 38 Alexandre Paradis RA CR-HMR S. Lesage Hematopoietic stem cell activation in chronic LCMV infections The IRF8 and IRF1 regulome: driver of pathological neuroinflammation An N-Ethyl-N-Nitrosourea Induced mutation in the GNL1 GTPase causes an NK cells deficiency and a susceptibility to Cytomegalovirus Vangl2 is required for intraretinal pathfinding of mouse retinal ganglion cell axons. Impact of Leishmanial Exosomes on Skin Hyperinflammatory Response During Cutaneous Leishmaniasis is GP63 Dependent. An ENU-induced mutation in Rel confers susceptibility to herpes simplex encephalitis The role of PINK1/Parkin in Parkinson's disease: repressing mitochondrial antigen presentation (MitAP) Essential role of c-rel in IL-33-mediated activation of group 2 innate lymphoid cells An unbiased linkage approach reveals that the p53 pathway is coupled to NK cell maturation Characteristics of monocytes and macrophages in B7.2 transgenic mice developing spontaneous autoimmune peripheral neuropathy. Altered Activity of Dendritic Cells in Cerebral Malaria Resistant Ccdc88b Mutant Mice IL-15 regulates the initiation of immune responses during systemic infections Biological profiles of patients with inflammatory bowel disease based on genetic risk factors 39 Sarah Rosen PhD student McGill J. Mogil T-cell Dependent Reversal of Allodynia in Pregnant Mice 40 Joaquín Sanz Postdoc CHU Ste- Justine L. Barreiro 41 Caitlin Schneider PhD student McGill J. Mandl 42 Mitra Shourian PhD student McGill S. Qureshi 43 Sabrina Torre PhD student McGill P. Gros 44 Kristin Van Den Ham PhD student McGill M. Olivier 45 Frances Wang MSc student McGill J. Zhang 46 Mu Yang Postdoc McGill J. Zhang 47 Mitra Yousefi Postdoc McGill S. Gruenheid 48 Dahn Hahm PhD student U. Ottawa SH Lee Genetic ancestry and natural selection drive population differences in immune responses to pathogens in humans The type-2 CD4 T cell effector bias associated with a DOCK8-mediated migration defect is T cell extrinsic and GMCSF-dependent Critical role of IL-1RI signaling in protection against Cryptococcus neoformans infection USP15 regulates type-i interferon response in vivo and is required for pathogenesis of neuroinflammation Protein Tyrosine Phosphatase Inhibition Attenuates Cerebral and Hepatic Pathology during Experimental Cerebral Malaria Potential Role of Macrophages/Microglia in a Mouse Model of Orofacial Pain Injury facilitates the development of autoimmune peripheral neuropathy in predisposed inflammatory environment Studying the role of microbiota and nutrition in the susceptibility to C. rodentium infection Modulation of Natural Killer cell function through 4-1BB stimulation 49 Saeedah Almutairi PhD student U. Ottawa SH Lee Reactive oxygen species as signaling molecules in immunity

11 1 slide - 3 min talks List of 3 minute talk presenters showcased on Nov 29 th, All speakers will be presenting on behalf of their laboratory. They are invited to present either an overview of their own research project, their lab research focus or a breakthrough story recently published by the lab. Presenter Lab Institution Fernando Alvarez Ciriaco Piccirillo McGill Patricio Artusa Judith Mandl McGill Vanessa Diniz Atayde Martin Olivier RI-MUHC Cindy Audiger Sylvie Lesage CR-HMR Christopher Cameron Mathieu Blanchette McGill Tyler Cannon Samantha Gruenheid McGill Jennifer Chu Jerry Pelletier McGill Brendan Cordeiro Connie Krawczyk McGill Todd Douglas Maya Saleh McGill Megan Eva Danielle Malo McGill Vinicius Medeiros Fava Erwin Schurr RI-MUHC Marija Landekic Donald Vinh RI-MUHC Minnie Lin Ana Nijnik McGill Mathieu Mancini Silvia Vidal McGill Barbara Mindt Jorg Fritz McGill Victor Mullins-Dansereau Sylvie Lesage CR-HMR José Navarro Ines Colmegna McGill Jean-Frédérick Olivier Philippe Gros McGill Simon Papillon-Cavanagh Nada Jabado RI-MUHC Joaquin Sanz Luis Barreiro CR-CHU Ste-Justine Mitra Shourian Salman Qureshi RI-MUHC Yibo Xue Sidong Huang McGill

12 We thank our generous sponsors! Premium Sponsor Major Sponsors Human Genetics General Sponsors

13 acknowledgements Thanks to the 215 participants for making this Symposium a success!! Symposium Organizing Committee Silvia Vidal, Prof. Dept. Human Genetics Samantha Gruenheid, Prof, Dept. Microbiology and Immunology Danielle Malo, Prof. Dept. Human Genetics Philippe Gros, Prof, Dept. Biochemistry Maya Saleh, Prof, Dept. Medicine Jörg Fritz, Prof, Dept. Microbiology and Immunology Ana Nijnik, Prof, Dept. Physiology Judith Mandl, Prof, Dept. Physiology Erwin Schurr, Prof, Dept. Human Genetics and Medicine David Langlais, PDF, Dept. Biochemistry Mathieu Mancini, Ph.D. student, Dept. Human Genetics Caitlin Schneider, Ph.D. student, Dept. Microbiology and Immunology Barbara Mindt, Ph.D. student, Dept. Microbiology and Immunology Todd Douglas, Ph.D. student, Dept. Microbiology and Immunology Marianne Provost, Senior Adm. Coordinator, Dept. Biochemistry MRCCT BBQ Organizing Committee David Langlais, PDF, Dept. Biochemistry Mathieu Mancini, Ph.D. student, Dept. Human Genetics Caitlin Schneider, Ph.D. student, Dept. Microbiology and Immunology Barbara Mindt, Ph.D. student, Dept. Microbiology and Immunology Benoit Charbonneau, Research Assistant, Dr Silvia Vidal lab Marianne Provost, Senior Adm. Coordinator, Dept. Biochemistry Volunteers Eugene Kang, Ph.D. Student, Dept. Microbiology and Immunology Tyler Cannon, M.Sc. student, Dept. Microbiology and Immunology Alanna Crouse, M.Sc. student, Dept. Human Genetics Dakota Rogers, Ph.D. student, Dept. Physiology Benjamin Forestell, Honour's Undergraduate student, Dept. Physiology Thiviya Jeyakumar, M.Sc. student, Dept. Biochemistry Benoit Charbonneau, Research Assistant, Dr Silvia Vidal lab Claudia Champagne, Research Assistant, Dr Maya Saleh lab Geneviève Perreault, Animal Technician, Dr Philippe Gros lab Line Larivière, Research Assistant, Dr Danielle Malo lab Nadia Prud homme, Animal Technician, Dr Danielle Malo lab Normand Groulx, Research Assistant, Dr Philippe Gros lab

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