Africa Centre HDSS, South Africa

Transcription

1 Africa Centre HDSS, South Africa Map Location of ACDIS Site, South Africa: Monitored Population 93,540 Brief Description The Africa Centre is a joint project of the University of KwaZulu-Natal and the Medical Research Council of South Africa. It is situated in the municipality of Mtubatuba, in the rural Umkhanyakude District of northern KwaZulu-Natal, South Africa. The Centre has a staff of 400, two-thirds of them local, working in its headquarters near Mtubatuba, 220km north of Durban, and its virology laboratory in Durban's Nelson R. Mandela Medical School. Total population in 2010 was 93,540 (Male 44,545; Female 48,995)

2 Population Pyramid yr 75-79yr 65-69yr 55-59yr 45-49yr 35-39yr 25-29yr 15-19yr 05-09yr -8.0% -6.0% -4.0% -2.0% 0.0% 2.0% 4.0% 6.0% 8.0% Males Females Demographic Characteristics: 2010 Crude Birth Rate (CBR) Total Fertility Rate (TFR) Crude Death Rate (CDR) Neonatal Mortality (residents) Infant Mortality (residents) Rate of Natural Increase In-Migration Out-Migration Growth Rate (residents) 16.5 per 1000 population 2.5 per woman 10.5 per 1000 population 4.8 per 1000 live births 44 per 1000 live births 6 per 1000 population 67 per 1000 population 70 per 1000 population -0.4 percent Objectives: To further improve understanding of HIV dynamics and the impact of ART roll-out at individual, household, clinic, community level To identify approaches to, and target groups for, interventions To evaluate interventions at individual, household and community level To implement and further evaluate HIV treatment and prevention programmes

3 Priority Research Areas HIV/AIDS surveillance Sexual and reproductive health Socioeconomic impact of HIV/AIDS Household dynamics HIV and STI intervention studies. Funders Wellcome Trust (Principal Funder) National Institute of Health (NIH) President s emergency plan for AIDS relief (PEPFAR) Department for International Development (DFID) Centre for International Migration (CIM) The European and Development Countries Clinical Trials Partnership (EDCTP) ANRS, France University of Aberdeen IMMPACT Swiss South African Joint Research Program (CSIR) Collaborators University College London London School of Tropical Hygiene and Medicine Centre for Population Studies ALPHA-Network University of Michigan University of Cape Town WHO (SURVART) Imperial College/Manicaland HIV Prevention Project Medical Research Council, Clinical Trials Unit, UK University of KwaZulu-Natal Schools/Research Units: HIVAN, School of Development Studies (SODS) Nelson Mandela Medical School; Princeton University, USA, INDEPTH Network University of Glasgow Harvard School of Public Health

4 Key Publications 1. Tanser F, Bärnighausen T, Hund L, Garnett G, McGrath N, Newell ML. Effect of concurrent sexual partnerships on the rate of new HIV infections in a high-prevalence, rural South African population: a cohort study. Lancet 2011; 378(9787): Herbst AJ, Mafojane T, Newell ML. Verbal autopsy-based cause-specific mortality trends in rural KwaZulu-Natal, South Africa, (Special issue on the Bali Verbal Autopsy Congress) Pop Health Metrics 2011; 9(1): Garrib A, Herbst AJ, Hosegood V, Newell ML. Injury mortality in rural South Africa : rates and associated factors. Trop Med Int Health. 2011; 16: Lessells RJ, Mutevedzi PC, Cooke GS, Newell ML. Retention in care for HIV infected individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal, South Africa. J Acquir Immmune Defic Syndr 2011; 56(3): 5. Chimbindi N, McGrath N, Herbst K, Tint KS, Newell ML. Socio-demographic determinants of condom use among sexually active young adults in rural KwaZulu-Natal, South Africa. Open AIDS J 2010; 4: Bärnighausen T, McWalter T, Rosner Z, Newell ML, Welte A. HIV incidence estimation using the BED capture enzyme immunoassay: systematic review and sensitivity analysis. Epidemiol 2010; 21(5): Camlin C, Hosegood V, Newell ML, McGrath N, Bärnighausen T, Snow RC. Gender, Migration and HIV in rural KwaZulu-Natal, South Africa. PLoS One 2010; 5(7) 8. Muhwava W, Hosegood V,Nyirenda M, Herbst AJ, Newell ML. Levels and determinants of population movements and migration in rural Kwa-Zulu Natal, South Africa. African Population Studies 2010; 24: Wallrauch C, Bärnighausen T, Newell ML. HIV prevalence and incidence in people 50 years and older in rural South Africa. SAMJ 2010; 100(12): Ndirangu J, Newell ML, Tanser F, Herbst K, Bland R. Decline in early life mortality in a high HIV prevalence rural area of South Africa: evidence of HIV prevention or treatment impact? AIDS 2010; 24 (4): Houlihan C, Bland RM, Mutevedzi P, Lessells R, Ndirangu J, Thulare H, Newell ML. Cohort profile: Hlabisa HIV Treatment and care programme. Int J Epidemiol 2010; 39(2): Mutevedzi P, Lessells R, Heller T, Bärnighausen T, Cooke G, Newell ML. Scale-up of a decentralised HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes? Bulletin of the WHO 2010; 88(8): Tanser F, Bärnighausen T, Cooke GS, Newell ML. Localized spatial clustering of HIV infections in a widely disseminated rural South African epidemic. Int J Epidemiol 2009, 38(4):p Hallett TB, Ghys P, Bärnighausen T, Yan P, Gernett GP. Errors in 'BED'-derived estimates of HIV incidence will vary by place, time and age. PLoS ONE 2009; 4 (5): e Welaga P, Hosegood V, Weiner R, Hill C, Herbst K, Newell ML. Coming home to die? The association between mortality and migration in rural South Africa. BMC Public Health 2009; 9: Herbst AJ, Cooke GS, Bärnighausen T, Kany Kany A, Tanser F, Newell ML. Adult mortality and antiretroviral treatment roll-out in rural Kwa-Zulu Natal, South Africa. Bulletin World Health Organ 2009; 87(10): Hill C, Hosegood V, Newell ML. Children's care and living arrangements in a high HIV prevalence area in rural South Africa. Vulnerable Children & Youth Studies; (1): p Bärnighausen T, Welz T, Hosegood V, Herbst K, Bätzing-Feigenbaum J, Tanser F, Hill C, Newell ML. High HIV incidence in a community with high HIV prevalence in rural South Africa: findings from a prospective population-based study. AIDS 2008; 22: p

5 Agincourt census launch August 2010 The Ethiopian HDSS and University visitors to Agincourt, 2010