An X-linked Locus Influences the Amount of Circulating Interferon Induced in the Mouse by Herpes Simplex Virus Type 1
|
|
- Olivia Paul
- 5 years ago
- Views:
Transcription
1 J. gen. Virl. (1982), 63, Printed in Great Britain 325 Key wrds: herpes simplex virus/interfern inductin/genetics f hst resistance~x-linkage An X-linked Lcus Influences the Amunt f Circulating Interfern Induced in the Muse by Herpes Simplex Virus Type 1 By RAINER ZAWATZKY, I* HOLGER KIRCHNER, 2 JAQUELINE DEMAEYER-GUIGNARD ~ AND EDWARD DEMAEYER 1 11nstitut Curie, Universit~ de Paris-Sud, Orsay, France and 2 Institute f Virlgy, German Cancer Research Center, Heidelberg, Federal Republic f Germany (Accepted 15 July 1982) SUMMARY Prductin f circulating interfern (IFN) was measured in inbred muse strains fllwing intravenus injectin f herpes simplex virus type 1 (HSV-1). IFN titres reached maximal levels 2 t 3 h after injectin f virus and a 10-fld difference was fund between C57BL/6 mice and BALB/c, as high and lw prducers respectively. Mendelian analysis revealed that HSV-induced IFN prductin is gverned by several lci, ne f which is X-linked. The strain distributin pattern btained frm results in recmbinant inbred lines and the results btained in the cngenic B6-C-H-28c-If-11 strain furthermre indicated an absence f clse linkage t If-1. It is cncluded that the levels f HSV-induced early IFN prductin are influenced by several autsmal lci and ne X-linked lcus. INTRODUCTION Several genetic lci in the muse influence the levels f circulating interfern (IFN) prductin in respnse t viruses. The lci cntrlling IFN prductin with ne virus d nt necessarily have an effect n interfern levels induced by anther virus; fr example, bth Newcastle disease virus (NDV) and Sendai virus induce 10-fld higher levels f serum IFN in C57BL/6 than in BALB/c mice but segregatin analysis and the use f recmbinant inbred (RI) muse strains have shwn that different lci are invlved in regulating IFN prductin in respnse t the tw viruses (DeMaeyer & DeMaeyer-Guignard, 1979). Injectin f herpes simplex virus (HSV-1) int mice als results in high levels f circulating IFN, and it culd again be shwn that the amunt f IFN prduced is influenced by the gentype f the hst, in that C57BL/6 mice prduce higher amunts f IFN than mice f ther strains such as DBA/2 r BALB/c (Zawatzky et al., 1981). It was therefre f interest t determine the number f lci invlved in the quantitative difference between high and lw IFN respnders t HSV, and the linkage f these lci t ther If-lci. In this paper, we present evidence that early (between 2 and 3 h) IFN prductin in respnse t HSV is under the quantitative cntrl f at least three lci, ne f which is X-linked. METHODS Virus. Herpes simplex virus type 1, strain WAL (HSV-1 WAL), derived frm a virus stck as previusly described (Kirchner et al., 1978), was plaque-purified and prpagated in RITA cells (a cntinuus line f mnkey kidney rigin screened fr the presence f mycplasma) in Medium 199 (Mrgan et al., 1950), supplemented with 5 % fetal bvine serum (FBS) at a multiplicity f infectin (m..i.) f Virus particles were recvered 24 h later frm the superuatant f RITA cells by sedimentatin at g fr 1 h. Extractin and purificatin f infectius virus DNA and subsequent infectin f BSC-1 ceils (African green mnkey kidney cells) were perfrmed essentially as described by Graham et al. (1973), using the calcium phsphate precipitatin technique. Plaques f HSV-I culd be identified 3 days after infectin f BSC-1 cells with virus DNA. Virus was then prpagated again in RITA cells at lw m..i. (0.02) t btain a new virus stck. Derived frm the latter, the first passage at high m..i. (1-5) was used in all the experiments f this study. The titre f this preparatin was 108 p.f.u./ml. It will be referred t belw as HSV. Interfern inductin. Mice received an intravenus injectin, int the retrrbital sinus, f 0.1 ml HSV /82/ $02.00 Dwnladed 1982 SGM frm by
2 326 R. ZAWATZKY AND OTHERS suspensin, crrespnding t 107 p.f.u./animal. Bld was drawn between 2 and 3 h later, frm the same site, and after vernight strage at 4 C, the serum was separated and stred at - 20 C. Befre the interfern titratins, all sera were pre-diluted 1 : 10 in minimal essential medium (MEM) and acidified t ph 2 by the additin f 0.5 M- HCI. Fur h f acid treatment was fund sufficient t inactivate any HSV remaining in the serum. The decisin t measure IFN 2 t 3 h after inculatin f the virus was based n the bservatin, frm preliminary experiments, that ptimal IFN inductin was achieved at that time. Interfern titres reached maximal levels 2 t 3 h fllwing virus inculatin, and n difference in kinetics f IFN prductin between parental strains (male C57BL/6 and BALB/c) culd be bserved. Titres remained at maximal levels fr 6 h after virus infectin and then declined slwly. N IFN prductin was bserved in either C57BL/6 r BALB/c mice fllwing intravenus injectin f supernatants frm uninfected RITA cells. Interfern assay. All IFN titratins were perfrmed using a micrtitre assay in 96-well tissue culture plates (Falcn). Apprpriate twfld dilutins f the acid-treated sera were incubated vernight in the presence f muse L cells. The challenge virus, cnsisting f encephalmycarditis virus (EMCV), was then added and the cell prtectin read 24 h later. Each serum was titrated in duplicate. One unit is defined as the reciprcal f the last serum dilutin cnferring at least 50 ~ prtectin against destructin f the L cells by EMCV, and crrespnds t 3 internatinal reference units, based n cmparable titratins f NIH muse interfern preparatin with reference number G h All units are expressed as lgl0 values. Mice. The inbred strains used in this study were riginally btained frm D. Bailey at the Jacksn Labratry, Bar Harbr, U.S.A., and have been maintained in Orsay, by brther-sister mating fr several years. All mice were 2 t 3 mnths ld at the time f the experiments. Statisticalanalysis f the data. The lg10 values f the titres were used fr the analysis by Student's t-test (Dixn & Massey, 1969), since it has been shwn previusly that values fr circulating IFN levels in mice have a clse t nrmal distributin when pltted n a lg~0 scale (DeMaeyer & DeMaeyer-Guignard, 1979). This was cnfirmed in the present study, as can be seen in Fig. h In additin, the results were analysed nn-parametrically by the Wilcxn rank sum test (Hllander & Wlfe, 1973). In general, there was a gd crrelatin between the utcmes f the tw tests. RESULTS Interfern titres in parental strains (BALB/c and C57BL/6) The mean titres in BALB/c and C57BL/6 mice differed by a factr f abut 10. When males and females were analysed separately, the average titre f the females, bth fr BALB/c and C57BL/6, was slightly higher than the average titre f the males. Fr bth strains, the difference between males and females was statistically significant (P < 0-005) (Table 1, Fig. 1). F1 generatin When IFN titres f F1 prgeny f reciprcal crsses were analysed, a striking difference between males and females was bserved. Fr bth crsses, BALB/c x C57BL/6, and C57BL/6 x BALB/c, the titres in the female prgeny were significantly higher than the titres in the male prgeny and much clser t the values f C57BL/6 than t thse f BALB/c. An analysis f the titres f the male prgeny revealed a significant difference (P < 0.01) between the prgeny f the tw crsses in that the titres f the C57BL/6 x BALB/c prgeny were higher than thse f the BALB/c x C57BL/6 prgeny. The female prgeny f bth crsses had cmparable titres (Table 1, Fig. 1). Table 1. HSV-induced 1FN titres in parental strains and F1 hybrids BALB/c C57BL/6 F1 BALB/c x C57BL/6 F1 C57BL/6 x BALB/c t & r A ~ t A ~ r A ~ 6`? 6` 9 6` ~ 6` Mean titre Standard deviatin Number f mice _ 17 9'~ Level f significance \ / \ / ~ / / ~ \ /7 between $ and 6' P < P < P < 0.00 P < between FI ~. / between F1 6` P < 0.01 Dwnladed frm by
3 Interfern and herpes simplex virus 327 4, I I I I I I! ~ ~ 3 g g g 2 :. ::. : g..... nr : ~..... : ~-...~ g... ~ $II" -- ZlIS I~,INNbO I 1 I C57BL/6 I I I I I I BALB/c C57BL/6 BALB/c BALB/c F1 F1 BALB/c F1 C57BL/6 F1 C57BL/6 F2 C57BL/6 BALB/c Fig. 1. Genetic analysis f HSV-induced circulating IFN levels. Titres were measured in parental strains, F1, F2 and backcrss generatins. The pen symbls represent values btained frm female animals, the clsed symbls males. Table 2. HSV-induced IFN titres in F2 and backcrss generatins F1 (BALB/c x C57BL/6) F1 (BALB/c x C57BL/6) F2 (BALB/c x C57BL/6) C57BL/6 backcrss x BALB/c backcrss g g f Mean titre Standard deviatin Number f mice Level f significance between? and c~ " P < P < P < F2 generatin: (BALB/c x C57BL/6)F1 x (BALB/c x C57BL/6)F1 The IFN titres f the F2 prgeny were als significantly different fr males and females. Again, the titres were higher in the female prgeny than in the male prgeny, and the difference between the mean values f bth was highly significant (P < 0.001). Furthermre, the values btained frm males were spread ver the whle range f BALB/c t C57BL/6 titres, whereas thse frm females were nly f intermediate and f C57BL/6 type (Table 2, Fig. 1). Dwnladed frm by
4 I I I I I i I I I I, i I I I I i I i! C57BL/6 BALB/c CXBD CXBE CXBG CXBH CXBI CXBJ CXBK HW94 Fig. 2. Genetic analysis f HSV-induced circulating IFN levels. Titres were measured in recmbinant inbred and cngenic lines. The pen symbls represent values btained frm female animals, the clsed symbls males. O0 N N O,..] Dwnladed frm by. c~ 0 ee e : : O 0 t O0 O 00 O ~ go gee 0 0 go0 000 O OOO0 000 OO 0 O0 O0 O0 0O0O eg e ee ~ 0 OOe 831"... l...
5 Backcrss generatin (BALB/c x C57BL/6)F1 x C57BL/6 Interfern and herpes simplex virus 329 The female prgeny f this backcrss had IFN titres cmparable t thse f C57BL/6, whereas the titres f the male prgeny were intermediate, between C57BL/6 and BALB/c values. Again, the difference between male and female values was highly significant (P < 0-001) (Table 2, Fig. 1). (BALB/c x C57BL/6)F1 x BALB/c Abut half f the titres f the female prgeny fell within the range f the female BALB/c values whereas the rest were intermediate between female C57BL/6 and BALB/c. The same was true fr male prgeny when cmpared t male C57BL/6 and BALB/c mice (Table 2, Fig. 1). Recmbinant inbred strains and the cngenic B6-C-H-28c-lf-P (HW94) strain The strain distributin pattern (SDP) f HSV-induced IFN levels was further examined in seven RI lines derived frm C57BL/6 and BALB/c (Bailey, 1971). Fr all these strains, the level f IFN prductin was intermediate between C57BL/6 and BALB/c. Again the females had higher IFN titres than the males, and the difference was statistically significant fr six strains, the exceptin being the CXBD strain. The females f ne RI strain (CXBE) prduced values that came clse t the female C57BL/6 values but were nevertheless significantly lwer (P < 0-025). The values frm males f anther RI strain (CXBH) were clse t the male BALB/c values, but still significantly different (P < 0.05) (Table 3, Fig. 2). T lk fr pssible linkage with If-1 (DeMaeyer & DeMaeyer-Guignard, 1969), HSVinduced IFN prductin was measured in the cngenic B6-C-H-28 -If-11 (HW94) strain (DeMaeyer et al., 1975). In this strain als the IFN prductin f females was significantly higher than that f males; hwever, the levels were nt significantly different frm C57BL/6 levels (Table 3, Fig. 2). DISCUSSION A striking feature f the analysis f HSV-induced IFN levels in the present study is the significantly higher titres btained in female animals in all the crsses examined as well as in the parental, the RI and the cngenic strains. There are several indicatins that this difference is X- linked. The mst imprtant evidence is the utcme f the determinatin f IFN levels in the male prgeny f the F1 crsses in bth directins. The fact that the IFN levels f the male prgeny f the C57BL/6 x BALB/c crss are significantly higher than thse f the prgeny f the BALB/c x C57BL/6 crss clearly indicates an X-linked influence in this crss, since IFN levels are higher when the X-chrmsme riginates frm C57BL/6 than frm BALB/c mice. This is further brne ut by the IFN titres f female prgeny f the F1 generatin in bth directins, which are n average 3.7 times (fr C57BL/6 x BALB/c) and 6 times (fr BALB/c x C57BL/6) higher than the titres f the male prgeny, whereas the difference between average titre f males and females in the parental strains is nly 1-5 times (BALB/c) and 2 times (C57BL/6). This indicates that, when tw X-chrmsmes are present, the influence f the high prducer X-linked allele f C57BL/6 rigin is dminant ver all ther alleles influencing HSVinduced IFN levels. This is als suggested by the utcme f the F2 and F1 x C57BL/6 backcrss, in which the mean titre in the female prgeny is abut 3 times that f the male prgeny. Analysis f the distributin f the titres f the male and female F2 prgeny als reveals that several lci are invlved, since, if we were nly dealing with ne lcus, 25 ~ f the female F2 prgeny wuld be expected t have titres cmparable t BALB/c values. This wuld crrespnd t 7 r 8 (i.e. 25~) animals, whereas in the bserved result nly 1 (i.e. 3~) f the prgeny fell within the range f female BALB/c values. By the same reasning, ne wuld expect 75 ~ f the male F2 prgeny t have titres crrespnding t male BALB/c r F1 values, which are indistinguishable because f the cnsiderable verlap f the bserved values; in fact, nly 15 ut f 30, r 50~ fall within this range. The actual number f lci invlved, in additin t the X- linked lcus, cannt be accurately deduced frm the segregatin results, since t many Dwnladed frm by
6 K ' P < HW94 3" '35 21 P < ~0 N...] N Z 0 Dwnladed frm by Table 3. HSV-induced 1FN titres in RI strains and in the cngenic HW 94 strain Strain D E G H I J Mean titre Standard deviatin Number f mice Mean titre Standard deviatin Number f mice t Level f significance between ~ and NS* P < P < P < P < P < * Ns, Nt significant.
7 Interfern and herpes simplex virus 331 Table 4. Estimatin f the number f lci invlved in determining the levels f HSV-indueed IFN prductin frm segregatin in the F2 prgeny Female prgeny: Expected percentage f BALB/c-type prducers Observed percentage Number f lci: ~ 6.2~ 1.5~ 3~ Male prgeny: Expected percentage f BALB/c- and Fl-type prducers Observed percentage Number f lci: ~ 56~ 42~ 50~ assumptins cncerning the relative dminance f the different alleles wuld have t be made; the segregatin values suggest that tw r three lci are invlved (see Table 4). The results btained in the RI strains cnfirm that the trait under study is under multifactrial influence, since nne f the RI strains has a clear-cut parental phentype, and fr all strains the bserved values are intermediate between BALB/c and C57BL/6. The SDP f HSV-induced IFN levels in the RI strains furthermre shws n bvius crrespndence with any f the previusly bserved SDPs fr IFN inductin by NDV, muse mammary tumur virus r Sendai virus, thereby suggesting lack f clse linkage t any f the If-lci previusly described. Lack f linkage t If-1 is furthermre cnfirmed by the results btained in the B6-C-H-28c-If-11 strain, in which the HSV-induced IFN titres were f C57BL/6 type rather than f BALB/c type. The cnclusin f this study, therefre, is that the levels f early HSV-induced IFN prductin are influenced by several (pssibly tw) autsmal lci and ne X-linked lcus: nne f these is clsely linked t If-l, and prbably nt t any f the ther If-lci either. The latter pint, hwever, will have t be cnfirmed by further linkage studies, since, with the exceptin f If-l, n cngenic strains fr the ther If-lci are available. These results have several implicatins: lci influencing levels f IFN prductin in the muse have been previusly described fr ther IFN-inducing viruses, but n evidence fr X- linkage f these genes was bserved. Hwever, in the case f these ther viruses, early IFN prductin was nt studied in detail, since nly IFN levels at later times (8 t 12 h) were cmpared. Therefre, the pssibility that with sme f the ther inducers the level f early IFN inductin is als t sme extent under X-linked cntrl can nt be excluded. This pint certainly merits further investigatin, since a mre general influence f the X-chrmsme n the levels f IFN prductin with several viruses wuld have implicatins fr the physipathlgy f virus diseases in males and females. A Mendelian analysis perfrmed by Lpez (1980), using C57BL/6 and BALB/c mice as parental strains, prvided evidence that primary resistance f C57BL/6 mice t HSV-induced encephalitis is mediated by tw independently segregating lci; n evidence fr X-linkage was reprted in the analysis by Lpez. Hwever, tw recent reprts have prvided evidence fr an X- linked lcus r lci influencing resistance f mice t HSV-2-induced hepatitis (Mgensen, 1977) and HSV-2 infectin (D. Armerding, persnal cmmunicatin) and we believe that these bservatins are directly relevant t the results reprted here. Several reprts in the literature prvide evidence fr the existence f X-linked genes in man influencing susceptibility t Epstein-Barr virus (EBV), which belngs t the herpesvirus grup. Males affected with the X-linked lymphprliferative syndrme are uncmmnly susceptible t infectius mnnuclesis, and this disease ften has a fatal curse in such patients (Purtil, 1980). Interestingly enugh, these males frequently have deficient natural killer cell activity (Sullivan et al., 1980). In additin, naspharyngeal carcinma, in which EBV has been implicated as a causative agent, ccurs mainly in genetically predispsed males (fr review, see Purtil, 1981). In view f the highly cnserved nature f the X-chrmsme, we believe that the pssibility that herpesvirus-induced IFN prductin is X-linked als in man merits full investigatin. REFERENCES BAILEY, D. W. (1971). Recmbinant-inbred strains. An aid t finding identity, linkage and functin f histcmpatibility and ther genes. Transplantatin 11, Dwnladed frm by
8 332 R. ZAWATZKY AND OTHERS DEMAEYER, E. & DEMAEYER-GUIGNARD, L (1969). Gene with quantitative effect n circulating interfern induced by Newcastle disease virus. Jurnal f Virlgy 3, DEMAEYER, E. & DEMAEYER-GUIGNARD, L (1979). Cnsideratins n muse genes influencing interfern prductin and actin. In Interfern 1979, pp Edited by I. Gresser. New Yrk & Lndn: Academic Press. DEMAEYER, E., DEMAEYER-GUIGNARD, J. & BAILEY, D. W. (1975). Effect f muse gentype n interfern prductin. Lines cngenic at the If-1 lcus. Immungenetics 1, DIXON, w. J. & MASSEY, F. J. (1969). Intrductin t Statistical Analysis, 3rd edn., p New Yrk: McGraw-Hill. GRAHAM, F. L., VELHUISEN, G. & WILKIE, N. M. (1973). Infectius herpesvirus DNA. Nature New Bilgy 245, HOLLANDER, M. & WOLFE, D. (1973). Nnparametrical Statistical Methds, p. 68. New Yrk: Jhn Wiley & Sns. K1RCHNER, H., KOCHEN, M., HIRT, H. i. & MUNK, K. (1978). Immunlgical studies f HSV infectin f resistant and susceptible inbred strains f mice. Zeitschrift fur Immuniti~tsfrschung 154, LOPEZ, C. (1980). Resistance t HSV-1 in the muse is gverned by tw majr independently segregating nn H-2 lci. Immungenetics 11, MOGENSEN, S. C. (1977) Genetics f macrphage-cntrlled resistance t hepatitis induced by herpes simplex virus type 2 in mice. Infectin and Immunity 17, MORGAN, J. F., MORTON, H. F. & PARKER, R. C. (1950). Nutritin f animal cells in tissue culture. I. Initial studies n a synthetic medium. Prceedings f the Sciety fr Experimental Bilgy and Medicine 73, 1-8. PURTILO, D. (1980). Epstein-Barr-virus induced ncgenesis in immune-deficient individuals. Lancet i, PURTILO, O. (1981). Immune deficiency predispsing t Epstein-Barr-virns induced lymphprliferative diseases: the X-linked lymphprliferative syndrme as a mdel. Advances in Cancer Research 34, SULLIVAN, J., BYRON, K., BREWSTER, E. & PURTILO, D. (1980). Deficient natural killer cell activity in X-linked lymphprliferative syndrme. Science 210, ZAWATZKY, R., HILFENHAUS, J., MARCUCCI, F. & KIRCHNER, H. (1981). Experimental infectin f inbred mice with herpes simplex virus type 1. I. Investigatin f humral and cellular immunity and f interfern inductin. Jurnal f General Virlgy 53, (Received 2 June 1982) Dwnladed frm by
Frequently Asked Questions: IS RT-Q-PCR Testing
Questins 1. What is chrnic myelid leukemia (CML)? 2. Hw des smene knw if they have CML? 3. Hw is smene diagnsed with CML? Frequently Asked Questins: IS RT-Q-PCR Testing Answers CML is a cancer f the bld
More informationThe estimator, X, is unbiased and, if one assumes that the variance of X7 is constant from week to week, then the variance of X7 is given by
ESTIMATION PROCEDURES USED TO PRODUCE WEEKLY FLU STATISTICS FROM THE HEALTH INTERVIEW SURVEY James T. Massey, Gail S. Pe, Walt R. Simmns Natinal Center fr Health Statistics. INTRODUCTION In April 97, the
More informationFurther Studies on the Influence of Steroids on
INFECTION AND IMMUNITY, Aug. 1973, p. 151-155 Cpyright ( 1973 American Sciety fr Micrbilgy Vl. 8, N. 2 Printed in U.S.A. Further Studies n the Influence f Sterids n Viral Infectin in Mice D. J. GIRON,
More informationBIOLOGY 101. CHAPTER 15: The Chromosomal Basis of Inheritance: Locating Genes Along Chromosomes
BIOLOGY 101 CHAPTER 15: The Chrmsmal Basis f Inheritance: Lcating Genes Alng Chrmsmes Lcating Genes Alng the Chrmsme CONCEPTS: 15.2 Sex-linked genes exhibit unique patterns f inheritance 15.3 Linked genes
More informationAP Biology Lab 12: Introduction to the Scientific Method and Animal Behavior
Name: AP Bilgy Lab 12: Intrductin t the Scientific Methd and Animal Behavir Overview In this lab yu will: -Observe an rganism and design an experiment t investigate their respnses t envirnmental variables.
More informationM.R.C.Path. causes to the raised plasma urea in patients admitted
Pstgradcuate Medical Jurnal (January 1979) 55, 1-14 The cause f the raised plasma urea f acute heart failure R D THOMAS MRCP D B MORGAN MRCPath ALISON NWILL AIMLS Departments f Cardilgy and Chemical Pathlgy,
More informationTick fever is a cattle disease caused by any one of the following blood parasites:
Tick fever Tick fever is a cattle disease caused by any ne f the fllwing bld parasites: Babesia bvis Babesia bigemina Anaplasma marginale These parasites are all transmitted by the cattle tick (Bphilus
More informationA Plasma Humoral Factor of Extrarenal Origin Causing Release of Reninlike Activity in Hypotensive Dogs
A Plasma Humral Factr f Extrarenal Origin Causing Release f Reninlike Activity in Hyptensive Dgs By E. De Vit, C. Wilsn, R. E. Shipley, R. P. Miller, and B. L. Mrtx ABSTRACT Plasma reninlike activity significantly
More informationSTUDIES WITH HUMAN INFLUENZA VIRUS CULTIVATED IN ARTIFICIAL MEDIUM
Published Online: 1 June, 1936 Supp Inf: http://di.rg/1.184/jem.63.6.83 Dwnladed frm jem.rupress.rg n August 13, 218 STUDIES WITH HUMAN INFLUENZA VIRUS CULTIVATED IN ARTIFICIAL MEDIUM BY T. P. MAGILL,
More informationQ 5: Is relaxation training better (more effective than/as safe as) than treatment as usual in adults with depressive episode/disorder?
updated 2012 Relaxatin training Q 5: Is relaxatin training better (mre effective than/as safe as) than treatment as usual in adults with depressive episde/disrder? Backgrund The number f general health
More informationHow to become an AME Online
Hw t becme an AME Online 1. Check that yu meet the minimum technical requirements in rder t use the AME Online system: Operating System: Windws Vista (Service Pack 2) Windws 7 Windws 8, 8.1 Windws 10 Please
More informationEXPLORING THE PROCESS OF ASSESSMENT AND OTHER RELATED CONCEPTS
1 SECTION 1 INTRODUCTION: EXPLORING THE PROCESS OF ASSESSMENT AND OTHER RELATED CONCEPTS The Nature Of Assessment The Definitin Of Assessment The Difference Between Testing, Measurement And Evaluatin Characteristics
More informationUS Public Health Service Clinical Practice Guidelines for PrEP
Webcast 1.3 US Public Health Service Clinical Practice Guidelines fr PrEP P R E S ENTED BY: M A R K T H R U N, M D A S S O C I AT E P R O F E S S O R, U N I V E R S I T Y O F C O L O R A D O, D I V I S
More informationPlaque Formation by Influenza Viruses in the Presence of Trypsin
J. gen. Virl. (I974), 25, 351-357 Printed in Great Britain 35I Plaque Frmatin by Influenza Viruses in the Presence f Trypsin By G. APPLEYARD AND H. B. MABER Micrbilgical Research Establishment, Prtn, Nr
More informationPROTOCOL 1850 Millrace Drive, Suite 3A Eugene, Oregon
PROTOCOL Cmplex II Enzyme Activity Micrplate Assay Kit 1850 Millrace Drive, Suite 3A Eugene, Oregn 97403 MS241 Rev.0 DESCRIPTION Cmplex II Enzyme Activity Micrplate Assay Kit Sufficient materials are prvided
More informationCorporate Governance Code for Funds: What Will it Mean?
Crprate Gvernance Cde fr Funds: What Will it Mean? The Irish Funds Industry Assciatin has circulated a draft Vluntary Crprate Gvernance Cde fr the Funds Industry in Ireland. 1. Backgrund On 13 June 2011,
More information(From the Laboratories of the International Health Division of The Rockefeller Foundation, New York)
THE QUANTITATIVE DETERMINATION OF INFLUENZA VIRUS AND ANTIBODIES BY MEANS OF RED CELL AGGLUTINATION BY GEORGE K. HLRST, M.D. (Frm the Labratries f the Internatinal Health Divisin f The Rckefeller Fundatin,
More informationDATA RELEASE: UPDATED PRELIMINARY ANALYSIS ON 2016 HEALTH & LIFESTYLE SURVEY ELECTRONIC CIGARETTE QUESTIONS
DATA RELEASE: UPDATED PRELIMINARY ANALYSIS ON 216 HEALTH & LIFESTYLE SURVEY ELECTRONIC CIGARETTE QUESTIONS This briefing has been specifically prepared fr the Ministry f Health t prvide infrmatin frm this
More informationCONSENT FOR KYBELLA INJECTABLE FAT REDUCTION
CONSENT FOR KYBELLA INJECTABLE FAT REDUCTION INSTRUCTIONS This is an infrmed cnsent dcument which has been prepared t help yur Dctr infrm yu cncerning fat reductin with an injectable medicatin, its risks,
More informationFDA Dietary Supplement cgmp
FDA Dietary Supplement cgmp FEBRUARY 2009 OVERVIEW Summary The Fd and Drug Administratin (FDA) has issued a final rule regarding current gd manufacturing practices (cgmp) fr dietary supplements that establishes
More informationImplementation of G6PD testing and radical cure in P. vivax endemic countries: considerations
Implementatin f G6PD testing and radical cure in P. vivax endemic cuntries: cnsideratins Malaria Plicy Advisry Cmmittee Geneva, Switzerland 16-18 September 2015 1 WHO Guidelines n Radical Cure WHO guidelines
More informationData Fusion for Predicting Breast Cancer Survival
Data Fusin fr Predicting Breast Cancer Linbailu Jiang, Yufei Zhang, Siyi Peng Mentr: Irene Kaplw December 11, 2015 1 Intrductin 1.1 Backgrund Cancer is mre f a severe health issue than ever in ur current
More informationSwindon Joint Strategic Needs Assessment Bulletin
Swindn Jint Strategic Needs Assessment Bulletin Swindn Diabetes 2017 Key Pints: This JSNA gives health facts abut peple with diabetes r peple wh might get diabetes in Swindn. This helps us t plan fr medical
More information23/11/2015. Introduction & Aims. Methods. Methods. Survey response. Patient Survey (baseline)
Intrductin & Aims Drug and Alchl Cnsultatin Liaisn (AOD CL) services aim t imprve identificatin and treatment f patients with AOD mrbidity. The csts and cnsequences f targeting AOD patients presenting
More informationIncrease of Induced Skin Tumors in the Mouse by the Lethal Yellow Gene (A 11) 1
Increase f Induced Skin Tumrs in the Muse by the Lethal Yellw Gene (A 11) 1 GEORGE VLAHAKIS and W. E. HESTON, Labratry f Bilgy, Natinal Cancer Institute,2 Bethesda, Maryland SUMMARY The lethal yellw gene
More informationBRCA1 and BRCA2 Mutations
BRCA1 and BRCA2 Mutatins ROBERT LEVITT, MD JESSICA BERGER-WEISS, MD ADRIENNE POTTS, MD HARTAJ POWELL, MD, MPH COURTNEY LEVENSON, MD LAUREN BURNS, MSN, RN, WHNP OBGYNCWC.COM v Cancer is a cmplex disease
More informationIn the last lesson we examined specific factors that affect ecosystems.
Lessn 3: Liming Factrs in Ecsystems In the last lessn we examined specific factrs that affect ecsystems. In this lessn, yu will see hw these and ther factrs limit ppulans and cmmunies within ecsystems. Bitic
More informationModule 6: Goal Setting
Mdule 6: Gal Setting Objectives T understand the cncept f gal setting in Brief CBT T acquire skills t set feasible and apprpriate gals in Brief CBT What is gal setting, and why is it imprtant t set gals
More informationTRANSPLANTATION AND CLINICAL IMMUNOLOGY. Proceedings of the Twenty-Second International Course, Lyon, May 1990
-----.---.----~ Reprinted frm: TRANSPLANTATION AND CLINICAL IMMUNOLOGY VOLUME XXII Multiple Transplants Prceedings f the Twenty-Secnd Internatinal Curse, Lyn, 2-23 May 99 This publicatin was made pssible
More informationThe principles of evidence-based medicine
The principles f evidence-based medicine By the end f this mdule yu shuld be able t: Describe what evidence based medicine is Knw where t find quality evidenced based medicine n the internet Be able t
More informationThyroglobulin levels in serum and saliva of patients with differentiated thyroid carcinoma
Pre, Indian Acad. Sci., Vl. 87 B (Experimental Bilgy-J), N.7, July 1978. pp. 169-1". @ printed in India Thyrglbulin levels in serum and saliva f patients with differentiated thyrid carcinma D SHAH, S DANDEKAR
More informationP02-03 CALA Program Description Proficiency Testing Policy for Accreditation Revision 1.9 July 26, 2017
P02-03 CALA Prgram Descriptin Prficiency Testing Plicy fr Accreditatin Revisin 1.9 July 26, 2017 P02-03 CALA Prgram Descriptin Prficiency Testing Plicy fr Accreditatin TABLE OF CONTENTS TABLE OF CONTENTS...
More informationTopic 12: Endocrine System. Function: Group of glands that produces regulatory chemicals ( )
Tpic 12: Endcrine System Functin: Grup f glands that prduces regulatry chemicals ( ) Hrmnes: Chemical messengers released directly int the bldstream that regulate: *May have wide-spread effects r nly affect
More informationLyme Disease Surveillance in North Carolina
Lyme Disease Surveillance in Nrth Carlina 2008-2014 Carl Williams DVM Megan Sanza MPH Cmmunicable Disease Branch Divisin f Nrth Carlina Public Health Lyme Disease Surveillance in Nrth Carlina 2008-2014
More informationBIOLOGY 101. CHAPTER 13: Meiosis and Sexual Life Cycles: Variations on a Theme
BIOLOGY 101 CHAPTER 13: Meisis and Sexual Life Cycles: Variatins n a Theme Meisis and Sexual Life Cycles: Variatins n a Theme CONCEPTS: 13.1 Offspring acquire genes frm their parents by inheriting chrmsmes
More informationSocial Learning Theories
Scial Learning Theries - Careful scientific prcedures and methdlgy that characterize the behaviurist apprach Albert Bandura - Brn in small twn Alberta - Plish decent - Only sn with 5 sisters - Interested
More informationCnsideratin fr Optimizatin: Optimizatin is a prgram transfrmatin technique, which tries t imprve the cde by making it cnsume fewer resurces (i.e. CPU, Memry) and deliver high speed. In ptimizatin, high-level
More informationCDC Influenza Division Key Points November 7, 2014
In this dcument: Summary Key Messages FluView Activity Update LAIV Effectiveness and Vaccinatin f Children H3N2 Match and Vaccinatin Vaccine Supply Summary Key Messages This week s FluView reprt indicates
More informationField Epidemiology Training Program
Field Epidemilgy Training Prgram Cancer Curriculum: Principles f Cancer Registries Case Study: Hspital-Based Cancer Registries FACILITATOR GUIDE FETP Cancer Curriculum: Principles f Cancer Registries Case
More informationCompleting the NPA online Patient Safety Incident Report form: 2016
Cmpleting the NPA nline Patient Safety Incident Reprt frm: 2016 The infrmatin cntained within this dcument is in line with the current Data Prtectin Act (DPA) requirements. This infrmatin may be subject
More informationBenefits for Anesthesia Services for the CSHCN Services Program to Change Effective for dates of service on or after July 1, 2008, benefit criteria
Benefits fr Anesthesia Services fr the CSHCN Services Prgram t Change Effective fr dates f service n r after July 1, 2008, benefit criteria fr anesthesia will change fr the Children with Special Health
More informationProtocol. Preparation Protocol for the Non-Targeted Vevo MicroMarker Contrast Agent
Prtcl Preparatin Prtcl fr the Nn-Targeted Vev MicrMarker Cntrast Agent System Cmpatibility: This guide cntains instructins and suggestins fr wrk n the Vev2100, VevLAZR, Vev 3100 systems and transducers
More informationNFS284 Lecture 3. How much of a nutrient is required to maintain health? Types and amounts of foods to maintain health
NFS284 Lecture 3 Chapter 2: Nutritin: Guidelines: Applying the Science f Nutritin 2.1 Nutritin Recmmendatin fr the Canadian Diet Nutrient-based apprach Hw much f a nutrient is required t maintain health?
More informationA Phase I Study of CEP-701 in Patients with Refractory Neuroblastoma NANT (01-03) A New Approaches to Neuroblastoma Therapy (NANT) treatment protocol.
SAMPLE INFORMED CONSENT A Phase I Study f CEP-701 in Patients with Refractry Neurblastma NANT (01-03) A New Appraches t Neurblastma Therapy (NANT) treatment prtcl. The wrd yu used thrughut this dcument
More informationLATENT VIRAL INFECTION OF CELLS IN TISSUE CULTURE BY JOHN P. BADER, PH.D., AND HERBERT R. MORGAN, M.D.
Published Online: 1 February, 1961 Supp Inf: http://di.rg/1.184/jem.113.2.271 Dwnladed frm jem.rupress.rg n August 22, 218 LATENT VIRAL INFECTION OF CELLS IN TISSUE CULTURE VII. ROLE OF V~ATER-SOLUBLE
More informationThe effect of orientation in binocular contour rivalry of real images and afterimages*
Perceptin & Psychphysics 1974, Vl. 15, N.2, 227-232 The effect f rientatin in bincular cntur rivalry f real images and afterimages* N.J. WADE University fdundee, Dundee DDI 4HN, Sctland Bincular rivalry
More informationNutrition Care Process Model Tutorials. Nutrition Monitoring & Evaluation: Overview & Definition. By the end of this module, the participant will:
Nutritin Care Prcess Mdel Tutrials Nutritin Care Prcess and Terminlgy Cmmittee Academy f Nutritin and Dietetics Nutritin Care Prcess Terminlgy 2015 Editin Nutritin Mnitring & Evaluatin: Overview & Definitin
More informationH1N1 Influenza 09 Guidance for Residential Aged Care
H1N1 Influenza 09 Guidance fr Residential Aged Care 11 June 2009 As knwledge abut H1N1 Influenza 09 develps, further advice will be prvided. Please check www.healthemergency.gv.au fr the latest infrmatin.
More informationChapter 6: Impact Indicators
Overview Chapter 6: Impact Indicatrs The best measure f the lng-term impact f all HIV preventin activities is the HIV incidence rate, namely the number f new cases f HIV infectin per year divided by the
More informationRelationship Between Fertility and the Nonprotein Sulfhydryl Concentration of Seminal Fluid in the Thoroughbred Stallion
Relatinship Between Fertility and the Nnprtein Sulfhydryl Cncentratin f Seminal Fluid in the Thrughbred Stallin Frederick M. Haag, D.V.M., * and N. T. Werthessen, Ph.D. IN AN EARLIER REPORT! it was shwn
More informationVariation in Tissue Carnitine Concentrations with Age and Sex in the Rat
Bichem. J. (1978) 176, 677-681 Printed in Great Britain 677 Variatin in Tissue Carnitine Cncentratins with Age and Sex in the Rat By PEGGY R. BORUM Divisin fnutritin, Department fbichemistry, Vanderbilt
More informationPublic consultation on the NHMRC s draft revised Australian alcohol guidelines for low-risk drinking
Public cnsultatin n the NHMRC s draft revised Australian alchl guidelines fr lw-risk drinking Recmmendatins frm The Cancer Cuncil Australia The Cancer Cuncil Australia is Australia s peak nn-gvernment
More informationVIRUS-INDUCED DIABETES MELLITUS I. HYPERGLYCEML~_ AND HYPOINSULINEMIA IN ~/IICE INFECTED WITH ENCEPHALOMYOCARDITIS VIRUS
VIRUS-INDUCED DIABETES MELLITUS I. HYPERGLYCEML~_ AND HYPOINSULINEMIA IN ~/IICE INFECTED WITH ENCEPHALOMYOCARDITIS VIRUS BY D. WARK BOUCHER AND ABNER LOUIS NOTKINS (Frm the Virlgy Sectin, Labratry q[ Micrbilgy
More informationExtraction of oleic acid from jojoba oil, soybean oil and olive oil Phase diagrams
IndianJurnalfChemicalTechnlgy Vl.3, Nvember1996,pp. 299-305 Extractin f leic acid frm jjba il, sybean il and live il Phase diagrams JaimeWisniak*,AlexanderApelblat&Ahu-AkelKhaled epartmentfchemicalengineering,ben-gurianuniversityf
More informationTopic Guide 4.2 & 10.1 Meiosis. 1. Define homologous chromosomes. 2. Explain reduction division. 3. State the function of meiosis.
IB Bilgy HL Tpic Guide 4.2 & 10.1 Meisis Name Per. 1. Define hmlgus chrmsmes. 2. Explain reductin divisin. 3. State the functin f meisis. 4. Add chrmsmes and anntate the diagram belw summarizing the steps
More informationVaccine Information Statement: LIVE INTRANASAL INFLUENZA VACCINE
Vaccine Infrmatin Statement: LIVE INTRANASAL INFLUENZA VACCINE Many Vaccine Infrmatin Statements are available in Spanish and ther languages. See www.immunize.rg/vis. Hjas de Infrmacián Sbre Vacunas están
More informationScientia Horticulturae, 3 (1975) Elsevier Scientific Publishing Company, Amsterdam -- Printed in The Netherlands
Scientia Hrticulturae, 3 (1975) 89--94 Elsevier Scientific Publishing Cmpany, Amsterdam -- Printed in The Netherlands EFFECT F NITRGEN FERTILIZATIN N YIELD AND FRUIT IL CNTENT F AVCAD TREES A.B. ABU AZIZ,
More informationCardiac Rehabilitation Services
Dcumentatin Guidance N. DG1011 Cardiac Rehabilitatin Services Revisin Letter A 1.0 Purpse The Centers fr Medicare and Medicaid Services (CMS) has detailed specific dcumentatin requirements fr Cardiac Rehabilitatin
More informationApplied veterinary Virology: The isolation and identification of viruses using embryonated chicken eggs
Applied veterinary Virlgy: The islatin and identificatin f viruses using embrynated Authrs: Prf. Estelle H Venter Licensed under a Creative Cmmns Attributin license. INTRODUCTION Viruses can nly grw in
More informationApril 23, 2008 Information Sheet: Safety of BPA-derived Can Liners. Summary
April 23, 2008 Infrmatin Sheet: Safety f BPA-derived Can Liners Summary The use f bisphenl A (BPA)-derived epxy resins t make prtective catings fr metal fd and beverage packaging helps prvide safe, whlesme
More informationPICO question In patients with glomerulonephritis what are patient preferences and values for immunosuppressive and non-immunosuppressive therapy?
KDIGO GN Guideline update Evidence summary Patient preferences fr glmerulnephritis treatment PICO questin In patients with glmerulnephritis what are patient preferences and values fr immunsuppressive and
More informationHIV Diagnostic Tests. HIV Testing Algorithm at SydPath (National Reference Laboratory)
HIV Diagnstic Tests HIV Testing Algrithm at SydPath (Natinal Reference Labratry) HIV1/2 Ab/Ag Cmbi is Architect HIV- 1 Ab/Ag EIA is Genscreen Sandwich EIA 4 th Generatin HIV Ab/Ag Chemiluminescene Micr
More information2017 Optum, Inc. All rights reserved BH1124_112017
1) What are the benefits t clients f encuraging the use f MAT? Withut MAT, 90% f individuals with Opiid Use Disrder (OUD) will relapse within ne year. With MAT, the relapse rate fr thse with OUD decreases
More informationCDC Influenza Technical Key Points February 15, 2018
CDC Influenza Technical Key Pints In this dcument: Summary Key Pints U.S. Vaccine Effectiveness U.S. Flu Activity Update Summary Key Pints On Thursday, tw influenza-related reprts appeared in the Mrbidity
More informationFORCES IN THE KNEE JOINT DURING EXERCISE OF TIlE KNEE EXTENSORS 1
10 THE AUSTRALIAN JOURNAL OF PHYSIOTHERAPY FORCES IN THE KNEE JOINT DURING EXERCISE OF TIlE KNEE EXTENSORS 1 R. S. HORSFIELD, B.SC., DIP.ED. (SYD.), M.PHYS. (U.N.S.W.), M.A.I.P., M.A.C.E. What frces arise
More informationFOUNDATIONS OF DECISION-MAKING...
Table f Cntents FOUNDATIONS OF DECISION-MAKING... Errr! Bkmark nt Describe the decisin-making prcess pp.62-66... Errr! Bkmark nt Explain the three appraches managers can use t make decisins pp.67-70 Errr!
More informationA pre-conference should include the following: an introduction, a discussion based on the review of lesson materials, and a summary of next steps.
NAU Mdel Observatin Prtcl The mdel prtcl was develped with supprt and expertise frm the Natinal Institute fr Excellence in Teaching (NIET) and is based in great part n NIET s extensive experience cnducting
More informationStructured Assessment using Multiple Patient. Scenarios (StAMPS) Exam Information
Structured Assessment using Multiple Patient Scenaris (StAMPS) Exam Infrmatin 1. Preparing fr the StAMPS assessment prcess StAMPS is an assessment mdality that is designed t test higher rder functins in
More informationThe Multiplication Cycle of Tobacco Rattle Virus in Tobacco Mesophyll Protoplasts
J. gen. Virl. (I976), 33, 237-248 Printed in Great Britain 237 The Multiplicatin Cycle f Tbacc Rattle Virus in Tbacc Mesphyll Prtplasts By B. D. HARRISON, S. KUBO,* D. J. ROBINSON AND AILEEN M. HUTCHESON
More informationPROTOCOL. SOD2 Protein Quantity Microplate Assay Kit. MS746 Rev.0 DESCRIPTION INTRODUCTION
PROTOCOL SOD2 Prtein Quantity Micrplate Assay Kit 1850 Millrace Drive, Suite 3A Eugene, Oregn 97403 MS746 Rev.0 DESCRIPTION SOD2 Prtein Quantity Micrplate Assay Kit Sufficient materials are prvided fr
More informationREGISTERED REPORTS AUTHOR AND REVIEWER GUIDELINES
REGISTERED REPORTS AUTHOR AND REVIEWER GUIDELINES A Registered Reprt is a frm f empirical article ffered at Nature Human Behaviur in which the methds and prpsed analyses are pre-registered and reviewed
More informationThe influence of one memory retrieval on a subsequent. 1* memory retrieva
Memry & Cgnitin 1974, Vl. 2, N.3, 467-471 The influence f ne memry retrieval n a subsequent. 1* memry retrieva GEOFFREY R. LOFTUS and ELIZABETH F. LOFTUS University f Washingtn, Seattle, Washingtn 98195
More informationReferral Criteria: Inflammation of the Spine Feb
Referral Criteria: Inflammatin f the Spine Feb 2019 1 5.7. Inflammatin f the Spine Backgrund Ankylsing spndylitis and axial spndylarthrpathy are fund in arund 0.3-1.2% f the ppulatin. Spndylarthritis encmpasses
More information~ LONG-TERM TREATMENT OF DAPSONE-RESISTANT LEPROSY WITH RIFAMPICIN: CLINICAL AND BACTERIOLOGICAL STUDIES
I NTERNATI ONAL J OURNAL OF L EPROSY Vlume 44. Numbers I & 2 Prinled in Ilu' U.S.A. ~ LONG-TERM TREATMENT OF DAPSONE-RESISTANT LEPROSY WITH RIFAMPICIN: CLINICAL AND BACTERIOLOGICAL STUDIES R.J.W. Rees,
More informationM.J. Guthriel, D.G. Wagner2
EFFECT OF SUPPLEMENTAL PROTEIN OR GRAIN ON INTAKE AND UTILIZATION OF MEDIUM QUALITY PRAIRIE HAY BY STEERS M.J. Guthriel, D.G. Wagner2 and D.C. Weakley3 Stry in Brief Sixteen 1,053 lb tw-year-ld Herefrd
More informationBreast Cancer Awareness Month 2018 Key Messages (as of June 6, 2018)
Breast Cancer Awareness Mnth 2018 Key Messages (as f June 6, 2018) In this dcument there are tw sectins f messages in supprt f Cancer Care Ontari s Breast Cancer Awareness Mnth 2018: 1. Campaign key messages
More informationCDC Influenza Division Key Points MMWR Updates February 20, 2014
CDC Influenza Divisin Key Pints MMWR Updates In this dcument: Summary Key Messages Seasnal Influenza Vaccine Effectiveness: Interim Adjusted Estimates Influenza Surveillance Update: September 29, 2013-February
More informationCancer Association of South Africa (CANSA)
Cancer Assciatin f Suth Africa (CANSA) Fact Sheet and Psitin Statement n Cannabis in Suth Africa Intrductin Cannabis is a drug that cmes frm Indian hemp plants such as Cannabis sativa and Cannabis indica.
More informationSTATISTICAL ANALYSIS PLAN. Addendum 1 (V 1 12SEP2015)
Pelvic Flr Disrder STATISTICAL ANALYSIS PLAN Addendum 1 (V 1 12SEP2015) PFDN Prtcl Number 22P01: Refractry Overactive Bladder: Sacral NEurmdulatin v. BTulinum Txin Assessment (ROSETTA) AUTHOR (S): Tracy
More informationWidening of funding restrictions for rituximab and eltrombopag
20 February 2014 Widening f funding restrictins fr rituximab and eltrmbpag PHARMAC is pleased t annunce the apprval f prpsals t widen the restrictin n rituximab use in DHB hspitals and expand the funding
More information1.11 INSULIN INFUSION PUMP MANAGEMENT INPATIENT
WOMEN AND NEWBORN HEALTH SERVICE CLINICAL GUIDELINES SECTION A: GUIDELINES RELEVANT TO OBSTETRICS AND GYNAECOLOGY 1 STANDARD PROTOCOLS 1.11 INSULIN INFUSION PUMP MANAGEMENT - INPATIENT Authrised by: OGCCU
More informationby Springer-Verlag 1977
Diabetlgia 13, 615-61 (177) Diabetlgia @ by Springer-Verlag 177 Prevalence f Residual B-Cell Functin in Insulin-Treated Diabetics Evaluated by the Plasma C-Peptide Respnse t Intravenus Giucagn C. Hendriksen,
More informationPost Distribution Monitoring Report
Pst Distributin Mnitring Reprt Hygiene Kit funded by IMC Backgrund Infrmatin Lcatin: Zaatari Camp (All districts) Dates f data cllectin: 1-2 f Octber, 2014 Objective: t understand t what extent the distributin
More informationGUIDANCE DOCUMENT FOR ENROLLING SUBJECTS WHO DO NOT SPEAK ENGLISH
GUIDANCE DOCUMENT FOR ENROLLING SUBJECTS WHO DO NOT SPEAK ENGLISH Aurra Health Care s Research Subject Prtectin Prgram (RSPP) This guidance dcument will utline the prper prcedures fr btaining and dcumenting
More informationSignature Assignment. Course. ANTH 2346: General Anthropology. Assignment ID (to be assigned) Outcomes/Rubrics to be Assessed by the Assignment
Signature Assignment ANTH 2346: General Anthrplgy Outcmes/Rubrics t be Assessed by the Assignment Cmmunicatin Critical Thinking Empirical and Quantitative Reasning Scial Respnsibility Assignment Descriptin
More informationCommissioning Policy: South Warwickshire CCG (SWCCG)
Cmmissining Plicy: Suth Warwickshire CCG (SWCCG) Treatment Indicatin Criteria FreeStyle Libre Flash Cntinuus Glucse Mnitring System Type I Diabetes Prir apprval must be requested frm the Individual Funding
More informationImaging tests allow the cancer care team to check for cancer and other problems inside the body.
IMAGING TESTS This infrmatin may help answer sme f yur questins and help yu think f ther questins that yu may want t ask yur cancer care team; it is nt intended t replace advice r discussin between yu
More informationDIRECTED FORGETIING: SHORT-TERM MEMORY OR CONDITIONED RESPONSE? WENDY S. MILLER and HARVARD L. ARMUS The University of Toledo
The Psychlgical Recrd, 1999, 49, 211-220 DIRECTED FORGETIING: SHORT-TERM MEMORY OR CONDITIONED RESPONSE? WENDY S. MILLER and HARVARD L. ARMUS The University f Tled Previus researchers have interpreted
More informationRisk factors in health and disease
Risk factrs in health and disease Index 1 Intrductin 2 Types f risk factrs 2.1 Behaviural risk factrs 2.2 Psychlgical risk factrs 2.3 Demgraphic risk factrs 2.4 Envirnmental risk factrs 2.5 Genetic risk
More informationAnnex III. Amendments to relevant sections of the Product Information
Changes t the Prduct infrmatin as apprved by the CHMP n 13 Octber 2016, pending endrsement by the Eurpean Cmmissin Annex III Amendments t relevant sectins f the Prduct Infrmatin Nte: These amendments t
More informationASSESSMENT OF PITUITARY FUNCTION IN PATIENTS WITH SERUM PROLACTIN LEVELS GREATER THAN 100 NG/ML*t
FERTILITY AND STERILITY Cpyright 1979 The American Fertility Sciety Vl. 32, N.2, August 1979 Printed in U.s.A. ASSESSMENT OF PITUITARY FUNCTION IN PATIENTS WITH SERUM PROLACTIN LEVELS GREATER THAN 100
More information* CORRESPO~~ING AUTHOR. YAWS/PMVH/jtf-88 IN CENTRAL AFRICA IMMUNOFLUORESCENCE FOR DIAGNOSIS GONZALEZ. MARTIN. M.H. GEORGES-COURBOT M.C. PALISSON. M.J.
YAWS/PMVH/jtf-88 YA~S IN CENTRAL AFRICA CLINICAL ASPECTS AND USEFULNESS OF INDIRECT ABSORBED IMMUNOFLUORESCENCE FOR DIAGNOSIS MARTIN. P.M.V.* GONZALEZ. J.P. MARTIN. M.H. GEORGES-COURBOT M.C. PALISSON.
More informationCode of employment practice on infant feeding
Cde f emplyment practice n infant feeding An Emplyer s guide t: Sectin 69Y f the Emplyment Relatins Act 2000 Frewrd As Minister f Labur, I am pleased t publish the Cde f Emplyment Practice n Infant Feeding.
More informationIf, then. Homework: Finish entire guided notes packet. Name: Pod: Date: Which variable does a scientist manipulate or control in an experiment?
Unit 1: Scientific Thinking and Inquiry 6.2B Hyptheses, Materials, Prcedure OBJECTIVE(S): Obj 1 SWBAT write a testable hypthesis that answers an investigatin s questin. Obj 2 SWBAT write a detailed materials
More informationBedfordshire and Hertfordshire DRAFT Priorities forum statement Number: Subject: Prostatism Date of decision: January 2010 Date of review:
Bedfrdshire and Hertfrdshire DRAFT Pririties frum statement Number: Subject: Prstatism Date f decisin: January 2010 Date f review: Referral criteria Mst men with lwer urinary tract symptms due t benign
More informationHEALTH SURVEILLANCE INDICATORS: CERVICAL CANCER SCREENING. Public Health Relevance. Highlights.
HEALTH SURVEILLANCE INDICATORS: CERVICAL CANCER SCREENING Public Health Relevance Cervical cancer is 90% preventable by having regular Papaniclau (Pap) tests. The Pap test, als knwn as a cervical smear,
More informationWHAT IS HEAD AND NECK CANCER FACT SHEET
WHAT IS HEAD AND NECK CANCER FACT SHEET This infrmatin may help answer sme f yur questins and help yu think f ther questins that yu may want t ask yur cancer care team; it is nt intended t replace advice
More informationTHE SORPTION OF INFLUENZA VIRUS BY CHICKEN ERYTHROCYTES*
THE SORPTION OF INFLUENZA VIRUS BY CHICKEN ERYTHROCYTES* BY THOMAS P. MAGILL, M.D. (Frm the Department f Micrbilgy and Immunlgy, State University f New Yrk Cllege f Medicine at New Yrk City) (Received
More informationpotassium status of patients with heart failure
Pstgraduate Medical Jurnal (June 1978) 54, 45-49. The effects f ptassium supplements, spirnlactne r amilride n the ptassium status f patients with heart failure C. DAVIDSON M.A., M.B., M.R.C.P. D. B. MORGAN
More informationForensic Science: Fundamentals & Investigations, 2e Chapter 2. All rights Reserved Cengage/NGL/South-Western 2016
1 Frensic Science: Fundamentals & Investigatins, 2e Cengage/NGL/Suth-Western 2016 Crime-Scene Investigatin and Evidence Cllectin By the end f this chapter yu will be able t: 2.1 Summarize Lcard s Principle
More information