Inflammatory Disease. Part I. Infections
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1 Inflammatory Disease Part I Infections
2 Bacterial, Fungal and Viral Infections of the Head and Neck
3 Sexually Transmitted Diseases Lomaki, Middle Mesa Petroglyphs Northern Arizona Herpesviruses I, II Clamydia Treponema Gonococci Papillomavirus HIV Hepatitis B, C
4 Bacterial Infections Pulpitis, periapical infections, spread of infection Space infections, osteomyelitis Periodontitis Sialadenitis Specific infections Syphilis (Treponema) Tuberculosis (Mycobacterium) Actinomycosis (Actinomycetes) Cat Scratch fever (Rochinella) Rhinoscleroma (Klebsiella)
5 SYPHILIS PRIMARY Chancre 2-4 weeks SECONDARY Maculopapular rash, Mucous patches Split papules TERTIARY Gummatous necrosis, Neurosyphilis, Aneurysm
6 SYPHILIS Treponema pallidum Diagnostic Tests VDRL FTA TPI
7 Primary Syphilis - Chancre
8 Secondary Syphilis
9 Tertiary Syphilis
10 CONGENITAL SYPHILIS Saddle Nose Mental Retardation Blindness Short Stature Saber Shins
11 Saber Shins
12 HUTCHINSON S TRIAD DENTAL DEFECTS Notched Screwdriver Centrals Pegged Laterals Mulberry Molars BLINDNESS DEAFNESS
13 Congenital Syphilis Notched Centrals, Mulberry Molars
14 TUBERCULOSIS Mycobacterium tuberculosum Primary, Secondary, Miliary Metastatic, Scrofula, Lupus vulgaris Mycobacterium aviium intracellulare HIV nonpulmonary infection
15 Tuberculosis Scrofula Oral Granuloma
16 ACTINOMYCOSIS Actinomycetes, elongated rods Sulfur Granules aggregated colonies Cervicofacial form Osteomyelitis of the mandible Soft tissue abscess Periapical abscess
17 Actinomycosis PAS stain
18 CAT SCRATCH FEVER Feline Claws Rochinella bergdorfdi Lymphadenitis Necrotizing Granuloma
19 Cat Scratch Fever Necrotizing granuloma
20 Fungal Infections Superficial Candidiasis Geotrichosis Invasive Histoplasmosis Coccidioidomycosis Blastomycosis Mucormycosis Asperigillosis Rhinosporidiosis Allergic fungal sinusitis (Bipolaris fungi)
21 CANDIDIASIS Pseudomembranous Erythematous Angular Cheilitis Median Rhomboid Glossitis
22 Pseudomembranous Candidiasis
23 Erythematous Candidiasis
24 Angular Cheilitis
25 Median Rhomboid Glossitis Multinodular mass Midline posterior tongue Adult onset Surface colonized by Candida
26 MYCELIA PAS STAIN Parakeratin layer, biospy Cytologic smear
27 Antifungals Nystatin Pastilles or Vaginal Tabs Nystatin Cream or ointment Chlotrimazole (Mycelex) Troches Ketaconazole (Nizoral) 100 mg
28 DEEP INVASIVE FUNGI Granulomatous Inflammation Special Stains (PAS, GMS) Microorganisms Histoplasmosis* Coccidioidomycosis* Blastomycosis* Cryptococcosis Tissue Tropism Pulmonary* and nonpulmonary
29 DEEP INVASIVE FUNGI Clinical Giant Cells with Fungus
30 Histoplasmosis
31 MUCORMYCOSIS Zygomycosis, Phycomycosis Large Mycelia Antral Involvement Vascular Invasion and Ischemic Necrosis Debilitation Brittle IDDM Immunosuppression
32 Mucormycosis Radiograph Fungal organisms GMS PAS
33 ALLERGIC FUNGAL SINUSITIS Bipolaris Pleomorphic Fungi Aspergillosis may show similar features Sinusitis, Expansion, Bone Resorption Lesion due to Allergy not organism Eosinophilic Infiltrate Brown Sludge in Antrum
34 Allergic Fungal Sinusitis Radiograph Bipolaris Fungi
35 Viral Infections Human Papillomavirus Herpesvirus types I and II Varicella zoster Epstein Barr Enteroviruses Coxsackieviruses Mumps virus HIV and oral opportunists
36 Benign HPV Oral Papillary Tumors Verruca vulgaris - HPV 2,4 Squamous papilloma - HPV 6,11 solitary Condyloma acuminatum - HPV 6,11 multiple
37 Verruca vulgaris Clinical Histopath and DNA
38 Clinical, Gross Squamous Papilloma Histopathology
39 Condyloma Acuminatum Clinical Histopath & DNA HPV 6
40 Condyloma
41 Focal Epithelial Hyperplasia HPV 13 and 32 are viruses with a restricted tropism for oral mucosa Lesions evolve as multiple papules then progress to flattened nodules of the lips and buccal mucosa Children (more often seen in Amerindians) and HIV infected subjects Lesions persist for 6-12 months, then spontaneously regress Microscopic: Focal parakeratosis and nodular acanthosis, mitosoid bodies resembling mitotic figures are found in the mid spinous layer.
42 Focal Epithelial Hyperplasia HPV 13,32
43 Heck Disease (FEH) in HIV+ Patients
44 HERPES SIMPLEX 1,2 LYTIC INFECTION Keratinocytes LATENT INFECTION Ganglia
45
46 Primary Herpetic Gingivostomatitis
47 Herpes Labialis
48 Recurrent Intraoral Herpes
49 HSV Vesicle and Antigen
50 BALLOONING DEGENERATION
51 HERPETIC WHITLOW
52
53
54 Primary Varicella-Zoster (Chicken Pox)
55 Secondary VZV (Shingles)
56 Infectious Mononucleosis Epstein Barr Virus Malaise Lymphadenopathy Palatal Petechia Atypical Lymphocytes in Blood Other EBV associated diseases Oral Hairy Leukoplakia Burkitt s Lymphoma Nasopharyngeal Carcinoma
57 ENTEROVIRUSES ENTEROVIRUSES ECHOVIRUSES COXSACKIEVIRUSES POLIOVIRUSES
58 Hand, Foot & Mouth Disease
59 Herpangina
60 Lymphonodular Pharyngitis
61 Koplik Spots -Rubeola-
62 ENDEMIC PAROTITIS (MUMPS) Mumps virus Bilateral Painful Parotid Enlargement Pain on Salivation Fever Ten Day Course Orchitis Complication
63 MUMPS
64 HIV CD4 Lymphocyte Target CD4 and CCR5 Chemokine Receptor Latency of years AIDS = <200 CD4 Lymphocytes/mm3
65 HIV ASSOCIATED DISEASES Opportunistic Infections Pneumocystis pneumonia HSV, VZV, CMV Toxoplasmosis, Cryptosporidium Mycobacterium Aviium Intracellulare Candida, Histoplasmosis Neoplasms Kaposi s Sarcoma Malignant Lymphoma
66 HIV ORAL LESIONS CANDIDIASIS HAIRY LEUKOPLAKIA PAPILLOMAVIRUS LESIONS HIV GINGIVITIS HIV PERIODONTITIS HISTOPLASMOSIS, OTHER DEEP FUNGI KAPOSI S SARCOMA NON-HODGKIN S LYMPHOMA
67 Oral Opportunistic Infections Candidiasis Pneumocystis Herpes
68 Oral Hairy Leukoplakia EBV DNA
69 EBV virions Keratinocyte nucleus ultrastructure
70 HIV - Kaposi s Sarcoma Herpesvirus type 8
71 Epstein Barr Virus HIV - Lymphoma
72 HIV Periodontal Lesions HIV Gingivitis HIV Periodontitis
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