21 st ANNUAL CLINICAL CYTOMETRY MEETING AND COURSE. LONG BEACH, California October 6-10, 2006 PRELIMINARY PROGRAM

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1 CCS 21 st 1 ANNUAL MEETING 1 21 st ANNUAL CLINICAL CYTOMETRY MEETING AND COURSE LONG BEACH, California October 6-10, 2006 PRELIMINARY PROGRAM For more information visit

2 2 CCS 21 st ANNUAL MEETING CCS MISSION STATEMENT The primary purposes for which the CCS was founded are: to foster the development and implementation of clinical applications of cytometry in the diagnosis and management of human pathologic conditions; to stimulate and promote research in new applications of cytometry and allied disciplines; to promote professional advancement of all aspects of clinical cytometry; to foster education and the exchange of information among persons engaged in clinical cytometry by means of an annual meeting and a variety of other educational activities; to issue publications in the field of clinical cytometry; to interact with agencies, both private and governmental, which regulate, oversee, monitor and control the practice of clinical cytometry, in the interest of and for the benefit of clinical cytometry and the patient it serves. CCS EDUCATIONAL OBJECTIVES The objective of the Clinical Cytometry Society is to provide education in the field of clinical flow cytometry that will meet the needs of the beginner as well as the more experienced members. Through education, the society strives to improve the quality of care in the field. The Society provides technical training in the form of lectures, workshops and data lab sessions where participants are exposed to computer analysis of actual patient data. In addition, members are introduced to cutting edge research in the field so that they can anticipate the advent of new clinical tests and educate clinicians in their institutions concerning new potential roles clinical flow cytometry can play in patient management. MEETING/COURSE LEARNING OBJECTIVES The primary learning objectives for the 2006 Annual Clinical Cytometry Meeting and Course are the following: to discuss new insights in the field of Clinical Flow Cytometry to discuss and explain research in new applications of cytometry and allied disciplines to discuss available and proper techniques in Clinical Flow Cytometry

3 CCS 21 st 3 ANNUAL MEETING 3 OFFICERS J. Philip McCoy, Jr. (President) Michael Borowitz (Vice-President) W. Roy Overton (Treasurer) Brent Wood (Senior Councilor) Maryalice Stetler-Stevenson (Past-President) COUNCIL Maryalice Stetler-Stevenson J. Philip McCoy, Jr. W. Roy Overton Michael Borowitz Brent Wood David Barnett Joseph Digiuseppe Bruce Greig Teri Oldaker Akin Abayomi Caribbean and African Liaison PROGRAM COMMITTEE Michael Borowitz (Chair) Maria Arroz Joe Digiuseppe Mike Keeney J. Philip McCoy, Jr. Jonni Moore Teri Oldaker Don Herbert (corporate liaison)

4 4 CCS 21 st ANNUAL MEETING PROGRAM AT A GLANCE 8:00 8:30 9:00 9:30 10:00 10:30 11:00 11:30 12:00 12:30 1:00 1:30 2:00 2:30 3:00 Sunday October 8 Registration Opens Plenary Session I Regulatory Affairs 1:00-2:30 PM Monday October 9 Plenary Session II Microbiology and Immunology Coffee Break/ Exhibits 9:50-10:10 AM Luncheon Workshops / Exhibits Plenary Session III Hematopathology 1:30-4:00 PM Coffee Break/ Exhibits 3:00 3:15 PM 3:30 Commercial 4:00 Tutorials TBA Business Meeting 4:00-4:30 PM 4:30 Poster Session 5:00 2 / Exhibits 4:30-5:30 PM 5:30 6:00 6:30 7:00 7:30 8:00 8:30 9:00 9:30 - Poster Session 1 / Exhibits 5:00-6:00 PM Wallace Coulter Distinguished Lecturer 7:30-9:00 PM Opening Reception 9:00-11:00 PM Banquet Queen Mary 6:00-11:00 PM Tuesday October 10 Plenary Session IV Pediatric Flow Cytometry Coffee Break/Exhibits 9:50-10:10 AM Luncheon Workshops/Exhibits Plenary Session V In The Lab 1:30-4:30 PM Coffee Break 2:50 3:10 PM Plenary Session VI New Dev. in Stem Cells 1:30 4:30 PM Coffee Break 2:50 3:10 PM CSI Long Beach Case Study Interpretations 4:30-6:00 PM Pubcrawl Wednesday October 11 Concurrent Post- Conference Sessions Session I TBA Session 2 TBA

5 CCS 21 st 5 ANNUAL MEETING 5 PRESENTATION PROGRAM Sunday October 8, 2006 PLENARY SESSION I: REGULATORY AFFAIRS 1:00 2:30 PM SYP 1.1 How can the flow cytometry community interact more effectively with regulatory agencies? D. Mongillo 1:00-1:45 PM General Discussion 1:45-2:30 PM Commercial Tutorials 2:30-5:00 PM Poster Session I / Exhibits 5:00-6:00 PM Wallace Coulter Distinguished Lecturer 7:30-9:00 PM Opening Reception 9:00-11:00 PM Monday October 9, 2006 PLENARY SESSION II: MICROBIOLOGY AND IMMUNOLOGY SYP 2.1 SYP 2.2 Susceptibility and detection of M. tuberculosis using cytometry. C Pina-Vaz 8:30-9:05 AM Talk 9:05-9:10 AM Discussion Clinical relevance of monitoring cytomegalovirus (CMV)-specific immune responses after allogeneic stem cell transplantation. JW Gratama 9:10-9:45 AM Talk 9:45-9:50 AM Discussion Coffee Break/Exhibits 9:50 10:10 AM SYP 2.3 SYP 2.4 Effector cells of allergic disease: Basophils and Th2 cells. C Prussin 10:10-10:45 AM Talk 10:45-10:50 AM Discussion Regulatory T cells in human disease. T Chatila 10:50-11:25 AM Talk 11:25-11:30 AM Discussion Luncheon Workshops Lunch will be provided (Pre-Registration Required) WS 1.1 WS 1.2 WS 1.3 B cell lymphoproliferative disorders/ B cell non- Hodgkin lymphomas. Acute lymphoblastic leukemia. Standardization. PLENARY SESSION III: HEMATOPATHOLOGY 1:30-4:00 PM SYP 3.1 SYP 3.2 Flow cytometry of plasma cells. P Greipp 1:30-2:10 PM Talk 2:10-2:15 PM Discussion HDAC Inhibitor assays by flow cytometry. EJ Chung 2:15 2:55 PM Talk 2:55 3:00 PM Discussion Coffee Break/Exhibits 3:00 3:15 PM SYP 3.3 Molecular surrogates of leukemia detected by flow cytometry. E Paietta 3:15 3:55 PM Talk 3:55 4:00 PM Discussion CCS Business Meeting 4:00-4:30 PM All meeting attendees are invited. Poster Session II/Exhibits 4:30-5:30 PM

6 6 CCS 21 st ANNUAL MEETING Banquet Queen Mary 6:00-11:00 PM Sponsored by BD Biosciences Tuesday October 10, 2006 PLENARY SESSION IV: PEDIATRIC FLOW CYTOMETRY SYP 4.1 SYP 4.2 Flow cytometry diagnosis in pediatric immunology. M Paessler 8:30-9:05 AM Talk 9:05-9:10 AM Discussion Thymus function and approaches for T cell reconstitution. G Sempowski 9:10-9:45 AM Talk 9:45-9:50 AM Discussion Coffee Break / Exhibits 9:50-10:10 AM SYP 4.3 SYP 4.3 Flow cytometry in the diagnosis of congenital platelet disorders. L Jennings 10:10-10:45 AM Talk 10:45-10:50 AM Discussion Megakaryocytic leukemias in childhood. B Lorsbach 10:50-11:25 AM Talk 11:25-11:30 AM Discussion Luncheon Workshops Lunch will be provided. (Pre-Registration Required) WS 2.1 WS 2.2 T cell lymphoproliferative disorders/ T cell non- Hodgkin s lymphomas. Acute myeloid leukemia. CONCURRENT SYMPOSIA 1:30-4:30 PM PLENARY SESSION V: IN THE LAB 1:30-4:30 PM SYP 5.1 SYP 5.2 Technical only flow cytometry the view from the reference lab. K Bloom 1:30-2:05 PM Talk 2:05-2:10 PM Discussion Technical only flow cytometry the view from the hospital lab. B Wood 2:10-2:45 PM Talk 2:45-2:50 PM Discussion Coffee Break 2:50 3:10 PM SYP 5.3 SYP 5.4 Issues in intracellular staining. A Bakke 3:10-3:45 PM Talk 3:45-3:50 PM Discussion Laboratory readiness in the era of unannounced inspections. J Carey 3:50-4:25 PM Talk 4:25-4:30 PM Discussion PLENARY SESSION VI: NEW DEVELOPMENTS IN STEM CELLS 1:30-4:30 PM SYP 6.1 SYP 6.2 Dissecting the hematopoietic stem cell hierarchy. L Barsky 1:30-2:05 PM Talk 2:05-2:10 PM Discussion Markers of leukemia stem cells and their detection during therapy. G Schuurhuis 2:10-2:45 PM Talk 2:45-2:50 PM Discussion Coffee Break 2:50 3:10 PM WS 2.3 Myelodysplasia.

7 CCS 21 st 7 ANNUAL MEETING 7 SYP 6.3 SYP 6.4 Bone marrow-derived non-hematopoietic stem cells. M Ratajczak 3:10-3:45 PM Talk 3:45-3:50 PM Discussion Solid tumor stem cells and their detection. C Eaves 3:50-4:25 PM Talk 4:25-4:30 PM Discussion CSI LONG BEACH CASE STUDY INTERPRETATIONS 4:30-6:00 PM