DNA vaccine, peripheral T-cell tolerance modulation 185

Transcription

1 Subject Index Airway hyperresponsiveness (AHR) animal models asthma inhibition 45 overview 41 mast cell modulation of T-cells respiratory tolerance 40, 41 Tregs inhibition role 44 respiratory tolerance role 40 roles 44, 45 Allergen-specific immunotherapy (SIT) asthma management 45 autoimmune disease 204, 205 B-cell regulation 165 dendritic cell regulation 165, 166 histamine and antihistamine roles mechanisms 158, 159 peripheral T-cell tolerance antibody isotypes and effector cell suppression 162, 163 histamine receptors mechanisms Tregs activity induction 153, 154, CD4 CD25 cells 164, 165 clinical relevance 168, 169 histamine receptors 170, 171 miscellaneous cells 165 suppression mechanisms Th3 cells 164 Tr1 cells 163, 164 Allergic contact dermatitis, see Contact hypersensitivity Antigen-presenting cell, see B-cell; Dendritic cell; Langerhans cell; Macrophage Antihistamines, see Histamine Asthma airway hyperresponsiveness inhibition 45 overview 41 antihistamine therapy 72, 73, 77, 78 glucocorticoid receptor and T-cell-specific transcription factors molecular targets for therapeutic intervention 84 T-box expressed in T-cells deficiency 87, 89 Treg interactions Th2 cells 85, 86 Th17 cells 86, 87 Atopic dermatitis tacrolimus therapy 195 T-cell regulation adaptive immune responses involving immunoglobulin E responses 102 aeroallergen-specific T-cells and eczematous responses 102, 103 autoantigen immune response 104 CD8 T-cells 105 cellular infiltrates 102 cytokine secretion and regulation endothelium interactions 104 food-specific T-cells

2 Atopic dermatitis (continued) innate immune response defects 103 keratinocyte interactions 108, 109 microorganism activation 104 Th17 role 107 Treg role 107, 108 Autoimmune lymphoproliferative syndrome (ALPS), stem cell transplantation therapy 216 Basophil, allergy role 64 B-cell allergen-specific immunotherapy regulation 165 helminth parasite infection response 166, 117 histamine effects 76 Treg interactions 34, 35 CD8 T-cell, atopic dermatitis role 105 Contact hypersensitivity (CHS) animal model 94, 95 antigen-presenting cells 93 dendritic cell orchestration of skin immune response Treg role ultraviolet-b-induced immune tolerance 94 Dendritic cell (DC) allergen-specific immunotherapy regulation 165, 166 functional overview 189 fungal infection response 127, 128 histamine effects 74 lung cells activation and allergic inflammation and remodeling allergic airway inflammation activity 191, 192 bridging of innate and adaptive immunity 190 therapeutic targeting 195, 196 tolerance induction 190, 191 Treg control 192 respiratory tolerance role 40 skin immune response orchestration Treg interactions allergic and inflammatory reactions dendritic cell maturation status and Treg induction potential 29, 30 suppression by Tregs Diabetes mellitus type 1, stem cell transplantation therapy 215, 216 DNA vaccine, peripheral T-cell tolerance modulation 185 Eczema, see Atopic dermatitis Eosinophil, histamine effects 72 Experimental autoimmune encephalitis (EAE), antigen-based therapy 204 Foxp3 mutation and disease 22, 24, 96 transcriptional regulation Foxp3 22 Treg transcriptome Treg expression 8, 9 roles development 18 function 17 FTY720, dendritic cell effects in allergic disease 195 Fungal infection adaptive immunity 128, 129 allergic diseases and features dendritic cell response 127, 128 innate immunity 126, 127 pathogens 124 reverse and noncanonical signaling Th17 response 129, 130 Th1/2 cell response 128, 129 Treg dampening of inflammation and allergy tryptophan catabolism 133, 134 Glucocorticoids, asthma management and resistance 45, Helminth parasite infection allergy and autoimmunity therapy lessons 120 autoimmune disease protection 115 epidemiology immune regulation animal model studies 117, 118 B-cells 166, 117 innate immunity 119, 120 T-cells 115, 116, 118 treatment of inflammatory diseases 117 Histamine allergen-specific immunotherapy roles antigen-presenting cell regulation 74 asthma and antihistamine therapy 72, 73, 77, Subject Index

3 B-cell effects 76 chronic inflammatory responses overview 67, 68 peripheral T-cell tolerance and receptors receptors regulatory/suppressor functions of HR2 161 synthesis and metabolism 70 T-cell effects Immune dysregulation, polyendocrinopathy, enteropathy X-linked (IPEX) syndrome Foxp3 mutations 22, 24, 96 stem cell transplantation therapy 216, 217 Immunoglobulin E (IgE), monoclonal antibody therapy 186 Indoleamine 2,3-dioxygenase (IDO) fungal allergy regulation 133, 134 therapeutic targeting in asthma 84 Interferon- (IFN- ) delayed-type hypersensitivity suppression by ocular-induced CD8 Treg mediation 145, 146 therapeutic targeting in asthma 84, 91 Interleukin-6 (IL-6), bridging of innate and adaptive immunity 84, 85 Interleukin-10 (IL-10), T-cell anergy role 181, 182 Interleukin-25 (IL-25), inflammatory response in allergic diseases 183 Keratinocyte, T-cell interactions in atopic dermatitis 108, 109 Langerhans cell, mast cell priming of adaptive immune responses and allergic sensitization 59, 60 Lung dendritic cells, see Dendritic cell Macrophage histamine effects 74 Treg interactions Mast cell functional overview 58, 59 priming of adaptive immune responses and allergic sensitization T-cell modulation in airway hyperresponsiveness Monocyte, see Macrophage Natural killer (NK) cell allergy role cytokine profiles inflammatory response in allergic diseases 183 lytic activity 50 receptors 50, 51 subsets Neutrophil, histamine effects 72 Omalizumab, peripheral T-cell tolerance modulation 186 Peptide immunotherapy (PIT) peripheral T-cell tolerance regulation 162, 184, 205 Treg expansion Peripheral T-cell tolerance aberrations in allergic disease 179, 181 allergen-specific immunotherapy antibody isotypes and effector cell suppression 162, 163 histamine receptors mechanisms , 184 allergic inflammatory response pathobiology immunotherapeutic approaches for regulation inflammatory response in allergic diseases interleukin natural killer cells 183 thymic stromal lymphopoietin 183 tumor necrosis factor- 182, 183 T-cell anergy 181, 182 Prostaglandin D 2, dendritic cell effects in allergic disease 195 Qa-1 b, restriction of delayed-type hypersensitivity suppression by ocular-induced CD8 Tregs 144, 145 Regulatory T cell, see Treg Retinoic acid, T-cell modulation 24 Rheumatoid arthritis (RA), stem cell transplantation therapy 215 Stem cell transplantation (SCT) autoimmune disorder management autoimmune lymphoproliferative syndrome 216 diabetes mellitus type 1 215, 216 Subject Index 223

4 Stem cell transplantation (SCT) (continued) immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome 216, 217 prospects 217, 218 rationale 213, 214 rheumatoid arthritis 215 systemic lupus erythematosus 214, 215 systemic sclerosis 215 goals 212, 213 overview 211, 212 safety and efficacy 213, 214 Systemic lupus erythematosus (SLE), stem cell transplantation therapy 214, 215 Systemic sclerosis, stem cell transplantation therapy 215 Tacrolimus, atopic dermatitis management 195 T-box expressed in T-cells (T-bet), deficiency in asthma 87, 89 Th1 cell cytokine profile 1, 2 differentiation 4, 5, 88 functional overview 2, 3 fungal infection response 128, 129 Th2 cell cytokine profile 1, 2 differentiation 4, 5, 88 functional overview 2, 3 fungal infection response 128, 129 Treg interactions in asthma 85, 86 Th17 cell atopic dermatitis role 107 cytokine profile 2 differentiation 4, 5, 88 fungal infection response 129, 130 inflammation role 4 Treg interactions in asthma 86, 87 Thymic stromal lymphopoietin (TSLP) inflammatory response in allergic diseases 183 lung dendritic cell maturation role 193, 194 Toll-like receptors (TLRs) fungal infection 126, 127, 134 Treg activity induction with ligands 154, 155 Transforming growth factor- (TGF- ) delayed-type hypersensitivity suppression by ocular-induced CD8 Treg mediation 146, 147 T-cell anergy role 181, 182 Treg airway hyperresponsiveness inhibition role 44 respiratory tolerance role 40 roles 44, 45 allergen-specific immunotherapy mediation activity induction 153, 154, CD4 CD25 cells 164, 165 clinical relevance 168, 169 histamine receptors 170, 171 miscellaneous cells 165 suppression mechanisms Th3 cells 164 Tr1 cells 163, 164 allergic disease inhibition induction of Treg activity allergen-specific immunotherapy 153, 154 Toll-like receptor ligands 154, 155 mechanisms mouse models 151 therapeutic prospects 155, 156 allergy role 3, 4 antigen-presenting cell interactions B-cells 34, 35 dendritic cells allergic and inflammatory reactions maturation status and Treg induction potential 29, 30 maturation suppression by Tregs macrophages atopic dermatitis role 107, 108 contact hypersensitivity modulation development 9 12, 17, 18, 88, 150, 151 Foxp3 expression 8, 9 mutation and disease 22, 24, 96 roles development 18 function 17 transcriptional regulation Foxp3 22 Treg transcriptome functional overview 2, 9, 12, 13 fungal infection and dampening of inflammation and allergy heritable disorders 22, 24 histamine effects lung dendritic cell control Subject Index

5 natural resolution of autoimmune and allergic inflammation natural versus induced cells 21, 22, 43, 44, 182 ocular-induced CD8 Tregs afferent and efferent mechanisms anterior chamber-associated immune deviation 141 delayed-type hypersensitivity suppression animal studies 140, 141 antigen specificity 143, 144 interferon- mediation 145, 146 Qa-1 b restriction 144, 145 transforming growth factor- mediation 146, 147 overview 138, 139 suppressor activity 139, 140 products 2, 16 subtypes 83, 150 Th2 cell interactions 85, 86 therapeutic interventions 24 Tumor necrosis factor- (TNF- ), inflammatory response in allergic diseases 182, 183 VAF347, dendritic cell effects in allergic disease 196 Subject Index 225

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