Index. in tissue, 87-89

Transcription

1 ANA titers, Adult atopic dermatitis, 239 Allergens, contact dermatitis, 253 Allergic contact dermatitis Acontact sensitivity, cellular participants in, 258 factors influencing incidence of, 254 'hardening', 252 immunization, routes of, 261 immunological aspects, 256 inflammation, mechanisms of, 262 in vitro diagnosis, 265 latent sensitivity, 253 lymphocyte mediated vasculitis, sensitizing agents, nature of, 256 tolerance and unresponsiveness, 263 llergic responses, vasculitis, 193 Allergic vasculitis, Anaphylatoxin activity, 194 ntibodies anti-nuclear (ANA), 32, anti-reticulin, 33-36, 50 auto-antibodies, 18,30,88, 168,251 circulating to cytoplasmic components III tissue, cytotoxic circulating, 174 DNA,102 heterologous, 177 histocompatability (HL-A), humoral, 88, 176 platlet, in SLE, 88 tracing, vasculitis, 196 tumor-specific cytotoxic, 174 Antigen antibody complexes, vasculitis, 193, 205 antibody reaction, vasculitis, 200 levels, 202 tracing, 195, 196 Anti-malarials and DLE, 119 Anti-nuclear antibodies (ANA) complement-fixing, ability of, dermatitis herpetiformis, 32 lupus erythematosus, Anti-reticulin antibodies, 32-35, 38 celiac disease, 35 detection of, 36 immunofluorescence, 50 Antisera, 197 Anti-tumor immunity, 154, 155, Anti-tumor reactivity to malignant melanoma, 157 by lymphocytes, by serum antibodies, Arthus reaction, I Arthus response, Ataxia-telangiectasia, 247 Atopic dermatitis, adult, 239 ataxia-telangiectasia, 247 auto-antibodies, 251 cell-mediated immunity, 249 childhood, 238 contact dermatitis, 250 distribution pattern of lymphocytes, 220 IgE, , 245 immunological aspects, 239 relation to immuno-deficiency states, selective IgA deficiency, 247 short-latency IgG, 243 skin sensitizing factors, 240 Auto-antibodies, 18, 30 atopic dermatitis, 251 melanoma, 168 SLE,88 Auto-immune character of SLE, 113 B-lymphocytes, 155, 208, 259 Barrier (secondary) filters, 4 Basement membrane antibodies, 40, 41 Basophil mediated release, Bovine serum albumin, 202 Bursa of Fabricius, 258, 259 Bursa-dependent system, 155, 259 Clq components of complement, 47 C3 immune adherance, 203 Celiac disease, 30 adult and childhood, 35 anti-reticulin antibodies, 35 exocrine levels of immunoglobulins, 40 Cell mediated hypersensitivity in vasculitis, 193, 221 immunity in atopic dermatitis, 249 Cellular hypersensitivity, vasculitis, 208 Chemotaxis, 14 Childhood atopic dermatitis, 238 Chronic disseminated DLE, 69 Circulating antibodies to cytoplasmic componenets in tissue, Circulating immune complexes,

2 286 Complement binding of, 13 Clq components, 47 C3 deposits, 41 fixation by ANA in lupus erythematosus, 82 pathways, 'classical' and 'alternate', 47 studies in dermatitis herpetiformis, 45 system in vasculitis, 194, Condensers, 5, 198 Contact dermatitis, see Allergic contact dermatitis Contact sensitivity of allergic contact dermatitis, 258 Coombs and Gcll's classification of allergic responses in vasculitis, 193 Corticosteroid therapy in D LE, Cross-reactivity between gluten and reticulin, 37, 49 Cryoglobulinemia, mixed IgG-IgM complexes in, 215, 216 Cytoplasm in immunofluorescent staining, 164, 167, 168 Cytostat section method, 196, 197 Cytotoxic circulating antibodies, 174 reactions in vasculitis, 193 DLE see discoid lupus erythematosus DNA and DNA antibodies, 102 Dapsone, of, 28, 29, 38, 55 Delayed hypersensitivity eczema, 262 reaction by tumors, 1 75 SLE, vasculitis, , 221 Dermatitis see eczema Dermatitis herpetiformis complement studies, 45 diagnosis, criterion for making, 45 Duhrings concept, epithelium, 27 exocrine levels of immunoglobulins, 40 histology, 25, 26 juvenile, 24, 25 small intestines, Dermatomyositis, co-existence with SLE, 119 Direct immunofluorescence, 8 vasculitis, 195, 196,212,218 Discoid lupus erythematosus, (DLE), 66 anti-malarials, 119 chronic disseminated, 69 clinical aspects, 68 genetic aspects, immunofluorescent bands, skin lesions resembling, 69 transition of into SLE, 68 ultra-violet light, role of, 110, III Immunological aspects of skin diseases Drug-induced SLE-like syndromes, 109 Duhrings concept of dermatitis herpetiformis, Eczema atopic dermatitis, classification of, contact dermatitis, immunological factors in various forms, 236 photoallergic contact dermatitis, 268, 269 secondary dissemination, 269, 270 Enteropathy, dermatitis herpetiformis, 27 Erythema lesions co-existent with D LE and SLE,99 Erythroderma, 271 Excitation filters, 4 Exocrine levels of immunoglobulins in celiac disease and dermatitis herpetiformis, 40 Fibrin deposition, 48 Filters, 4, 197, 198 Fluorescence, 3 Flourescent microscopy, 4 anti-tumor reactivity, 169 vasculitis, 197, 198 Fluorescent patterns, lupus erythematosus, Generalized Schwartzman reaction, 205 Genetic aspects of lupus erythematosus, Genetic factors of contact dermatitis, 254 Gluten challenge, 41 cross-reactivity with reticulin, 37, 49 fraction III, 49 free diet, 24, 27-29, 35 effect on skin lesions, 24, 28 sensitivity, 27 Gougerot-Rutter syndrome, 211, 212 HL-A see histocompatability antigens Hapten-protein complexes, 257, 258 Hardening, allergic contact dermatitis, 252 Hematoxyphil bodies, 87 Hemorragic arthus reaction, 199 Heterologous antibodies, 177 Histocompatability antigens (HL-A), Histology of dermatitis herpetiformis, 25 Human vasculitis in relation to experimental models, Humural antibodies melanoma, 176 SLE, 88 IgA deficiency, 29, 30, 38 selective, 39, IgA mediated immune complex reaction, 41

3 IgA secretory piece, 48 IgE in atopic dermatitis, , 245 IgE mediated hypersensitivity mechanisms involved in, vasculitis, 193 IgG antigen, 199, 200 IgM deficiency, 30 IgND, 241, 242 Illumination, 198 Immune complex disease see serum sickness Immune responses, vasculitis, 193 Immunization, routes of in allergic contact dermatitis, 261 Immuno-defiCiency states, rclation of to atopic dermatitis, Immunofluorescence anti-reticulin antibodies, 50 melanoma, 164, 169 vasculitis, Immunofluorescent (IF) bands in lupus erythematosus, Immunofluorescent test, 3-11 staining procedures, 8, 9 Immunoglobulin bearing lymphocytes, 208 classes of ANA, 82 deficiencies in atopic dermatitis, 248, 249 deposits, 42 E, , 245 levels, 29 gut, 29, Immunohistochemical studies of the skin, Immunological aspects allergic contact dermatitis, 256 atopic dermatitis, 239 Schwartzman reaction, 207 Immunoreactivity against melanomas detecting, methods of, incidence, stimulation by specific immunization, 174 Immunosuppressants, 12 1 Immunotherapy for melanoma, 177 Indirect immunofluorescence, 9, 32, 33 vasculitis, 196 Infantile atopic dermatitis, 238 Inflammatory lesions, vasculitis, 202 Intraepitheliallymphocytes, 41 III vilro complement-fixation by ANA, diagnosis of allergic contact dermatitis, 265 immunoreactivity, significance of, 174 Juvenile dermatitis herpetiformis, 24, 25 LE panniculitis see lupus erythematosus profundus Kaposi-Irgang LE phenomena, Lamina propria, lymphocytic infiltration of, 53 Latent sensitivity in allergic contact dermatitis, 253 Leprosy, 221, 222 Leukoclastic vasculitis, 212, 213 Light microscopy, 25, 26 Lipopolysaccharide (LPS), 205, 206 Local Schwartzman reaction, 205 Lupus erythematosus profundus Kaposi Irgang (LE panniculitis), 70, 71 Lymphocytes, 53, 258, 259 anti-tumor reactivity by, blast transformation in SLE, 113 intraepithelial, 41 mediated responses in vasculitis, mediated vasculitis, transformation test, 265 Lymphocytic infiltration, 27 Tessner, 69 iamina propria, 53 melanoma, 175 Lymphoma of the small intestine, 53 Lymphoreticular dysfunction, 30 Malignant melanoma auto-antibodies, 168 experimental data on melanoma immunity, history, immunological reactivity against mechanisms, immunoreactivity against, incidence of, immunoreactivity ill vitro, mechanisms of detecting, Melanoma immunity, in animals, 176, 177 Membrane-bound vacuoles, 28, 48, 55 Membrane immunofluorescent staining, 164, 165 Meningococcemia, 2 17 Microabscesses, 26 Microscopes, 4 Microscopy see fluorescent microscopy Migration inhibition factor (MIH), vasculitis, 209, 210 test, 266 Mixed IgG-IgM complexes in cryoglobulinemia, 215 Monocyte, 208 Mononuclear cells, vasculitis, 193 Myasthenia gravis and SLE, 116 Mycobacteria, 213 Mycobacterium ieprae, 221 Mycoplasma hyorhillis, 214

4 288 Neutrophil mediated release, 203 response, vasculitis, Nickel sensitivity, 250 Nodular vasculitis, 213 Nucleophagocytosis, 86 PMN leukocytes, 211, 212 Passive arthus reaction, 199, 200 Passive cutaneous anaphylaxis (pea), 244 Passive transference, 16 Patch testing, 266, 267 Pathways, complement, 47 Pemphigoid, 11-16, 22 Pemphigus, co-existence with DLE, 117 Penicillin reaction, toxicodermia, 222 Periarteritis nodosa, co-existence with SLE, 119 Phagocytosis of melanoma cells, 176 Photoallergic contact dermatitis, 252, 268 Photoallergic drug eruptions, 222, 223 Photohemagglutinin in (PHA), 266 Platlet activating factor (PAF), 203, 204 Platlet antibodies in SLE, 88 Polio vaccine and celiac disease, 39 Polyarthritis, 214 Polymorphonuclear leukocytes, chemotaxis of,14 Porphyria cutanea tarda, 96 Prausnitz-Kustner (PK) test, 240, 241, 244 Procoagulant activity, 206 Proteins in complement system, 194 Purified protein derivative (PPD), 208 Purpurid pigmented lichenoid dermatitis, 212 Reactive passive artbus reaction, 199 Reiter's syndrome, 214 Renal lesions in vasculitis, 2 I 5 Reticulin, cross-reactivity with gluten, 37, 49 Rheumatoid arthritis SLE,118 vasculitis, 2 I 4 Rheumatoid factor in SLE, 88 SLE see systematic lupus erythematosus SLE-like syndromes drug-induced, 109 in experimental animals, 108 Secondary dissemination, 269, 270 Secondary filters see barrier fllters Selective IgA deficiency, 39, Senear-Usher syndrome, I 17 Sensitivity in allergic contact dermatitis, 253 Immunological aspects of skin diseas e Serum complement levels in SLE, 88 system in vasculitis, 194, 195 Serum cycroglobulins, 215 Serum cytotoxicity in malignant melanomas, 163 Serum-immunoglobulin levels in dermatitis herpetiformis, 29, 30 Serum sickness, , Short latency IgG, 243 Schwartzman reaction, 194, ,217,218 Sjogren's syndrome, 118 Skin, immunity of, Skin lesions effect of gluten-free diet, 28 immunofluorescent bands, 95 resemblance to DLE, 69 Skin sections, preparation of in vasculitis, 196, 197 Skin-sensitizing factors in atopic dermatitis, 240 Small intestine dermatitis herpetiformis, epithelium, 27 lymphoma, 53 Specific immunization, stimulation of immunoreactivity by, 174 Splenic atrophy, 30, 54 Staining cytoplasm immunofluorescent, 164, 167, 168 membrane immunofluorescent, 164, 165 procedures, 8, 9 Sulphapyridine, 24 Sulphones, 24 Syndromes drug-induced SLE-like, 109 Reiter's, 214 SLE-like in experimental animals, 108 Senear-Usher, I I 7 Sjogren's, 118 Wiskott-Aldrich, 247, 249 Systematic lupus erythematosus (SLE), 67 as an immune complex disease, auto-antibodies, 88 auto-immune character of, I 13 circulating antibodies, 87 clinical aspects of, co-existence with other auto-immune disease, 113-II 9 corticosteroid therapy, delayed hypersensitivity, I I I-I 13 genetic aspects of, immunofluorescent bands, rheumatoid arthritis, I 18 rheumatoid factor, 88 transition of from DLE, 68 ultraviolet light, role of, 110, II I

5 vasculitis, 216 viruses, p o s ~ rde i b lof, e T-Iymphocytes, 155, 259 Tests anti-reticul!n antibody, detection of, 36, 37 cytoplasm Immunofluorescent staining, , 168 ' immunofluorescent, 3-11 lymphocyte transformation, 265 membrane immunofluorescent staining ', migration inhibition, 266 patch testing, 266, 267 P r ~ u ~ n i t z(pk), - K u240, s t244 n e r stalrung procedures, 8, 9 Thymus-dependent system Tissue injury in Arthus r e a ~ t200 i o n 201 ' Vacuoles, membrane-bound, Vasculitis ', antibody tracing, 196 antigen tracing, 195, 196 antisera, 197 definition, 192 human vasculitis, immunofluorescent methods, 195 lymphocyte mediated responses, , allergic contact dermatitis, leprosy, 221, 222 p h ~ t o a ldrug l e reruptions, g i c 222, 223 toxlcodermia, 222 microscopy, 197 neutrophil mediated responses, ' Arthus reaction, , serum sickness, , Toxic reactions involved in' S h ~ a r t z m a n reaction, 207 Toxicodermia, 222 Tumor-specific cytotoxic antibodies, 174 Schwartzman phenomenon, , ' Vasoactive amines, 202, 203 Viruses, possible role of in SLE, Ultraviolet light, role of in lupus erythematosus, 101, 111 White Arthus reaction, 199 Wiskott-Aldrich syndrome, 247, 249