Opinion on QRA SCCP 24 June 2008
|
|
- Roland Harrison
- 5 years ago
- Views:
Transcription
1 Opinion on QRA SCCP 24 June 2008 Jeanne Duus Johansen National Allergy Research Centre Department of Dermato-allergology Copenhagen University Hospital Gentofte Denmark
2
3 Background Many commonly used fragrance substances have a well-known sensitization potential. Necessary to establish concentration limits below which they do not pose a danger for consumers IFRA submission of documents to The Commission on the QRA approach
4 Submission
5 Terms of reference
6 Introduction IFRA standards Most concerns sensitization Historically: 1/10 of no-effect concentrations determined in experimental sensitization assays, such as Human Repeated Insult Patch Test New models Based on: Predicted no effect levels of sensitization from experimental models Safety factors Exposure assessment
7 Assessment I. Target population II. Dose-response assessment or hazard quantification III. Sensitization assessment factors (SAFs) IV. Exposure assessment V. Risk characterization VI. Confirmation of predicted use levels for fragrance ingredients VII. General discussion/summary VIII. Conclusion
8 QRA-expert group: I.a Target population
9 I.b Target population QRA-expert group: SCCP:
10 II. Dose-response assessment or hazard quantification QRA-expert group:
11 SCCP:
12 III. Sensitization assessment factor Diseased skin?
13 SAFs
14 SAFs
15 Matrix
16
17 SAFs
18 IV. Exposures
19 V. Risk characterization/limits Old IFRA standard: Isoeugenol Restricted 1998: 0.02% The QRA model allows: 0.1% in hydroalcoholic products 0.04% for shaved skin 0.01% for deodorants Out of 33 product categories: - 25 are cosmetics with skin contact in 22/25 (88%) isoeugenol will be permitted in higher concentrations Isoeugenol is often used in hydroalcoholic products were the permitted concentration will be increased and rarely in deodorants were it will be lowered.
20 Pragmatic levels
21 Pragmatic levels
22 VI. Confirmation of use levels N=3223 patients from Leuven, 133 reacting to their own products
23
24 Example Products which have caused fragrance allergy Analysis of patients ; 10.1% had a fragrance allergy Heisterberg M et al. 2011
25 Causative fragrance ingredients HICC Heisterberg M et al. 2011
26 Trend of HICC allergy 3.5 Figure 1. Prevalence of positive patch test reactions to hydroxyisohexyl 3-cyclohexene carboxaldehyde over time Subjects tested by the Danish Contact Dermatitis Group women and men men women Trend line (women and men) IFRA-limit: 1.5% 0.15% 0.02% Heisterberg M 2012
27 Relevant exposures to HICC unchanged 100 Figure 2. Frequency of clinical relevance of a positive patch test reactions to hydroxyisohexyl 3-cyclohexene carboxaldehyde overtime N= 928 with a positve patch test Current relevance Clincal relevance (past and present) present relevance past relevance Lineær (Clincal relevance (past and present))
28 Summary HRIPT lack of in-depths method description No clear guidance for the choice of test concentration No experience outside industry: reliabilty, sensitivity. Ethical concerns Does not consider protection of consumers who have already become sensitized Unclear how the QRA model covers the substantial part of the population, who suffer from skin disease (SAFs?)
29 Summary The QRA does not seem to consider: The contents of: structurally similar ingredients cocktails of allergens Aggregated exposures (from several product types) Occupational exposures
30 Summary No scientific data exist to support the levels as safe for the consumer other that the calculations in the model itself. Implementation of the model will allow increased exposure to well-known allergens in most product types compared to the current situation Use of pragmatic levels makes it difficult to use out-side industry This makes it difficult to have confidence in the model.
31 Conclusion
32 Conclusion
Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients*
Contact Dermatitis Original Article COD Contact Dermatitis Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients* Maria V. Heisterberg 1,TorkilMenné 1, Klaus E. Andersen
More informationSkin allergy to chemicals
Skin allergy to chemicals clinical, epidemiological and public health perspectives Jeanne Duus Johansen National Allergy Research Centre Department of Dermato allergology Copenhagen University Hospital
More informationDermal Sensitization Quantitative Risk Assessment (QRA) For Fragrance Ingredients
Dermal Sensitization Quantitative Risk Assessment (QRA) For Fragrance Ingredients Anne Marie Api, PhD Vice President, Human Health Sciences Research Institute for Fragrance Materials, Inc. Tel.: 201.689.8089
More informationAnnex III: Tabular summary of dose-elicitation studies in sensitised patients
Annex III: Tabular summary of dose-elicitation studies in sensitised patients Contents Chloroatranol... 2 Cinnamal... 4 Hydroxycitronellal... 6 Hydroxyisohexyl 3-cyclohexenecarboxaldehyde (HICC)... 8 Isoeugenol...
More informationCritical Comment. Evaluation of. selected sensitizing. fragrance. substances
1 Critical Comment on Evaluation of selected sensitizing fragrance substances A LOUS follow-up project The Danish EPA, Copenhagen (2016) Prof. Dr. med. Axel Schnuch IVDK / University of Göttingen Von Bar
More informationPotency classification of skin sensitizers (EC WG on Sensitization)
Potency classification of skin sensitizers (EC WG on Sensitization) Carola Lidén, Professor, MD 1 Occupational and environmental dermatology Clinical, experimental and epidemiological research Risk assessment
More informationSCIErfflFIC COÍYÖVHTTE'E OM COWSUIVCEÄ ЗАЖТУ. 'R«iļH«sl ier a sdfiötffic opaíloa: Submissiën II «n íregraace ysm'frryi acetate -
SCIErfflFIC COÍYÖVHTTE'E OM COWSUIVCEÄ ЗАЖТУ 'R«iļH«sl ier a sdfiötffic opaíloa: Submissiën II «n íregraace ysm'frryi acetate - 1, _ Yeîiveryl acetate (CAS n, 62JÕ3-8Ü-Õ/ 84U82-84-S/ 117-98-0) has a long
More informationClinical relevance of positive patch test reactions to the 26 EU-labelled fragrances van Oosten, Eleonoor J; Schuttelaar, Maria; Coenraads, Pieter
University of Groningen Clinical relevance of positive patch test reactions to the 26 EU-labelled fragrances van Oosten, Eleonoor J; Schuttelaar, Maria; Coenraads, Pieter Published in: CONTACT DERMATITIS
More informationMemorandum on use of Human Data in risk assessment of skin sensitisation
Scientific Committee on Consumer Safety SCCS Memorandum on use of Human Data in risk assessment of skin sensitisation The SCCS adopted this memorandum at its 12th Plenary meeting on 15 December 2015 1
More informationOPINION ON HYDROXYISOHEXYL 3-CYCLOHEXENE CARBOXALDEHYDE (HICC)
SCCP/1456/11 Revision of 27 July 2012 Scientific Committee on Consumer Safety SCCS OPINION ON HYDROXYISOHEXYL 3-CYCLOHEXENE CARBOXALDEHYDE (HICC) The SCCP adopted this opinion at its 13 th plenary of 13-14
More informationPatch testing with fragrance mix II: results of the IVDK
Contact Dermatitis 2010: 63: 262 269 Printed in Singapore. All rights reserved 2010 John Wiley & Sons A/S CONTACT DERMATITIS Patch testing with fragrance mix II: results of the IVDK 2005 2008 Andrea Krautheim
More informationIdentification of the causes of an allergic reaction to a fragranced consumer product #
Recommended Practice Received 30 March 2010; Revised 2 June 2010; Accepted 20 July 2010; Published online in Wiley Online Library (wileyonlinelibrary.com) DOI 10.1002/ffj.2021 Identification of the causes
More informationValidity of the QRA Methodology & Possibilities of Further Refinement
Report on the IDEA Workshop on Validity of the QRA Methodology & Possibilities of Further Refinement March 11-13, 2014 Dolce La Hulpe Brussels Chaussée de Bruxelles, 135 B-1310 La Hulpe, Belgium 1. Background
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCCP
SCCP0084704 EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion
More informationFeasibility of a study to assess the effectiveness of QRA
Rapporteur s Progress Report on the 2 nd IDEA Working Group meeting on the Feasibility of a study to assess the effectiveness of QRA February 15 th, 2017 from 9:00 to 16:00 Martin s Klooster Hotel Onze
More informationThe Critical Review of Methodologies and Approaches to Assess the Inherent Skin Sensitization Potential (skin allergies) of Chemicals No
The Critical Review of Methodologies and Approaches to Assess the Inherent Skin Sensitization Potential (skin allergies) of Chemicals No 2009 61 04 Executive Agency for Health and Consumers 1 Purpose and
More informationOPINION CONCERNING FRAGRANCE ALLERGY IN CONSUMERS
SCCNFP/0017/98 Final December 1999 THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS OPINION CONCERNING FRAGRANCE ALLERGY IN CONSUMERS A REVIEW OF THE PROBLEM ANALYSIS
More informationSCCP. Opinion on. Hydroxyisohexyl 3-cyclohexene carboxaldehyde (sensitisation only)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion on Hydroxyisohexyl
More informationScent Perfique Limited
SANTAL FRAGRANCE 403051 Page 1(6) 1.Identification of the substance/preparation and company ----- Product name : SANTAL FRAGRANCE 403051 Company name Company address Emergency phone : 01358 725360 Fax
More informationEthylhexylglycerin: a low-risk, but highly relevant, sensitizer in hypo-allergenic cosmetics
Contact Dermatitis Original Article COD Contact Dermatitis Ethylhexylglycerin: a low-risk, but highly relevant, sensitizer in hypo-allergenic cosmetics Olivier Aerts 1, Lien Verhulst 2 and An Goossens
More informationKey words: allergy; cross-sensitization; hair dyes; p-phenylenediamine; relevance. # 2009 John Wiley & Sons A/S.
Contact Dermatitis 2009: 60: 314 319 Printed in Singapore. All rights reserved Copyright # 2009 John Wiley & Sons A/S CONTACT DERMATITIS p-phenylenediamine sensitization is more prevalent in central and
More informationScent Perfique Limited
ALIEN FRAGRANCE 403084 Page 1(6) 1.Identification of the substance/preparation and company ----- Product name : ALIEN FRAGRANCE 403084 Company name : SCENT PERFIQUE LIMITED Company address : UNIT 18 CASTLE
More informationContact allergy to fragrances with a focus on oak moss absolute
Contact allergy to fragrances with a focus on oak moss absolute MOWITZ, MARTIN 2014 Link to publication Citation for published version (APA): Mowitz, M. (2014). Contact allergy to fragrances with a focus
More informationContact Allergy to Fragrance Substances
U N I V E R S I T Y O F C O P E N H A G E N F A C U L T Y O F H E A L T H A N D M E D I C A L S C I E N C E S Contact Allergy to Fragrance Substances Epidemiological Aspects and Experimental Investigations
More informationSyddansk Universitet. Published in: Acta Dermato-Venereologica DOI: / Publication date: 2016
Syddansk Universitet Contact Allergy in Danish Healthcare Workers A Retrospective Matched Case-control Study Schwensen, Jakob F; Menné, Torkil; Sommerlund, Mette; Andersen, Klaus Ejner; Mørtz, Charlotte
More informationIFRA & Safety Assessment of Fragrance Materials
IFRA & Safety Assessment of Fragrance Materials An Overview Bhashkar Mukerji, PhD, Head, Regulatory & Product Safety, Givaudan DISCLAIMER The views expressed in this presentation belong to the presenter
More informationCOD. Summary. Contact Dermatitis
Contact Dermatitis Original Article COD Contact Dermatitis Patch test results with fragrance markers of the baseline series analysis of the European Surveillance System on Contact Allergies (ESSCA) network
More informationRecent clinical studies on oxidized fragrance terpenes
Recent clinical studies on oxidized fragrance terpenes Johanna Bråred Christensson, MD, PhD Department of Dermatology, Sahlgrenska University Hospital Dermatochemistry and Skin Allergy, University of Gothenburg,
More informationUpdates in Contact Dermatitis
Updates in Contact Dermatitis Brian P. Peppers, DO, PhD 1/22/16 Osteopathic Adult & Pediatric Allergy and Immunology Fellowship University Hospitals Regional Hospitals/LECOMT Allergy and Immunology Associates
More informationCross-reactivity between citral and geraniol can it be attributed to oxidized geraniol?
Contact Dermatitis riginal Article CD Contact Dermatitis Cross-reactivity between citral and geraniol can it be attributed to oxidized geraniol? Lina Hagvall 1 and Johanna Bråred Christensson 1,2 1 Department
More informationNordic. Contact allergy to the preservative methyldibromoglutaronitrile. Charlotte Devantier Jensen. dermato-venereology.
forum for Nordic dermato-venereology Contact allergy to the preservative methyldibromoglutaronitrile SUPPLEMENTUM NO. 8 vol. 10, May 2005 ISSN 1402-2915 OFFICIAL JOURNAL OF THE NORDIC DERMATOLOGY ASSOCIATION
More informationNice, France, 4 th June, 2018 E.F.E.O. European Federation of Essential Oils. Legislation update
Nice, France, 4 th June, 2018 E.F.E.O. European Federation of Essential Oils Legislation update Current EU legislation and legal developments relating to Essential Oils 2017/2018 Lutz Düshop Attorney at
More informationEUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL. Held on 20 September 2005 in Brussels MINUTES
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C Public Health and Risk Assessment C7 Risk assessment Scientific Committee on Consumer Products SCIENTIFIC COMMITTEE ON
More informationPosition Statement on The Chemical Identity of Fragrances (Approved by the Board of Directors: October 24, 1998)
Position Statement on The Chemical Identity of Fragrances (Approved by the Board of Directors: October 24, 1998) The American Academy of Dermatology (AAD) supports identification of the common allergens
More informationEuropean Society of Contact Dermatitis guideline for diagnostic patch testing recommendations on best practice
Contact Dermatitis Review Article COD Contact Dermatitis European Society of Contact Dermatitis guideline for diagnostic patch testing recommendations on best practice Jeanne D. Johansen 1, Kristiina Aalto-Korte
More informationPattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database
Contact Dermatitis Original Article COD Contact Dermatitis Pattern of contact sensitization in patients with and without atopic dermatitis in a hospital-based clinical database Kim Katrine Bjerring Clemmensen
More informationFragrance mix I and II: results of breakdown tests
Special Issue: Research Article Received: 19 October 2014, Revised: 17 February 2015, Accepted: 23 February 2015 Published online in Wiley Online Library: 2 April 2015 (wileyonlinelibrary.com) DOI 10.1002/ffj.3247
More informationCosmetic Habits and Cosmetic Contact Dermatitis in Children
Curr Treat Options Allergy (2015) 2:228 234 DOI 10.1007/s40521-015-0057-x Pediatric Allergy (AM Giménez-Arnau, Section Editor) Cosmetic Habits and Cosmetic Contact Dermatitis in Children An Goossens, R.
More informationDeclaration B - from the manufacturer/supplier of the raw material used for the production of laundry detergents
Declaration B - from the manufacturer/supplier of the raw material used for the production of laundry detergents Declaration B is fulfilled by the supplier(s) of raw materials forming part of the formulation.
More informationOccupational dermatitis in hairdressers influence of individual and environmental factors
Contact Dermatitis Original Article COD Contact Dermatitis Occupational dermatitis in hairdressers influence of individual and environmental factors Tanja K. Carøe 1, Niels E. Ebbehøj 1 and Tove Agner
More informationCOSMETIC PRODUCT SAFETY REPORT
1 Antigonis str 14451 Metamorfosis, Athens, Greece Tel : +30-210-2934745 e-mail : info@qacs.gr Fax : +30-210-2934606 web : www.qacs.gr COSMETIC PRODUCT SAFETY REPORT According to EC Regulation 1223/2009
More informationTo: Member Associations (FOR ACTION) Members of the Scientific Committee. Cc: RIFM Customer Associations Members of the JAG.
To: Member Associations (FOR ACTION) Members of the Scientific Committee Cc: RIFM Customer Associations Members of the JAG June 10, 2015 NOTIFICATION OF IFRA STANDARDS No. 13 48 th Amendment to the IFRA
More informationPre & Pro Haptens in Fragrance: Part 2 - Hydrolysis
Pre & Pro Haptens in Fragrance: Part 2 - Hydrolysis 1. Chemistry and Theory From an analysis of the perfumer s palette three classes of ingredients were identified as hydrolysable, and therefore with potential
More informationMaterial Safety Data Sheet
The Soapmakers Store Celan House Unit 13 Lawson Hunt Industrial Estate Guildford Road, Broadbridge Heath Horsham, West Sussex, RH12 3JR Tel: 0870 240 1251 Fax: 01403 254 493 Web-Site: www.soapmakers-store.com
More informationDeclaration B - from the manufacturer/supplier of the raw materials used for the production of hand dishwashing detergents
Declaration B - from the manufacturer/supplier of the raw materials used for the production of hand dishwashing detergents Declaration B is to be filled in by the supplier(s) of raw materials used as part
More informationEmission of Isothiazolinones from Water-Based Paints
pubs.acs.org/est Emission of Isothiazolinones from Water-Based Paints Michael D. Lundov,*, Barbara Kolarik, Rossana Bossi, Lars Gunnarsen, and Jeanne D. Johansen National Allergy Research Centre, Department
More informationOverview of thoughts on skin testing
Overview of thoughts on skin testing Social Dialogue, 9 February 2016 COIFFURE EU - Miet Verhamme Coiffure EU Working group skin testing (23 June 2015) group skin testing within CEU (23 June 2015) 7 countries:
More informationMaterial Safety Data Sheet
The Soapmakers Store Celan House Unit 13 Lawson Hunt Industrial Estate Guildford Road, Broadbridge Heath Horsham, West Sussex, RH12 3JR Tel: 0870 240 1251 Fax: 01403 254 493 Web-Site: www.soapmakers-store.com
More informationSCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP. Memorandum Classification and categorization of skin sensitisers and grading of test reactions
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Memorandum Classification
More informationQuick Guide to Contact Dermatitis. Jeanne Duus Johansen Jean-Pierre Lepoittevin Jacob P. Thyssen Editors
Quick Guide to Contact Dermatitis Jeanne Duus Johansen Jean-Pierre Lepoittevin Jacob P. Thyssen Editors 123 Quick Guide to Contact Dermatitis Jeanne Duus Johansen Jean-Pierre Lepoittevin Jacob P. Thyssen
More informationOfficial Journal of the European Union
L 66/26 11.3.2003 DIRECTIVE 2003/15/EC OF THE EUROPEAN PARLIAMT AND OF THE COUNCIL of 27 February 2003 amending Council Directive 76/768/EEC on the approximation of the laws of the Member States relating
More informationThe Commission Services invite interested parties for their comments.
SCCNFP/0017/98 30 September 1999 The Scientific Committee on Cosmetic and Non-Food-Products intended for Consumers (SCCNFP) has been requested to give an opinion on the issue of fragrance allergy in consumers.
More informationScientific Committee on Consumer Safety (SCCS) 8 th PLENARY Venue: Luxembourg. Meeting date: 16 December Minutes
Scientific Committee on Consumer Safety (SCCS) 8 th PLENARY Venue: Luxembourg Meeting date: 16 December 2014 Minutes 1. WELCOME AND APOLOGIES The Chair welcomed all the participants. There was one apology.
More informationExplanatory Memorandum to the Food Labelling (Declaration of Allergens) (Wales) Regulations 2008
Explanatory Memorandum to the Food Labelling (Declaration of Allergens) (Wales) Regulations 2008 This Explanatory Memorandum has been prepared by the Food Standards Agency Wales and is laid before the
More informationFragrance and Cosmetic Contact Allergy in Children Martine Vigan, PhD * Florence Castelain, PhD
Current Treatment Options in Allergy (2014) 1:310 316 DOI 10.1007/s40521-014-0027-8 Pediatric Allergy (A Giménez-Arnau, Section Editor) Fragrance and Cosmetic Contact Allergy in Children Martine Vigan,
More informationDeclaration B - from the manufacturer/supplier of the raw materials used for the production of hard surface cleaning products
Declaration B - from the manufacturer/supplier of the raw materials used for the production of hard surface cleaning products Declaration B is to be filled in by the supplier(s) of raw materials used as
More informationOPINION ON. Methylisothiazolinone (P94) Submission II. (Sensitisation only)
Scientific Committee on Consumer Safety SCCS OPINION ON Methylisothiazolinone (P94) Submission II (Sensitisation only) The SCCS adopted this opinion at its 4 th plenary meeting on 12 December 2013 About
More informationMETHYLDIBROMO GLUTARONITRILE
OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS CONCERNING METHYLDIBROMO GLUTARONITRILE Colipa n P77 adopted by the SCCNFP during the 0 th plenary
More informationTopical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study
Contact Dermatitis Original Article COD Contact Dermatitis Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre Italian study Monica Corazza 1, Alessandro
More informationCitation for published version (APA): Christoffers, W. (2014). Hand eczema: interventions & contact allergies [S.l.]: [S.n.]
University of Groningen Hand eczema Christoffers, Wianda IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version
More informationData management system (based on ESSCA experience) Wolfgang Uter
Data management system (based on ESSCA experience) Wolfgang Uter Different levels of documentation ESSCA or IVDK standard (local installation): Full documentation of patch tested patients Possible extensions
More informationAnnex I to the CLH report
Annex I to the CLH report Proposal for Harmonised Classification and Labelling Based on Regulation (EC) No 1272/2008 (CLP Regulation), Annex VI, Part 2 International Chemical Identification: Geraniol;
More informationOpinion on. Risk Assessment Report on NITROBENZENE. Human Health Part. CAS No: EINECS No:
Scientific Committee on Health and Environmental Risks SCHER Opinion on Risk Assessment Report on NITROBENZENE Human Health Part CAS No: 98-95-3 EINECS No: 202-95-3 The SCHER adopted this opinion at its
More informationSCCP. Opinion on. Commiphora Erythrea Glabrescens Gum Extract and Oil (Opoponax) (sensitisation only)
SCCP087105 EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion
More informationMethyldibromoglutaronitrile
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion on Methyldibromoglutaronitrile
More informationInsects as a Potential Food Allergens. Phil Johnson
Insects as a Potential Food Allergens Phil Johnson Overview Food Allergy Cross-reactivity Current evidence for cross-reactivity Opinions on handling food insects as allergens Gaps in our knowledge Cross-reactivity:
More informationIPCS Project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals
IPCS Project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals GENERAL CONCLUSIONS AND RECOMMENDATIONS 1 OF AN IPCS INTERNATIONAL WORKSHOP ON SKIN SENSITIZATION IN
More informationSYMBOLIC LUXURY SOAP 40G
1 Antigonis str 14451 Metamorfosis, Athens, Greece Tel : +30-210-2934745 e-mail : info@qacs.gr Fax : +30-210-2934606 web : www.qacs.gr SAFETY ASSESSMENT According to EC Regulation 1223/2009 SYMBOLIC LUXURY
More informationSCCP. Opinion on. Methyldibromo glutaronitrile (sensitisation only)
EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion on Methyldibromo
More informationAction Levels and Allergen Thresholds What they will mean for the Food Industry Dr. Rachel WARD r.ward consultancy limited
Action Levels and Allergen Thresholds What they will mean for the Food Industry Dr. Rachel WARD r.ward consultancy limited 1 Allergenic Foods Are Unique! More than 160 foods are known to provoke allergic
More informationAmended Safety Assessment of Methylisothiazolinone as Used in Cosmetics
Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics Status: Tentative Report for Public Comment Release Date: June 20, 2014 Panel Meeting Date: September 8-9, 2014 All interested persons
More informationRisk Assessment Report on Chlorine. Human Health Part. CAS No.: EINECS No
Scientific Committee on Health and Environmental Risks SCHER Risk Assessment Report on Chlorine Human Health Part CAS No.: 7782-50-5 EINECS No. 231-959-5 The SCHER adopted this opinion at its 22 nd plenary
More informationSCCP. Opinion on. Liquidambar spp. Balsam Extracts and Oils (Storax) (sensitisation only)
SCCP087205 EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment SCIENTIFIC COMMITTEE ON CONSUMER PRODUCTS SCCP Opinion
More informationThe hands in health and disease of individuals with filaggrin loss-of-function mutations: clinical reflections on the hand eczema phenotype
Contact Dermatitis Review Article COD Contact Dermatitis The hands in health and disease of individuals with filaggrin loss-of-function mutations: clinical reflections on the hand eczema phenotype Jeanette
More informationToy Safety Directive 2009/48/EC. Bärbel Vieth Federal Institute for Risk Assessment/Berlin FOR RISK ASSESSMENT FEDERAL INSTITUTE
FEDERAL INSTITUTE FOR RISK ASSESSMENT Toy Safety Directive 2009/48/EC Bärbel Vieth Federal Institute for Risk Assessment/Berlin he Federal Institute for Risk Assessment (BfR, Berlin Germany) Biological
More informationCommittee for Risk Assessment (RAC) Committee for Socio-economic Analysis (SEAC)
Committee for Risk Assessment (RAC) Opinion Committee for Socio-economic Analysis (SEAC) draft Opinion on an Annex XV dossier proposing restrictions on Chromium (VI) compounds in leather articles ECHA/RAC/
More informationContamination versus Preservation
Contamination versus Preservation Michael Dyrgaard Lundov Ph.D.-student, Cand.Scient. National Allergy Research Centre and Pharmaceutical Faculty, University of Copenhagen Allergic contact dermatitis to
More informationMATERIAL SAFETY DATA SHEET
MATERIAL SAFETY DATA SHEET SECTION 1. Identification of the Material and Supplier Product Name: Pine Disinfectant Recommended Use: Disinfectant and deodorize. Used at the rate of 1 part to 40 parts water.
More informationMaterial Safety Data Sheet Black Soap (Hard)
SECTION: 1. COMPANY IDENTIFICATION Company: Material Safety Data Sheet (Hard) Worldwide Wholesale Warehouse Inc. Address: PO Box 52, 314 Dakota Ave, Wahpeton, ND 58074 Telephone No: 1 (701) 640-0836 Email:
More informationTatiana A. Vogel, Rakita W. Heijnen, Pieter-Jan Coenraads and Marie-Louise A. Schuttelaar
Contact Dermatitis Original Article COD Contact Dermatitis Two decades of p-phenylenediamine and toluene-2,5-diamine patch testing focus on co-sensitizations in the European baseline series and cross-reactions
More informationONE LIFE LUXURY SOAP 30G
1 Antigonis str 14451 Metamorfosis, Athens, Greece Tel : +30-210-2934745 e-mail : info@qacs.gr Fax : +30-210-2934606 web : www.qacs.gr SAFETY ASSESSMENT According to EC Regulation 1223/2009 ONE LIFE LUXURY
More informationCLINICAL REPORT. (Accepted December 16, 2003.) Acta Derm Venereol 2004; 84:
Acta Derm Venereol 2004; 84: 291 295 CLINICAL REPORT Are Adverse Skin Reactions to Cosmetics Underestimated in the Clinical Assessment of Contact Dermatitis? A Prospective Study among 1075 Patients Attending
More informationThe National Council of Women of Canada Le Conseil national des femmes du Canada
The National Council of Women of Canada Le Conseil national des femmes du Canada FOUNDED 1893 (INCORPORATED BY ACT OF PARLIAMENT) IN FEDERATION WITH THE INTERNATIONAL COUNCIL OF WOMEN Annual Brief to the
More informationOfficial Journal of the European Union L 168/5
21.6.2006 Official Journal of the European Union L 168/5 COMMISSION REGULATION (EC) No 907/2006 of 20 June 2006 amending Regulation (EC) No 648/2004 of the European Parliament and of the Council on detergents,
More informationPotency Values from the Local Lymph Node Assay: Application to Classification, Labelling and Risk Assessment. Document No. 46
Potency Values from the Local Lymph Node Assay: Application to Classification, Labelling and Risk Assessment Document No. 46 Brussels, December 2008 ECETOC DOCUMENT NO. 46 Copyright ECETOC AISBL European
More informationClarification on the Opinions SCCNFP/0653/03 and SCCP/0882/05
Scientific Committee on Consumer Products SCCP Clarification on the Opinions SCCNFP/0653/03 and SCCP/0882/05 on the Safety of Fluorine Compounds in Oral Hygiene Products for Children under the Age of 6
More informationFoodDrinkEurope Position on GLP studies
FoodDrinkEurope Position on GLP studies Content of the presentation Introduction to GLP Importance of GLP for the food industry Use of GLP based on the example of novel foods Conclusions GLP what is it?
More informationAn immune response study of oakmoss absolute and its constituents atranol and chloroatranol
Contact Dermatitis Original Article COD Contact Dermatitis An immune response study of oakmoss absolute and its constituents atranol and chloroatranol Charlotte Menné Bonefeld 1, Morten Milek Nielsen 1,ElenaGimenéz-Arnau
More informationSAFETY DATA SHEET according to 1907/2006/EC, Article 31
SAFETY DATA SHEET according to 1907/2006/EC, Article 31 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product name 1.2. Relevant identified uses
More informationPrecautionary allergen labelling Are we ready to quantify risk? Dr. Chun-Han Chan Anaphylaxis Campaign Corporate Conference 2016
Precautionary allergen labelling Are we ready to quantify risk? Dr. Chun-Han Chan Anaphylaxis Campaign Corporate Conference 2016 What information needs to be provided Mandatory Declare deliberate use of
More informationOccupational contact dermatitis in painters an analysis of patch test data from the Danish Contact Dermatitis Group
Contact Dermatitis Original Article COD Contact Dermatitis Occupational contact dermatitis in painters an analysis of patch test data from the Danish Contact Dermatitis Group Anja P. Mose 1, Michael D.
More informationMEMORANDUM ON HAIR DYE SUBSTANCES AND THEIR SKIN SENSITISING PROPERTIES
Scientific Committee on Consumer Products SCCP MEMORANDUM ON HAIR DYE SUBSTANCES AND THEIR SKIN SENSITISING PROPERTIES Adopted by the SCCP during the 10 th plenary of 19 December 2006 About the Scientific
More informationMETHYLISOTHIAZOLINONE AND METHYLCHLOROISOTHIAZOLINONE: NEW INSIGHTS
METHYLISOTHIAZOLINONE AND METHYLCHLOROISOTHIAZOLINONE: NEW INSIGHTS *Ana Rita Rodrigues-Barata, Luis Conde-Salazar Contact Dermatitis Unit, Department of Dermatology, Grupo Dermatología Pedro Jaén, Madrid,
More informationA Review of the Expert Opinion on Latex Allergy
A Review of the Expert Opinion on Latex Allergy Author(s) Pete Phillips BPharm, MRPharmS, DMS (Health) Deputy Director Surgical Materials Testing Laboratory Princess of Wales Hospital, Bridgend, Wales.
More informationScent Perfique Limited
COCONUT MILK & HONEY FRAGRANCE 263858 Page 1(5) 1.Identification of the substance/preparation and company ----- Product name : COCONUT MILK & HONEY FRAGRANCE 263858 Company name : SCENT PERFIQUE LTD Company
More informationPatching the Gaps in Our Diagnostic Knowledge. By Tyler Hooton MS3 UWSOM
Patching the Gaps in Our Diagnostic Knowledge By Tyler Hooton MS3 UWSOM Disclosures The author has no financial disclosures or conflicts of interest The following patient has given permission for this
More informationAssessing Risks of Exposure to Allergens from Foods
Assessing Risks of Exposure to Allergens from Foods Joe Baumert, Ph.D. Co-Director Food Allergy Research & Resource Program University of Nebraska The National Academies of Science Institute of Medicine
More informationReducing the risk of allergen contamination in the factory
Reducing the risk of allergen contamination in the factory Barbara Hirst RSSL Sponsored by Reactions To Food ADVERSE REACTIONS TO FOOD GENERIC May occur in anyone who consumes sufficient quantity of the
More informationMATERIAL SAFETY DATA SHEET
MATERIAL SAFETY DATA SHEET SECTION 1: PRODUCT IDENTIFICATION 1.1 Product name: Rosemary essential oil French type 1.2 Botanical name: Rosmarinus officinalis 1.3 USA INCI: Rosmarinus officinalis (Rosemary)
More informationState of knowledge on abiotic hapten formation (hydrolysis) using examples of fragrance ingredients and state of the art on the technical management
State of knowledge on abiotic hapten formation (hydrolysis) using examples of fragrance ingredients and state of the art on the technical management of those transformations 1. Chemistry and Theory Hypothesis:
More information