Discover the connection

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1 Susan lives with daily rhinitis symptoms. Pollen House dust mites Timothy grass Underlying allergens affect rhinitis Discover the connection Specific IgE blood testing helps you identify allergic triggers, allowing you to develop a management plan.

2 Allergic and non-allergic symptoms may look the same 1,2 Overlapping symptoms complicate diagnosis, delivery of effective care, and increase healthcare costs. 3,4 Office visit costs Medication costs Insurance Issues Common Rhinitis Symptoms Nasal congestion Rhinorrhea Sneezing Itchy nose/eyes Medication changes Symptom recurrence Limited treatment options Clinical history may not be enough % 65 % ALLERGIC Types of rhinitis include 3 : NON-ALLERGIC Nearly 2/3 of patients prescribed antihistamines for their reported allergic rhinitis have symptoms that are not due to allergy 2 Study of 1-year managed care records among 4,643 patients who received 1 or more prescriptions for an oral antihistamine (loratadine, fexofenadine, or cetirizine) 2 ALLERGIC NON-ALLERGIC INFECTIOUS $7.3 billion annually spent in the U.S. for patients with allergic rhinitis. 3 In allergic and non-allergic rhinitis accurate diagnosis is essential. 2 3

3 Specific IgE blood test results play a key role in making the correct diagnosis Rhinitis clinical pathway 3 For most Rhinitis patients, the causes are cumulative. Managing a patient s symptoms is about their allergic sensitizations even the ones that are hidden Order specific IgE blood test to help determine whether allergic or nonallergic JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC SYMPTOM THRESHOLD Grasses Weeds Mold Dust mite The allergic symptom threshold is the level at which a patient s allergic sensitization causes symptoms. A patient s threshold is often exceeded when spring allergens and perennial allergens add up to create a cumulative effect. 5,6 * Due to the probability of polysensitization in patients with allergic rhinitis, a combination of regionally relevant seasonal allergens and perennial allergens is recommended. 4 5

4 Specific IgE blood testing helps you develop a plan for the effective management of rhinitis Case history alone may not be enough... Confidence in diagosis has been shown to increase when specific IgE results are added to clinical history 7,8 Clear results are easy to interpret and explain to patients. The higher the sige, the more likely it is contributing to symptoms but even very low levels can contribute to symptoms. 9,10 % of patients % Case history only 90 % Addition of Specific IgE Study among patients with symptoms of eczema, wheezing and/or asthma, and rhinitis in primary care. 7,8 (n=1101) Adapted from: Duran-Tauleria E. Allergy 2004; 59 (suppl 78): Niggemann B. Pediatr Allergy Immunol. 2008; 19: Proportion of individuals with symptomatic allergy (probability %) Symptom Relation Uncommon Low Common IgE antibody concentration (ku A /l) CONVENIENT: Results come back in a week or less, similar to a lipid panel test; simple blood draw; can be drawn in the office or at any lab High Very High COMPREHENSIVE: Reports sensitizations with a customized profile of aeroallergens tailored to your region SENSITIVE: Specific IgE blood tests detect sensitization in up to 95% of atopic patients. 11 As in all diagnostic testing, any diagnosis or treatment plan must be made by the physician based on test results, individual patient history, the physician s knowledge of the patient, and the physician s clinical judgement. 6 7

5 Specific IgE blood testing helps you to identify allergic triggers and develop a diagnosis. Your diagnosis will allow you to: Determine if patient s symptoms are allergic or non-allergic Develop a plan to efficiently manage and treat your patient s allergic symptoms Prevent time consuming call backs Increase productivity at work or school 1 References 1. Tran NP, Vickery J, Blaiss MS. Management of Rhinitis: allergic and non-allergic. Allergy Asthma Immunol Res. 2011;3(3): Szeinbach SL, Williams B, Muntendam P, et al. Identification of allergic disease among users of antihistamines. J Manag Care Pharm. 2004;10(3): Wallace DV, et al. J Allergy Clin Immunol. 2008;122(2 suppl):s1-s Wheeler PW, et al. Am Fam Physician. 2005;72: Halken S, H0st A, Niklassen U, et al. Effect of mattress and pillow encasings on children with asthma and house dust mite allergy. J Allergy Clin lmmunol. 2003;111(11): Morgan WJ, Crain EF, Gruchalla RS, et al. Results of a home-based environmental intervention among urban children with asthma. N Eng/ J Med. 2004;351 (11 ): Adapted from Duran-Tauleria E, et al. Allergy. 2004;59 Suppl 78: Adapted from Niggemann B, et al. Pediatr Allergy Immunol. 2008;19: NIH. Guidelines for the Diagnosis and Management of Asthma, NIH publication Yunginger JW, et al. J Allergy Clin Immunol. 2000;105(6pt1): Data on File, Thermo Fisher Scientific 2015 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc., and its subsidiaries. Thermo Fisher Scientific 4169 Commercial Avenue, Portage, MI 49002,