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1 Dermatophagoidus pteronyssinus freeze dried extract Page: 1/6 1. Identification of the substance & the company Chemical name : Dermatophagoidus pteronyssinus freeze dried extract Chemical formula biological material Synonym CAS number EINECS number Product code (supplier) : Biological Material extract : Proteins, salt, starch and other biological material Molecular weight Type of product and use : Allergen Company identification : Citeq Biologics Address and telephone : Admiraal de Ruyterlaan GN Groningen The Netherlands Postbus CB Groningen Tel : Fax : info@citeq.com 2. Hazards identification NFPA ratings (scale 0-4) Important hazards Adverse human health effects Inhalation: Skin contact: Eye contact: Ingestion: Additional data Environmental hazards : health=3 fire=0 reactivity=0 : May be irritating if inhaled to people who are allergic to this mite. Avoid breathing dust. Avoid contact with eyes, skin and clothing. Keep container tightly closed. Wash thoroughly after handling. Use only with adequate ventilation. Use dust mask P2. : No information is available on significant adverse effects. : May cause wheezing and asthma. : May cause rash. : May cause tearing. : May cause redness and swelling of the eyes. : May cause allergy.

2 Dermatophagoidus pteronyssinus freeze dried extract Page: 2/6 3. Composition / information on ingredients Substance/preparation Ingredients : substance : Dermatophagoidus pteronyssinus freeze dried extract R-Phrases: R20/ R21/R22 - Harmful by inhalation and if swallowed - Harmful in contact with skin Other hazardous component(s) : none 4.First-aid measures General Inhalation Skin contact Eye Contact Ingestion NOTE TO PHYSICIAN Antidote : Remove contaminated clothing. : FIRST AID- Remove from exposure area to fresh air immediately. Perform artificial respiration if necessary. Keep person warm and at rest. Treat symptomatically and supportively. Get medical attention immediately. : FIRST AID- Remove contaminated clothing and shoes immediately. Wash with soap or mild detergent and large amounts of water until no evidence of mixture remains (at least minutes). Get medical attention immediately. : FIRST AID- Wash eyes immediately with large amounts of water or normal saline, occasionally lifting upper and lower lids, until no evidence of mixture remains (at least minutes). Get medical attention immediately. : FIRST AID- If vomiting does not completely empty the stomach, proceed with the following: Induce emesis with syrup of ipecac and water. When vomiting occurs, keep head lower than hips to help prevent aspiration. Do not give anything by mouth or induce vomiting if person is unconscious or otherwise unable to swallow. Treat symptomatically and supportively. Get medical attention immediately. Qualified medical personnel should consider performing gastric lavage (Dreisbach & Robertson; Handbook of Poisoning; 12th Ed.). : No specific antidote. Treat symptomatically and supportively. Protection of first-aiders : In case of insufficient ventilation, wear suitable respiratory equipment.

3 Dermatophagoidus pteronyssinus freeze dried extract Page: 3/6 5. Fire- fighting measures General Flash point Auto-ignition temperature Extinguishing media Fire fighting procedure Usual fire and explosion hazards Protection of fire-fighters Hazardous combustion products : Negligible fire hazard when exposed to heat or flame. : Dry chemical, carbon dioxide, water spray or regular foam. For larger fires, use water spray, fog or regular foam. : Move container from fire area if you can do it without risk. Extinguish using agent suitable for type of surrounding fire. Avoid breathing vapours and dusts. Keep upwind. : None : In case of insufficient ventilation, wear suitable respiratory equipment. : Thermal decomposition products may include fumes of organic substances. 6. Accidental release measures Personal precautions Environmental precautions After spillage/leakage : Keep away from sources of ignition No smoking. : In case of insufficient ventilation, wear suitable respiratory equipment. : Avoid generation of dust. : Do not touch spilled material. Stop leak if you can do it without risk. For small spills, take up with sand or other absorbent material and place into containers for later disposal. For small dry spills, place the material into clean, dry container with a clean shovel and cover. Move containers from spill area. 7. Handling and storage Handling Storage Application : Avoid inhaling and contact. : Keep container tightly closed. Store protected from light. Storage temp.: recommended temperature -20 C. : Allergen.

4 Dermatophagoidus pteronyssinus freeze dried extract Page: 4/6 8. Exposure controls/personal protection Exposure limits Ventilation requirements : Not known. : Provide local exhaust ventilation to meet published exposure limits. Ventilation equipment should be explosion-proof if explosive concentrations Personal protection equipment Respiratory protection : Dust mask P2. Gloves Eye protection Others Industrial hygiene : Working gloves. : Employee must wear splash-proof or dust-resistant safety goggles to prevent eye contact with this substance. : Working clothing. Employee must wear appropriate protective (impervious) clothing and equipment to prevent repeated or prolonged skin contact with this substance. : Avoid contact. Safety shower and eye bath should be provided. Do not eat, drink or smoke until afterwork showering and changing clothes. 9. Physical and chemical properties Appearance : powder Colour : Light yellow/beige Odour : Light characteristic Odour range ph Melting point/range Boiling point/range Flash point Evaporation rate (ether=1) Inflammable Inflammable or explosion range Vapour pressure Vapour density Relative density (air=1) Solubility : - solubility in water : Slightly in water at 25 C. - solvent solubility : 96% Distribution coefficient Spontaneous combustion temp. Thermal decomposition : > 300 C Viscosity Explosion characteristics Oxidation characteristics

5 Dermatophagoidus pteronyssinus freeze dried extract Page: 5/6 10. Stability and reactivity Stability Materials to avoid Conditions to avoid Hazardous decomposition products Hazardous polymerization : Stable at normal temperatures and pressures. : Stable at normal temperatures and pressures. : Stable at normal temperatures and pressures. : Thermal decomposition products may include fumes of organic nature. : No 11. Toxicological information Toxicity data Mouse LD50 Rat LD50 Human mutagenic data (RTECS) reproductive Carcinogen status Additional data Health effects Inhalation Skin contact: Eye contact Ingestion : Intravenous-human Anaphylactic shock can appear to this compound sensitive allergic people. : No data known. : No data known. : No data known. : Parenteral administration has been reported to cause at sensitive allergic people anaphylactic shock, anaphylactic-like reactions. : HIGHLY ALLERGIC Inhalation may cause transient bronchial irritation. : Could induce specific allergy. : Contact may rarely produce skin irritation. : This mixture of allergens could cause an irritating sensation, lacrimation and conjunctival hyperemia.

6 Dermatophagoidus pteronyssinus freeze dried extract Page: 6/6 12. Ecological information Acute aquatic toxicity Degradability Log bioconcentration factor (BCF) Log octanol/water partition coefficient 13. Disposal considerations Waste disposal : In closed containers. Observe all national, state and local environmental regulations when disposing of this material. 14. Transportation information Not submitted to transport regulation. 15. Regulatory information EEC - symbol(s) - R Phrase(s) : R20/ R21/R22 - Harmful by inhalation and if swallowed - Harmful in contact with skin - S Phrase(s) : 7/9 keep container tightly closed 26 in case of contact with eyes rinse immediately with plenty of water and seek medical advice. 16. Other information None

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