Focusing our energy on saving lives

Transcription

1 October 2017 The Outlook for Oncology: The Shrinking, Affordable Proton Therapy Center Focusing our energy on saving lives Jonathan Farr, DSc Senior Vice President Medical Physics

2 Forward Looking Statement This presentation may contain certain projections and other forward-looking statements with respect to the financial condition, results of operations, businesses and prospects of Advanced Oncotherapy plc ( AVO, Advanced Oncotherapy or the Company ). These statements are based on current expectations and involve risk and uncertainty because they relate to events and depend upon circumstances that may or may not occur in the future. There are a number of factors which could cause actual results or developments to differ materially from those expressed or implied by these forward-looking statements. Any of the assumptions underlying these forward-looking statements could prove inaccurate or incorrect and therefore any results contemplated in the forward-looking statements may not actually be achieved. Nothing contained in this presentation should be construed as a profit forecast or profit estimate. Investors or other recipients are cautioned not to place undue reliance on any forward-looking statements contained herein. Advanced Oncotherapy undertakes no obligation to update or revise (publicly or otherwise) any forward-looking statement, whether as a result of new information, future events or other circumstances. Neither this presentation nor any verbal communication shall constitute an invitation or inducement to any person to subscribe for or otherwise acquire securities in Advanced Oncotherapy.

3 How do we improve the targeted dose delivery with protons? Proton beam properties compared to photon Protons are charged particles That is why they release their energy in a precisely defined penetration depth in tissue In contrast, photons emit their energy along their entire path through tissue 1

4 Comparative Doses: Proton vs. Photon Therapy Approximately 40% of body doses are spared This is why it is especially suitable for children Organ damage can be reduced Higher doses are made possible Retreatments: Patients treated previously treated with radiation therapy 2

5 Proton therapy compared with photon therapy: Craniospinal (paediatric) 3

6 Expansion of Proton Therapy Worldwide >200 MeV Operating Under construction 4

7 Equipment Size Comparison Proton vs. Photon Accelerator Gantry 5

8 Proton Therapy Accessibility Goals Smaller, lighter: accelerators, beamlines, and gantries. Efficiency equal or better than photon LINAC systems. Reduced maintenance costs. Flexible system fitting a range of geometries. Reduced install costs (shielding). Reduced decommissioning cost (up to 3x cost of the installation). Reduced operational costs (manpower, energy use). Ease of use, lower barriers to entry. 6

9 Harley Street Project 141/143 Harley Street Grade 2 listed buildings Challenge: Install and Operate a high energy Proton Therapy Center here Simon Baynham, Property Director at the Howard de Walden Estate, explains the Estate s decision to approach AVO saying; Such a facility should further enhance the tremendous work already being carried out in Harley Street, by some of the world s top oncologists and radiologists in the field of cancer. 7

10 Solution: the LIGHT System Proton Source RFQ Modulator SCDTL CCL Vacuum / Support system Treatment room Smaller emittance, pulsed energy changes efficiency, lightweight transport, less shielding Modular, no moving parts Reduced operational and maintenance costs. High flux hypofractionation 8

11 Solution: Gantry Alternative 9

12 AVO Harley Street Proton Therapy Centre Design 10

13 AVO Harley Street Progress Update Deconstruct began on site January Demolition and enabling work completed. Stage II sub-structural works (groundworks, piling and excavation) well underway. Building readiness on schedule for installation by H LIGHT system installation and commissioning First patient. 11

14 Pebble Mill Project AVO is actively working with the Calthorpe Estate to deliver a compact LIGHT system in Birmingham 12

15 Thank you for your attention