2011 ANNUAL REPORT CGCM Australian Regional Group

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1 2011 ANNUAL REPORT CGCM Australian Regional Group Associate Professor Dennis Chang Centre for Complementary Medicine Research University of Western Sydney, Australia National Registration of Traditional Chinese Medicine (1) First western country officially recognises TCM practitioners National registration board has been established in July 2011 Practitioners will meet registration standards developed by the Board Registration for practitioners will commence from 1 July 2012 Victorian legislation provided model for national scheme. Victorian practitioners will be transitioned automatically

2 National Registration of Traditional Chinese Medicine (2) Register of Chinese medicine practitioners with 3 divisions Acupuncture Chinese herbal medicine practitioners Chinese herbal dispensers Each Division has registration types (e.g. general, limited, provisional) Endorsement of registration required for: Acupuncture practitioners from other professions Practitioners to prescribe restricted (scheduled) herbs Policy for grand-parenting (non-formal qualifications) will be developed by National Board HEALTHPAC CENTRE OF EXCELLENCE FOR INTEGRATIVE MEDICINE The Healthpac Centre of Excellence for Integrative Medicine is a collaborative platform set up by: The Healthpac Medical Group China s State Administration of Traditional Chinese Medicine SATCM Health Department of NSW Australian and Chinese Universities Leading Chinese TCM teaching hospitals, and Leading China s TCM industry companies EoC aims to provide the whole person medical care by integrating evidence-based complementary medicine with mainstream medical practice.

3 Centre for Complementary Medicine Research (CompleMED) University of Western Sydney Evidence based CM healthcare solutions Safety, efficacy, use of CM >> translating into clinical practice or public policy to facilitate integration of CM into mainstream healthcare CompleMED Key Research Programs Herbal Analytical & Pharmacology Laboratories Clinical Trials Social & Public Health Policy PG research Building capability

4 Key Research Projects (1) NICM Collaborative Centre in Traditional Chinese Medicine Researchers: Prof Bensoussan, A/Prof C Smith, A/Prof D Chang Funding body: National Institute of Complementary Medicine (NICM) Business Portal A NSW government Initiative Researcher: Prof Bensoussan, A/Prof D Chang, Prof K Chan, Dr X Zhu Funding body: NSW State Government Clinical and physiological evaluation of constipation predominant Irritable Bowel Syndrome Researcher: Prof. A Bensoussan Funding Body: National Health and Medical Research Council (NHMRC) Treating bowel disorders with traditional Chinese Medicine Researcher: Prof. Alan Bensoussan, Prof. Brian Berman et al in collaboration with the University of Maryland, Baltimore, Chinese University of Hong Kong, University of Illinois,Chicago and Mayo Medical Centres. Partner/Funding Body: US National Institutes of Health (NIH) - International Collaborative Research Centre Project Establishment of a mass spectrometry facility for natural products and proteomics research and teaching at the College of Health and Sciences with UWS, Campbelltown Campus Researcher: Prof. Nikolaus Sucher, A/Prof. Dennis Chang Funding Body: UWS Research Infrastructure Fund (RIF) Acupuncture and mucosal immunity in the upper respiratory tract Researcher: A/Prof. Caroline Smith Partner/Funding Body: National Health and Medical Research Council (NHMRC) Effect of herbal medicine and acupuncture on memory, attention and learning Researchers: A/Prof Dennis Chang, Dr Ben Colagiuri, A/Prof Luo Rong Partern/Funding Body: University of Western Sydney Molecular effects of Chinese herbal medicines on oxidative stress resistance and ageing in yeast: a functional genomics and phytochemistry approach. Researcher: Prof. Nikolaus Sucher, Dr Suresh Govindaraghavan Partner/Funding Body: UWS Partnership Program Cancer fatigue study Researcher: A/Prof Caroline Smith Partner/Funding Body: NSW Cancer Insitute Key Research Projects (2) Acupuncture and reproductive health outcomes: building evidence in an integrated care setting Researchers: A/Prof Caroline Smith Partner/Funding Body: National Institute for Complementary Medicine, IVF Australia Use and attitudes towards complementary therapies among women of reproductive age Researchers: A/Prof Caroline Smith, Dr D Bateson Partner/Funding Body: Family Planning New South Wales

5 Health Innovations Research Institute - TCM Program 1. Herbal medicine resources and quality control Group leader: Prof Edwin Pang (Plant science) 2. Medicinal chemistry and chemical profiling Group leader: Assoc Prof Helmut Hugel (Medicinal chemistry) 4. Molecular pharmacology for diabetes Group leaders: Assoc Prof Jiming Ye/Dr Juan Carlos Molero (Biomedical science drug discovery) 3. Herbal pharmacology and toxicology Group leader: Assoc Prof Chun Guang Li (Biomedical science drug toxicity) 5. Computer modeling for drug delivery optimisation Group leader: Prof Jiyuan Tu (Bio-engineering) 6. Acupuncture and herbal medicine clinical trials Group leader: Prof Charlie Xue (Clinical trial) Research Activities Quality control studies Developments of innovative DNA microarrays for fingerprinting medicinal plants Herbal farming and quality control of Chinese herbal medicines Pre-clinical studies Molecular pharmacology for diabetes and anti-diabetic drugs Mechanisms of herbal medicines for cardiovascular and respiratory diseases Drug metabolism and deposition Clinical trials Several acupuncture trials for seasonal allergic rhinitis, chronic musculoskeletal pain and acute pain. RCT trial for a herbal medicine in patients with moderate COPD

6 Research outcomes Competitive grants Our core researchers currently held a number of research grants including 1 NHMRC Program grant (joint with Garvan Institute, Ye) 6 NHMRC Project Grants (Xue, 5, Ye 1) International Collaborative Research Grants and Linkage Grant (3) APA scholarhsips Publications Our research team has published extensively in the research area as mentioned above. HDR students We currently have over 30 HDR students. TCM Research at the University of Sydney Faculty of Pharmacy Quality Efficacy Safety

7 Faculty of Pharmacy Restructure Five Theme structures including CVD and Diabetes HMREC closed Continuation of research and teaching as Herbal Medicines Research Group TCM Academic Group in China Studies Centre (Uni Centre) Higher degree research students PhD 8 Recent Progress New publication Herbal medicines and nutraceuticals for diabetic vascular complications: mechanisms of action and bioactive phytochemicals, Current Pharmaceutical Design, 2010;16(34): Grant received G Li, K Chan, B Roufogalis, AJ McLachlan, K Li, V Naumovski, J Poon. Regulation and authentication of scheduled and toxic Chinese herbs in Australia. China Studies Centre research grant $40,000. Quality Quality standardisation and anti-inflammation activities of Chinese and Australian medicinal plants Propolis Punica granatum Pueraria lobata/thomsonii Centella asiatica Morinda officinale Hypericum perforatum Linking antiinflammation to anti-atherosclerosis activity From endothelial cellular studies Medicinal Herb Herbarium Contains specimen used in Traditional Chinese Medicine, Ayurvedic Medicine and Western Herbal Medicine P1 P2 P5 P4 STD P3

8 Efficacy TCM and Anti-diabetic Agents Major Aims Reduce blood sugar and lipid levels (multi-target actions) Overcome insulin resistance Prevention of cardiovascular/liver lipotoxicity Manage metabolic syndrome PPAR s, LXR, HMGCoA Reductase, Liver LDL receptor Overcome diabetic complications Safety The IMgateway Sydney University Interactions database The Online Herb-Drug database provides specific interaction data, rated by evidence and supplies quick and easy data for clinical relevance at point of care. Interaction data can be accessed online by:- Herb name (English name, Botanical name, Plant Family Herbal Preparation) Drug Drug Class Any key word search

9 THA K YOU

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