RSM. Indications For Use

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1 NEXT GENERATION SOLUTIONS RSM PATRIOT-RSM Amniotic Allograft Membrane is a human placental-based tissue product. The membrane forms a protective covering over the wound while providing the key components found in human amnion including Placental Exctracellular Matrix (ECM), Lamin, Proteoglycans, Hyaluronic Acid, Fibronectin and other Growth Factors. Collagens 1,3,4,5,6,7 all in the bioscaffold of the ECM, provide an environment for healthy well organized tissue to develop minimizing adhesions, fibrosis and scarring. The presence of the above components provides an environment to help reduce inflammation and reduce the risk of infection. Down regulates TGF-B, suppresses pro-inflammatory interleukins, and inhibiting Matrix metallopreteinasis (MMPs) PRSM-2017-V1M

2 PATRIOT-RSM Membrane provides anti-microbial, anti-adhesion, and anti-fibrotic properties. Useful in tissue reinforcement during surgery, as an adhesion barrier and scar reduction, treatment of burns and wounds. Product is used with a wide range of provider specialties: Orthopedic Surgeon Neurosurgeons Spinal Surgeons OB/GYN General & Plastic Surgeons Wound Specialists Burn Specialists Cardio-thoracic Surgeons FDA Regulation PATRIOR-RSM Membrane is regulated as a Human Cellular and Tissue-Based Product (HCT/P) under Section 361 of the Public Health Service Act and is governed by the FDA Center for Biologics Evaluation and Research (CBER). The presence of integrins and definsin create an environment that potentially reduces the bacterial colonization of wounds, and surgical sites Product is sterilized post packaging via ebeam sterilization Benefits: PATRIOT-RSM PRSM M PRSM M PRSM M PRSM M PRSM M Easy to apply either topically and intra-operatively Shown to minimize scar, adhesions and promote healthy tissue regeneration Stored at room temperature with 1-5 year shelf life Adheres well, no glue, or sutures necessary, hydrostatic tension holds in place Ideal handling capabilities, provided in dry format, to facilitate placement, then when hydrated, molds in place Sizes RSM 2cm x 4cm Amniotic Membrane 3cm x 6cm Amniotic Membrane 4cm x 4cm Amniotic Membrane 4cm x 6cm Amniotic Membrane 4cm x 8cm Amniotic Membrane Larger sizes available on request. Some sizes are considered special orders, may take up to 30 days to deliver RegeniSource LLC Hwy 281N # San Antonio, TX (877) Serving our Patriots with Advanced Regenera ve Therapies PRSM-2017-V1M

3 NEXT GENERATION SOLUTIONS RSF PATRIOT-RSF is human tissue allograft derived from placental tissue; amniotic membrane and amniotic fluid. Amniotic Fluid and Tissue are rich in components for tissue regeneration, including: Growth Factor proteins, Cytokines, Collagen (all substrates, Fibronectin, Laminin), Hyaluronic Acid, mirna, Associated Exosomes, and Secretomes. Cellular components: Pluripotent MSC s (Medicinal Signaling Cells), Fibroblasts, Keratinocytes, Epithelial cells. AnuGenX: Anu Life Science s proprietary, patent pending process PRSF-2017-V1F

4 PATRIOT-RSF optimizes the full spectrum of growth factors. Preserving mirna, Exosomes, Secretomes and cellular components. Patriot-RSF maximizes extracellular matrix. RSF Allows for cell adherence and growth in the ECM Natural human structural and biochemical ECM Packaged in our unique vial in vial system for safety then shipped in our high-tech packaging system Safety: Clinical Application to Repair, Reconstruct, and Replace for: Orthopedics augment tendon, fasciae, ligament and capsule repair Neurosurgery chronic neuritis and pain Spinal Surgery facet inflammation General Surgery augment tissue repair A 100 year history has been documented with no reported recipient rejections, since the amniotic tissue does not express HLA type antigens There is a significant body of peer reviewed literature documenting anti-microbial, anti-inflammatory and anti-tumorigenic characteristics. Additionally, the literature demonstrates up-regulation of healthy, strong tissue regeneration. PATRIO T-RSF Sizes PRSF 0050F.50 ml Cryopreserved Amniotic Fluid PRSF 0100F 1.0 ml Cryopreserved Amniotic Fluid PRSF 0200F 2.0 ml Cryopreserved Amniotic Fluid FDA Regulation Once donor tissue is collected it is minimally manipulated utilizing Anu Life Sciences proprietary AnuGenX process within the regulations of FDA 21CFR part 1271/PHS 361. Product is shipped and stored at -65C or colder. One year expiration. Some sizes are considered special orders, may take up to 30 days to deliver Release criteria includes extensive bioburden testing to ensure safety as well as quality protocols and review. RegeniSource LLC Hwy 281N # San Antonio, TX (877) Serving our Patriots with Advanced Regenera ve Therapies PRSF-2017-V1F

5 NEXT GENERATION SOLUTIONS REGEN ANU Rheo is human tissue allograft derived from placental tissue; amniotic membrane and amniotic fluid. Amniotic Fluid and Tissue are rich in components for tissue regeneration, including: Growth Factor proteins, Cytokines, Collagen (all substrates, Fibronectin, Laminin), Hyaluronic Acid, mirna, Associated Exosomes, and Secretomes. Cellular components: Pluripotent MSC s (Medicinal Signaling Cells), Fibroblasts, Keratinocytes, Epithelial cells. AnuGenX: Anu Life Science s proprietary, patent pending process RAR-2017-V1F

6 REGEN ANU RHEO optimizes the full spectrum of growth factors. Preserving mirna, Exosomes, Secretomes and cellular components. Rheo maximizes extracellular matrix. Allows for cell adherence and growth in the ECM Natural human structural and biochemical ECM Packaged in our unique vial in vial system for safety then shipped in our high-tech packaging system Safety: A 100 year history has been documented with no Clinical Application to Repair, Reconstruct, and Replace for: reported recipient rejections, since the amniotic tissue does not express HLA type antigens There is a significant body of peer reviewed literature Orthopedics augment tendon, fasciae, ligament and capsule repair Neurosurgery chronic neuritis and pain Spinal Surgery facet inflammation General Surgery augment tissue repair documenting anti-microbial, anti-inflammatory and anti-tumorigenic characteristics. Additionally, the literature demonstrates up-regulation of healthy, strong tissue regeneration. REGEN ANU Rheo Sizes ml Cryopreserved Amniotic Fluid ml Cryopreserved Amniotic Fluid ml Cryopreserved Amniotic Fluid FDA Regulation Once donor tissue is collected it is minimally manipulated utilizing Anu Life Sciences proprietary AnuGenX process within the regulations of FDA 21CFR part 1271/PHS 361. Product is shipped and stored at -65C or colder. One year expiration. Some sizes are considered special orders, may take up to 30 days to deliver Release criteria includes extensive bioburden testing to ensure safety as well as quality protocols and review. RegeniSource LLC Hwy 281N # San Antonio, TX (877) Serving our Patriots with Advanced Regenera ve Therapies RAR-2017-V1F

7 NEXT GENERATION SOLUTIONS REGEN ANU Vendaje Amniotic Allograft Membrane is a human placental-based tissue product. The membrane forms a protective covering over the wound while providing the key components found in human amnion including Placental Exctracellular Matrix (ECM), Lamin, Proteoglycans, Hyaluronic Acid, Fibronectin and other Growth Factors. Collagens 1,3,4,5,6,7 all in the bioscaffold of the ECM, provide an environment for healthy well organized tissue to develop minimizing adhesions, fibrosis and scarring. The presence of the above components provides an environment to help reduce inflammation and reduce the risk of infection. Down regulates TGF-B, suppresses pro-inflammatory interleukins, and inhibiting Matrix metallopreteinasis (MMPs) RAV-2017-V1M

8 REGEN ANU Vendaje Membrane provides anti-microbial, anti-adhesion, and anti-fibrotic properties. Useful in tissue reinforcement during surgery, as an adhesion barrier and scar reduction, treatment of burns and wounds. Product is used with a wide range of provider specialties: Orthopedic Surgeon Neurosurgeons Spinal Surgeons OB/GYN General & Plastic Surgeons Wound Specialists Burn Specialists Cardio-thoracic Surgeons The presence of integrins and definsin create an environment that potentially reduces the bacterial colonization of wounds, and surgical sites Product is sterilized post packaging via ebeam sterilization Benefits: Easy to apply either topically and intra-operatively Shown to minimize scar, adhesions and promote healthy tissue regeneration Stored at room temperature with 5 year shelf life Adheres well, no glue, or sutures necessary, hydrostatic tension holds in place Ideal handling capabilities, provided in dry format, to facilitate placement, then when hydrated, molds in place PATRIOT-RSM Sizes cm x 1cm Amniotic Membrane cm x 2cm Amniotic Membrane cm x 4cm Amniotic Membrane cm x 6cm Amniotic Membrane FDA Regulation REGEN ANU Vendaje Membrane is regulated as a Human Cellular and Tissue-Based Product (HCT/P) under Section 361 of the Public Health Service Act and is governed by the FDA Center for Biologics Evaluation and Research (CBER) cm x 4cm Amniotic Membrane 4cm x 6cm Amniotic Membrane 4cm x 8cm Amniotic Membrane Larger sizes available on request. Some sizes are considered special orders, may take up to 30 days to deliver RegeniSource LLC Hwy 281N # San Antonio, TX (877) Serving our Patriots with Advanced Regenera ve Therapies RAV-2017-V1M

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