Balgrist Shoulder Course 2017
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1 How do we define a glenoid component at risk for clinical failure? Joseph P. Iannotti MD, PhD Maynard Madden Professor and Chairman Orthopaedic and Rheumatologic Institute Cleveland Clinic
2 Conflict of Interest DePuy Synthes Royalties Wright - Tornier Royalties DJO Consulting and Royalties Custom Orthopaedic Solutions Equity Lippincott WW Royalties None related to this talk
3 Acknowledgements Eric Ricchetti MD Bong Jae Jun PhD Tom Patterson PhD Kyle Walker MD Residents and Fellows Funding State of Ohio Technology Development Fund Department of Orthopaedic Surgery
4 Literature: TSA Failure Glenoid component is the most common cause for clinical failure TSA Component failure results from wear and loosening Uncertain definition of a loose glenoid Early glenoid loosening is often asymptomatic
5 Literature: Measuring Component Loosening Defining glenoid movement by x-ray is imprecise RSA is a very accurate method for measurement of implant loosening in many joints RSA is not able to evaluate the implant bone interface Need x-rays or CT scans
6 The early migration of a partially cemented fluted pegged glenoid component using radiostereometric analysis David Nuttall, PhD*, John F. Haines, FRCS, Ian A. Trail, MD, FRCS JSES patients with RSA measurements 6/11 (55%) patients migrated by RSA Post op CT Scan at last follow up demonstrated central peg osteolysis on all cases Suggesting 55% of cases had a loose glenoid No correlation with clinical scores at follow up
7 Our Goals Develop and validate 3D MAR CT scanning to Define implant migration Bone implant interface Correlation of implant failure Patient pathology Surgical factors and Implant factors
8 Study Criteria 170 patients prospectively enrolled Two shoulder surgeons Anatomic TSA DePuy Global AP with APG or Step Tech APG Intact rotator cuff OA 3D CT planning and use of PSI MAR 3D CT wilthin 2 months of surgery MAR 3D CT 2-3 years after surgery Routine x-rays performed at same time of CT
9 The Question Early results of the first 64 patients completing the protocol Development and validation of 3D CT imaging What are the patterns of glenoid component shift and osteolysis around the center peg
10 Radiopaque Tantalum Markers Intra-operative insertion DePuy Anchor Peg Glenoid and Steptech Glenoid Current standard of care at Cleveland Clinic Performed on >60 patients, ~ 5 minutes additional OR time Tantalum Marker Inserted Glenoid Component with Three Tantalum Markers Inserted Custom-made Tantalum Marker Insertion Tool Insertion Steps
11 Registration Process: Implants Glenoid implant registration: Marker Visualization CT Implant Registration stl model
12 Advanced 3D clinical CT imaging allows defining an anatomic coordinate system An anatomic, scapular coordinate system defined based on bony landmarks from the pre-operative CT scan Plane of the scapula
13 Advanced 3D clinical CT imaging allows super-imposition of multiple 3-D CT volumes Multiple 3D CT volumes (immediate post-operative and follow-up) with respect to a pre-operative scapula bone Pre-op
14 Advanced 3D clinical CT imaging allows super-imposition of multiple 3-D CT volumes Multiple 3D CT volumes (immediate post-operative and follow-up) with respect to a pre-operative scapula bone Pre-op Post-op
15 Advanced 3D clinical CT imaging allows super-imposition of multiple 3-D CT volumes Multiple 3D CT volumes (immediate post-operative and follow-up) with respect to a pre-operative scapula bone Pre-op Post-op Follow-up
16 Advanced 3D clinical CT imaging allows super-imposition of multiple 3-D CT volumes Multiple 3D CT volumes (immediate post-operative and follow-up) with respect to a pre-operative scapula bone Pre-op Post-op Follow-up Superimposition of post-op & follow-up to pre-op scapular bone
17 Advanced 3D clinical CT imaging allows super-imposition of multiple 3-D CT volumes Multiple 3D CT volumes (immediate post-operative and follow-up) with respect to a pre-operative scapula bone Pre-op Post-op Follow-up Superimposition of post-op & follow-up to pre-op scapular bone Superimposed Scapulae
18 Advanced 3D clinical CT imaging allows quantification of glenoid component migration Intra-operative insertion of three-tantalum bead markers allows automatic detection of glenoid and head component position based on 3-D spatial relationships of the markers and humeral head size
19 Case Example: What you are missing on x-rays
20 Pre op 1/13
21 1 month post op
22 1 year post op
23 2 year post op Shoulder score = 100/100 points
24 Implant position at 3 months post operative
25 Implant Migration at Two Year Follow up
26 Advanced 3D clinical CT imaging allows quantification of glenoid component migration Phantom study Measurement accuracy of quantifying component migration of glenoid and head component was 0.10 mm in translation and 0.19 º in rotation In vivo patient study (n = 6 patients) In vivo measurement errors in measuring glenoid component positional shift using advanced CT imaging analysis were 0.3mm, 0.4mm, 0.2mm for translations and 0.4⁰, 0.5⁰, 0.6 ⁰ for rotations, compared to radiostereometric analysis (RSA) method C-arm X-ray C-arm X-ray Before Post-image Processing After Post-image Processing
27 A Preliminary Study of Advanced 3D CT Imaging Analysis in a Cohort of Patients A total of 64 patients who underwent an anatomic total shoulder arthroplasty between 2013 and 2015 Gender Age Male: 44 Female: ± 8 years old Advanced 3-D CT imaging analysis was performed using sequential clinical CT pre-, post-op, & min 2yr Implant migration was analyzed for rotations in superior/inferior and anterior/posterior directions Central peg osteolysis grade (1, 2, and 3) was assessed using the minimum 2 year follow up CT scan
28 Glenoid Component Min 2 Year Follow Up Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
29 Glenoid Component Min 2 Year Follow Up 3 degrees Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
30 Glenoid Component Min 2 Year Follow Up 6 degrees Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
31 Central Peg Osteolysis Grade Grade 1 Grade 2 Grade 3 Central peg osteolysis grade was assessed threedimensionally through anterior-posterior and superiorinferior view
32 Glenoid Component Migration & Central Peg Osteolysis Grade Grade Patients Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
33 Glenoid Component Migration & Central Peg Grade Grade 2 15 Patients Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
34 Glenoid Component Migration & Central Peg Grade? Grade 3 37 Patients Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
35 Center Peg Bent Overtime: Importance of 4 Markers CT3 CT3 The center peg location remains the same as immediate post-op (CT2: red) Other three-peg beads of follow-up (CT3: green) indicate implant shift in version
36 Glenoid Component Migration & Central Peg Osteolysis Grade Grade 1 Grade 2 Grade Posterior Tilt (-) Anterior Tilt (+) Inferior Tilt (-) Superior Tilt (+)
37 Patterns of Glenoid Component Loosening Assessed by Advanced 3D Clinical CT Imaging Non-migrated Implant Implant Migration Migrated Implant Non-migrated implant without central peg osteolysis STABLE IMPANT 28/64 (44%) Without Osteolysis Central Peg Osteolysis With Osteolysis Rotation < 3.0 Rotation 3.0 Grade 2 & 3 Grade 1 Non-migrated implant with central peg osteolysis 1/64 (1.6) Migrated implant without central peg osteolysis 24/64 (37.5%) Migrated implant with central peg osteolysis LOOSE IMPLANT 10/64 (17%)
38 Preliminary Results of Advanced 3D CT Imaging Analysis in a Cohort of Patients Non-migrated implant without central peg osteolysis 28/64 (43.8%) patients Implant migration Mean version: 0.9 ± 0.7 Mean inclination: 1.2 ± 0.8 Central peg osteolysis Grade 1: 0 patient Grade 2: 9 patients Grade 3: 19 patients
39 Preliminary Results of Advanced 3D CT Imaging Analysis in a Cohort of Patients Non-migrated implant with central peg osteolysis 1/64 (1.6%) patients Implant migration Posterior tilt: -1.0 Inferior tilt: -1.3 Central peg osteolysis Grade 1: 1 patient
40 Preliminary Results of Advanced 3D CT Imaging Analysis in a Cohort of Patients Migrated implant without central peg osteolysis 24/64 (37.5%) patients Implant migration Mean version: 2.6 ± 2.7 Mean inclination: 4.3 ± 2.0 Central peg osteolysis Grade 1: 0 patient Grade 2: 6 patients Grade 3: 18 patients
41 Preliminary Results of Advanced 3D CT Imaging Analysis in a Cohort of Patients Migrated implant with central peg osteolysis 11/64 (17.1%) patients Implant migration Mean version: 2.5 ± 4.7 Mean inclination: 1.8 ± 2.4 Central peg osteolysis Grade 1: 11 patient
42 Summary of Advanced 3D CT Imaging Analysis in a Cohort of Patients Patterns of implant migration more than 3 Superior tilt (27 pts) was the major direction of the implant migration, followed by posterior (8 pts) and anterior tilt (5pts) No inferior tilt was found Patterns of central peg osteolysis Grade 1 found in 12/64 patients (19%) Grade 2 found in 15/64 patients Grade 3 found in 37/64 patients Relations between implant migration and osteolysis 11/12 patients with central peg osteolysis grade 1 had shown implant migration more than 3 24/64 Implants with migration (34%) more than 3 was not always associated with central peg osteolysis
43 Summary of Advanced 3D CT Imaging Analysis in a Cohort of Patients Implant migration may occur prior to development of central peg osteolysis Implant migration may causes later onset of central peg osteolysis Development of central peg osteolysis may promote implant migration
44 Conclusions We have developed a 3D CT based imaging method that has a detection accuracy for glenoid implant shift, validated in vivo patients, to be < 1 degree of translational or < 1 degree of rotational movement when compared to RSA measurements.
45 Conculsions In a series of 64 patients using this CT based method, at two years follow up, we demonstrated that 34/64 (53%) patients have at least 3 degrees of shift In patients with shift there are patients with and without radiolucency around the pegs. 70% with shift have no radiolucency Shift = Loosening
46 Conclusions At this time we have not defined the progression of these imaging findings over time. At this length of follow these finding are not correlated with a significant decrease in PRO or revision surgery. It is our current working hypothesis that those implants with greater than 3 degrees of shift AND radiolucency are at risk for progression and earlier clinical failure defined by a decrease in PRO and the need for revision surgery.
47 Conclusions Our study demonstrates the novel finding of glenoid implant shift without radiolucency which we currently interpret to be a stable implant. The fate of these implants are not know but we anticipate that progression of implant shift may not be as likely or will result in earlier clinical failure.
48 Conclusions When assessing shift of a glenoid implant it is important to assess the implant bone interface to assess if the shift is associated with resorbtion of bone around the implant as an additional feature of an implant at risk for clinically relevant loosening.
49 Future Studies Additional 110 patients due for 2 year 3D CT scans by June Correlation with: Pre op Walch type and humeral head subluxation Correction of retroversion and inclination, joint line medialization Back side contact and Humeral head position Trabecular bone patterns and bone quality Correlation with x-rays findings Longer term follow up 5-10 years
50
Conflicts of Interest Consulting (C), Royalty (R)
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