Key words: rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, treatment access
|
|
- Julia Barker
- 6 years ago
- Views:
Transcription
1 6, 21...,.,..,..,. - (RA) -,. (AS) (PsA). (Disease-modifying antirheumatic drugs, DMARDs). DMARDs RA, AS PsA. 21. RA, DMARDs. Leflunomide (Arava)., RA Methotrexate Leflunomid. DMARDs RA AS. (NSAIDs DMARDs) AS. -,, 12. TNF-.42% RA.4% AS., DMARDs... 75%., DMARDs. -,,, :,,, R. Stoilov,. Ivanova, N. Stoilov and S. Marincheva. COST ANALYSIS OF THE TREATMENT OF RHEUMATOID ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH SYN- THETIC AND BIOLOGIC DISEASE MODIFYING ANTIRHEUMATIC DRUGS FOR 21 IN BULGARIA Summary. Early diagnosis and early aggressive treatment of rheumatoid arthritis (RA) are among the major factors for delaying the rate of bone-tendon destructions and, respectively, of invalidism. Such observations have also been reported in patients with ankylosing spondylitis (AS) and psoriatic arthritis (PsA). Regarding this, great hopes are reposed in disease-modifying antirheumatic drugs (DMARDs) and, particularly, in biologic agents. The aim of this study was to determine and evaluate the utilization of synthetic and biologic DMARDs in the treatment of RA, AS and PsA for 21 in Bulgaria. For 21, an increase of the number of RA treatments with synthetic DMARDs was registered, predominantly attributed to treatments with leflunomide (Arava). This fact can be explained by the consensus achieved by the members of the Bulgarian Society for Rheumatology that a biologic agent is to be included in the treatment of RA, only after a lack of response to methotrexate and leflunomide. In 21, expenditures for biologic DMARDs were 5 times higher compared with these for the preceding 29. This increase was attributed mostly to RA and AS treatments. The lack of sufficiently effective synthetic medicinal products (NSAIDs and DMARDs) for the treatment of AS, has stimulated the use of biologic agents. Despite the increased utilization of biologic agents in the treatment of inflammatory joint diseases in Bulgaria, the proportion of their users is too small, compared with the average 12% in the other EU countries. In our country,.42% of the RA patients and.4% of the AS patients are on TNF- blockers. This indicates that the access to expensive and highly effective treatments with biologic DMARDs is very limited in Bulgaria. The reimbursement policy of the health insurance system is the key to improving the access to biologic agent treatment. The reimbursement of only 75% of the cost of this treatment is still far beyond patient affordability. The proportion of patients treated with synthetic DMARDs is still too low. Of course, reimbursement of synthetic DMARDs is of importance, but it has no such heaviness as this of biologic agents. Rheumatologist s opinion and patient's compliance are of greater importance. Key words: rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, treatment access
2 61... (RA) [5]. [1]. RA % [7, 2]. - : -.85% [28],.8% [11]. RA -.31%,.46% [21, 29],.5 1% [25]. - RA.48% [15] , - RA [15]. - RA [17], ( ) [7]., RA HAQ-DI Steinbrocker criteria V [14]. ACR 3 RA -, [3]. (NSAIDs),, - (Disease-modifying antirheumatic drugs, DMARDs). -. DMARDs - ( )., RA DMARDs,, DMARDs [16] , TNF [8, 17, 27, 3], -. - DMARDs. -, : 1) - RA DAS28 5.1; 2) - - DMARDs, -,. TNF- - (AS) (PsA). AS HLA-B % [19]. AS.8% [22],.55% [6],.13%.52% [12]., -.2.3% [15]. -,, AS PsA.5 1% [15]. - -,. - - DMARDs RA, AS PsA. : ISM Methotrexate, Leflunomide (Arava), Sulfasalazine (Salazopyrin), Penicillamine (Cuprenil), Hydroxychloroquine, Azathioprine (Imuran), Ciclosporin A, Cyclophosphamide, Adalimumab (Humira), Etanercept (Enbrel), Infliximab (Remicade), Rituximab (Mabthera) 21.;
3 62.,.,.. TNF- ; - RA, AS PsA., RA, - - [9]. - -, - [31]. DMARDs, -, RA., - RA,, -, RA. - TNF- Arava, , Methotrexate, Sulfasalazine DMARDs. DMARDs ( TNF- Adalimumab Etanercept). 1 -, DMARDs,., RA..25% - (. 1). 1., DMARDs Adalimumab (Humira) % Etanercept (Enbrel) % Infliximab (Remicade) NA NA NA NA Rituximab (Mabthera) NA NA NA NA Methotrexate % Leflunomide (Arava) % Sulfasalazine (Salazopyrin) % Penicillamine (Cuprenil) 3 NA 262 NA 786 NA Hydroxychloroquine % Azathioprine (Imuran) % Ciclosporin A NA NA NA NA Cyclophosphamide NA NA NA NA 21. TNF- (Adalimumab Etanercept) 21 (RA 125, AS 61, PsA 15) , 72, 179% TNF- (Adalimumab Etanercept) , - 144% (. 1). - TNF- -
4 63... [16] RA, TNF-. - Adalimumab (Humira) Etanercept (Enbrel).42% RA ( ). - TNF RA % - TNF- [13] % [13]., 12% R TNF- [13]., -. ( ) - (75%) % % % TNF ( ) ,.4% - AS (15 4 ), Adalimumab Etanercept. TNF- AS NSAIDs, - DMARDs KS. - TNF- AS. PsA -, 15, -, Adalimumab (Humira) Etanercept (Enbrel) -.. 1, - TNF , TNF-, %, 25%, 36% % TNF-, % (. 1,. 2).. 2, - DMARDs Enbrel Humira
5 64.,.,.. 2. DMARDs 1 - [1].. Sulfasalazine (Salasopyrin) Aurothiomalic acid NA Hydroxychloroquine Penicillamine (Cuprenil) Auranofin NA Methotrexate 1 mg/ Azathioprine (Imuran) 1978 NA 146 Cyclosprorin A NA Leflunomide (Arava) Etanercept (Enbrel) Infliximab (Remicade) NA Anakinra (Kinret) NA Adalimumab (Humira) Rituximab (Mabthera) NA Abatacept (Orencia) NA Humira Enbrel. Infliximab (Remicade), -TNF-, [2]. 1, - Humira 61%, Enbrel 39%., 65% TNF- Humira 35% Enbrel (. 2) HUMIRA, ENBREL REMICADE. 21. ( )
6 65... DMARDs RA DMARDs., 11.6% -., DMARDs,., RA. - -, -, (.. 2). Methotrexate ( ) , % RA ( 1%), Arava. Leflunomide (Arava).9% RA (.. 1). 36% TNF- - Methotrexate Leflunomide. Sulfasalazine Hydroxychloroquine, 43% 75% % Sulfasalazine (Salasopyrin).3% Hydroxychloroquine. Penicillamine (Cuprenil) Imuran, Cyclosprorin A Cyclophosphamide RA (.. 1)., , -, TNF [13].. 2, - DMARDs,, -. Methotrexate 1 mg/ 36, (Sulfasalazine, Hydroxychloroquine, Leflunomide), Arava Arava , 31%. DMARDs TNF-, 87.7 %. DMARDs , 12.3% DMARDs (. 3). 29. DMARDs , , , 47%, 53% : 1) - 2) DMARDs. 29. DMARDs 47 53%, % (.. 3)., - -,, -. -, - - DMARDs,. - - /,., /. TNF - Etanercep Adalimumab ( ) - DMARDs. TNF - RA - Methotrexate., - TNF [18].
7 66.,.,.. - TNF RA [23]. (, ) DMARDs RA , , Leflunomide 21, Azathio- prine 1878, Sulfasalazine 119, Methotrexate 78, Hydroxychloroquine 684 [24]., - DMARDs a a. -, % - TNF % % % 47 % , % , DMARDs 18%.13% % DMARDs.,. 9% -, 9%. -,,., - -, ,, ,, -., TNF - -, -, -, [4].
8 % % % ( ) ( ) TNF - RA, AS PsA [26].,.. -, -. -., [13].., - -,,, TNF,.,, - ( ), -, - [13]. - - DMARDs ( -, )., TNF., RA, DMARDs. Leflunomide (Arava) Methotrexate., RA Methotrexate Leflunomid. DMARDs -. RA AS. (NSAIDs DMARDs) - AS , -., - DMARDs , 5, 15, (,, ), [1]. DMARDs , 1 mg/
9 68.,.,.., -,.. - DSA28 ACR RA, AS, PsA TNF-., - [7].,. TNF, -,,.. 1.,.,... -., 19, 211, 4, ,.,... -, -., 19, 211, 4, A m e r i c a n College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis. Arthritis Rheum., 46, 28, 2, A d a m s, C. P. et V. V. Brantner. Estimating the cost of new drug development: is it really 82 million dollars? Health Aff. (Millwood), 25, 26, A n t o n i, M. R. et al. Cooperative of QoL in rheumatic disease: results of a survey among 6, patients across 11 European countries. Arthritis Rheum., 46, 22, ACR (abstract). 6. B r a u n, J., J. Listing et J. Sieper. Overestimation of the prevalence of ankylosing spondylitis in the Berlin study. Arthritis Rheum., 52, 25, B e n u c c i, M. et al. Cost effectiveness analysis of diseasemodifying antirheumatic drugs in rheumatoid arthritis. A systematic rewiev literature. Int. J. Rheum., 211, Article ID , 6 pages. 8. B a t h o n, J. M. et al. A comparison of etanercept and methotrexate in patient with early rheumatoid arthritis. N. Engl. J. Med., 343, 2, 22, E F P I A The European Federation of Pharmaceutical Industries and Associations annual report. org/6_publ/annual. 1. F e x, E. et al. Impact of rheumatoid arthritis on work status and social and leisure time activities in patients followed 8 years from onset. J. Rheumatol., 25, 1997, H a k a l a, M., R. Pollanen et P. Nieminen. The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J. Rheumatol., 2, 1993, 1, H e l m i c k, C. G. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum., 58, 28, J ö n s s o n, B., G. Kobelt et J. Smolen. The burden of rheumatoid arthritis and access to treatment: uptake of new therapies. Eur. J. Health Econ., 8, 28, Suppl. 2, S61-S L e a r d i n i, G. et al. A multicenter cost-of-illness study on rheumatoid arthritis in Italy. Clin. Exp. Rheum., 2, 22, 4, K o b e l t, G. et F. Kasteng. Access to innovative treatmens in rheumatoid arthritis in Europe. October K o b e l t, G. et al. Modeling the progression of rheumatoid arthritis: a two-country model to estimate costs and consequences of rheumatoid arthritis. Arthritis Rheum., 46, 22, 9, K l a r e s k o g, L. et al. Therapeutic effect of the combination of etanercept and methotrexate compared wuth each treatment alone in patients with rheumatoid arthritis: doubleblind randomised controlled trial. Lancet, 363, 24, 941, M e r k e s d a l, S. et J. Ruof. Curent aspects of cost effectivness of TNF-alfa blocking agents in patients with rheumatoid arthritis. Zeitschrift fur Rheumatol., 61, 22, 3, P o d d u b n y y, D. Improving Diagnosis of Ankylosing Spondylitis and Spondyloarthritis in General, CME. Medscape, Q u a n, V. D., Chiun-Fang Chiou and R. Duboas. Review of eight pharmacoeconomic studies of the value of biologic DMARDs (Adalimumab, Etanercept and Infliximab) in the management of rheumatoid arthritis. J. Manag. Care Pharm., 12, 26, 7, R o u x, C. H. et al. Rheumatoid arthritis and spondyloarthropathies: geographical variations in prevalence in France. J. Rheumatol., 34, 27, 1, S a r a u x, A. et al. Prevalence of spondyloarthropathies in France: 21. Ann. Rheum. Dis., 64, 25, S c o t t, D. L. et G. Kingsley. Clinical effectiveness of biologics in clinical practice. Arthr. Reas Ther., 23, 21, S c h a d l i c h, P. K. et al. Modelling cost effectivness and cost utility of sequential DMAR therapy including leflunomide in rheumatoid arthritis in Germany: I. Selected DMARs and patient-related costs. FarmacoEconomics, 23, 25, 4, S i l m a n, A. J. et J. E. Pearson. Epdemiology and genetics of rheumatoid arthritis. Arthritis Res., 22, 4, suppl. 3, S m o l e n, J. S. et al. New therapies for the treatment of rheumatoid arthritis. Lancet, 37, 27, S m o l e n, J. S. et al. Predictors of joint damage in patients with early rheumatoid arthritis with high-dose methotrexate with or without concomitant infliximab: results from the AS- PIRE trial. Arthritis Rheum., 54, 26, 3, S y m m o n s, D. et al. The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford), 41, 22, 7, T o r r a n c e, G. W. Measurement of health state utilitifor economic appraisal: a review. J. Health Econ., 5, 1986, 1, Weinblatt, M. E. et al. A trial of etanercept, a recombinant tumor necrosis factor receptor: Fc fusion protein, in patients with rheumatoid arthritis reseiving methotrexate. N. Engl. J. Med., 34, 1999, 4, W o r l d Health Organisation. Dearth and DALY estimated for 22 by cause for WHO member states. In: WHO, Geneva, :. -.. " " Address for correspondence: Assoc. Prof. R. Stoilov, M. D. Clinic of Rheumatology Medical University 13, Urvitch Str. Bg 1612 Sofia
Regulatory Status FDA- approved indication: Simponi and Simponi ARIA are tumor necrosis factor (TNF) blockers indicated for the treatment of: (2-3)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.51 Subject: Simponi / Simponi ARIA Page: 1 of 9 Last Review Date: March 16, 2018 Simponi / Simponi
More informationOtezla. Otezla (apremilast) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 Subject: Otezla Page: 1 of 5 Last Review Date: March 16, 2018 Otezla Description Otezla (apremilast) Background
More informationCimzia. Cimzia (certolizumab pegol) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.50.11 Section: Prescription Drugs Effective Date: April 1, 2018 Subject: Cimzia Page: 1 of 5 Last Review
More informationFirst Name. Specialty: Fax. First Name DOB: Duration:
Prescriber Information Last ame: First ame DEA/PI: Specialty: Phone - - Fax - - Member Information Last ame: First ame Member ID umber DOB: - - Medication Information: Drug ame and Strength: Diagnosis:
More informationDr. Lyubomir Marinchev Chief of Rheumatology Department, MHAT SOFIAMED, Sofia, Bulgaria
Dr. Lyubomir Marinchev Chief of Rheumatology Department, MHAT SOFIAMED, Sofia, Bulgaria Inter-Balkan meeting Open the frontiers and exchange of experiences, 27 th April 2013, Rhodes, Greece Patients with
More informationCosentyx. Cosentyx (secukinumab) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.90.11 Subject: Cosentyx Page: 1 of 7 Last Review Date: September 20, 2018 Cosentyx Description Cosentyx
More informationRegulatory Status FDA- approved indication: Simponi and Simponi ARIA are tumor necrosis factor (TNF) blockers indicated for the treatment of:
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.51 Subject: Simponi / Simponi ARIA Page: 1 of 8 Last Review Date: March 17, 2017 Simponi / Simponi
More informationPharmacy Medical Necessity Guidelines: Cimzia (certolizumab pegol)
Pharmacy Medical Necessity Guidelines: Cimzia (certolizumab pegol) Effective: January 1, 2018 Prior Authorization Required Type of Review Care Management Not Covered Type of Review Clinical Review Pharmacy
More informationCIMZIA (certolizumab pegol)
Pre - PA Allowance None Prior-Approval Requirements Age Diagnoses 18 years of age or older Patient must have ONE of the following: 1. Moderate to severe Crohn s Disease (CD) a. Inadequate response, intolerance
More information1 P a g e. Systemic Juvenile Idiopathic Arthritis (SJIA) (1.3) Patients 2 years of age and older with active systemic juvenile idiopathic arthritis.
LENGTH OF AUTHORIZATION: Initial: 3 months for Crohn s or Ulcerative Colitis; 1 year for all other indications. Renewal: 1 year dependent upon medical records supporting response to therapy and review
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: golimumab_simponi 8/2013 2/2018 2/2019 3/2018 Description of Procedure or Service Golimumab (Simponi and
More informationQUALITY OF LIFE OF PATIENTS WITH RHEUMATOID ARTHRITIS IN BULGARIA
22 PHARMACIA, vol. 63, No. 2/2016 L. Marinov, I. Nikolova, K. Mitov, M. Kamusheva, G. Petrova QUALITY OF LIFE OF PATIENTS WITH RHEUMATOID ARTHRITIS IN BULGARIA L. Marinov 1, I. Nikolova 1, K. Mitov 2,
More informationRHEUMATOID ARTHRITIS DRUGS
Rheumatology Biologics Criteria from the Exceptional Access Program RHEUMATOID ARTHRITIS DRUGS DRUG NAME BRS REIMBURSED DOSAGE FORM/ STRENGTH Adalimumab Humira 40 mg/0.8 syringe and 40mg/0.8 pen for Anakinra
More informationC. Assess clinical response after the first three months of treatment.
Government Health Plan (GHP) of Puerto Rico Authorization Criteria Tumor Necrosis Factor Alpha (TNFα) Adalimumab (Humira ) Managed by MCO Section I. Prior Authorization Criteria A. Physician must submit
More informationClinical Policy: Certolizumab (Cimzia) Reference Number: PA.CP.PHAR.247 Effective Date: 01/18 Last Review Date: 08/17 Line of Business: Medicaid
Clinical Policy: (Cimzia) Reference Number: PA.CP.PHAR.247 Effective Date: 01/18 Last Review Date: 08/17 Line of Business: Medicaid Coding Implications Revision Log Description (Cimzia ) is a tumor necrosis
More informationCimzia. Cimzia (certolizumab pegol) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.50.11 Subject: Cimzia Page: 1 of 5 Last Review Date: December 8, 2017 Cimzia Description Cimzia (certolizumab
More informationSimponi / Simponi ARIA (golimumab)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.51 Subject: Simponi / Simponi ARIA Page: 1 of 6 Last Review Date: September 15, 2016 Simponi / Simponi
More informationCimzia. Cimzia (certolizumab pegol) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 Subject: Cimzia Page: 1 of 5 Last Review Date: March 17, 2017 Cimzia Description Cimzia (certolizumab pegol)
More informationClinical Policy: Anakinra (Kineret) Reference Number: ERX.SPA.135 Effective Date:
Clinical Policy: (Kineret) Reference Number: ERX.SPA.135 Effective Date: 10.01.16 Last Review Date: 05.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationETANERCEPT Generic Brand HICL GCN Exception/Other ETANERCEPT ENBREL GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW)
Generic Brand HICL GCN Exception/Other ETANERCEPT ENBREL 18830 GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW) 1. Does the patient have a diagnosis of moderate to severe rheumatoid
More informationFml Limits. Azathioprine (Imuran) 50mg, 75mg, 100mg - $26.85 Cyclosporine, 25mg, 100mg. $ Leflunomide (Arava) 10mg Tablet - $144.
MEDICATION COVERAGE POLICY PHARMACY AND THERAPEUTICS ADVISORY COMMITTEE POLICY: Rheumatoid Arthritis (RA) P&T DATE: 2/15/2017 CLASS: Rheumatology/Anti-inflammatory Disorders REVIEW HISTORY 2/16, 5/15,
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: abatacept_orencia 4/2008 2/2018 2/2019 2/2018 Description of Procedure or Service Abatacept (Orencia ), a
More informationThe legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION. 21 July 2010
The legally binding text is the original French version TRANSPARENCY COMMITTEE OPINION 21 July 2010 Examination of the dossier of medicinal products included on the reimbursement list for a period of 5
More informationClinical Policy: Abatacept (Orencia) Reference Number: ERX.SPA.123 Effective Date:
Clinical Policy: (Orencia) Reference Number: ERX.SPA.123 Effective Date: 10.01.16 Last Review Date: 05.18 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationSAMPLE IgE: ESR: CRP: # Joints: %BSA: Height: Weight: BMI:
Please Note: Medical Necessity Prior Authorization may be overrided for both formulary coverage and benefit design restrictions. They are issued at the full discretion of the benefit manager. PRIOR AUTHORIZATION
More informationXeljanz. Xeljanz, Xeljanz XR (tofacitinib) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.24 Subject: Xeljanz Page: 1 of 6 Last Review Date: March 16, 2018 Xeljanz Description Xeljanz, Xeljanz
More informationImmune Modulating Drugs Prior Authorization Request Form
Patient: HPHC member ID #: Requesting provider: Phone: Servicing provider: Diagnosis: Contact for questions (name and phone #): Projected start and end date for requested Requesting provider NPI: Fax:
More informationRegulatory Status FDA-approved indication: Orencia is a selective T cell co-stimulation modulator indicated for: (1)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 Subject: Orencia Page: 1 of 9 Last Review Date: September 20, 2018 Orencia Description Orencia (abatacept)
More informationADALIMUMAB Generic Brand HICL GCN Exception/Other ADALIMUMAB HUMIRA GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW)
Generic Brand HICL GCN Exception/Other ADALIMUMAB HUMIRA 24800 GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW) 1. Does the patient have a diagnosis of moderate to severe rheumatoid
More informationNICE DECISION SUPPORT UNIT
SEQUENTIAL TNF-α INHIBITORS AND NON BIOLOGIC DMARDS ANALYSIS OF THE NATIONAL DATABANK FOR RHEUMATIC DISEASES. NICE DECISION SUPPORT UNIT Allan Wailoo School of Health and Related Research, University of
More informationAmjevita (adalimumab-atto)
*- Florida Healthy Kids Amjevita (adalimumab-atto) Override(s) Prior Authorization Quantity Limit Medications Amjevita 20 mg/0.4 ml prefilled syringe Amjevita (adalimumab-atto) 40 mg/0.8 ml 2 #* ^ prefilled
More informationUstekinumab (Stelara) for psoriatic arthritis second line after disease modifying anti rheumatic drugs (DMARDs)
Ustekinumab (Stelara) for psoriatic arthritis second line after disease modifying anti rheumatic drugs (DMARDs) January 2010 This technology summary is based on information available at the time of research
More informationClinical Policy: Certolizumab (Cimzia) Reference Number: CP.PHAR.247 Effective Date: Last Review Date: Line of Business: HIM, Medicaid
Clinical Policy: (Cimzia) Reference Number: CP.PHAR.247 Effective Date: 08.16 Last Review Date: 05.18 Line of Business: HIM, Medicaid Coding Implications Revision Log See Important Reminder at the end
More information2017 PERIOPERATIVE MEDICINE SYMPOSIUM Peri-operative use of immunosuppression in rheumatology patients
2017 PERIOPERATIVE MEDICINE SYMPOSIUM Peri-operative use of immunosuppression in rheumatology patients Dr Alberta Hoi Rheumatologist MBBS, FRACP, PhD NEW ERA IN MUSCULOSKELETAL MEDICINE New drugs - Biologics,
More informationINFLIXIMAB Remicade (infliximab), Inflectra (infliximab-dyyb), Ixifi* (infliximabqbtx), Renflexis (infliximab-abda)
Pre - PA Allowance None Prior-Approval Requirements Diagnoses Patient must have ONE of the following: 6 years of age or older 1. Moderate to severe Crohn s disease (CD) a. Patient has fistulizing disease
More informationCanadian Society of Internal Medicine Annual Meeting 2016 Montreal, QC
Canadian Society of Internal Medicine Annual Meeting 2016 Montreal, QC Update on the Treatment of Rheumatoid Arthritis Sabrina Fallavollita MDCM McGill University Canadian Society of Internal Medicine
More informationThe Hospital for Sick Children Technology Assessment at SickKids (TASK)
The Hospital for Sick Children Technology Assessment at SickKids (TASK) THE USE OF BIOLOGIC RESPONSE MODIFIERS IN POLYARTICULAR-COURSE JUVENILE IDIOPATHIC ARTHRITIS Report No. 2010-01 Date: January 11,
More informationCertolizumab pegol (Cimzia) for psoriatic arthritis second line
Certolizumab pegol (Cimzia) for psoriatic arthritis second line This technology summary is based on information available at the time of research and a limited literature search. It is not intended to
More informationSpondyloarthropathies: Disease Perception Limits Market
Spondyloarthropathies: Disease Perception Limits Market Psoriatic arthritis and ankylosing spondylitis form part of the group of diseases known as the spondyloarthropathies. Psoriatic arthritis is a form
More informationPerioperative Medicine:
Perioperative Medicine: Management of rheumatologic agents Divya Gollapudi, MD May 2016 Medical Operative Consult Clinic Harborview Medical Center Your patient Ms. L is a 55 year-old F w/ h/o RA who presents
More informationRegulatory Status FDA-approved indication: Enbrel and Erelzi are tumor necrosis factor (TNF) blockers indicated for the treatment of: (2-3)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.27 Subject: Enbrel Page: 1 of 10 Last Review Date: June 22, 2018 Enbrel Description Enbrel (etanercept),
More informationClinical Policy: Certolizumab (Cimzia) Reference Number: CP.PHAR.247 Effective Date: 08/16 Last Review Date: 08/17 Line of Business: Medicaid
Clinical Policy: (Cimzia) Reference Number: CP.PHAR.247 Effective Date: 08/16 Last Review Date: 08/17 Line of Business: Medicaid Coding Implications Revision Log See Important Reminder at the end of this
More informationClinical Policy: Etanercept (Enbrel) Reference Number: PA.CP.PHAR.250 Effective Date: 01/18 Last Review Date: 08/17 Line of Business: Medicaid
Clinical Policy: (Enbrel) Reference Number: PA.CP.PHAR.250 Effective Date: 01/18 Last Review Date: 08/17 Line of Business: Medicaid Coding Implications Revision Log Description (Enbrel ) is tumor necrosis
More informationHARVARD PILGRIM HEALTH CARE RECOMMENDED MEDICATION REQUEST GUIDELINES
Generic Brand HICL GCN Exception/Other CERTOLIZUMAB PEGOL CIMZIA 35554 GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW) 1. Is the request for a patient with a diagnosis of moderate
More informationTRANSPARENCY COMMITTEE OPINION. 26 April 2006
TRANSPARENCY COMMITTEE OPINION 26 April 2006 REMICADE 100 mg powder for concentrate for solution for infusion Box of 1 (CIP code: 562 070.1) Applicant : laboratoires Schering Plough List I Drug for hospital
More informationRegulatory Status FDA-approved indication: Enbrel and Erelzi are tumor necrosis factor (TNF) blockers indicated for the treatment of: (2-3)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.27 Subject: Enbrel Page: 1 of 8 Last Review Date: March 16, 2018 Enbrel Description Enbrel (etanercept),
More informationDrug Class Prior Authorization Criteria Therapeutic Agents in Rheumatic and Inflammatory Diseases
Drug Class Prior Authorization Criteria Therapeutic Agents in Rheumatic and Inflammatory Diseases Line of Business: Medicaid P & T Approval Date: August 16, 2017 Effective Date: August 16, 2017 This policy
More informationHARVARD PILGRIM HEALTH CARE RECOMMENDED MEDICATION REQUEST GUIDELINES HUMIRA PEDIATRIC
Generic Brand HICL GCN Exception/Other ADALIMUMAB HUMIRA 24800 HUMIRA PEDIATRIC GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW) 1. Is the patient currently taking Humira? If
More informationClinical Policy: Anakinra (Kineret) Reference Number: CP.PHAR.244 Effective Date: Last Review Date: Line of Business: HIM, Medicaid
Clinical Policy: (Kineret) Reference Number: CP.PHAR.244 Effective Date: 08.16 Last Review Date: 11.18 Line of Business: HIM, Medicaid Coding Implications Revision Log See Important Reminder at the end
More informationRegulatory Status FDA-approved indication: Orencia is a selective T cell costimulation modulator indicated for: (1)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.18 Subject: Orencia Page: 1 of 8 Last Review Date: March 16, 2018 Orencia Description Orencia (abatacept)
More informationReport on New Patented Drugs - Orencia
Report on New Patented Drugs - Orencia Under its transparency initiative, the PMPRB publishes the results of the reviews of new patented drugs by Board Staff, for purposes of applying the Board s Excessive
More informationQUAN V. DOAN, PharmD; CHIUN-FANG CHIOU, PhD; and ROBERT W. DUBOIS, MD, PhD
SUBJECT REVIEW Review of Eight Pharmacoeconomic Studies of the Value of Biologic DMARDs (Adalimumab, Etanercept, and Infliximab) in the Management of Rheumatoid Arthritis QUAN V. DOAN, PharmD; CHIUN-FANG
More informationadalimumab, 40mg/0.8mL, solution for injection (Humira ) SMC No. (858/13) AbbVie Ltd (previously part of Abbott)
adalimumab, 40mg/0.8mL, solution for injection (Humira ) SMC No. (858/13) AbbVie Ltd (previously part of Abbott) 08 March 2013 The Scottish Medicines Consortium (SMC) has completed its assessment of the
More informationClinical Policy: Certolizumab (Cimzia) Reference Number: ERX.SPA.167 Effective Date:
Clinical Policy: (Cimzia) Reference Number: ERX.SPA.167 Effective Date: 10.01.16 Last Review Date: 11.17 Revision Log See Important Reminder at the end of this policy for important regulatory and legal
More informationClinical Policy: Certolizumab (Cimzia) Reference Number: ERX.SPA.167 Effective Date:
Clinical Policy: (Cimzia) Reference Number: ERX.SPA.167 Effective Date: 1.1.16 Last Review Date: 11.17 Revision Log See Important Reminder at the end of this policy for important regulatory and legal information.
More informationRheumatoid arthritis 2010: Treatment and monitoring
October 12, 2010 By Yusuf Yazici, MD [1] The significant changes in the way rheumatoid arthritis has been managed include earlier, more aggressive treatment with combination therapy. Significant changes
More informationWe are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists. International authors and editors
We are IntechOpen, the world s leading publisher of Open Access books Built by scientists, for scientists 3,700 108,500 1.7 M Open access books available International authors and editors Downloads Our
More informationHARVARD PILGRIM HEALTH CARE RECOMMENDED MEDICATION REQUEST GUIDELINES
Generic Brand HICL GCN Exception/Other GOLIMUMAB SIMPONI 22533, 22536, 34697, 35001 ROUTE = SUBCUTANE. GUIDELINES FOR USE INITIAL CRITERIA (NOTE: FOR RENEWAL CRITERIA SEE BELOW) 1. Is the request for a
More informationR heumatoid arthritis is a chronic debilitating disease that
924 EXTENDED REPORT Pharmacoeconomic study of patients with chronic inflammatory joint disease before and during infliximab treatment K Laas, R Peltomaa, H Kautiainen, K Puolakka, M Leirisalo-Repo... Ann
More informationHorizon Scanning Centre November Secukinumab for active and progressive psoriatic arthritis. SUMMARY NIHR HSC ID: 5330
Horizon Scanning Centre November 2012 Secukinumab for active and progressive psoriatic arthritis. SUMMARY NIHR HSC ID: 5330 Secukinumab is a high-affinity fully human monoclonal antibody that antagonises
More informationRemicade (infliximab), Inflectra (infliximab-dyyb), Renflexis (infliximababda)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.50.02 Subject: Infliximab Page: 1 of 13 Last Review Date: December 8, 2017 Infliximab Description Remicade
More informationPsoriatic Arthritis- Second Line Treatments
Psoriatic Arthritis- Second Line Treatments Second line treatments for Psoriatic Arthritis (PsA) are usually prescribed by a Rheumatologist, Dermatologist, or in a combined clinic where both the Dermatologist
More informationStelara. Stelara (ustekinumab) Description
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.90.04 Subject: Stelara Page: 1 of 9 Last Review Date: September 20, 2018 Stelara Description Stelara
More informationMedication Policy Manual. Topic: Xeljanz, tofacitinib Date of Origin: January 21, 2013
Medication Policy Manual Policy No: dru289 Topic: Xeljanz, tofacitinib Date of Origin: January 21, 2013 Committee Approval Date: January 19, 2015 Next Review Date: January 2016 Effective Date: April 1,
More informationClinical Policy: Tofacitinib (Xeljanz, Xeljanz XR) Reference Number: ERX.SPA.110 Effective Date:
Clinical Policy: Tofacitinib (Xeljanz, Xeljanz XR) Reference Number: ERX.SPA.110 Effective Date: 10.01.16 Last Review Date: 05.18 Revision Log See Important Reminder at the end of this policy for important
More informationPharmacy Medical Necessity Guidelines:
Pharmacy Medical Necessity Guidelines: Effective: January 1, 2018 Prior Authorization Required Type of Review Care Management Not Covered Type of Review Clinical Review Pharmacy (RX) or Medical (MED) Benefit
More informationProposal relating to the funding of TNF inhibitors (Humira and Enbrel) and gabapentin (Neurontin)
14 July 2015 Proposal relating to the funding of TNF inhibitors (Humira and Enbrel) and gabapentin (Neurontin) PHARMAC is seeking feedback on a proposal relating to the funding of the TNF-inhibitor medicines
More informationMedication Policy Manual. Topic: Otezla, apremilast Date of Origin: May 9, 2014
Medication Policy Manual Policy No: dru342 Topic: Otezla, apremilast Date of Origin: May 9, 2014 Committee Approval Date: January 19, 2015 Next Review Date: January 2016 Effective Date: April 1, 2015 IMPORTANT
More informationSubject: Remicade (Page 1 of 5)
Subject: Remicade (Page 1 of 5) Objective: I. To ensure that Health Share/Tuality Health Alliance (THA) has a process by which the appropriate utilization of Remicade (Infliximab) for members whose diagnosis
More information2010 Annual Meeting of the Canadian Rheumatology Association February 3 to 6, Quebec City, Quebec. Copyright. Not for Sale or Commercial Distribution
21 Annual Meeting of the Canadian Rheumatology Association February 3 to 6, Quebec City, Quebec Copyright In February 21, Quebec City hosted the annual meeting of the Canadian Rheumatology Association
More informationRegulatory Status FDA-approved indication: Humira and Amjevita are tumor necrosis factor (TNF) blockers indicated for the treatment of: (2-3)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.29 Subject: Humira Page: 1 of 14 Last Review Date: June 22, 2018 Humira Description Humira (adalimumab),
More informationClinical Policy: Baricitinib (Olumiant) Reference Number: CP.PHAR.135 Effective Date: Last Review Date: 11.18
Clinical Policy: (Olumiant) Reference Number: CP.PHAR.135 Effective Date: 07.24.18 Last Review Date: 11.18 Line of Business: Medicaid Revision Log See Important Reminder at the end of this policy for important
More informationACTEMRA (tocilizumab)
Pre - PA Allowance None Prior-Approval Requirements Diagnoses Patient must have ONE of the following: 1. Active Polyarticular Juvenile Idiopathic Arthritis (PJIA) b. Patient has an intolerance or has experienced
More informationCertolizumab pegol (Cimzia) for the treatment of ankylosing spondylitis second or third line
Certolizumab pegol (Cimzia) for the treatment of ankylosing spondylitis second or third line August 2011 This technology summary is based on information available at the time of research and a limited
More informationCost-effectiveness analysis of biological treatments for rheumatoid arthritis Chiou C F, Choi J, Reyes C M
Cost-effectiveness analysis of biological treatments for rheumatoid arthritis Chiou C F, Choi J, Reyes C M Record Status This is a critical abstract of an economic evaluation that meets the criteria for
More informationFml Limits. Azathioprine (Imuran) 50mg, 75mg, 100mg - $24.20 Cyclosporine, 25mg, 100mg. $ Leflunomide (Arava) 10mg Tablet - $148.
MEDICATION COVERAGE POLICY PHARMACY AND THERAPEUTICS ADVISORY COMMITTEE POLICY: Rheumatoid Arthritis (RA) P&T DATE: 2/15/2018 CLASS: Rheumatology/Anti-inflammatory Disorders REVIEW HISTORY 02/17, 2/16,
More informationMedical Policy An independent licensee of the Blue Cross Blue Shield Association
Otezla (apremilast) Page 1 of 7 Medical Policy An independent licensee of the Blue Cross Blue Shield Association Title: Otezla (apremilast) Prime Therapeutics will review Prior Authorization requests Prior
More informationTo help you with terms and abbreviations used in this document that may be unfamiliar to you, a glossary is provided on the last pages.
ARTHRITIS CONSUMER EXPERTS 910B RICHARDS STREET VANCOUVER BC V6B 3C1 CANADA T: 604.974-1366 F: 604.974-1377 WWW.ARTHRITISCONSUMEREXPERTS.ORG Arthritis Consumer Experts In Health Care and Research Decision-making
More informationSimponi ARIA (golimumab) (Intravenous)
Simponi ARIA (golimumab) (Intravenous) Last Review Date: 10/31/2017 Date of Origin: 09/05/2013 Document Number: MODA-0176 Dates Reviewed: 12/2013, 8/2014, 3/2015, 6/2015, 9/2015, 12/2015, 3/2016, 6/2016,
More informationSIMPONI ARIA (GOLIMUMAB) INJECTION FOR INTRAVENOUS INFUSION
UnitedHealthcare Commercial Medical Benefit Drug Policy SIMPONI ARIA (GOLIMUMAB) INJECTION FOR INTRAVENOUS INFUSION Policy Number: PHA031 Effective Date: March 1, 2019 Table of Contents Page COVERAGE RATIONALE...
More information2. Is the patient responding to Remicade therapy? Y N
09/29/2015 Prior Authorization AETA BETTER HEALTH OF MICHIGA (MEDICAID) Remicade (MI88) This fax machine is located in a secure location as required by HIPAA regulations. Complete/review information, sign
More informationPatient #1. Rheumatoid Arthritis. Rheumatoid Arthritis. 45 y/o female Morning stiffness in her joints >1 hour
Patient #1 Rheumatoid Arthritis Essentials For The Family Medicine Physician 45 y/o female Morning stiffness in her joints >1 hour Hands, Wrists, Knees, Ankles, Feet Polyarticular, symmetrical swelling
More informationThe GPs role with biologics for immune-mediated inflammatory diseases David Gardner Rheumatologist GPCME 2015
The GPs role with biologics for immune-mediated inflammatory diseases David Gardner Rheumatologist GPCME 2015 The views and opinions expressed in the following presentation are those of the presenter and
More informationUnitedHealthcare Pharmacy Clinical Pharmacy Programs
UnitedHealthcare Pharmacy Clinical Pharmacy Programs Program Number 2018 P 1017-7 Program Prior Authorization/Notification Medication Cimzia (certolizumab) P&T Approval Date 1/2007, 6/2008, 4/2009, 6/2009,
More informationSee Important Reminder at the end of this policy for important regulatory and legal information.
Clinical Policy: Infliximab (Remicade, Inflectra, Renflexis) Reference Number: CP.PHAR.254 Effective Date: 07.16 Last Review Date: 05.18 Line of Business: Medicaid Coding Implications Revision Log See
More informationClinical Policy: Etanercept (Enbrel) Reference Number: CP.PHAR.250 Effective Date: 08/16 Last Review Date: 08/17 Line of Business: Medicaid
Clinical Policy: (Enbrel) Reference Number: CP.PHAR.250 Effective Date: 08/16 Last Review Date: 08/17 Line of Business: Medicaid Coding Implications Revision Log See Important Reminder at the end of this
More informationRegulatory Status FDA-approved indication: Humira and Amjevita are tumor necrosis factor (TNF) blockers indicated for the treatment of: (2-3)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.29 Subject: Humira Page: 1 of 13 Last Review Date: September 20, 2018 Humira Description Humira (adalimumab),
More informationDrugs and Applicable Coding: J-code: Enbrel-J1438; Humira-J0135; Remicade-J1745; Inflectra-Q5102; Cimzia-J0718; Simponi-J1602 Renflexis - pending
Policy Subject: Anti-TNF Agents Policy Number: SHS PBD16 Category: Rheumatology & Autoimmune Policy Type: Medical Pharmacy Department: Pharmacy Product (check all that apply): Group HMO/POS Individual
More informationAbatacept (Orencia) for active rheumatoid arthritis. August 2009
Abatacept (Orencia) for active rheumatoid arthritis August 2009 This technology summary is based on information available at the time of research and a limited literature search. It is not intended to
More informationRegulatory Status FDA-approved indication: Humira and Amjevita are tumor necrosis factor (TNF) blockers indicated for the treatment of: (2-3)
Federal Employee Program 1310 G Street, N.W. Washington, D.C. 20005 202.942.1000 Fax 202.942.1125 5.70.29 Subject: Humira Page: 1 of 10 Last Review Date: June 22, 2017 Humira Description Humira (adalimumab),
More information(tofacitinib) are met.
Xeljanz (tofacitinib) Policy Number: 5.01. 560 Origination: 3/2014 Last Review: 3/2014 Next Review: 3/2015 Policy BCBSKC will provide coverage for Xeljanz (tofacitinib) when it is determined to be medically
More informationBIOLOGIC THERAPY : A NEW OPTION FOR TREATMENT JUVENILE IDIOPATHIC ARTHRITIS DR TON THAT HOANG
BIOLOGIC THERAPY : A NEW OPTION FOR TREATMENT JUVENILE IDIOPATHIC ARTHRITIS DR TON THAT HOANG INTRODUCTION JIA is the most common chronic rheumatic inflammatory disease of childhood. If not successfully
More information2017 Blue Cross and Blue Shield of Louisiana
Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana, Inc.(collectively referred to as the Company ), unless otherwise provided
More informationCyltezo (adalimumab-adbm) CG-DRUG-64, CG-DRUG-65
Market DC Cyltezo (adalimumab-adbm) CG-DRUG-64, CG-DRUG-65 Override(s) Prior Authorization Quantity Limit Medications Cyltezo (adalimumab-adbm) 40 mg/0.8 ml prefilled syringe #* ^ Approval Duration 1 year
More informationClinical Trials in Rheumatology
Clinical Trials in Rheumatology Rüdiger Müller Johannes von Kempis Clinical Trials in Rheumatology Authors Rüdiger Müller Division of Rheumatology and Rehabilitation Department of Internal Medicine Kantonsspital
More information