Guttate psoriasis =ﻒدﺼﻠا ﻲﻄﻘﻨﻠا

Size: px
Start display at page:

Download "Guttate psoriasis =ﻒدﺼﻠا ﻲﻄﻘﻨﻠا"

Transcription

1 1 / 69

2 Psoriasis Psoriasis may be divided into psoriasis vulgaris, generalized pustular psoriasis, and localized pustular ps Psoriasis Vulgaris Clinical Features 2 / 69

3 Psoriasis vulgaris is a common chronic inflammatory skin disorder that affects approximately 1.5% to 2% 3 / 69

4 associated with acute group A ~-hemolytic streptococcal infections. Involvement of the nails is common 4 / 69

5 5 / 69

6 Psoriatic arthritis characteristically involves the terminal interphalangeal joints, but frequently the large jo Generalized Pustular Psoriasis Clinical Features Generalized pustular psoriasis includes (a) acute generalized pustular psoriasis (von Zumbusch type an 6 / 69

7 This cutaneous eruption is characterized by the presence of variable numbers of sterile pustules appear The four variants of generalized pustular psoriasis show considerable resemblance and overlapping in th mainly in the mode of onset and the distribution of the lesions. Frequently, all four diseases show oral pu Acute generalized pustular of psoriasis von Zumbusch is generally diagnosed when exanthe the 7 / 69

8 Generalized pustular psoriasis of In some instances of pregnancy is a rare pustular eruption impetigo that a subacute annular pustular thepsoriasis annular or gyrate lesions show a clinical resemblanc 8 / 69

9 Very rarely, children develop infantile generalized and juvenile pustular pustular In psoriasis, these psoriasis. patients also known the disease as has a benign course with f Localized Pustular Psoriasis Clinical Features 9 / 69

10 There are three types of localized pustular psoriasis: (a) "psoriasis with pustules", in which only one or a 10 / 69

11 Acrodermatitis continua of Hallopeau is the term used when the pustu Pustulosis palmaris et plantaris is a chronic, relapsing disorder. occurring on the Crops palms,of soles, small, ordeep-seated both pus 11 / 69

12 Psoriasis and AcquiredClinical Immunodeficiency Features Syndrome 12 / 69

13 The association between. psoriasis and human immunodeficiency Extensive erythrodermic virus (HIV) psoriasis infection mayisoccur commonly (109).seen Palm 13 / 69

14 Psoriasis Vulgaris Histopathology 14 / 69

15 The histologic picture of psoriasis vulgaris varies considerably with the stage of the lesion and usually is The earliest pinhead-sized macules or smooth-surfaced papules show subtle histologic changes with a p 15 / 69

16 exocytosis of neutrophils, they may aggregate in the uppermost portion of the spinous layer to form sma 16 / 69

17 In the fully developed lesions of psoriasis, as best seen at the margin of enlarging plaques, the histologic 17 / 69

18 Of the listed features, only the spongiform pustules of Kogoj and Munro microabscesses are truly diagno The rete ridges show considerable elongation and extend downward to a uniform level, resulting in regul 18 / 69

19 show thickening ("clubbing") in their lower portion. Not infrequently, adjacent rete ridges seem to coalesc 19 / 69

20 The suprapapillary epidermis appears relatively thin in comparison with the markedly elongated rete ridg 20 / 69

21 In some instances the cornified layer consists entirely of confluent parakeratosis forming a platelike scale Munro microabscesses are located within the parakeratotic areas of the cornified layer. They consist of 21 / 69

22 The dermal papillae, in accordance with the elongation and basal thickening of the rete ridges, are elong 22 / 69

23 An entirely typical histologic picture as described earlier is not always found, even if the biopsy specimen indicates a fluctuation in the activity of the psoriasis. The bleeding points that may be produced by gentle scraping of the skin (Au spitz sign) correspond to th 23 / 69

24 Guttate or eruptive psoriasis shows the histologic features of an early or active lesion of psoriasis, where ther The histologic picture of erythrodermic psoriasis in some instances shows enough of the characteristics o Generalized Pustular Psoriasis 24 / 69

25 Histopathology 25 / 69

26 Whereas in ordinary psoriasis the spongiform pustule of Kogoj is a very small micropustule and is seen o 26 / 69

27 In addition to the large spongiform pustules, the epidermal changes in generalized pustular psoriasis are 27 / 69

28 In the healing stage, the lesions of all types of generalized pustular psoriasis may present the same histo Localized Pustular Psoriasis 28 / 69

29 Histopathology In the variants of localized pustular psoriasis "psoriasis with pustules" and localized annular pustular pso In localized acrodermatitis continua of Hallopeau, the nail bed is mainly affected, showing marked epithe 29 / 69

30 In pustulosis palmaris et plantaris there is a fully developed large intraepidermal unilocular pustule. It is e the ustule, most commonly at the junction of the lateral walls and the overlying epidermis. These spongi 30 / 69

31 Very early lesions may show spongiosis and exocytosis of lymphocytes in the lower epidermis overlying Psoriasis and Acquired Immunodeficiency Syndrome 31 / 69

32 Histopathology The histologic picture in most cases is similar to that of psoriasis. In others, the histologic sections may s 32 / 69

33 Pathogenesis of Psoriasis Vulgaris Although the cause of psoriasis is unknown, there is increasing evidence of a complex interaction among 33 / 69

34 Electron Microscopy 34 / 69

35 The earliest recognizable morphologic events in psoriasis have been investigated in lesions that cleared 35 / 69

36 36 / 69

37 Ultrastructural studies of the spongiform pustule of Kogoj, one of the most characteristic histologic struct The ultrastructure of the capillary loops in the dermal papillae shows them to be different from normal ca 37 / 69

38 Epidermal Cell Cycle Kinetics 38 / 69

39 The rate of epidermal cell replication is markedly accelerated in active lesions of psoriasis, as shown by 39 / 69

40 Early calculations made it appear likely that in psoriatic lesions there was a great acceleration of the tran 2 Further investigations have found that (a) the germinative of epidermal cellsurface cycle isarea, shortened and (c)from 311 to 36 hours, i 40 / 69

41 100% of the germinative cells of the epidermis enter the growth fraction instead of only 60% for normal s The source of the cycling cells in the suprabasal layers of the epidermis is not well defined. They could b 41 / 69

42 Recent studies suggested that psoriatic epidermis shows aberrant expression of apoptosis-related molec 42 / 69

43 Keratinocyte Differentiation 43 / 69

44 Keratinocytes undergo the process of differentiation as they migrate upward through the epidermis from 44 / 69

45 45 / 69

46 Immunopathology 46 / 69

47 Immunologic factors playa very important role in the pathogenesis of psoriasis. Psoriasis is now regarde 47 / 69

48 CD4+ T cells produce a variety of cytokines, including interleukin-2 (IL-2), tumor necrosis factor-a (TN Fa 48 / 69

49 Keratinocytes stimulated by TNFa may produce IL-B, which is a potent T-Iymphocyte and neutrophil che 49 / 69

50 50 / 69

51 51 / 69

52 ylfn is believed to play an important role in the initiation of psoriatic lesions as demonstrated by the indu 52 / 69

53 ylfn induces the expression of the ICAM-1 in keratinocytes and endothelial cells. This molecule mediate 53 / 69

54 not to be responsive to the growth inhibition effects of yifn, leading to their hyperproliferative state in the 54 / 69

55 Increased expression of p53 and downregulation of Bcl-2, consistent with the dynamics of psoriasis, hav 55 / 69

56 Pathogenesis of Localized Pustular Psoriasis 56 / 69

57 A relationship of pustulosis palmaris et plantaris with psoriasis is not generally accepted, although two fa 57 / 69

58 Pathogenesis of Psoriasis and AIDS 58 / 69

59 There is evidence of the role of both CD8+ and CD4+ T lymphocytes and ylfn in the pathogenesis of ps 59 / 69

60 . Paradoxically, as T-helper cell counts decline, it appears that psoriatic lesions exacerbate until a prete 60 / 69

61 The immunodysregulation resulting from HIV infection may trigger psoriasis in those genetically predispo 61 / 69

62 Differential Diagnosis 62 / 69

63 Two histologic features are atopic of great dermatitis, value nummular in the or diagnosis dermatitis, of psoriasis vulgaris: allergic (a) contact mounds dermatitis, of parakerato which th 63 / 69

64 64 / 69

65 including Reiter's disease, pustular histologically dermatophytosis, typical spongiform and bacterialpustules impetigo,may pustular candidiasis, occurdrug alsoeruptions, in 65 / 69 particula

66 Because of the clinical and, particularly, the histologic resemblance of the tongue lesions in pustular pso 66 / 69

67 67 / 69

68 68 / 69

69 69 / 69

Psoraisis = ﻒدﺼﻠا 1 / 84

Psoraisis = ﻒدﺼﻠا 1 / 84 1 / 84 2 / 84 3 / 84 4 / 84 5 / 84 6 / 84 Psoriasis Psoriasis may be divided into psoriasis vulgaris, generalized pustular psoriasis, and localized pustular ps Psoriasis Vulgaris Clinical Features 7 /

More information

Retrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA)

Retrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA) Retrospective 10 years review of 100 patients with psoriasis in the Kingdom of Saudi Arabia (KSA) Ahmed Abdullah Alhumidi King saud university, Riyadh, kingdom of Saudi Arabia Abstract Background: This

More information

Original Article. Palmoplantar Psoriasis versus Eczema: Major Histopathologic Clues for Diagnosis

Original Article. Palmoplantar Psoriasis versus Eczema: Major Histopathologic Clues for Diagnosis Iranian Journal of Pathology (2014) 9 (4), 251-256 251 Original Article Palmoplantar Psoriasis versus Eczema: Major Histopathologic Clues for Diagnosis Kambiz Kamyab Hesari, Zahra Safaei Naraghi, Azita

More information

Difference Between Seborrheic Dermatitis and Psoriasis

Difference Between Seborrheic Dermatitis and Psoriasis Difference Between Seborrheic Dermatitis and Psoriasis www.differencebetween.com Key Difference Seborrheic Dermatitis vs Psoriasis Dermatological conditions are perhaps the most worrisome diseases in the

More information

Psoriasis Case presentation 2 Ahmad is 50 years old male came to the on call dermatologist with a 3 day history of feeling generally unwell and

Psoriasis Case presentation 2 Ahmad is 50 years old male came to the on call dermatologist with a 3 day history of feeling generally unwell and Psoriasis Case presentation 2 Ahmad is 50 years old male came to the on call dermatologist with a 3 day history of feeling generally unwell and redness of all skin associated with de-sequamation scaling.

More information

Inflammatory skin disease I Jade Wititsuwannakul, MD Chulalongkorn University, Thailand

Inflammatory skin disease I Jade Wititsuwannakul, MD Chulalongkorn University, Thailand Inflammatory skin disease I Jade Wititsuwannakul, MD Chulalongkorn University, Thailand Superficial Perivascular Dermatitis Interface Dermatitis Vacuolar Dermatitis Lichenoid Dermatitis Barnhill Textbook

More information

PSORIASIS PSORIASIS. Anatomic sites FACTS ABOUT PROSIASIS PSORIASIS 11/16/2017 STIGMATA OF PSORIASIS

PSORIASIS PSORIASIS. Anatomic sites FACTS ABOUT PROSIASIS PSORIASIS 11/16/2017 STIGMATA OF PSORIASIS PSORIASIS Dr. Sami Alsuwaidan President, Saudi Society of Dermatology & Dermatologic Surgery Associate Professor and Consultant Department of Dermatology, College of Medicine King Saud University PSORIASIS

More information

MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB. Friday, February 12, :30 am 11:00 am

MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB. Friday, February 12, :30 am 11:00 am MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB Friday, February 12, 2012 9:30 am 11:00 am FACULTY COPY GOALS: Describe the basic clinical and morphologic features of various

More information

Some skin conditions

Some skin conditions Some skin conditions Some skin conditions Acute Inflammatory Dermatoses Chronic Inflammatory Dermatoses Blistering (Bullous) Diseases Panniculitis Disorders of Epidermal Appendages -Urticaria -Acute eczematous

More information

MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB. Friday, February 13, :30 am 11:00 am

MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB. Friday, February 13, :30 am 11:00 am MECHANISMS OF HUMAN DISEASE: LABORATORY SESSION PATHOLOGY OF THE SKIN LAB Friday, February 13, 2009 9:30 am 11:00 am FACULTY COPY GOALS: Describe the basic clinical and morphologic features of various

More information

Histopathology: skin pathology

Histopathology: skin pathology Histopathology: skin pathology These presentations are to help you identify, and to test yourself on identifying, basic histopathological features. They do not contain the additional factual information

More information

CD30 + cells in benign inflammatory infiltrate of some dermatological diseases. Abstract. Latef M. El Balshy. Benha University-Benha, Egypt.

CD30 + cells in benign inflammatory infiltrate of some dermatological diseases. Abstract. Latef M. El Balshy. Benha University-Benha, Egypt. CD30 + cells in benign inflammatory infiltrate of some dermatological diseases 1 Asmaa M. El Refaeie, 1 Osama H. Abdel Salam, 1 Sherine H.Abd EL-Rahman and 2 Abdel Latef M. El Balshy. 1 Dermatology & Andrology

More information

المركب النموذج--- سبيتز وحمة = Type Spitz's Nevus, Compound SPITZ NEVUS 1 / 7

المركب النموذج--- سبيتز وحمة = Type Spitz's Nevus, Compound SPITZ NEVUS 1 / 7 SPITZ NEVUS 1 / 7 Epidemiology An annual incidence rate of 1.4 cases of Spitz nevus per 100,000 individuals has been estimated in Australia, compared with 25.4 per 100,000 individuals for cutaneous melanoma

More information

What are the functions of the integumentary system? What are some disorders of the integumentary system?

What are the functions of the integumentary system? What are some disorders of the integumentary system? Essential Questions: What are the functions of the integumentary system? What are some disorders of the integumentary system? How are integumentary system disorders treated? How do you relate the integumentary

More information

Actinic keratosis (AK): Dr Sarma s simple guide

Actinic keratosis (AK): Dr Sarma s simple guide Actinic keratosis (AK): Dr Sarma s simple guide Actinic keratosis is a very common lesion that you will see in your day-to-day practice. First, let me explain the name Actinic keratosis. It means keratosis

More information

=ﻰﻤاﻤﺤﻠا ﺔﻴﻘﻠﺤﻠا ﺔذﺒاﻨﻠا

=ﻰﻤاﻤﺤﻠا ﺔﻴﻘﻠﺤﻠا ﺔذﺒاﻨﻠا 1 / 15 Erythema Annulare Centrifugum and Other Figurate Erythemas The figurate erythemas include a variety of eruptions characterized by annular and polycyclic lesions. Classification of this group has

More information

Psoriasis Penis - A Two Case Report

Psoriasis Penis - A Two Case Report Article ID: WMC003176 ISSN 2046-1690 Psoriasis Penis - A Two Case Report Corresponding Author: Dr. Ilko Bakardzhiev, MD, PhD, Medical College, Medical University of Varna, 9000 - Bulgaria Submitting Author:

More information

Supplementary Tables. Psoriasis a

Supplementary Tables. Psoriasis a Supplementary Tables Supplementary Table S1 Age-sex distribution of patients with psoriasis and PPP subdivided by the department specified in a claim with a diagnosis code of psoriasis and PPP in Japanese

More information

Pathology of the skin. Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE

Pathology of the skin. Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE Pathology of the skin Dr Fónyad László, 1sz. Patológiai és Kísérleti Rákkutató Intézet, SE The skin Biggest organ Kb. 1.8 nm Kb. 10 kg Most frequent site for tumor development (BCC) Pathology of the skin

More information

Commonly Coded Conditions in Dermatology

Commonly Coded Conditions in Dermatology Commonly Coded Conditions in Dermatology No part of this presentation may be reproduced or transmitted in any form or by any means (graphically, electronically, or mechanically, including photocopying,

More information

4. Pityriasis lichenoides

4. Pityriasis lichenoides Go Back to the Top To Order, Visit the Purchasing Page for Details usually more than 5 cm in diameter and accompanied by poikiloderma. Some but not all patients may develop mycosis fungoides (Fig. 22.35).

More information

Citation The Journal of Dermatology, 37(8), available at

Citation The Journal of Dermatology, 37(8), available at NAOSITE: Nagasaki University's Ac Title Two cases of blaschkitis with promi Author(s) Utani, Atsushi Citation The Journal of Dermatology, 37(8), Issue Date 2010-08 URL Right http://hdl.handle.net/10069/25634

More information

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis

The histopathological spectrum of acute generalized exanthematous pustulosis (AGEP) and its differentiation from generalized pustular psoriasis J Cutan Pathol 2010: 37: 1220 1229 doi: 10.1111/j.1600-0560.2010.01612.x John Wiley & Sons. Printed in Singapore Copyright 2010 John Wiley & Sons A/S Journal of Cutaneous Pathology The histopathological

More information

Effect of Methotrexate Therapy on p53 and Bcl2 Expression in Patients with Psoriasis: A Prospective Hospital-Based Cohort Study

Effect of Methotrexate Therapy on p53 and Bcl2 Expression in Patients with Psoriasis: A Prospective Hospital-Based Cohort Study Original Article Effect of Methotrexate Therapy on p53 and Bcl2 Expression in Patients with Psoriasis: A Prospective Hospital-Based Cohort Study Sonali Kalyan 1, Nadia Shirazi 1 *, Rashmi Jindal 2, Dushyant

More information

Psoriasis. What is Psoriasis? What causes psoriasis? Medical Topics Psoriasis

Psoriasis. What is Psoriasis? What causes psoriasis? Medical Topics Psoriasis 1 Psoriasis What is Psoriasis? Psoriasis is a long standing inflammatory non-contagious skin disease which waxes and wanes with triggering factors. There is a genetic predisposition in psoriasis. Internationally,

More information

What is Psoriasis? Common Areas Affected. Type Who Does it Affect Characteristics

What is Psoriasis? Common Areas Affected. Type Who Does it Affect Characteristics What is? is a term derived from the Greek word psōra which means itch and is a common, long lasting, inflammatory skin condition which affects 1-3% of the UK population and about 80 million people worldwide.

More information

Malignant tumors of melanocytes: Part 1. Deba P Sarma, MD., Omaha

Malignant tumors of melanocytes: Part 1. Deba P Sarma, MD., Omaha Malignant tumors of melanocytes: Part 1 Deba P Sarma, MD., Omaha The melanocytic tumor is one of the most difficult and confusing areas in Dematopathology. It is true that most (95%) of such lesions are

More information

Dermatology elective for yr. 5. Natta Rajatanavin, MD. Div. of dermatology Dep. Of Medicine, Ramathibodi Hospital Mahidol University 23 rd Feb 2015

Dermatology elective for yr. 5. Natta Rajatanavin, MD. Div. of dermatology Dep. Of Medicine, Ramathibodi Hospital Mahidol University 23 rd Feb 2015 Dermatology elective for yr. 5 Natta Rajatanavin, MD. Div. of dermatology Dep. Of Medicine, Ramathibodi Hospital Mahidol University 23 rd Feb 2015 How to diagnosis and manage eczema and psoriasis. Objectives

More information

LENTIGO SIMPLEX. Epidemiology

LENTIGO SIMPLEX. Epidemiology LENTIGO SIMPLEX Epidemiology The frequency of lentigo simplex in children and adults has not been determined. There does not appear to be a racial or gender predilection. Lentigo simplex is the most common

More information

Pathology of the skin. 2nd Department of Pathology, Semmelweis University

Pathology of the skin. 2nd Department of Pathology, Semmelweis University Pathology of the skin 2nd Department of Pathology, Semmelweis University Histology of the skin Epidermis: Stratum corneum Stratum granulosum Stratum spinosum Stratum basale Dermis: papillary and reticular

More information

insight Exceptional SKINTELL in-depth, non-invasive dermatological solution HealthCare

insight Exceptional SKINTELL in-depth, non-invasive dermatological solution HealthCare Optical Coherence Tomography insight Exceptional SKINTELL in-depth, non-invasive dermatological solution HealthCare From outside, exceptional insight inside SKINTELL from Agfa HealthCare enables you to

More information

Grover s disease: A case report.

Grover s disease: A case report. 320 Case report Thai J Dermatol, October-December 2011 ABSTRACT: Grover s disease: A case report. Supicha Chavanich MD, Praneet Sajjachareonpong MD. CHAVANICH C, SAJJACHAREONPONG P. GROVER S DISEASE: A

More information

Gastrooesophageal reflux disease. Jera Jeruc Institute of pathology, Faculty of Medicine, Ljubljana, Slovenia

Gastrooesophageal reflux disease. Jera Jeruc Institute of pathology, Faculty of Medicine, Ljubljana, Slovenia Gastrooesophageal reflux disease Jera Jeruc Institute of pathology, Faculty of Medicine, Ljubljana, Slovenia Reflux esophagitis (RE) GERD: a spectrum of clinical conditions and histologic alterations resulting

More information

COPYRIGHTED MATERIAL. Introduction CHAPTER 1. Introduction

COPYRIGHTED MATERIAL. Introduction CHAPTER 1. Introduction CHAPTER 1 Introduction OVERVIEW The clinical features of skin lesions are related to the underlying pathological processes. Broadly skin conditions fall into three clinical groups: (a) those with a well-defined

More information

Case No. 5; Slide No. B13/8956/2

Case No. 5; Slide No. B13/8956/2 Interface diseases Case No. 5; Slide No. B13/8956/2 Histological findings Severe hydropic vacuolation of epidermal and follicular basal cells/ interface dermatitis Multifocally apoptotic keratinocytes

More information

RELEVANT MEDICAL TERMS AND CONDITIONS

RELEVANT MEDICAL TERMS AND CONDITIONS Acrokeratosis Paraneoplastica Paraneoplastic acrokeratosis, Bazex syndrome (also known as acrokeratosis paraneoplastica of Bazex and acrokeratosis neoplastica) is a cutaneous condition characterized by

More information

Eczema. By:- Dr. Naif Al-Shahrani Salman bin Abdazziz University

Eczema. By:- Dr. Naif Al-Shahrani Salman bin Abdazziz University Eczema By:- Dr. Naif Al-Shahrani Salman bin Abdazziz University Dermatitis= Eczema =Spongiosis Eczema Atopic Seborrheic Contact Allergic Irritant Nummular Asteatotic Stasis Neurodermatitis/Lichen Simplex

More information

A Histopathologic Study of Papulosquamous Lesions of Skin

A Histopathologic Study of Papulosquamous Lesions of Skin Original 404 Article Indian Journal of Pathology: Research and Practice Volume 6 Number 2, April - June 2017 (Part 2) DOI: http://dx.doi.org/10.21088/ijprp.2278.148x.6217.11 A Histopathologic Study of

More information

Psoriasis. Overview. Epidemiology. Epidemiology 08/08/2015. Dr Nigel Burrows Consultant Dermatologist Addenbrooke s Hospital

Psoriasis. Overview. Epidemiology. Epidemiology 08/08/2015. Dr Nigel Burrows Consultant Dermatologist Addenbrooke s Hospital Overview Psoriasis 1. Epidemiology of psoriasis 2. Histology Dr Nigel Burrows Consultant Dermatologist Addenbrooke s Hospital Aug 2015 3. Types of psoriasis 4. Assessing severity 5. Treatments Topical

More information

Histopathological spectrum of non-infectious erythematous, papulo-squamous lesions

Histopathological spectrum of non-infectious erythematous, papulo-squamous lesions Histopathological spectrum of non-infectious erythematous, papulo-squamous lesions B. Rajasekhar Reddy 1*, Nalini Krishna.M 2 1 Associate Professor, Department of Pathology, Mediciti Institute of Medical

More information

Skin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs

Skin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs Skin and Body Membranes Body Membranes Function of body membranes Cover body surfaces Line body cavities Form protective sheets around organs Classification of Body Membranes Epithelial membranes Cutaneous

More information

OBSERVATION. Efalizumab-Associated Papular Psoriasis. skin disease that affects 1% to 3% of the world s population. 1 Cellular changes

OBSERVATION. Efalizumab-Associated Papular Psoriasis. skin disease that affects 1% to 3% of the world s population. 1 Cellular changes OBSERVATION Efalizumab-Associated Papular Psoriasis Akmal S. Hassan, MD; Dagmar Simon, MD; Hans-Uwe Simon, PhD; Lasse R. Braathen, MD, PhD, MHA; Nikhil Yawalkar, MD Background: Efalizumab is a human anti-cd11a

More information

Recognizing common Dermatologic conditions. Case presentations. CAPA 2015 Annual Conference. Tanya Nino, MD St. Joseph Heritage Medical Group

Recognizing common Dermatologic conditions. Case presentations. CAPA 2015 Annual Conference. Tanya Nino, MD St. Joseph Heritage Medical Group Recognizing common Dermatologic conditions Tanya Nino, MD St. Joseph Heritage Medical Group Case presentations 65 year old female referred for rule out melanoma a lesion on back 30 year old female has

More information

Vol. 10, No. 1, 2012 Review Article Introduction Psoriasis vulgaris in childhood is a wellrecognized disease contributing to about 4% of the childhood

Vol. 10, No. 1, 2012 Review Article Introduction Psoriasis vulgaris in childhood is a wellrecognized disease contributing to about 4% of the childhood Review Article Vol. 10, No. 1, 2012 Pustular Psoriasis in Children- a Review Malathi M 1, Thappa DM 2 1 Senior Resident, 2 Professor and Head, Department of Dermatology and STD, Jawaharlal Institute of

More information

A. Erythema multiforme and related diseases

A. Erythema multiforme and related diseases Go Back to the Top To Order, Visit the Purchasing Page for Details Chapter Erythema, Erythroderma (Exfoliative Dermatitis) Erythema is caused by telangiectasia or hyperemia in the papillary and reticular

More information

CLINCOPATHOLOGICAL CASE

CLINCOPATHOLOGICAL CASE CLINCOPATHOLOGICAL CASE Generalized vesiculo-bullous and pustular eruption in an adult man Hassab El-Naby H, MD, El-Khalawany M, MD Department of Dermatology, Al-Azhar University, Cairo, Egypt CLINICAL

More information

Diagnosis and Management of Common and Infective Skin Diseases in Children at primary care level

Diagnosis and Management of Common and Infective Skin Diseases in Children at primary care level Diagnosis and Management of Common and Infective Skin Diseases in Children at primary care level Dr Ng Su Yuen Paediatrician and Paediatric Dermatologist Hospital Pulau Pinang Outline Common inflammatory

More information

THERE IS A GROUP OF PAtients. Defining Urticarial Dermatitis. A Subset of Dermal Hypersensitivity Reaction Pattern

THERE IS A GROUP OF PAtients. Defining Urticarial Dermatitis. A Subset of Dermal Hypersensitivity Reaction Pattern STUDY Defining Urticarial Dermatitis A Subset of Dermal Hypersensitivity Reaction Pattern Steven Kossard, FACD; Ian Hamann, FACD; Barbara Wilkinson, BSc Background: Urticarial dermatitis may represent

More information

It is estimated that about 26,000 new cases of

It is estimated that about 26,000 new cases of Focus on CME at Dalhousie University Set On Soothing Psoriasis A. H. Murray, MD, FRCP(C) Presented at the 76th Annual Dalhousie Refresher Course It is estimated that about 26,000 new cases of psoriasis

More information

Skin (Integumentary System) Wheater, Chap. 9

Skin (Integumentary System) Wheater, Chap. 9 Skin (Integumentary System) Wheater, Chap. 9 Skin (Integument) Consists of skin and associated derivatives Largest organ of body (21 ft 2 ; 9 lbs.; has 11 miles of blood vessels) Functions: Protection

More information

News Release. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA

News Release. Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA News Release Title Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA Key Points Deficiency of IL-36 receptor antagonist (DITRA) model mice has been established. The involvement

More information

Rashes Not To Be Missed In Children

Rashes Not To Be Missed In Children May 2016 Rashes Not To Be Missed In Children Dr Chan Yuin Chew Dermatologist Dermatology Associates Gleneagles Medical Centre Scope of presentation Focus on rashes May lead to significant morbidity if

More information

Psoriasis TEXTBOOK OF. P.C.M. van de Kerkhof DEPARTMENT OF DERMATOLOGY UNIVERSITY MEDICAL CENTRE NIJMEGEN ST RADBOUD NIJMEGEN THE NETHERLANDS

Psoriasis TEXTBOOK OF. P.C.M. van de Kerkhof DEPARTMENT OF DERMATOLOGY UNIVERSITY MEDICAL CENTRE NIJMEGEN ST RADBOUD NIJMEGEN THE NETHERLANDS TEXTBOOK OF Psoriasis Edited by P.C.M. van de Kerkhof DEPARTMENT OF DERMATOLOGY UNIVERSITY MEDICAL CENTRE NIJMEGEN ST RADBOUD NIJMEGEN THE NETHERLANDS SECOND EDITION TEXTBOOK OF Psoriasis TEXTBOOK OF

More information

Effects of biological response modifiers in psoriasis and psoriatic arthritis Goedkoop, A.Y.

Effects of biological response modifiers in psoriasis and psoriatic arthritis Goedkoop, A.Y. UvA-DARE (Digital Academic Repository) Effects of biological response modifiers in psoriasis and psoriatic arthritis Goedkoop, A.Y. Link to publication Citation for published version (APA): Goedkoop, A.

More information

Pimples and Boils!! Dr Nathan Harvey Anatomical Pathology, PathWest

Pimples and Boils!! Dr Nathan Harvey Anatomical Pathology, PathWest Pimples and Boils!! Dr Nathan Harvey Anatomical Pathology, PathWest Overview & Learning Objectives Review the cardinal signs/symptoms of acute inflammation Review the histological features of acute inflammation

More information

DERMATOLOGY & VENEREOLOGY

DERMATOLOGY & VENEREOLOGY DECEMBER 2O1O DERMATOLOGY & VENEREOLOGY PAPER - I Time : 3 hours Max. Marks : 100 DVD/D/10/06/l '.i Attempt all questions in order. Each question carries 10 marks 1. Discuss the differential diagnosis

More information

Papulosquamous: clinicopathological

Papulosquamous: clinicopathological International Journal of Research in Medical Sciences Narayankar SL et al. Int J Res Med Sci. 2018 Jan;6(1):309-316 www.msjonline.org pissn 2320-6071 eissn 2320-6012 Original Research Article DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20175740

More information

Lichenoid Tissue Reaction in Malignant Melanoma A Potential Diagnostic Pitfall

Lichenoid Tissue Reaction in Malignant Melanoma A Potential Diagnostic Pitfall natomic Pathology / LICHENOID TISSUE RECTION IN MLIGNNT MELNOM Lichenoid Tissue Reaction in Malignant Melanoma Potential Diagnostic Pitfall CPT Scott R. Dalton, MC, US, 1,3 Capt Matt. aptista, USF, MC,

More information

A case of psoriasis pustulosa. Treatment with potassium. iodide and measurement of oxygen intermediates

A case of psoriasis pustulosa. Treatment with potassium. iodide and measurement of oxygen intermediates s-11 A case of psoriasis pustulosa. Treatment with potassium iodide and measurement of oxygen intermediates Kyoko Nakajima, Jinro Komura, Setsuko Nishijima, Yasuo Asada and Yukie Niwa* Department of Dermatology,

More information

Appendix : Dermoscopy

Appendix : Dermoscopy Go Back to the Top To Order, Visit the Purchasing Page for Details APP Appendix : Dermoscopy Dermoscopy, also known as dermatoscopy, epiluminoscopy and epiluminescent microscopy, is an effective non-invasive

More information

Skin lesions & Abrasions

Skin lesions & Abrasions Skin lesions & Abrasions What Are Skin Lesions? A skin lesion is a part of the skin that has an abnormal growth or appearance compared to the skin around it Types of Skin Lesions Two types of skin lesions

More information

Mucinoses Diverse group of disorders which have in common deposition of basophilic, finely granular and stringy material in the connective tissues of

Mucinoses Diverse group of disorders which have in common deposition of basophilic, finely granular and stringy material in the connective tissues of Cutaneous Mucinoses Nathan C. Walk, M.D. Mucinoses Diverse group of disorders which have in common deposition of basophilic, finely granular and stringy material in the connective tissues of the dermis.

More information

DISTRIBUTION OF HUMAN Β-DEFENSIN 2, TNF-ALPHA, IL-1 ALPHA, IL-6 AND IL-8 IN PSORIATIC SKIN

DISTRIBUTION OF HUMAN Β-DEFENSIN 2, TNF-ALPHA, IL-1 ALPHA, IL-6 AND IL-8 IN PSORIATIC SKIN Papers on Anthropology XX, 2011, pp. 289 302 DISTRIBUTION OF HUMAN Β-DEFENSIN 2, TNF-ALPHA, IL-1 ALPHA, IL-6 AND IL-8 IN PSORIATIC SKIN E. Mozeika 1,2, M. Pilmane 1, J. Kisis 2 1 Institute of Anatomy and

More information

TREATMENT OPTIONS FOR PSORIASIS. Sandra Hanlon Dermatology Senior Charge Nurse NHS Ayrshire and Arran 07/03/17

TREATMENT OPTIONS FOR PSORIASIS. Sandra Hanlon Dermatology Senior Charge Nurse NHS Ayrshire and Arran 07/03/17 TREATMENT OPTIONS FOR PSORIASIS Sandra Hanlon Dermatology Senior Charge Nurse NHS Ayrshire and Arran 07/03/17 PSORIASIS A chronic, non-infectious inflammatory skin condition that has no cure Characterised

More information

CPT Codes: The following ICD-10-CM codes support the medical necessity of CPT code 82306:

CPT Codes: The following ICD-10-CM codes support the medical necessity of CPT code 82306: CPT s: 82306 Vitamin D; 25 hydroxy, includes fraction(s), if performed 82652 Vitamin D; 1, 25 dihydroxy, includes fraction(s), if performed The following ICD-10-CM codes support the medical necessity of

More information

Unit 4 - The Skin and Body Membranes 1

Unit 4 - The Skin and Body Membranes 1 Unit 4 - The Skin and Body Membranes 1 I. Unit 4: Skin and Body Membranes A. Body Membranes 1. Function of body membranes a) Cover body surfaces b) Line body cavities c) Form protective sheets around organs

More information

Juvenile pityriasis rubra pilaris: a case report with immunohistochemical and electromicroscopic studies

Juvenile pityriasis rubra pilaris: a case report with immunohistochemical and electromicroscopic studies ERMTOLOGI SINI 28 (2010) 46 50 Juvenile pityriasis rubra pilaris: a case report with immunohistochemical and electromicroscopic studies Jeng-Feng hen 1, Hong-Wei Gao 2, Wei-Ming Wang 1 * 1 epartment of

More information

PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes

PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College Skin and Body Membranes 4 Body Membranes Function of body membranes Cover body surfaces Line body cavities

More information

Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more

Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more Benign and malignant epithelial lesions: Seborrheic keratosis: A common benign pigmented epidermal tumor occur in middle-aged or older persons more common on the trunk; but extremities, head and neck are

More information

Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis

Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis Open Access Case Report DOI: 10.7759/cureus.3943 Low-dose Naltrexone: An Alternative Treatment for Erythrodermic Psoriasis Eduardo P. Beltran Monasterio 1 1. Dermatology, Universidade Gama Filho (instituto

More information

The Integumentary System. Mosby items and derived items 2010, 2006, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc.

The Integumentary System. Mosby items and derived items 2010, 2006, 2002, 1997, 1992 by Mosby, Inc., an affiliate of Elsevier Inc. The Integumentary System The Skin Structure two primary layers called epidermis and dermis Epidermis Outermost and thinnest primary layer of skin Composed of several layers of stratified squamous epithelium

More information

SELF-TEST QUESTIONNAIRE PSORIASIS. Plaque a raised lesion where the diameter is greater than the thickness. Number 2

SELF-TEST QUESTIONNAIRE PSORIASIS. Plaque a raised lesion where the diameter is greater than the thickness. Number 2 Number 2 CORE TUTORIALS IN DERMATOLOGY FOR PRIMARY CARE PDP SELF-TEST QUESTIONNAIRE AYERS ROCK, ULURU PSORIASIS NATIONAL PARK, AUSTRALIA Plaque a raised lesion where the diameter is greater than the thickness

More information

Histopathology of Melanoma

Histopathology of Melanoma THE YALE JOURNAL OF BIOLOGY AND MEDICINE 48, 409-416 (1975) Histopathology of Melanoma G. J. WALKER SMITH Department ofpathology, Yale University School ofmedicine, 333 Cedar Street, New Haven, Connecticut

More information

THE SPECTRUM OF HISTOPATHOLOGICAL FEATURES IN ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS: A STUDY OF 102 CASES

THE SPECTRUM OF HISTOPATHOLOGICAL FEATURES IN ACUTE GENERALISED EXANTHEMATOUS PUSTULOSIS: A STUDY OF 102 CASES These articles have been accepted for publication in the British Journal of Dermatology and are currently being edited and typeset. Readers should note that articles published below have been fully refereed,

More information

Phototherapy and Photochemotherapy Treatment (Ultraviolet A [PUVA] and B [UBV])

Phototherapy and Photochemotherapy Treatment (Ultraviolet A [PUVA] and B [UBV]) Origination: 09/27/07 Revised: 08/2/17 Annual Review: 11/2/17 Purpose: To provide Phototherapy and Photochemotherapy Treatment (PUVA and UBV) guidelines for the Medical Department staff to reference when

More information

Volume 7, Edition 1 / Winter 07 93

Volume 7, Edition 1 / Winter 07 93 Picture This. CPT Karen T. Guerrero A 20 year old active duty Soldier complains of a sudden appearance of a nonpruritic generalized eruption one week after having a streptococcal throat infection. Lesions

More information

Ch. 4: Skin and Body Membranes

Ch. 4: Skin and Body Membranes Ch. 4: Skin and Body Membranes I. Body Membranes A. Function of body membranes 1. Cover body surfaces 2. Line body cavities 3. Form protective sheets around organs II. Classification of Body Membranes

More information

A Pilot Study. Name of investigational product:

A Pilot Study. Name of investigational product: An Open Label, Multi Center Clinical Study to Evaluate the Efficacy and Safety of a New Topical Cosmeceutical in Relieving the Redness, Scaling and Flaking Associated with Severe Skin Conditions A Pilot

More information

السكري للداء مرافقة فقاعات diabeticorum= Bullosis

السكري للداء مرافقة فقاعات diabeticorum= Bullosis 1 / 6 Bullosis diabeticorum Bullous disease of diabetes (bullosis diabeticorum) is a distinct, spontaneous, noninflammatory, blistering condition of acral skin unique to patients with diabetes mellitus.

More information

The authors have declared no conflicts of interest.

The authors have declared no conflicts of interest. Lingual Pustular Psoriasis and Acrodermatitis Continua of Hallopeau Successfully Treated with Adalimumab: A Rare Case Report and Review of Oral Psoriasis Authors: Sarah J.J. Touyz, 1 *Melanie Pratt 2 1.

More information

An Atlas of PSORIASIS Second edition

An Atlas of PSORIASIS Second edition An Atlas of PSORIASIS Second edition THE ENCYCLOPEDIA OF VISUAL MEDICINE SERIES An Atlas of PSORIASIS Second edition Lionel Fry MD FRCP Professor Emeritus of Dermatology Imperial College London, UK This

More information

My Algorithm. Questions to ask. Do you or your family have a history of?... Allergic rhinitis, Sensitive skin, Asthma Skin Cancer

My Algorithm. Questions to ask. Do you or your family have a history of?... Allergic rhinitis, Sensitive skin, Asthma Skin Cancer Tracey C. Vlahovic, DPM Associate Professor, Temple University School of Podiatric Medicine My Algorithm Inflammatory Skin Disorder on Feet Family hx, clinical exam, look at hands! Defined plaques: Psoriasis

More information

Hole s Human Anatomy and Physiology Eleventh Edition. Mrs. Hummer. Chapter 6

Hole s Human Anatomy and Physiology Eleventh Edition. Mrs. Hummer. Chapter 6 Hole s Human Anatomy and Physiology Eleventh Edition Mrs. Hummer Chapter 6 1 Chapter 6 Skin and the Integumentary System Composed of several tissues Maintains homeostasis Protective covering Retards water

More information

Cutaneous Adverse Drug Reactions in Domestic Animals. Katherine Doerr, DVM, Dip. ACVD. Veterinary Dermatology Center

Cutaneous Adverse Drug Reactions in Domestic Animals. Katherine Doerr, DVM, Dip. ACVD. Veterinary Dermatology Center Cutaneous Adverse Drug Reactions in Domestic Animals Katherine Doerr, DVM, Dip. ACVD Veterinary Dermatology Center Maitland, Rockledge, Waterford Lakes, FL Not highly studied in veterinary medicine Unknown

More information

B. Autoimmune blistering diseases

B. Autoimmune blistering diseases Go Back to the Top To Order, Visit the Purchasing Page for Details formation immediately above the basal layer. The dermal papillae, which are covered by basal cells in the single layer that is left in

More information

This section covers the basic knowledge of normal skin structure and function required to help understand how skin diseases occur.

This section covers the basic knowledge of normal skin structure and function required to help understand how skin diseases occur. Background Knowledge Functions of normal skin Background Knowledge This section covers the basic knowledge of normal skin structure and function required to help understand how skin diseases occur. Learning

More information

Dermatopathology: The tumor is composed of keratinocytes which show atypia, increase mitoses and abnormal mitoses.

Dermatopathology: The tumor is composed of keratinocytes which show atypia, increase mitoses and abnormal mitoses. Squamous cell carcinoma (SCC): A common malignant tumor of keratinocytes arising in the epidermis, usually from a precancerous condition: 1- UV induced actinic keratosis, usually of low grade malignancy.

More information

A Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute

A Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute MVP Journal of Medical Sciences, Vol 1(1), 30 35, January 2014 A Descriptive Study on Patients of Papulosquamous Lesion at Tertiary Care Institute S. D. Chavhan 1*, S. V. Mahajan 2 and A. J. Vankudre 3

More information

Chapter 6 Skin and the Integumentary System. Skin Cells. Layers of Skin. Epidermis Dermis Subcutaneous layer beneath dermis not part of skin

Chapter 6 Skin and the Integumentary System. Skin Cells. Layers of Skin. Epidermis Dermis Subcutaneous layer beneath dermis not part of skin Chapter 6 Skin and the Integumentary System Composed of several tissues Maintains homeostasis Protective covering Retards water loss Regulates body temperature Houses sensory receptors Contains immune

More information

Minami-Hori M, Tsuji H, Takahashi H, Hanada K, Iizuka H

Minami-Hori M, Tsuji H, Takahashi H, Hanada K, Iizuka H The Journal of Dermatology (2013.Jan) :. Optic neuritis in a psoriatic arthritis patient treated by infliximab Minami-Hori M, Tsuji H, Takahashi H, Hanada K, Iizuka H 1 Optic neuritis in a psoriatic arthritis

More information

Original Article. A Study of Histopathological Changes Seen in Chronic Plaque Psoriasis, Before and After Treatment with Narrow Band Ultraviolet B

Original Article. A Study of Histopathological Changes Seen in Chronic Plaque Psoriasis, Before and After Treatment with Narrow Band Ultraviolet B Original Article A Study of Histopathological Changes Seen in Chronic Plaque Psoriasis, Before and After Treatment with Narrow Band Ultraviolet B Amoolya Bhat 1 *, Subramanya H 2, PS Murthy 3 and Santosh

More information

Introduction. Skin and Body Membranes. Cutaneous Membranes Skin 9/14/2017. Classification of Body Membranes. Classification of Body Membranes

Introduction. Skin and Body Membranes. Cutaneous Membranes Skin 9/14/2017. Classification of Body Membranes. Classification of Body Membranes Introduction Skin and Body Membranes Body membranes Cover surfaces Line body cavities Form protective and lubricating sheets around organs Classified in 5 categories Epithelial membranes 3 types- cutaneous,

More information

Degos Disease: A Case Report and Review of Literature

Degos Disease: A Case Report and Review of Literature Degos Disease: A Case Report and Review of Literature Monira waked Egyptian Dermatology Online Journal 4 (1): 5, June 2008 Al Houd Al Marsod Hospital Submitted for publication: May 25 th, 2008 Accepted

More information

The Integumentary System. Chapter 6

The Integumentary System. Chapter 6 The Integumentary System Chapter 6 What is the integumentary system? skin hair nails glands blood vessels sensory receptors What is your skin made of? 3 layers epidermis (outside) dermis (middle) subcutaneous

More information

Basal cell carcinoma 5/28/2011

Basal cell carcinoma 5/28/2011 Goal of this Presentation A practical approach to the diagnosis of cutaneous carcinomas and their mimics Thaddeus Mully, MD University of California San Francisco To review common non-melanoma skin cancers

More information

Cutanous Manifestation of Lupus Erythematosus. Presented By: Dr. Naif S. Al Shahrani Salman Bin Abdaziz university

Cutanous Manifestation of Lupus Erythematosus. Presented By: Dr. Naif S. Al Shahrani Salman Bin Abdaziz university Cutanous Manifestation of Lupus Erythematosus Presented By: Dr. Naif S. Al Shahrani Salman Bin Abdaziz university A 50-year old lady, who is otherwise healthy, presented to the dermatology clinic with

More information

Table of Contents: Part 1 Medical Dermatology. Chapter 1 Acneiform Disorders. Acne. Acne Vulgaris. Pomade Acne. Steroid Acne

Table of Contents: Part 1 Medical Dermatology. Chapter 1 Acneiform Disorders. Acne. Acne Vulgaris. Pomade Acne. Steroid Acne Table of Contents: Part 1 Medical Dermatology Chapter 1 Acneiform Disorders Acne Acne Vulgaris Pomade Acne Steroid Acne Infantile Acne Pediatric Perspectives Neonatal Acne (Acne Neonatorum) Pediatric Perspectives

More information

Vitamin D Assay Testing For services performed on or after

Vitamin D Assay Testing For services performed on or after 2018 MEDICARE LOCAL COVERAGE DETERMINATION (LCD) - L36692 CPT CODES: 82306, 82652 Vitamin D Assay Testing For services performed on or after 2-3-2017 DLS TEST CODE AND NAME 49907 (1,25 DIHYDROXY) (CPT

More information

The Role of Plasmacytoid Dendritic Cells in Psoriasis

The Role of Plasmacytoid Dendritic Cells in Psoriasis 6 ème Journée du Groupe de Recherche sur le Psoriasis Paris, 9 novembre 2012 The Role of Plasmacytoid Dendritic Cells in Psoriasis Dr Curdin Conrad, PD & MER Department of Dermatology Psoriasis: Clinical

More information