CLINICAL COURSE AND REMISSION RATE IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS: RELATIONSHIP TO OUTCOME AFTER 5 YEARS
|
|
- Liliana Cummings
- 6 years ago
- Views:
Transcription
1 British Journal of Rheumatology 1998;37: CLINICAL COURSE AND REMISSION RATE IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS: RELATIONSHIP TO OUTCOME AFTER 5 YEARS K. EBERHARDT and E. FEX* Department of Rheumatology, Lund University Hospital, Lund, Sweden SUMMARY Objective. To investigate the clinical course in early rheumatoid arthritis (RA) patients followed prospectively, to relate course to outcome after 5 yr, and to try to identify prognostic features. Methods. A total of 183 patients with definite RA and a mean disease duration of 11 months were included. Of these, 75% were rheumatoid factor ( RF) positive; 85% carried the shared epitope, 32% on both alleles. Most patients were assessed every 6 months. Disability was evaluated with the Health Assessment Questionnaire ( HAQ) and radiographic findings according to Larsen. Remission was defined in two ways: with the American Rheumatism Association (ARA) criteria and as no arthritis at least at one follow-up visit. Results. Twenty per cent achieved ARA-defined remission periods of at least 6 months duration; 21 were spontaneous and 18 drug induced. Average length of remission was 20.5 months. The remission periods constituted 7% of follow-up for all patients. Another 36% achieved remission according to the second definition. All 56% were considered to have a relapsingremitting disease pattern, in contrast to the remaining 44% with a persistent disease pattern. More patients with persistent disease were treated with disease-modifying anti-rheumatic drugs (DMARDs) and had also received a larger number of different drugs. Outcome after 5 yr regarding disability, joint inflammation and joint damage was worse for patients with persistent disease. Neither ARA-defined remission nor disease pattern could be accurately predicted. Conclusions. Long-term ARA-defined remission was rare, constituting 7% of follow-up for the entire cohort. For those 20% achieving remission, this period represented 34% of their follow-up. A total of 56% had a relapsing-remitting disease pattern and 44% had a persistent disease pattern. This classification had prognostic implications with persistency being a bad prognostic sign. KEY WORDS: Rheumatoid arthritis, Remission, Disease course, Prognosis, Outcome. THE prognosis for patients with rheumatoid arthritis in remission is rarely reported. However, in a retrospective ( RA) varies considerably. Early prediction of outcome study of established RA patients, the median has, therefore, been the subject of numerous investi- length of remission was 10 months [7]. gations focusing on, for example, sociodemographic, Different patterns of disease have been described. clinical or laboratory variables. No features of early The two main patterns are chronic persistent and the disease have so far shown sufficient power to allow relapsing-remitting disease course. Twenty-six per cent clinically meaningful prediction [1, 2]. In most studies, of patients in the Middlesex early RA study were prognosis of RA was related to the state of the disease chronic persistent over 3 yr [8], while in a Canadian at a certain defined end point. However, prognostic study of a 1985 inception cohort 40% had a persistent information may also be gained by evaluation of the disease course during 6 7 yr. The disease pattern may disease course up to that point in time. have prognostic implications. In the Canadian study, The most desirable patient outcome is probably patients with chronic persistent disease had worse achievement of stable remission. The length of remis- outcome at study finish [9]. sion periods during the course of the disease is consequently In this study, we examined the disease course in our a relevant prognostic measure. Remission cohort of early RA patients especially regarding ARA- can be defined according to the rigorous American defined remission and different disease patterns. The Rheumatism Association (ARA) criteria shown in disease course was related to outcome after 5 yr followup Table I [3]. More clinical definitions like being symptom and the prognostic value of different features, free or no arthritis on examination have also including rheumatoid factor ( RF) and shared epitope, been used. Remission criteria can either be examined was investigated. at a single point in time or during a longer time period. Reported cross-sectional remission rates in early RA TABLE I patients vary from 32% [4] to 7% after ~6 yr [5, 6 ]. Preliminary ARA remission criteria Various methods to define remission and different Five or more of the following criteria must be fulfilled patient selection are factors that contribute to the wide for at least two consecutive months: variation of remission rate. The length of time spent Duration of morning stiffness not exceeding 15 min No fatigue Submitted 30 March 1998; revised version accepted 24 August No joint pain (by history) No joint tenderness or pain on motion No soft-tissue swelling in joints or tendon sheaths Correspondence: K. Eberhardt, Department of Rheumatology, Erythrocyte sedimentation rate ( Westergren method) <30 mm Lund University Hospital, S Lund, Sweden. after 1 h for a female or <20 mm after 1 h for a male *Deceased British Society for Rheumatology
2 EBERHARDT AND FEX: CLINICAL COURSE IN EARLY RA 1325 PATIENTS AND METHODS ation at least at one follow-up visit, and persistent if Patients the patient had active joints at all evaluation points. The patients were taking part in an ongoing prospective study of course and outcome of RA at the Statistical analyses Lund University Hospital in Southern Sweden [10]. Differences between groups regarding continuous The inclusion criteria were definite RA with disease variables were estimated by Mann Whitney s test for duration of <24 months and age >18 yr. Disease independent samples. The x2 test was used for discrete duration was defined as time from onset of symptoms. variables. Logistic multiple regression analyses were Most patients were referred from primary care as a performed in an attempt to predict ARA remission result of a special campaign to recruit cases of recent and clinical course, respectively. Demographics, RF onset. One hundred and eighty-three patients were status, genotype, and clinical and laboratory variables enrolled during the years at baseline, were used as independent variables. All The study group consisted of all the 183 patients, tests were two-tailed and the level of significance was 67 men and 116 women, with a mean (S.D.) age of 51.4 set at P = (12.4) yr at onset. Mean (S.D.) duration of joint symptoms at inclusion in the study was 11.1 (6.1) months. RESULTS Clinical features Table II shows some clinical and laboratory charac- Clinical assessment teristics at study start. Fifty-two per cent of the patients The patients were assessed at least every 6 months had no erosions. Onset of the disease was acute (within with the exception of a few patients in sustained 1 day) for 33 patients, intermediate (within 1 week) remission who were seen once a year. These patients for 32, insidious (within weeks to months) for 99, and were told to make contact with the clinic earlier if they palindromic for 19. One hundred and twenty-eight got joint symptoms. Joint tenderness was estimated (75%) were RF positive. One hundred and seventy according to Ritchie et al. [11]. Joint inflammation patients were genotyped, 145 (85%) of these carried was assessed by an active joint count (defined as the shared epitope. Fifty-four (32%) carried the epitope swollen and either tender or painful on motion). The on both alleles. 50 joints evaluated included all but two from the Patients with active disease were offered treatment Ritchie index, namely the neck and subtalar joints. with DMARDs and 114 (62%) received this treatment Disability was evaluated with a Swedish version of the some time during follow-up. Sixty-seven received one Stanford Health Assessment Questionnaire ( HAQ) drug, 27 two drugs and 18 received 3 5 drugs. disability index [12]. Radiographs of hands and feet Most commonly used was chloroquine (68 patients), were taken at study start and annually thereafter. We followed by D-penicillamine ( 51), gold compounds used standard film and an anterior posterior projec- (25), sulphasalazine (21) and methotrexate (6). tion. The radiographic findings were scored by the Twenty-nine (16%) were treated with oral cortico- Larsen method, grading changes from 0 (normal ) to 5 steroids. Active disease was defined as the presence of (maximal damage) [13]. Thirty-two joints were evalusix or more swollen joints and at least two of following ated. The wrist score was multiplied by five, then all features: (i) 9 tender joints; (ii) morning stiffness scores were added to give a joint damage score with a lasting at least 45 min; (iii) an ESR of 28 mm/h. theoretical range of Clinical and laboratory During a follow-up time of 5 yr, seven patients were information was not available at the time of the lost. Five died (three had malignant disease; two radiological evaluation. The erythrocyte sedimentation carcinoma in the lungs and one in the uterus; one had rate ( ESR) was measured according to Westergren. cardiovascular disease and one committed suicide). Rheumatoid factor of IgM class was analysed with an One patient moved to another part of the country and enzyme-linked immunosorbent assay ( ELISA) [ 14]. one stopped attending due to psychiatric disease. HLA-DRB alleles were typed by restriction fragment length polymorphism analysis with sequence-specific Remission primers as previously described [15]. Twenty per cent (37 patients: 16 men/21 women) had 39 remission periods of at least 6 months. Mean Clinical course (S.D.) remission time was 20.5 (12.9) months with a Remission was defined according to the ARA criteria range of 6 48 months. The patients were in remission [3] as shown in Table I. Fatigue was not measured in this study, and remission was therefore considered TABLE II present if a patient fulfilled four of the remaining five Some clinical and laboratory features at the start of the study in criteria. Concomitant use of disease-modifying antias the median (interquartile range) 183 RA patients with ~1 yr disease duration. All values are given rheumatic drugs (DMARDs) and/or oral corticosteroids was allowed. The patients had to fulfil Active joint count (0 50) 6 (4 10) remission criteria at least at two consecutive follow-up HAQ disability index (0 3) 0.8 ( ) visits (6 months apart). Joint damage score (0 200) 6 (3 11) (available for 151 patients) The course of the disease was regarded as relapsing ESR (mm/h) 29 ( ) remitting if the patient had no active joints on examin-
3 1326 BRITISH JOURNAL OF RHEUMATOLOGY VOL. 37 NO % of their follow-up time. Mean (S.D.) disease dura- free episode within the first study year, and another tion at achievement of the first remission period was 20% within 2 yr (14.3) months with a range of 9 64 months. Most patients had during the course of the 5 yr Twenty-one remissions were spontaneous and 18 drug both large and small joint involvement (82% in the induced (chloroquine 8, D-penicillamine 6, aurothio- relapsing-remitting group and 86% in the persistent malate 3, and sulphasalazine 1). group). Twenty-nine patients ( 16%) had involvement Figure 1 illustrates the remission rate over time. The of hands and feet only. Nine of them had a limited number of patients moving in and out of remission disease with involvement of four or less small joints. during each 6 month period in the study is displayed. Five of the nine with limited disease, compared to 32 Figure 2 shows the starting point and length of remission of 142 with more widespread disease, had remission for each individual patient during the course of periods of 6 months or more (P < 0.02). follow-up. Table III shows a comparison of demographics and The time spent in remission constituted 7.0% of disease characteristics between patients with persistent follow-up for all patients. and relapsing-remitting disease. The only significant Cross-tabulation comparing patients with (n = 37) finding was that patients with persistent disease were and without remission periods of at least 6 months more often RF positive (P = 0.04). No clinical or (n = 146) showed that remitting patients were signifi- laboratory variable at baseline differed between the cantly less often RF positive (P = 0.01) and less often two groups. We obtained no logistic regression model carried two shared epitopes (P = 0.05). Age, gender that could predict the disease course with any accuracy. and mode of onset did not differ between the two Seventy-two per cent of the patients with persistent groups. Comparison between the clinical and labora- disease had received DMARD therapy compared to tory variables at onset displayed in Table II showed 58% of the patients with relapsing-remitting disease. that patients with remission periods had a significantly Patients with persistent disease had also received a lower active joint count (P = 0.05). Prediction of larger number of different drugs (P = 0.01). Ten remission by means of logistic regression analysis did patients with relapsing-remitting disease and 19 not yield any clinically meaningful model, only 26% of patients with persistent disease had oral corticosteroid the patients with remission periods could be correctly treatment some time during the 5 yr. This difference classified. was significant (P = 0.02). Table IV shows some clinical and laboratory features Clinical course for the 176 patients who remained at study finish, One hundred and two patients (56%) had a subdivided according to clinical course. Patients with relapsing-remitting disease course and 81 (44%) had a persistent disease fared significantly worse in all persistent disease course. Forty per cent of patients respects. They were more disabled, had more joint with relapsing-remitting disease had their first arthritis- inflammation and more erosive radiographic changes. Table V displays the relationship between remission and DMARD treatment. More non-treated patients went into remission according to either definition. DISCUSSION In this early RA cohort, the patients were followed prospectively with standardized measures. The followup period was the same for all the patients, and the drop-out rate was only 4%. Remission was defined according to the rigorous ARA criteria. However, the required observation period of 2 months was prolonged to 6 months due to our study design. Twenty per cent of our patients achieved remission some time during the 5 yr follow-up time. Remission was mostly long lasting with an average length of almost 2 yr. Onethird of the follow-up time for these patients was spent in remission. However, the remission periods constituted only 7% of the entire follow-up time for the cohort. Other authors applying similar methods to calculate remission rates have reported findings in accord with ours both in early and established RA [7, 16]. In other studies of early RA patients, remission criteria were applied at a single point in time. The highest cross-sectional rates were found in a Finnish study [4] where 27% of the patients were in ARA- defined remission at the 2 yr follow-up and 32% at FIG. 1. ARA-defined remission rates over time in originally 183 early-ra patients with a mean disease duration of ~1 yr at study start. Altogether, 37 patients achieved 39 remission periods during follow-up. The numbers of patients moving in and out of remission during each 6 month period in the study are shown. The number of patients left in the study in each period is displayed below.
4 EBERHARDT AND FEX: CLINICAL COURSE IN EARLY RA 1327 FIG. 2. Remission periods (n = 39) for each individual patient (n = 37) during the course of follow-up. Each line denotes the starting point and length of remission. Mean (S.D.) remission time was 20.5 (12.9) months. TABLE III TABLE IV Demographic data and disease characteristics subdivided according Clinical and laboratory features subdivided according to clinical to clinical course for all the 183 patients course for 176 patients who remained in the study at the 5 yr follow- up. Median (interquartile range) Persistent Relapsing-remitting disease disease Relapsing-remitting (n = 81) (n = 102) Persistent disease disease (n = 78) (n = 98) Age at onset 50.7 (11.7) 52 (13) [yr; mean (S.D.)] Active joint count 5 (2 8) 1 (0 4)** Gender (% women) HAQ disability index 1.2 ( ) 0.8 ( )** Single epitope Joint damage score 53 (32 74) 27 (12 53)** (% positive) Double epitope ESR 31 (15 55) 21 (9 31)* (% positive) *P = 0.01, **P < 0.001; Mann Whitney s test. Rheumatoid factor 78* 64 (% positive) TABLE V Disease onset 14/20/59/7 21/16/50/13 Relationship between remission and DMARD treatment during (% acute/intermediate/ follow-up insidious/palindrome) Treated Non-treated *P = 0.04 (x2 test). (n = 114) (n = 69) ARA remission n (%) 18 (16) 21 (30) the 6 yr follow-up. Harrison et al. [17] studied a No arthritis on examination n (%) 60 (53) 42 (61) community-based cohort and found that 19% of their RA cases were in remission after 2 yr. Remission was defined as no arthritis on examination and no sion was often a temporary state with new patients DMARD or steroid treatment within the previous 3 achieving remission or relapsing at any point in time. months. Two other studies reported a cross-sectional Cross-sectional remission rates do not measure this remission rate of ~7% after 3 and 7 yr, respectively longitudinal aspect and are therefore less reliable, as [5, 6]. Both studies used being symptom free as a also pointed out by Harrison et al. [17]. Comparisons definition for remission. As illustrated in Fig. 1, remis- between different studies are thus not only hampered
5 1328 BRITISH JOURNAL OF RHEUMATOLOGY VOL. 37 NO. 12 by differences in defining remission and different ACKNOWLEDGEMENTS patient referral and selection, the different methods to Grants were obtained from the Medical Faculty of estimate remission rates are also rendering difficulties. Lund, the Österlund and Kock Foundations, the King Remission was more likely in seronegative patients Gustaf V 80-year Fund, and Reumatikerförbundet. having no or only a single shared epitope and fewer active joints at baseline. However, even in combination, REFERENCES these factors were not strong enough to allow accurate prediction of remission. Wolfe and Hawley [7] found 1. Hochberg MC. Predicting the prognosis of patients with rheumatoid arthritis: Is there a crystal ball? J Rheumatol that female sex, onset before the age of 60 yr and 1993;20: early development of erosions were associated with 2. Wollheim FA. Predictors of joint damage in rheumatoid decreased proportions of remission periods. Harrison arthritis. APMIS 1996;104: et al. [17] could confirm their finding of association 3. Pinals RS, Masi AT, Larsen RA. Preliminary criteria for with gender, but not with age. Like us, they found clinical remission in rheumatoid arthritis. Arthritis association to less widespread joint involvement at Rheum 1981;24: baseline. 4. Möttönen T, Paimela L, Ahonen J, Helve T, Hannonen In this study, we also applied a less rigorous definrheumatoid P, Leirisalo-Repo M. Outcome in patients with early arthritis treated according to the Sawtooth ition of remission, namely having no arthritis on examination at least at one follow-up visit. Defined in strategy. Arthritis Rheum 1996;39: Nissilä M, Isomäki H, Kaarela K, Kiviniemi P, Martio this way, 56% of our patients had achieved remission J, Sarna S. Prognosis of inflammatory joint diseases. at least once during the 5 yr. They were considered to A three-year follow-up study. Scand J Rheumatol have a relapsing-remitting disease pattern, in contrast 1983;12:33 8. to the 44% with chronic persistent joint inflammation. 6. Wolfe F, Ross K, Hawley D, Roberts K, Cathey MA. This classification turned out to be clinically useful, The prognosis of rheumatoid arthritis and undifferentiated identifying two groups of patients with different polyarthritis syndrome in the clinic: A study of prognosis. Our findings confirm a previous study of 1141 patients. J Rheumatol 1993;20: a 1985 inception cohort [9]. Young et al. [ 8] have 7. Wolfe F, Hawley D. Remission in rheumatoid arthritis. reported that only 26% of their patients had a persistent J Rheumatol 1985;12: Young A, Bielawska C, Corbett M, Roitt I. A prospective disease course. The lower figure is probably due to the study of early onset rheumatoid arthritis over fifteen fact that probable RA cases were also included in years: prognostic features and outcome. Clin Rheumatol their study. 1987;6(suppl. 2):12 9. It was not possible to predict the disease pattern 9. Suarez-Almazor MW, Soskolne CL, Saunders LD, with any accuracy. The only significant variable was Russel AS. Outcome in rheumatoid arthritis. A 1985 positive RF, which was weakly associated with persist- inception cohort study. J Rheumatol 1994;21: ence. It is noteworthy that genotype did not influence 10. Eberhardt K, Rydgren LC, Petersson H, Wollheim FA. disease pattern. Only 40% of the patients in the relapsover 2 years. Rheumatol Int 1990;10: Early rheumatoid arthritis onset, course and prognosis ing-remitting group had their first evaluation without 11. Ritchie DM, Boyle JA, McInnes JM et al. Clinical signs of arthritis during the first study year and another studies with an articular index for the assessment of joint 20% during the second year. This feature therefore had tenderness in patients with rheumatoid arthritis. Q J Med small predictive power. 1968;37: Mode of onset had no prognostic value in this study. 12. Ekdahl C, Eberhardt K, Andersson SI, Svensson B. Acute onset was associated with better prognosis in Assessing disability in patients with rheumatoid the Middlesex study [18], but others [9, 19] have not arthritis. Use of a Swedish version of the Stanford Health confirmed this. Assessment Questionnaire. Scand J Rheumatol 1988; The influence of DMARD therapy on the course of 17: the disease was fairly limited, inducing ARA-defined 13. Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard remission in only 16% and short-term arthritis-free reference films. Acta Radiol Diagn (Stockh) 1977; periods in another 37%. The frequency of drug-induced 18: ARA-defined remission is in accord with previous 14. Truedsson L, Sjöholm AG, Sturfelt G. Complement findings [ 7]. Patients not treated with DMARDs had activating rheumatoid factors in rheumatoid arthritis higher remission rates, probably reflecting a less severe studied by haemolysis in gel: relation to antibody class disease. Any conclusions regarding effects of treatment and response to treatment with podophyllotoxin deriv- vs non-treatment can therefore not be drawn. ates. Clin Exp Rheumatol 1985;3: To conclude, in this early RA cohort, 20% of 15. Eberhardt K, Fex E, Johnson U, Wollheim FA. the patients achieved ARA-defined remission periods Associations of HLA-DRB and DQB genes with two and five year outcome in rheumatoid arthritis. Ann of 6 months or more. Average length of remission Rheum Dis 1996;55:34 9. was almost 2 yr. If a wider definition of remission was 16. Prevoo MLL, van Gestel AM, van T Hof MA, van applied, almost 60% had a relapsing-remitting disease Rijswijk MH, van de Putte LBA, van Riel PLCM. course. These patients had better outcome after 5 yr Remission in a prospective study of patients with rheumatoid than patients with chronic persistent disease. arthritis. American Rheumatism Association prelim-
6 EBERHARDT AND FEX: CLINICAL COURSE IN EARLY RA 1329 inary remission criteria in relation to the disease activity 18. Fleming A, Crown JM, Corbett M. Prognostic value of score. Br J Rheumatol 1996;35: early features in rheumatoid arthritis. Br Med J 17. Harrison BJ, Symmons DPM, Brennan P, Barrett EM, 1976;1: Silman AJ. Natural remission in inflammatory polyarthritis: 19. Luukkainen R, Isomäki H, Kajander A. Prognostic value issues of definition and prediction. Br J Rheumatol 1996;35: of type of onset of rheumatoid arthritis. Ann Rheum Dis 1983;42:274 5.
Chapter 4. Advances in Rheumatology 2004 volume 2
Chapter 4 Sustained remission in a cohort of patients with rheumatoid arthritis: association with absence of IgM rheumatoid factor and absence of anti-ccp antibodies. Advances in Rheumatology 2004 volume
More informationNATURAL REMISSION IN INFLAMMATORY POLYARTHRITIS: ISSUES OF DEFINITION AND PREDICTION
British Journal of Rheumatology 1996;3S:1096-l 100 NATURAL REMISSION IN INFLAMMATORY POLYARTHRITIS: ISSUES OF DEFINITION AND PREDICTION B. J. HARRISON, D. P. M. SYMMONS, P. BRENNAN, E. M. BARRETT* and
More informationPROGNOSTIC VALUE OF QUANTITATIVE MEASUREMENT OF RHEUMATOID FACTOR IN EARLY RHEUMATOID ARTHRITIS
British Journal of Rheumatology 1995;34:1146-1150 PROGNOSTIC VALUE OF QUANTITATIVE MEASUREMENT OF RHEUMATOID FACTOR IN EARLY RHEUMATOID ARTHRITIS L. PAEVDELA, T. PALOSUO,* M. LEIRISALO-REPO,t T. HELVE
More informationDEVELOPMENT OF RADIOGRAPHIC DAMAGE DURING THE FIRST 5-6 YR OF RHEUMATOID ARTHRITIS. A PROSPECTIVE FOLLOW-UP STUDY OF A SWEDISH COHORT
British Journal of Rheumatology 1996;35:1106 1115 DEVELOPMENT OF RADIOGRAPHIC DAMAGE DURING THE FIRST 5-6 YR OF RHEUMATOID ARTHRITIS. A PROSPECTIVE FOLLOW-UP STUDY OF A SWEDISH COHORT E. FEX, K. JONSSON,*
More informationCORRELATES OF FUNCTIONAL DISABILITY IN EARLY RHEUMATOID ARTHRITIS: A CROSS-SECTIONAL STUDY OF 706 PATIENTS IN FOUR EUROPEAN COUNTRIES
British Journal of Rheumatology 1996;35:746-751 CORRELATES OF FUNCTIONAL DISABILITY IN EARLY RHEUMATOID ARTHRITIS: A CROSS-SECTIONAL STUDY OF 706 PATIENTS IN FOUR EUROPEAN COUNTRIES L. M. SMEDSTAD,*t T.
More informationJ. van Aken* H. van Dongen* S. le Cessie F.C. Breedveld T.W.J. Huizinga. * both authors contributed equally
CHAPTER Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study J. van Aken* H. van
More informationfunctional declines from the beginning of the Questionnaire ( HAQ) [14] is more effective than any
Rheumatology 2000;39:34 42 Disease-modifying anti-rheumatic drug use according to the sawtooth treatment strategy improves the functional outcome in rheumatoid arthritis: results of a long-term follow-up
More informationSerum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis
Rheumatology 2003;42:83 88 doi:10.1093/rheumatology/keg037, available online at www.rheumatology.oupjournals.org Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis M.J.Green,A.K.S.Gough,J.Devlin,J.Smith,P.Astin,
More informationOUTCOME OF EARLY RHEUMATOID ARTHRITIS
Department of Medicine, Division of Rheumatology, Helsinki University Central Hospital, Helsinki, Finland OUTCOME OF EARLY RHEUMATOID ARTHRITIS -With special reference to early institution of drug treatment
More informationUtility of disease modifying antirheumatic drugs in sawtooth strategy. A prospective study of early rheumatoid arthritis patients up to 15 years
68 Ann Rheum Dis 999;58:68 622 EXTENDED REPORTS Department of Medicine, Jyväskylä Central Hospital, Keskussairaalantie 9, FIN 462 Jyväskylä, Finland Correspondence to: Dr T Sokka. Accepted for publication
More informationR heumatoid arthritis (RA) is a chronic autoimmune
274 EXTENDED REPORT Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis J van Aken, L R Lard, S le Cessie, J M W Hazes, F
More informationR heumatoid arthritis (RA) is a chronic autoimmune
274 EXTENDED REPORT Radiological outcome after four years of early versus delayed treatment strategy in patients with recent onset rheumatoid arthritis J van Aken, L R Lard, S le Cessie, J M W Hazes, F
More informationJ. Asikainen 1, E. Nikiphorou 1, K. Kaarela 2, E. Lindqvist 3, A. Häkkinen 4, H. Kautiainen 5,6, P. Hannonen 1, T. Rannio 1, T.
Is long-term radiographic joint damage different between men and women? Prospective longitudinal data analysis of four early RA cohorts with greater than 15 years of follow-up J. Asikainen 1, E. Nikiphorou
More informationThe Relationship Between Disease Activity and Radiologic Progression in Patients With Rheumatoid Arthritis
ARTHRITIS & RHEUMATISM Vol. 50, No. 7, July 2004, pp 2082 2093 DOI 10.1002/art.20350 2004, American College of Rheumatology The Relationship Between Disease Activity and Radiologic Progression in Patients
More informationPrognostic laboratory markers of joint damage in rheumatoid arthritis.
Prognostic laboratory markers of joint damage in rheumatoid arthritis. Lindqvist, Elisabet; Eberhardt, Kerstin; Bendtzen, Klaus; Heinegård, Dick; Saxne, Tore Published in: Annals of the Rheumatic Diseases
More informationThe links between joint damage and disability in rheumatoid arthritis
Rheumatology 2000;39:122 132 Review The links between joint damage and disability in rheumatoid arthritis D. L. Scott, K. Pugner1, K. Kaarela2, D. V. Doyle, A. Woolf, J. Holmes1 and K. Hieke3 Clinical
More informationI nuovi criteri ACR/EULAR per la classificazione dell artrite reumatoide
I nuovi criteri ACR/EULAR per la classificazione dell artrite reumatoide Pierluigi Macchioni Struttura Complessa di Reumatologia, Ospedale di Reggio Emilia Topics 1987 ACR classification criteria for RA
More informationReceived: 27 May 2003 Revisions requested: 26 Jun 2003 Revisions received: 14 Aug 2003 Accepted: 19 Aug 2003 Published: 1 Oct 2003
Research article Etanercept versus etanercept plus methotrexate: a registrybased study suggesting that the combination is clinically more efficacious Ronald F van Vollenhoven 1, Sofia Ernestam 2, Anders
More informationPDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/23314
More informationJuvenile Idiopathic Arthritis in Adults: Long-Term Observation of Ukrainian Patients
Archive of Clinical Medicine 2017 Vol. 23, Issue 1, E201715 DOI: 10.21802/acm.2017.1.5 Research Article Juvenile Idiopathic Arthritis in Adults: Long-Term Observation of Ukrainian Patients Marta Dzhus
More informationCARPAL ANKYLOSIS IN JUVENILE RHEUMATOID ARTHRITIS
125 1 CARPAL ANKYLOSIS IN JUVENILE RHEUMATOID ARTHRITIS JOSE A. MALDONADO-COCCO, OSVALDO GARCIA-MORTEO, ALBERT0 J. SPINDLER, OSVALDO HUBSCHER. and SUSANA GAGLIARDI Forty-seven of 100 consecutive juvenile
More informationDeclines of tender and swollen joint counts between 1985 and 2001 in patients. with rheumatoid arthritis seen in standard care:
ARD Online First, published on December 8, 2005 as 10.1136/ard.2005.044131 1 2 3 1 Declines of tender and swollen joint counts between 1985 and 2001 in patients with rheumatoid arthritis seen in standard
More informationPredictors of radiological progression and changes in hand bone density in early rheumatoid arthritis
Rheumatology 2003;42:268 275 doi:10.1093/rheumatology/keg077, available online at www.rheumatology.oupjournals.org Predictors of radiological progression and changes in hand bone density in early rheumatoid
More informationV. P. K. Nell 1, K. P. Machold 1, G. Eberl 2, T. A. Stamm 1, M. Uffmann 3 and J. S. Smolen 1,2
Rheumatology 2004;43:906 914 Advance Access publication 27 April 2004 Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid
More informationComparison between ESR and C-Reactive Protein(CRP) as a Marker of Disease activity in Patients with Rheumatoid Arthritis
Original Article Comparison between ESR and C-Reactive Protein(CRP) as a Marker of Disease activity in Patients with Rheumatoid Arthritis Ali M.E. Yousef 1, Fatemah A. Elshabacy 2, Sherry K. Abdelrahman
More informationA 3-page standard protocol to evaluate rheumatoid arthritis (SPERA): Efficient capture of essential data for clinical trials and observational studies
A 3-page standard protocol to evaluate rheumatoid arthritis (SPERA): Efficient capture of essential data for clinical trials and observational studies T. Pincus Division of Rheumatology and Immunology,
More informationAssessing Remission in Rheumatoid Arthritis on the Basis of Patient Reported Outcomes
136 Bulletin of the Hospital for Joint Diseases 2014;72(2):136-41 Assessing Remission in Rheumatoid Arthritis on the Basis of Patient Reported Outcomes Advantages of Using RAPID3/MDHAQ in Routine Care
More informationOptimal responses in disease activity scores to treatment in rheumatoid arthritis: Is a DAS28 reduction of >1.2 sufficient?
Mian et al. Arthritis Research & Therapy (2016) 18:142 DOI 10.1186/s13075-016-1028-8 RESEARCH ARTICLE Optimal responses in disease activity scores to treatment in rheumatoid arthritis: Is a DAS28 reduction
More informationLearned helplessness predicts functional disability, pain and fatigue in patients with recent-onset inflammatory polyarthritis
RHEUMATOLOGY Rheumatology 2013;52:1233 1238 doi:10.1093/rheumatology/kes434 Advance Access publication 18 February 2013 Original article Learned helplessness predicts functional disability, pain and fatigue
More informationT. Uhlig, E. A. Haavardsholm and T. K. Kvien
Rheumatology 2006;45:454 458 Advance Access publication 15 November 2005 Comparison of the Health Assessment Questionnaire (HAQ) and the modified HAQ (MHAQ) in patients with rheumatoid arthritis T. Uhlig,
More informationRadiological progression in early rheumatoid arthritis after DMARDS: a one-year follow-up study in a clinical setting
Rheumatology 2003;42:1044 1049 doi:10.1093/rheumatology/keg284, available online at www.rheumatology.oupjournals.org Advance Access publication 16 April 2003 Radiological progression in early rheumatoid
More informationOpen Access NY, USA. Keywords: HAQ, early RA, disease activity, DAS, cohort, correlation, longitudinal.
Send Orders for Reprints to reprints@benthamscience.net 58 The Open Rheumatology Journal, 2013, 7, 58-63 Open Access The Relationship Between Function and Disease Activity as Measured by the HAQ and DAS28
More informationRheumatology function tests: Quantitative physical measures to monitor morbidity and predict mortality in patients with rheumatic diseases
Rheumatology function tests: Quantitative physical measures to monitor morbidity and predict mortality in patients with rheumatic diseases T. Pincus Division of Rheumatology and Immunology, Department
More informationInflammatory rheumatic diseases
Learning objectives Inflammatory rheumatic diseases Bruce Kidd Barts & The London, Queen Mary, University of London To understand: 1. prevalence and range of the rheumatological s 2. clinical features
More informationArthritis Research & Therapy 2006, 8:216 (doi: /ar1983)
Review Aspects of early arthritis Definition of disease states in early arthritis: remission versus minimal disease activity Annette HM van der Helm-van Mil, Ferdinand C Breedveld and Tom WJ Huizinga Department
More informationJOINT ASSESSMENT IN RHEUMATOID ARTHRITIS
British Journal of Rheumatology 1996;35(suppl.2):14-18 JOINT ASSESSMENT IN RHEUMATOID ARTHRITIS D. L. SCOTT and D. A. HOUSSIEN Academic Rheumatology Unit, King's College School of Medicine and Dentistry,
More informationJOINT ASSESSMENT IN RHEUMATOID ARTHRITIS
British Journal of Rheumatology 1996;35(suppl.2):14-18 JOINT ASSESSMENT IN RHEUMATOID ARTHRITIS D. L. SCOTT and D. A. HOUSSIEN Academic Rheumatology Unit, King's College School of Medicine and Dentistry,
More informationSupplemental Table 1. Key Inclusion Criteria Inclusion Criterion OPTIMA PREMIER 18 years old with RA (per 1987 revised American College of General
Supplemental Table 1. Key Inclusion Criteria Inclusion Criterion OPTIMA PREMIER 18 years old with RA (per 1987 revised American College of General Rheumatology classification criteria) 34 ; erythrocyte
More informationNew Evidence reports on presentations given at ACR Improving Radiographic, Clinical, and Patient-Reported Outcomes with Rituximab
New Evidence reports on presentations given at ACR 2009 Improving Radiographic, Clinical, and Patient-Reported Outcomes with Rituximab From ACR 2009: Rituximab Rituximab in combination with methotrexate
More informationRheumatoid Arthritis. Manish Relan, MD FACP RhMSUS Arthritis & Rheumatology Care Center. Jacksonville, FL (904)
Rheumatoid Arthritis Manish Relan, MD FACP RhMSUS Arthritis & Rheumatology Care Center. Jacksonville, FL (904) 503-6999. 1 Disclosures Speaker Bureau: Abbvie 2 Objectives Better understand the pathophysiology
More informationComparing Five Year Out-Come in Two Cohorts of Patients with Early Rheumatoid Arthritis - A BARFOT Study.
Comparing Five Year Out-Come in Two Cohorts of Patients with Early Rheumatoid Arthritis - A BARFOT Study. Andersson, Maria; Forslind, Kristina; Hafström, Ingiäld Published in: Open Rheumatology Journal
More informationFaith Matcham, Sam Norton, David L Scott, Sophia Steer, Matthew Hotopf FA I T H M AT C H A M P H D S T U D E N T,
The impact of baseline and persistent symptoms of depression and anxiety on long-term physical health outcomes and response to treatment in Rheumatoid Arthritis Faith Matcham, Sam Norton, David L Scott,
More informationK. Laas 1, R. Peltomaa 1, K. Puolakka 2, H. Kautiainen 3, M. Leirisalo-Repo 1
Early improvement of health-related quality of life during treatment with etanercept and adalimumab in patients with rheumatoid arthritis in routine practice K. Laas 1, R. Peltomaa 1, K. Puolakka 2, H.
More informationComparison of long-term clinical outcome with etanercept and adalimumab treatment of rheumatoid arthritis with respect to immunogenicity
7 Comparison of long-term clinical outcome with etanercept and adalimumab treatment of rheumatoid arthritis with respect to immunogenicity Charlotte Krieckaert* Anna Jamnitski* Mike Nurmohamed Piet Kostense
More informationScintigraphic Findings and Serum Matrix Metalloproteinase 3 and Vascular Endothelial Growth Factor Levels in Patients with Polymyalgia Rheumatica
The Open General and Internal Medicine Journal, 29, 3, 53-57 53 Open Access Scintigraphic Findings and Serum Matrix Metalloproteinase 3 and Vascular Endothelial Growth Factor Levels in Patients with Polymyalgia
More informationF or the management of rheumatoid arthritis, there is
1294 EXTENDED REPORT Effectiveness of systematic monitoring of rheumatoid arthritis disease activity in daily practice: a multicentre, cluster randomised controlled trial J Fransen, H Bernelot Moens, I
More informationRelative effect (95% CI) RR LOW 2,3 due to indirectness, imprecision. RR 1.45 (0.43 to 4.84) due to indirectness, imprecision. (0.18 to 20.
Appendix: Evidence Reports Question In patients with early RA with moderate or high disease activity, who are DMARD-naive, what is the impact of combination double DMARD therapy vs. mono-dmard therapy
More informationEfficacy and Safety of Tocilizumab in the Treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis
New Evidence reports on presentations given at EULAR 2010 Efficacy and Safety of Tocilizumab in the Treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Report on EULAR 2010 presentations
More informationConcordance with the British Society of Rheumatology (BSR) 2010 recommendations on eligibility criteria for the first biologic agent
Concordance with the British Society of Rheumatology (BSR) 2010 recommendations on eligibility criteria for the first biologic agent Michela Frendo, John Paul Caruana Galizia, Andrew A Borg Abstract Aims:
More informationFrequency and duration of clinical remission in patients with peripheral psoriatic arthritis requiring second-line drugs
Rheumatology 2008;47:872 876 Advance Access publication 9 April 2008 doi:10.1093/rheumatology/ken059 Frequency and duration of clinical remission in patients with peripheral psoriatic arthritis requiring
More informationCitation for final published version:
This is an Open Access document downloaded from ORCA, Cardiff University's institutional repository: http://orca.cf.ac.uk/97756/ This is the author s version of a work that was submitted to / accepted
More information1.0 Abstract. Title. Keywords. Rationale and Background
1.0 Abstract Title A Prospective, Multi-Center Study in Rheumatoid Arthritis Patients on Adalimumab to Evaluate its Effect on Synovitis Using Ultrasonography in an Egyptian Population Keywords Synovitis
More informationPDF hosted at the Radboud Repository of the Radboud University Nijmegen
PDF hosted at the Radboud Repository of the Radboud University Nijmegen The following full text is a publisher's version. For additional information about this publication click this link. http://hdl.handle.net/2066/23689
More informationGenetic variation in FOXO3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis
Genetic variation in FOXO3 is associated with reductions in inflammation and disease activity in inflammatory polyarthritis Sebastien Viatte 1, James C. Lee 3,4, Bo Fu 1,5, Marion Espéli 6, Mark Lunt 7,
More informationR.T. Keenan 1, C.J. Swearingen 2, Y. Yazici 1
Erythrocyte sedimentation rate and C-reactive protein levels are poorly correlated with clinical measures of disease activity in rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis patients
More informationseverity of rheumatoid arthritis
94 Annals of the Rheumatic Diseases 1996; 55: 94-98 Immuno- Rheumatology Gui de Chauliac Hospital, 34295 Montpellier Cedex 5, France C Jorgensen C Bologna J Sany Medical Data Processing and Statistical
More informationHAND IMPAIRMENTS and hand-related activity limitations 1
96 ORIGINAL ARTICLE Predictors of Stenosing Tenosynovitis in the Hand and Hand-Related Activity Limitations in Patients With Rheumatoid Arthritis Jennie Ursum, MSc, Noortje C. Horsten, MD, Agnes F. Hoeksma,
More informationR heumatoid arthritis is a chronic debilitating disease that
924 EXTENDED REPORT Pharmacoeconomic study of patients with chronic inflammatory joint disease before and during infliximab treatment K Laas, R Peltomaa, H Kautiainen, K Puolakka, M Leirisalo-Repo... Ann
More informationand eyes and have also looked at histocompatibility and 1980 were identified as having had either rate (ESR) and all ANA results were noted. ANA.
Archives of Disease in Childhood, 1986, 61, 168-172 Antinuclear antibody studies in juvenile chronic arthritis A M LEAK, B M ANSELL, AND S J BURMAN Division of Rheumatology, Canadian Red Cross Memorial
More informationOverview of Work Disability in Rheumatoid Arthritis Patients as Observed in Cross-Sectional and Longitudinal Surveys
Arthritis & Rheumatism (Arthritis Care & Research) Vol. 51, No. 3, June 15, 2004, pp 488 497 DOI 10.1002/art.20419 2004, American College of Rheumatology REVIEW Overview of Work Disability in Rheumatoid
More informationASSOCIATION OF HLA-DR WITH SUSCEPTIBILITY TO AND CLINICAL EXPRESSION OF RHEUMATOID ARTHRITIS: RE-EVALUATION BY MEANS OF GENOMIC TISSUE TYPING
British Journal of Rheumatology 1998;37:411 416 ASSOCIATION OF HLA-DR WITH SUSCEPTIBILITY TO AND CLINICAL EXPRESSION OF RHEUMATOID ARTHRITIS: RE-EVALUATION BY MEANS OF GENOMIC TISSUE TYPING C. H. M. VAN
More informationAbstract. for DNA extraction. Serum is also stored. The patient completes a Health Assessment Questionnaire (HAQ) [2] adapted for British use [3].
Available online http://arthritis-research.com/content/8/4/214 Review Aspects of early arthritis What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from
More informationNew Evidence reports on presentations given at EULAR Safety and Efficacy of Tocilizumab as Monotherapy and in Combination with Methotrexate
New Evidence reports on presentations given at EULAR 2009 Safety and Efficacy of Tocilizumab as Monotherapy and in Combination with Methotrexate Report on EULAR 2009 presentations Tocilizumab inhibits
More informationSocio-economic consequences of rheumatoid arthritis in the first years of the disease
Rheumatology 1999;38:423 430 Socio-economic consequences of rheumatoid arthritis in the first years of the disease J. M. C. Albers, H. H. Kuper1, P. L. C. M. van Riel, M. L. L. Prevoo, M. A. Van t Hof2,
More informationLOCALLY AVAILABLE BIOLOGIC AGENTS IN THE TREATMENT OF PSORIATIC ARTHRITIS
Locally Available Biologic Agents in the Treatment of Psoriatic Arthritis 253 Phil. J. Internal Medicine, 47: 253-259, Nov.-Dec., 2009 LOCALLY AVAILABLE BIOLOGIC AGENTS IN THE TREATMENT OF PSORIATIC ARTHRITIS
More informationPerformance of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients under biological therapies
Performance of the Ankylosing Spondylitis Disease Activity Score (ASDAS) in patients under biological therapies 1. Introduction The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a new instrument
More informationMichael Ziegelasch 1*, Kristina Forslind 2,3, Thomas Skogh 1, Katrine Riklund 4, Alf Kastbom 1 and Ewa Berglin 5
Ziegelasch et al. Arthritis Research & Therapy (2017) 19:195 DOI 10.1186/s13075-017-1403-0 RESEARCH ARTICLE Open Access Decrease in bone mineral density during three months after diagnosis of early rheumatoid
More informationUnderstanding Rheumatoid Arthritis
Understanding Rheumatoid Arthritis Understanding Rheumatoid Arthritis What Is Rheumatoid Arthritis? 1,2 Rheumatoid arthritis (RA) is a chronic autoimmune disease. It causes joints to swell and can result
More informationDoes cigarette smoking influence disease expression, activity and severity in early rheumatoid arthritis patients?
Does cigarette smoking influence disease expression, activity and severity in early rheumatoid arthritis patients? N.G. Papadopoulos, Y. Alamanos 1, P.V. Voulgari, E.K. Epagelis, N. Tsifetaki, A.A. Drosos
More informationAnnual Rheumatology & Therapeutics Review for Organizations & Societies
Annual Rheumatology & Therapeutics Review for Organizations & Societies Comparative Effectiveness Studies of Biologics Learning Objectives Understand the motivation for comparative effectiveness research
More informationHANDICAP IN INFLAMMATORY ARTHRITIS
British Journal of Rheumatology 19;35:891-897 HANDICAP IN INFLAMMATORY ARTHRITIS R. H. HARWOOD, A. J. CARR,* P. W. THOMPSON* and S. EBRAHEM Department of Public Health, Royal Free Hospital Medical School,
More informationTreat - to - Target Pathway Commissioning Chronic and Complex Care MIDLANDS RHEUMATOLOGY & MUSCULOSKELETAL (MSK) COMMISSIONING NETWORK
Treat - to - Target Pathway Commissioning Chronic and Complex Care MIDLANDS RHEUMATOLOGY & MUSCULOSKELETAL (MSK) COMMISSIONING NETWORK Dr Bruce Kirkham Consultant Rheumatologist Guy s & St Thomas NHS Foundation
More informationHorizon Scanning Centre November Secukinumab for active and progressive psoriatic arthritis. SUMMARY NIHR HSC ID: 5330
Horizon Scanning Centre November 2012 Secukinumab for active and progressive psoriatic arthritis. SUMMARY NIHR HSC ID: 5330 Secukinumab is a high-affinity fully human monoclonal antibody that antagonises
More informationN J Wiles, D G I Scott, E M Barrett, P Merry, E Arie, K GaVney, A J Silman,
Ann Rheum Dis ;: ARC Epidemiology Unit, University of Manchester Medical School, Oxford Road, Manchester M PT, UK N J Wiles A J Silman D P M Symmons Department of Rheumatology, Norfolk and Norwich Hospital,
More informationThe new ACR/EULAR remission criteria: rationale for developing new criteria for remission
RHEUMATOLOGY Rheumatology 2012;51:vi16 vi20 doi:10.1093/rheumatology/kes281 The new ACR/EULAR remission criteria: rationale for developing new criteria for remission Vivian P. Bykerk 1,2 and Elena M. Massarotti
More informationCross-validation of a clinical pharmacogenetic model to predict the efficacy of MTX monotherapy in established
Chapter 5: Cross-validation of a clinical pharmacogenetic model to predict the efficacy of MTX monotherapy in established RA Jaap Fransen 1, Wouter M. Kooloos 2, Judith AM Wessels 2, Tom WJ Huizinga 3,
More informationRadiological progression in rheumatoid arthritis:
332 Annals of the Rheumatic Diseases 1993; 52: 332-337 The Tifton Medical Clinic, Tifton, Georgia and the Joe and Betty Alpert Arthritis Center, Denver, Colorado, USA J T Sharp Arthritis Center, Wichita,
More informationT he negative consequences of rheumatoid arthritis on the
59 EXTENDED REPORT Pain and joint mobility explain individual subdimensions of the health assessment questionnaire (HAQ) disability index in patients with rheumatoid arthritis A Häkkinen, H Kautiainen,
More informationJOINT DESTRUCTION AFTER GLUCOCORTICOIDS ARE WITHDRAWN IN EARLY RHEUMATOID ARTHRITIS
British Journal of Rheumatology 1998;37:930 936 JOINT DESTRUCTION AFTER GLUCOCORTICOIDS ARE WITHDRAWN IN EARLY RHEUMATOID ARTHRITIS P. HICKLING, R. K. JACOBY,* J. R. KIRWAN and the ARTHRITIS AND RHEUMATISM
More informationValidation of Leiden Score in Predicting Progression of Rheumatoid Arthritis in Undifferentiated Arthritis in Indian Population
Original Article Validation of Leiden Score in Predicting Progression of Rheumatoid Arthritis in Undifferentiated Arthritis in Indian Population Ghosh K, Chatterjee A 1, Ghosh S 2, Chakraborty S 3, Chattopadhyay
More informationDoes the age of onset of rheumatoid arthritis influence phenotype?: a prospective study of outcome and prognostic factors
Rheumatology 1999;38:228 234 Does the age of onset of rheumatoid arthritis influence phenotype?: a prospective study of outcome and prognostic factors C. T. Pease, B. B. Bhakta, J. Devlin and P. Emery
More informationBritish Journal of Rheumatology 1998;37:
British Journal of Rheumatology 1998;37:874 882 PROGRESSION OF JOINT DAMAGE IN EARLY ACTIVE SEVERE RHEUMATOID ARTHRITIS DURING 18 MONTHS OF TREATMENT: COMPARISON OF LOW-DOSE CYCLOSPORIN AND PARENTERAL
More informationFatigue in rheumatoid arthritis reflects pain, not disease activity
Rheumatology 2006;45:885 889 Advance Access publication 31 January 2006 doi:10.1093/rheumatology/kel021 Concise Report Fatigue in rheumatoid arthritis reflects pain, not disease activity L. C. Pollard,
More informationNew Evidence reports on presentations given at EULAR Rituximab for the Treatment of Rheumatoid Arthritis and Vasculitis
New Evidence reports on presentations given at EULAR 2011 Rituximab for the Treatment of Rheumatoid Arthritis and Vasculitis Report on EULAR 2011 presentations Anti-TNF failure and response to rituximab
More informationMeta-analysis of long-term joint structural deterioration in minimally treated patients with rheumatoid arthritis
Jansen et al. BMC Musculoskeletal Disorders (2016) 17:348 DOI 10.1186/s12891-016-1195-4 RESEARCH ARTICLE Open Access Meta-analysis of long-term joint structural deterioration in minimally treated patients
More informationBritish Journal of Rheumatology 1991; 30:
British Journal of Rheumatology 1991; 30:468-470 CASE REPORT CARPAL TUNNEL SYNDROME COMPLICATED BY REFLEX SYMPATHETIC DYSTROPHY SYNDROME BY M.-A. FITZCHARLES AND J.M. ESDAILE Rheumatic Disease Unit, McGill
More informationThe Relationship Between Clinical Activity And Function In Ankylosing Spondylitis Patients
Bahrain Medical Bulletin, Vol.27, No. 3, September 2005 The Relationship Between Clinical Activity And Function In Ankylosing Spondylitis Patients Jane Kawar, MD* Hisham Al-Sayegh, MD* Objective: To assess
More informationIntroduction ORIGINAL ARTICLE
Mod Rheumatol (2007) 17:28 32 Japan College of Rheumatology 2007 DOI 10.1007/s10165-006-0532-0 ORIGINAL ARTICLE Hisashi Yamanaka Yoshiya Tanaka Naoya Sekiguchi Eisuke Inoue Kazuyoshi Saito Hideto Kameda
More informationTreatment of early RA in clinical practice: A comparative study of two different DMARD/corticosteroid options
Treatment of early RA in clinical practice: A comparative study of two different DMARD/corticosteroid options B. Svensson 1, M. Ahlmén 2 and K. Forslind 1, for the BARFOT study group # 1 Section of Rheumatology,
More informationBest Parameters for Assessment of Anti-Rheumatoid. (Economical, Clinical and Humanistic Outcome)
Int. J. Bioinformatics and Biological Sci.: v.2 n.1&2, p. 85-94. March and June 2014 Best Parameters for Assessment of Anti-Rheumatoid Arthritic Drugs is ECHO MODEL (Economical, Clinical and Humanistic
More informationReceived: 23 Mar 2005 Revisions requested: 18 Apr 2005 Revisions received: 22 Apr 2005 Accepted: 11 May 2005 Published: 14 Jun 2005
Available online http://arthritis-research.com/content/7/5/r949 Vol 7 No 5 Research article Open Access Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
More informationNew Evidence reports on presentations given at EULAR Tocilizumab for the Treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis
New Evidence reports on presentations given at EULAR 2011 Tocilizumab for the Treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Report on EULAR 2011 presentations Benefit of continuing
More informationTuulikki Sokka. Extensive use of antirheumatic drugs improves long-term outcomes in patients with rheumatoid arthritis
Tuulikki Sokka Extensive use of antirheumatic drugs improves long-term outcomes in patients with rheumatoid arthritis ABSTRACT Sokka, Tuulikki. Extensive use of antirheumatic drugs improves long-term outcomes
More informationEtiology: Pathogenesis Clinical manifestation Investigation Treatment Prognosis
Etiology: Pathogenesis Clinical manifestation Investigation Treatment Prognosis JIA is the most common rheumatic disease in childhood and a major cause of chronic disability. Etiology: Unknown, but may
More informationThe relationship between soft tissue swelling, joint space narrowing and erosive damage in hand X-rays of patients with rheumatoid arthritis
Rheumatology 2001;40:297±301 The relationship between soft tissue swelling, joint space narrowing and erosive damage in hand X-rays of patients with rheumatoid arthritis J. Kirwan, M. Byron and I. Watt
More informationA. Kopchev, S.Monov, D. Kyurkchiev, I.Ivanova, T. Georgiev (UMHAT St. Ivan Rilski, Medical University - Sofia, Bulgaria)
International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 6 Issue 7 July 2017 PP. 08-12 Vascular endothelial growth factor (VEGF), cartilage oligomeric
More informationFigure 1. Study flow diagram. Reasons for withdrawal during the extension phase are included in the flow diagram. 508 patients enrolled and randomized
508 patients enrolled and randomized 126 assigned to sequential monotherapy (group 1) 121 assigned to step-up combination therapy (group 2) 133 assigned to initial combination therapy with prednisone (group
More informationWAIT TIMES TO RHEUMATOLOGY AND REHABILITATION SERVICES: IS RHEUMATOID ARTHRITIS PRIORITIZED?
WAIT TIMES TO RHEUMATOLOGY AND REHABILITATION SERVICES: IS RHEUMATOID ARTHRITIS PRIORITIZED? Ashley Delaurier PT M.Sc. Candidate Biomedical Sciences University of Montreal ashley.delaurier@umontreal.ca
More informationO ver many decades disease modifying antirheumatic
63 CONCISE REPORT Practical progress in realisation of early diagnosis and treatment of patients with suspected rheumatoid arthritis: results from two matched questionnaires within three years D Aletaha,
More information