3 rd Muenster symposium on autoinflammatory syndromes in children and adolescents: Genetics, pathomechanisms, diagnostics and therapeutic targets

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1 3 rd Muenster symposium on autoinflammatory syndromes in children and adolescents: Genetics, pathomechanisms, diagnostics and therapeutic targets May 12-14, 2011 Dear Colleagues We cordially invite you to Muenster for a forthcoming international symposium with focus on autoinflammatory syndromes. Following the very successful international meeting in Muenster last year, the event continues to translate recent advances in basic sciences into clinical management of autoinflammatory diseases and to explore potential future strategies for treatment. This translational effort will refer to and encompass the orchestrated action of factors and processes eventually leading to the manifest disease: these include genetic and immunologic factors, diagnostic approaches and pathogenetic implications. The symposium is also the third meeting of a research consortium (AID-Net) which is funded by the German government through the BMBF. The vision of the AID-Net consortium and as well of our symposium is to foster bridges between basic scientists and clinicians. We will also provide a discussion platform for both internationally renowned senior investigators and young researchers dedicated to unravel the intricacies of the pathogenesis of autoinflammatory diseases. The meeting will take place in a university town and cultural centre with a long-standing tradition. In close proximity to the Netherlands and Germany's Ruhr Area, Muenster combines the cultural and infrastructural advantages of a modern science and service community with the beautiful countryside of the Muensterland region with its many moated castles and internationally renowned bicycle paths. It is a city with plenty of history as well as a unique supply of activities to enjoy art and culture alongside other pleasures. Muenster has been awarded the title of World s Most Liveable City (LivCom Award 2004, category: 250,000 to 700,000 inhabitants). It is our personal wish and hope that the symposium participants will thoroughly enjoy the scientific program as well as the atmosphere of an old university town. Welcome to Muenster, we look forward to seeing your there in May Sincerely, Dirk Foell Helmut Wittkowski Johannes Roth

2 Preliminary Program May 12, 2010 (Thursday) Session I: Introduction Chairs: Dirk Foell / Johannes Roth Welcome (Johannes Roth, Muenster; confirmed) Overview of the AID-Net concept (Uli Neudorf, Essen, confirmed) Update on immune disease classification from the autoinflammatory perspective (Dennis McGonagle, Leeds; confirmed) Coffee Break Session II: Autoinflammation - an underlying mechanism in various diseases Chair: Dirk Foell Chronic Urticaria as a predictor for autoinflammatory diseases (Marcus Maurer, Berlin; invited) Gouty Arthritis - an autoinflammatory disease (Rieke Alten, Berlin; invited) Morbus Behcet - between autoimmunity and autoinflammation (Ina Kötter, Tübingen; invited) New approaches in difficult to treat FMF patients (Riva Brik, Haifa; invited) Dinner at the restaurant Eat

3 May 13, 2010 (Friday) Autoinflammatory Session III: Translation of disease mechanisms into clinic Chair: Ulrich Neudorf Systemic JIA as an autoinflammatory disease (Marco Gattorno, Genova; confirmed) Specific gene expression patterns in SJIA (Alexej Grom, Cincinnati, confirmed) Targets for therapies in SJIA (Nico Wulffraat, Utrecht; confirmed) Coffee Break Session IV: Hypersecretion of pro-inflammatory molecules Chair: Johannes Roth The unconventional secretion of Fibroblast Growth Factor 2 (Walter Nickel, Heidelberg; confirmed) Non-classical secretion of annexin A1 (Volker Gerke, Muenster; invited) NF-kB mediates regulatory mechanisms of IL-1β secretion (Florian Greten, Munich; confirmed) Molecular characterization of two unusual nuclear IkappaB proteins (Klaus Schulze-Osthoff, Tuebingen; confirmed) Lunch Session V: Inflammasomes and beyond Chair: Thomas Vogl Overview of Inflammasomes (Hans-Dietmar Beer, Zürich; confirmed) Mechanisms of autoinflammation: Activation pathways and modulators (Seth Masters, Dublin; confirmed) Activation of inflammasomes by RNA/DNA (Veit Hornung, Bonn; confirmed) Bus transfer to the Picasso Museum Guided tour of the Picasso Museum Dinner at the restaurant Ratskeller

4 May 14, 2010 (Saturday) Session VI: Innate immunity from bench to bedside and back Chair: Helmut Wittkowski Immune modulation: IL-1 as a cornerstone of innate immunity (Aisling Dunne, Dublin; confirmed) The genetic and clinical spectrum of TRAPS (Michael F McDermott, Leeds; confirmed) CAPS: What is new in 2011 (Raphaela Goldbach-Mansky, Bethesda; confirmed) Stress-induced inflammation (Anna Rubartelli, Genova; confirmed) Coffee Break Session VII: Future research on rare disease Chair: Marco Gattorno European Union perspectives (Berent Prakken, Utrecht; invited) PRINTO as a platform on research in rare paediatric diseases (Alberto Martini, Genova; confirmed) Summary and Farewell (Dirk Foell, Muenster; confirmed) Lunch Internal meeting of the AID-Net consortium The meeting is supported by grants from the German ministry of education and science (BMBF) and Novartis Pharma AG.

5 REGISTRATION I register for the meeting (registration fee 130,- ) I will need a hotel room from May to May, 2011 (total of nights at 100,- per night, Factory Hotel Muenster; all meals included except congress dinner in the Ratskeller on Friday) I will join the dinner on May 12, 2011 (included at no cost) I will join the guided tour of the Picasso Museum and the dinner at the restaurant Ratskeller on May 13,2011 (cost 35,- ) Total amount to be paid Name, Surname Institution Adress Date/Signature Please transfer the total amount to be paid to the following account (indicate the reference ): Account Holder: Universitätsklinikum Münster Bank: Westdeutsche Landesbank Münster BLZ ; Konto-Nr SWIFT/BIC: WELADEDD; IBAN: DE In case of any questions or requests please contact our secretariat, Nicole Schnieder: Phone +49 (0) ; Fax +49 (0) or via Nicole.Schnieder@ukmuenster.de

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