Immune tolerance, autoimmune diseases
|
|
|
- Jayson Nelson
- 5 years ago
- Views:
Transcription
1 Immune tolerance, autoimmune diseases
2 Immune tolerance Central: negative selection during thymic education deletion of autoreactive B-lymphocytes in bone marrow
3 Positive selection in the thymus
4 Negative selection in the thymus
5 Tolerance Central
6 Immune tolerance Peripheral: Clonal deletion - elimination of autoreactive cells by apoptosis Clonal anergy - costimulatory signals are lacking Clonal ignorance - to low concentration of antigen does not stimulate immune response Suppression - autoreactivity is blocked by regulatory cells
7
8 Tolerance Peripheral
9 Regulatory T cells T reg cells naturally occurring regulatory cells causing tolerance of autoantinegens. They cause active tolerance of autoantigens. Development in the thymus. Involved in inborn tolerance. Also the induction of these cells in periphery by foreign antigens seems to be possible. T H 3 (T r 1) cells: induced in periphery. They cause acquired tolerance.
10 Acquired immune tolerance Low-zone tolerance: repeated injections of very low doses of antigen. Suppressor cells are stimulated. High-zone tolerance: induced by highdoses of antigen. Clonal deletion is induced. Oral tolerance
11 Mechanisms of breakage of immune tolerance Visualization of hidden antigens Alteration of body antigens by chemical substances, burns, necrosis Cross reactivity of antigens Excessive stimulation of the immune system, abnormal expression of HLA-II antigens. Defect in suppressor function of lymphocytes
12 Systemic autoimmune diseases Systemic lupus erythematosus Rheumatoid arthritis Sjogren s syndrome Polymyositis Dermatomyositis Scleroderma (progressive systemic sclerosis)
13 SLE A prototypic multi-system autoimmune and immune complex disease Involvement of skin, kidneys, lungs, heart blood vessels Immunoregulatory abnormalities Many autoantibodies ANA ds DNA ENA Phospholipids
14 Systemic lupus etythematodes (SLE) Systemic autoimmune disease affecting various tissues and organs Many symptoms are caused by deposition of immune complexes (type-iii immunopathological reaction) Female : male ratio is 10:1 Usually begins in early adulthood
15 Systemic lupus erythematodes Clinical presentation General: fever, malaise, loss on weight Artralgia Skin: butterfly rash, urticaria Vascular: Raynaud s phenomenon Neurological: vasculitis, seisures, neuritis Glomerulonephritis Haematological: leukopenia, thrombocytopenia anemia Recurrent serositis
16 Systemic lupus etythematodes Butterfly rash
17 Systemic lupus etythematodes
18 Autoantibodies in SLE - 1 Anti-nuclear anibody (anti-nuclear factor) Indirect immunofluorescence on Hep2 cells Staining pattern may be clinically useful Interpretation depends on clinical story, titre and age Sensitive but not specific Good screening test for lupus (prevalence ~ 100%)
19 Positivity of antinuclear antibodies (ANA, ANF) SLE: % Rheumatoid arthritis: % Systemic scleroderma: % Autoimmune hepatitis: % Healthy persons: 0-4 % Seniors: %
20 ANA - homogenous type
21 ANA granular type
22 Systemic lupus erythematosus
23 Livedo reticularis
24 Systemic lupus etythematodes
25 Organ-specific autoimmune diseases Endocrine system Autoimmune (Hasimoto s) thyroiditis Hyperthyroidism (Graves disease; thyrotoxicosis) Type I diabetes mellitus (insulin-dependent or juvenile diabetes) Autoimmune adrenal insufficiency (Addison s disease) Autoimmune oophritis Hermatopoietic system Autoimmune hemolytic anemia autoimmune thrombocytopenia Autoimmune neutropenia Neuromuscular system Myasthenia gravis Autoimmune polyneuritis Multiple sclerosis Skin Pemphigus and other bullous diseases Cardiopulmonary System Rheumatic carditis Postcardiotomy syndrome (Dressler s syndrome) Gastrointestina tract Atrophic gastritis Crohn s disease Ulcerous colitis Autoimmune hepatitis
26 Anti- parietal cells antibodies
27 Pernicious anemia Antibodies against gastric parietal cells cause atrophic gastritis. Decreased production of gastric juice results in dyspeptic problems. Also production of intrinsic factor is decreased causing disturbed resorption of vitamin B 12. Low serum levels of vitamin B 12 result in megaloblastic anemia.
28 Anti-receptor antibodies Stimulatory Graves disease. Antibodies against TSHreceptors stimulate function of thyroid gland causing hypertyreosis. Inhibitory Myastenia gravis. Antibodies against acetylcholine receptor block activation of muscle in neuromuslular junction.
29 Treatment of autoimmune diseases Substitution of function of the affected organ (insulin treatment, parenteral treatment by vitamin B12.) Anti-inflammatory drugs Immunosuppressive treatment Tolerance induction
30 Systemic Immunosuppression High-dose steroids Purine antagonists: Azathioprin Alkylating agents: Cyclophosphamide Anti-pholates: Methotrexate Calcineurin antagonists: Cyclosporine A, Rapamycin, Tacrolymus Block of purins synthesis: Mycophemolate Antilymphocytic serum Monoclonal antobodies: anti CD3, anti CD20, anti CD54...
31 Imunostimulatory drugs Synthetic immunostimulators: inosiplex Cytokines: IL-2, interferons Thymic hormones Bacterial immunomodulators: Ribomunyl, Broncho-vaxom, Luivac, Imudon, Biostim...
Bachelor of Chinese Medicine ( ) AUTOIMMUNE DISEASES
Bachelor of Chinese Medicine (2002 2003) BCM II Dr. EYT Chan February 6, 2003 9:30 am 1:00 pm Rm 134 UPB AUTOIMMUNE DISEASES 1. Introduction Diseases may be the consequence of an aberrant immune response,
Diseases of Immunity 2017 CL Davis General Pathology. Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc.
Diseases of Immunity 2017 CL Davis General Pathology Paul W. Snyder, DVM, PhD Experimental Pathology Laboratories, Inc. Autoimmunity Reflects a loss of immunologic tolerance Mechanisms Auto-antibodies
What is Autoimmunity?
Autoimmunity What is Autoimmunity? Robert Beatty MCB150 Autoimmunity is an immune response to self antigens that results in disease. The immune response to self is a result of a breakdown in immune tolerance.
What is Autoimmunity?
Autoimmunity What is Autoimmunity? Robert Beatty MCB150 Autoimmunity is an immune response to self antigens that results in disease. The immune response to self is a result of a breakdown in immune tolerance.
Immunology 2011 Lecture 20 Autoimmunity 18 October
Immunology 2011 Lecture 20 Autoimmunity 18 October APC Antigen processing (dendritic cells, MΦ et al.) Antigen "presentation" Ag/Ab complexes Antigenspecific triggering B T ANTIGEN Proliferation Differentiation
. Autoimmune disease. Dr. Baha,Hamdi.AL-Amiedi Ph.D.Microbiology
. Autoimmune disease Dr. Baha,Hamdi.AL-Amiedi Ph.D.Microbiology, Paul Ehrich The term coined by the German immunologist paul Ehrich ( 1854-1915) To describe the bodys innate aversion to immunological
10/25/2018. Autoimmunity and how to treat it. Disclosure. Why do we get autoimmunity? James Verbsky MD/PhD Pediatric Rheumatology/Immunology
Autoimmunity and how to treat it James Verbsky MD/PhD Pediatric Rheumatology/Immunology Disclosure None I will mention drug names and some brand names but I have no financial interest or any other ties
Autoimmune diseases, their pathogenic mechanisms and treatment of unwanted immune responses (Janeway s Immunobiology)
Autoimmune diseases, their pathogenic mechanisms and treatment of unwanted immune responses (Janeway s Immunobiology) Picture source: https://www.klini kum.uniheidelberg.de/fil eadmin/pressest elle/pm_neu/20
Self-tolerance. Lack of immune responsiveness to an individual s own tissue antigens. Central Tolerance. Peripheral tolerance
Autoimmunity Self-tolerance Lack of immune responsiveness to an individual s own tissue antigens Central Tolerance Peripheral tolerance Factors Regulating Immune Response Antigen availability Properties
[AUTOIMMUNITY] July 14, 2013
![[AUTOIMMUNITY] July 14, 2013](/thumbs/72/66734585.jpg "[AUTOIMMUNITY] July 14, 2013")
This sheet includes only the extra notes. Slide 5,6: [AUTOIMMUNITY] July 14, 2013 Autoimmunity is the condition or case where the immune system is activated by self antigensand when the immune system no
Medical Immunology Practice Questions-2016 Autoimmunity + Case Studies
Medical Immunology Practice Questions-2016 Autoimmunity + Case Studies Directions: Each of the numbered items or incomplete statements in this section is followed by answers or by completions of the statement.
Autoantibodies panel ANA
Autoantibodies panel ANA Anti-nuclear antibodies, ANA screening General: Anti-nuclear antibodies (ANA) contain all kinds of autoantibodies against nuclear antigens. Their targets are cell components in
MOLECULAR IMMUNOLOGY Manipulation of immune response Autoimmune diseases & the pathogenic mechanism
MOLECULAR IMMUNOLOGY Manipulation of immune response Autoimmune diseases & the pathogenic mechanism SCHMAIEL SHIRDEL CONTENT 2 Introduction Autoimmune diseases Classification Involved components Autoimmune
Autoimmunity Origins. Horror autotoxicus: Literally, the horror of self-toxicity.
Autoimmunity Autoimmunity Origins Horror autotoxicus: Literally, the horror of self-toxicity. A term coined by the German immunologist Paul Ehrlich (1854-1915) to describe the body's innate aversion to
Immune responses in autoimmune diseases
Immune responses in autoimmune diseases Erika Jensen-Jarolim Dept. of Pathophysiology Medical University Vienna CCHD Lecture January 24, 2007 Primary immune organs: Bone marrow Thymus Secondary: Lymph
Editing file. Color code: Important in red Extra in blue. Autoimmune Diseases
Editing file Color code: Important in red Extra in blue Autoimmune Diseases Objectives To know that the inflammatory processes in autoimmune diseases are mediated by hypersensitivity reactions (type II,
Anti-Nuclear Antibodies (ANA). (Incorporating Anti-double stranded DNA (dsdna) and Anti-Extractable Nuclear Antigen (ENA) Antibodies)
Autoimmune Antibody Testing Points of Note: The interpretation of all autoantibody tests is highly dependent on the likelihood of disease in the patient. The results should always be interpreted with the
Reporting Autoimmune Diseases in Hematopoietic Stem Cell Transplantation
Reporting Autoimmune Diseases in Hematopoietic Stem Cell Transplantation Marcelo C. Pasquini, MD, MSc HVD05_1.ppt Outline Review of autoimmune diseases (AID). Role of transplantation for AID Data collection:
AUTOIMMUNE DISORDERS IN THE ACUTE SETTING
AUTOIMMUNE DISORDERS IN THE ACUTE SETTING Diagnosis and Treatment Goals Aimee Borazanci, MD BNI Neuroimmunology Objectives Give an update on the causes for admission, clinical features, and outcomes of
Disruption of Healthy Tissue by the Immune Response Autoimmune diseases: Inappropriate immune response against self-components
Chapter 13 Disruption of Healthy Tissue by the Immune Response Autoimmune diseases: Inappropriate immune response against self-components Humoral imm 胞外 胞內 CMI: CD8 T Self Ag Self(Auto) antigen (encoded
What will we discuss today?
Autoimmune diseases What will we discuss today? Introduction to autoimmune diseases Some examples Introduction to autoimmune diseases Chronic Sometimes relapsing Progressive damage Epitope spreading more
Autoimmunity and autoinflammation
Autoimmunity and autoinflammation Primary immunodeficiencies Autoimmunity and autoinflammation 1 Primary immunodeficiencies List of some common abbreviations APECED CAPS CGD CINCA CRMO CVID FCAS FMF HIDS
Autoimmune diagnostics. A comprehensive product line for the detection of autoantibodies
Autoimmune diagnostics A comprehensive product line for the detection of autoantibodies Autoimmune diagnostics Autoimmune diseases are chronic inflammatory processes with an indeterminate etiology. They
Autoimmune diseases. SLIDE 3: Introduction to autoimmune diseases Chronic
SLIDE 3: Introduction to autoimmune diseases Chronic Autoimmune diseases Sometimes relapsing : and remitting. which means that they present as attacks Progressive damage Epitope spreading more and more
IMMUNODEFICIENCY DISORDERS
IMMUNODEFICIENCY DISORDERS CHAPTER 21 PRIMARY IMMUNODEFICIENCY DISORDERS 2 CONGENITAL. INHERITED. SECONDARY (ACQUIRED) IMMUNODEFICIENCY DISORDERS 3 MALNUTRITION. INFECTION (HIV). FROM: NEOPLASIA (LYMPHOMA,
Manipulation of the Immune Response - Immunomodulation -
Manipulation of the Immune Response - Immunomodulation - Janeway s Immunobiology, 9 th ed., 2017. Ivana Novak Nakir Immune system Immune system make components, cells and organs that act together to defend
PHM142 Autoimmune Disorders + Idiosyncratic Drug Reactions
PHM142 Autoimmune Disorders + Idiosyncratic Drug Reactions 1 Autoimmune Disorders Auto-reactivity: low physiological levels (e.g. tolerance) vs. pathogenic levels 80+ types of autoimmune diseases affect
Alida R Harahap & Farida Oesman Department of Clinical Pathology Faculty of Medicine, University of Indonesia
Alida R Harahap & Farida Oesman Department of Clinical Pathology Faculty of Medicine, University of Indonesia Foreign molecules = antigens Immune response Immune system non-specific specific cellular humoral
Immunological Tolerance
Immunological Tolerance Introduction Definition: Unresponsiveness to an antigen that is induced by exposure to that antigen Tolerogen = tolerogenic antigen = antigen that induces tolerance Important for
Autoimmune Disease. Autoimmunity. Epidemiology. ACR Criteria for Diagnosis. Signs and Symptoms. Autoreactivity: Reactivity to self antigens:
Autoimmunity Reactivity to self antigens: Autoreactivity: Autoimmune Disease T cells B cells Leading to tissue damage or dysfunction Occurring in the absence of ongoing infection Epidemiology SLE Pathogenesis
LUPUS CAN DO EVERYTHING, BUT NOT EVERYTHING IS LUPUS LUPUS 101 SLE SUBSETS AUTOIMMUNE DISEASE 11/4/2013 HOWARD HAUPTMAN, MD IDIOPATHIC DISCOID LUPUS
LUPUS 101 LUPUS CAN DO EVERYTHING, BUT NOT EVERYTHING IS LUPUS HOWARD HAUPTMAN, MD IDIOPATHIC DISCOID LUPUS SLE SUBSETS SUBACUTE CUTANEOUS LUPUS DRUG INDUCED LUPUS NEONATAL LUPUS LATE ONSET LUPUS ANTI-PHOSPHOLIPID
Autoimmunity. Autoimmune Disease
Autoimmunity Reactivity to self antigens: T cells B cells Autoimmune Disease Autoreactivity: Leading to tissue damage or dysfunction Occurring in the absence of ongoing infection 1 SLE Pathogenesis Immune
Central tolerance. Mechanisms of Immune Tolerance. Regulation of the T cell response
Immunoregulation: A balance between activation and suppression that achieves an efficient immune response without damaging the host. Mechanisms of Immune Tolerance ACTIVATION (immunity) SUPPRESSION (tolerance)
Mechanisms of Immune Tolerance
Immunoregulation: A balance between activation and suppression that achieves an efficient immune response without damaging the host. ACTIVATION (immunity) SUPPRESSION (tolerance) Autoimmunity Immunodeficiency
Autoimmunity and Principles of Transplantation Immunology
Module Code: Module Title: IMM III Autoimmunity and Principles of Transplantation Immunology Module Convenors: Emeritus Professor Jennifer Rolland and Dr Karla Lemmert Discipline: Professor Allan Cripps
Mucosal Immune System
Exam Format 100 points - 60 pts mandatory; 40 points where 4, 10 point questions will be chosen Some open-ended questions, some short answer. Kuby question Cytokines Terminology How do cytokines achieve
3.Autoimmunity. a. Self-recognition of all body components. a. Auto-antibody directed against a self antigen.
3.Autoimmunity I. Introduction A. Introduction 1. Normal individuals do not produce destructive immune responses to their own tissues due to immune tolerance. a. Self-recognition of all body components.
An Update On Autoimmune Diseases
California Association for Medical Laboratory Technology Distance Learning Program An Update On Autoimmune Diseases by Paula J. D Amore, Ph.D., D(AMBLI) Assistant Professor, Division of Health Sciences
MANAGING THE PATIENT WITH POSITIVE ANA
MANAGING THE PATIENT WITH POSITIVE ANA Rafael F. Rivas-Chacon, M.D. Disclosures Grant/Research support for: Pfizer Study JIA A3921104 Tofacitinib not related to this presentation 1 Positive Antinuclear
PROBLEMS WITH THE IMMUNE SYSTEM. Blood Types, Transplants, Allergies, Autoimmune diseases, Immunodeficiency Diseases
PROBLEMS WITH THE IMMUNE SYSTEM Blood Types, Transplants, Allergies, Autoimmune diseases, Immunodeficiency Diseases Antigens on red blood cells determine whether a person has type A, B, AB, or O blood
AUTOIMMUNE DISEASES. chronic and usually irreversible incidence: 5% - 7% of population, higher frequencies in women, increases with age
AUTOIMMUNE DISEASES AUTOIMMUNE DISEASES chronic and usually irreversible incidence: 5% - 7% of population, higher frequencies in women, increases with age Autoimmune diseases Immunological tolerance is
Tolerance 2. Regulatory T cells; why tolerance fails. FOCiS. Lecture outline. Regulatory T cells. Regulatory T cells: functions and clinical relevance
1 Tolerance 2. Regulatory T cells; why tolerance fails Abul K. Abbas UCSF FOCiS 2 Lecture outline Regulatory T cells: functions and clinical relevance Pathogenesis of autoimmunity: why selftolerance fails
Clinical Laboratory. 14:41:00 Complement Component 3 50 mg/dl Oct-18
Clinical Laboratory Procedure Result Units Ref Interval Accession Collected Received Thyroid Peroxidase (TPO) Antibody 5.0 IU/mL [0.0-9.0] 18-289-900139 16-Oct-18 Complement Component 3 50 mg/dl 18-289-900139
Test Name Results Units Bio. Ref. Interval
LL - LL-ROHINI (NATIONAL REFERENCE 135091593 Age 25 Years Gender Male 30/8/2017 91600AM 30/8/2017 93946AM 31/8/2017 84826AM Ref By Final COLLAGEN DISEASES ANTIBODY ANEL ANTI NUCLEAR ANTIBODY / FACTOR (ANA/ANF),
DISCLOSURE. Relevant relationships with commercial entities none. Potential for conflicts of interest within this presentation none
AUTOIMMUNITY DISCLOSURE Relevant relationships with commercial entities none Potential for conflicts of interest within this presentation none Steps taken to review and mitigate potential bias N/A MODULE
Autoimmunity. Autoimmunity arises because of defects in central or peripheral tolerance of lymphocytes to selfantigens
Autoimmunity Autoimmunity arises because of defects in central or peripheral tolerance of lymphocytes to selfantigens Autoimmune disease can be caused to primary defects in B cells, T cells and possibly
Clinical Laboratory. [None
Clinical Laboratory Procedure Result Units Ref Interval Accession Collected Received Double-Stranded DNA (dsdna) Ab IgG ELISA Detected * [None 18-289-900151 Detected] Double-Stranded DNA (dsdna) Ab IgG
Staging of Type 1 Diabetes: Clinical Implications. April Deborah Hefty, MN, RN, CDE.
Staging of Type 1 Diabetes: TT Clinical Implications April 2016 Deborah Hefty, MN, RN, CDE dhefty@benaroyaresearch.org BRI s major contributions to type 1 diabetes research Identified type 1 diabetes susceptibility
Immunology. Lecture- 8
Immunology Lecture- 8 Immunological Disorders Immunodeficiency Autoimmune Disease Hypersensitivities Immunodeficiency 1. Immunodeficiency --> abnormal production or function of immune cells, phagocytes,
ONE of the following:
Medical Coverage Policy Belimumab (Benlysta) EFFECTIVE DATE: 01 01 2012 POLICY LAST UPDATED: 11 21 2017 OVERVIEW Belimumab (Benlysta ) is indicated for the treatment of adult patients with active, autoantibody-positive,
Test Name Results Units Bio. Ref. Interval
135091662 Age 45 Years Gender Male 29/8/2017 120000AM 29/8/2017 100215AM 29/8/2017 110825AM Ref By Final RHEUMATOID AUTOIMMUNE COMREHENSIVE ANEL ANTI NUCLEAR ANTIBODY / FACTOR (ANA/ANF), SERUM ----- 20-60
Introduce the important components of the immune system Show how they interact & protect the body
Immunology in Rheumatic Diseases Knowledge of immunology forms the basis of understanding many of the Rheumatologic diseases and has become the focus of many exciting new treatment strategies. AIMS OF
Tolerance 2. Regulatory T cells; why tolerance fails. Abul K. Abbas UCSF. FOCiS
1 Tolerance 2. Regulatory T cells; why tolerance fails Abul K. Abbas UCSF FOCiS 2 Lecture outline Regulatory T cells: functions and clinical relevance Pathogenesis of autoimmunity: why selftolerance fails
A. Incorrect! The duodenum drains to the superior mesenteric lymph nodes. B. Incorrect! The jejunum drains to the superior mesenteric lymph nodes.
USMLE Step 1 Problem Drill 11: Immunology Question No. 1 of 10 1. A 67 year old man is discovered to have metastatic disease involving his inferior mesenteric lymph nodes. His primary cancer is most likely
Living with Lupus: An Insider s Perspective
Living with Lupus: An Insider s Perspective Pamela Thorpe, MD, FACP Lupus Foundation of America, Inc. Philadelphia Tri-State Chapter Volunteer May 2014 My Own Story Is it Lupus Yet? The What What is this?
2/23/18. Disclosures. Rheumatic Diseases of Childhood. Making Room for Rheumatology. I have nothing to disclose. James J.
Making Room for Rheumatology James J. Nocton, MD Disclosures I have nothing to disclose Rheumatic Diseases of Childhood Juvenile Idiopathic Arthritis (JIA) Systemic Lupus Erythematosus (SLE) Juvenile Dermatomyositis
Autoimmunity. Mark S. Anderson, MD, PhD University of California San Francisco
Autoimmunity Mark S. Anderson, MD, PhD University of California San Francisco Autoimmunity Definition: immune response against self (auto-) antigen General principles: Significant health burden, 5% of
TYPE II IMMUNOPATHOLOGY
TPE II IMMUNOPATHOLOG TPE II. This form of immunopathology is due to the actions of antibodies directed against a specific target tissue or cell; so it is one of the forms of autoimmunity. Type III immunopathology,
The Lymphatic System and Body Defenses
PowerPoint Lecture Slide Presentation by Patty Bostwick-Taylor, Florence-Darlington Technical College The Lymphatic System and Body Defenses 12PART B Adaptive Defense System: Third Line of Defense Immune
Essentials In Immunology Prof. Anjali A. Karande Department of Biochemistry Indian Institute of Science, Bangalore
Essentials In Immunology Prof. Anjali A. Karande Department of Biochemistry Indian Institute of Science, Bangalore Lecture No. # 16 Autoimmunity Autoimmuno-deficiencies f the B cells So, in today s class,
Insights into the DX of Pediatric SLE
Insights into the DX of Pediatric SLE Dr. John H. Yost Pediatric Rheumatology Children s Hospital at Dartmouth Assistant Professor of Medicine Geisel School of Medicine at Dartmouth john.h.yost@hitchcock.org
Foundations in Microbiology Seventh Edition
Lecture PowerPoint to accompany Foundations in Microbiology Seventh Edition Talaro Chapter 16 To run the animations you must be in Slideshow View. Use the buttons on the animation to play, pause, and turn
Immunosuppressants. Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia
Immunosuppressants Assistant Prof. Dr. Najlaa Saadi PhD Pharmacology Faculty of Pharmacy University of Philadelphia Immunosuppressive Agents Very useful in minimizing the occurrence of exaggerated or inappropriate
Environmental Influence in Autoimmune Diseases. Mark Gourley, MD
Environmental Influence in Autoimmune Diseases Mark Gourley, MD Newsweek January, 2003 Current Knowledge of Environment and Myositis Environment Genes Autoimmunity What Is an Environmental Exposure?
Lecture outline. Immunological tolerance and immune regulation. Central and peripheral tolerance. Inhibitory receptors of T cells. Regulatory T cells
1 Immunological tolerance and immune regulation Abul K. Abbas UCSF 2 Lecture outline Central and peripheral tolerance Inhibitory receptors of T cells Regulatory T cells 1 The immunological equilibrium:
Test Name Results Units Bio. Ref. Interval
135091660 Age 44 Years Gender Male 29/8/2017 120000AM 29/8/2017 100219AM 29/8/2017 105510AM Ref By Final EXTRACTABLENUCLEAR ANTIGENS (ENA), QUANTITATIVE ROFILE CENTROMERE ANTIBODY, SERUM 20-30 Weak ositive
Neuroimmunology. Innervation of lymphoid organs. Neurotransmitters. Neuroendocrine hormones. Cytokines. Autoimmunity
Neuroimmunology Innervation of lymphoid organs Neurotransmitters Neuroendocrine hormones Cytokines Autoimmunity CNS has two ways of contacting and regulating structures in the periphery Autonomic
3.Autoimmunity. a. Self-recognition of all body components.
3.Autoimmunity I. Introduction A. Introduction 1. Normal individuals do not produce destructive immune responses to their own tissues due to immune tolerance. a. Self-recognition of all body components.
NATIONAL LABORATORY HANDBOOK. Laboratory Testing for Antinuclear antibodies
NATIONAL LABORATORY HANDBOOK Laboratory Testing for Antinuclear antibodies Document reference number CSPD013/2018 Document developed by National Clinical Programme for Pathology Revision number Version
Pathophysiology, Mechanisms for the Induction and Animal Models of
Pathophysiology, Mechanisms for the Induction and Animal Models of Autoimmune Diseases Eun Wha Choi, DVM, PhD Laboratory Animal Research Center, Samsung Biomedical Research Institute (From New therapeutic
Chapter 13 Lecture Outline
Chapter 13 Lecture Outline See separate PowerPoint slides for all figures and tables preinserted into PowerPoint without notes. Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction
Definition Chronic autoimmune disease The body s immune system starts attacking itself Can affect most organs and tissues in the body Brain, lungs, he
LIVING WITH SYSTEMIC LUPUS ERYTHEMATOSUS Stacy Kennedy, M.D.,M.B.A. Rowan Diagnostic Clinic Salisbury, N.C. May 11, 2013 Agenda What is lupus Who is affected Causes of lupus Symptoms and organ involvement
Please fill in all the blanks or check the appropriate boxes, the starred fields (*) are optional:
Alopecia Areata Registry: Short Form Questionnaire: Date of Revision: June 2010 Page 1 of 5 This questionnaire is only for people who live in the U.S.A and who have personal or family documentation of
Corporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: belimumab_benlysta 6/2011 2/2018 2/2019 3/2018 Description of Procedure or Service Belimumab (Benlysta) is
TYPE II IMMUNOPATHOLOGY
TYPE II IMMUNOPATHOLOGY TYPE II. This form of immunopathology is due to the actions of antibodies directed against a specific target tissue or cell; so it is one of the forms of autoimmunity. Type III
TYPE II IMMUNOPATHOLOGY
TYPE II IMMUNOPATHOLOGY TYPE II. This form of immunopathology is due to the actions of antibodies directed against a specific target tissue or cell; so it is one of the forms of autoimmunity. Type III
Autoantibodies in childhood connective tissue diseases
Archives of Disease in Childhood, 1975, 50 419, Autoantibodies in childhood connective tissue diseases and in normal children K. M. GOEL, R. A. SHANKS, K. WHALEY, MARY MASON, and R. N. M. MacSWEEN From
VARIOUS AUTOANTIBODIES IN HASHIMO 0'S THYROIDITIS. First Department of Internal Medicine, Kurume University School of Medicine, Kurume, 830, Japan
THE KURUME MEDICAL JOURNAL Vol.25, No.4, p.283-289, 1978 VARIOUS AUTOANTIBODIES IN HASHIMO 0'S THYROIDITIS NOBUMITSU OKITA, KENICHI KODAMA, YOICHI ITO, JIRO NAKAYAMA, KENICH NAKASHIMA, KENICHIRO IIMORI,
Anaphylactic response in rabbit Part II
Anaphylactic response in rabbit Part II Introduction Four types of hypersensitivity reactions: Type I: allergy Type II: antibodies Type III: immune complex Type IV: T-cells Type I Hypersensitivity ALLERGY
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A
HYPERSENSITIVITY REACTIONS D R S H O AI B R AZ A HYPERSENSITIVITY REACTIONS Are exaggerated immune response upon antigenic stimulation Individuals who have been previously exposed to an antigen are said
Systemic Lupus Erythematosus
Systemic Lupus Erythematosus Marc C. Hochberg, MD, MPH Professor of Medicine and Head, Division of Rheumatology University of Maryland School of Medicine CASE: HISTORY A 26-year-old woman is seen for migratory
I-Brite - Ocular/Medical/General Information
I-Brite - Ocular/Medical/General Information Na me Date Gender (First) (Middle) (Last) Date of Birth Age Occupation Phone No. Address City State Zip Please describe what is abnormal about the appearance
The Diagnosis of Lupus
The Diagnosis of Lupus LUPUSUK 2017 This information booklet has been produced by LUPUS UK 2017 LUPUS UK LUPUS UK is the registered national charity for people with systemic lupus erythematosus (SLE) and
SEVENTH EDITION CHAPTER
Judy Owen Jenni Punt Sharon Stranford Kuby Immunology SEVENTH EDITION CHAPTER 16 Tolerance, Autoimmunity, and Transplantation Copyright 2013 by W. H. Freeman and Company Immune tolerance: history * Some
Budsakorn Darawankul, MD. Maharat Nakhon Ratchasima Hospital
Budsakorn Darawankul, MD. Maharat Nakhon Ratchasima Hospital Outline What is ANA? How to detect ANA? Clinical application Common autoantibody in ANA diseases Outline What is ANA? How to detect ANA? Clinical
Clinical Laboratory. 14:42:00 SSA-52 (Ro52) (ENA) Antibody, IgG 1 AU/mL [0-40] Oct-18
![Clinical Laboratory. 14:42:00 SSA-52 (Ro52) (ENA) Antibody, IgG 1 AU/mL [0-40] Oct-18](/thumbs/95/125595183.jpg "Clinical Laboratory. 14:42:00 SSA-52 (Ro52) (ENA) Antibody, IgG 1 AU/mL [0-40] Oct-18")
Clinical Laboratory Procedure Result Units Ref Interval Accession Collected Received Rheumatoid Factor
Cellular Pathology of immunological disorders
Cellular Pathology of immunological disorders SCBM344 Cellular and Molecular Pathology Witchuda Payuhakrit, Ph.D (Pathobiology) witchuda.pay@mahidol.ac.th Objectives Describe the etiology of immunological
LABORATORY STANDARDS IN THE DIAGNOSIS AND THERAPY MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS
LABORATORY STANDARDS IN THE DIAGNOSIS AND THERAPY MONITORING OF SYSTEMIC LUPUS ERYTHEMATOSUS Prof. Sandor Sipka, M.D., Ph.D. 3rd Department of Medicine, Institute for Internal Medicine, Medical and Health
Is it Autoimmune or NOT! Presented to AONP! October 2015!
Is it Autoimmune or NOT! Presented to AONP! October 2015! Four main jobs of immune system Detects Contains and eliminates Self regulates Protects Innate Immune System! Epithelial cells, phagocytic cells
Essential Rheumatology. Dr Ellen Bruce Consultant Rheumatologist CMFT
Essential Rheumatology Dr Ellen Bruce Consultant Rheumatologist CMFT Saving the best for last! Apparently people recall best the first and last thing they re told. Far too difficult to include everything.
Autoimmune diseases. Autoimmune diseases. Autoantibodies. Autoimmune diseases relatively common
Autoimmune diseases Fundamental abnormality: the adaptive immune system is triggered by self antigens to initiate a sustained immune response against self molecules that results in tissue injury Specificity
Mechanisms of Autontibodies
Mechanisms of Autontibodies Production in Rheumatic Diseases Eisa Salehi PhD Tehran University of Medical Sciences Immunology Department Introduction Rheumatic diseases: Cause inflammation, swelling, and
Immune System. Biology 105 Lecture 16 Chapter 13
Immune System Biology 105 Lecture 16 Chapter 13 Outline: Immune System I. Functions of the immune system II. Barrier defenses III. Non-specific defenses A. Immune system cells B. Inflammatory response
Marilina Tampoia, MD; Vincenzo Brescia, MD; Antonietta Fontana, MD; Antonietta Zucano, PhD; Luigi Francesco Morrone, MD; Nicola Pansini, MD
Application of a Combined Protocol for Rational Request and Utilization of Antibody Assays Improves Clinical Diagnostic Efficacy in Autoimmune Rheumatic Disease Marilina Tampoia, MD; Vincenzo Brescia,
.,Dr Ali Alkazzaz Babylon collage of medicine 2016
.,Dr Ali Alkazzaz Babylon collage of medicine 2016 Lupus history Lupus is the Latin word for wolf 1 st used medically in the 10 th century Described clinically in the 19 th century Butterfly rash in 1845
AUTOIMMUNITY CLINICAL CORRELATES
AUTOIMMUNITY CLINICAL CORRELATES Pamela E. Prete, MD, FACP, FACR Section Chief, Rheumatology VA Healthcare System, Long Beach, CA Professor of Medicine, Emeritus University of California, Irvine Colonel
AUTOIMMUNITY TOLERANCE TO SELF
AUTOIMMUNITY CLINICAL CORRELATES Pamela E. Prete, MD, FACP, FACR Section Chief, Rheumatology VA Healthcare System, Long Beach, CA Professor of Medicine, Emeritus University of California, Irvine Colonel
Topics. The Body s Defenses against Disease and Injury. Infectious Agents. Bacteria (1 of 2) Bacteria (2 of 2)
Topics The Body s Defenses against Disease and Injury The Immune System and Immune Response Aging and the Immune Response Inflammation Response Variances in Immunity and Inflammation The body has powerful
Immune System. Biol 105 Lecture 16 Chapter 13
Immune System Biol 105 Lecture 16 Chapter 13 Outline Immune System I. Function of the Immune system II. Barrier Defenses III. Nonspecific Defenses A. Immune system cells B. Inflammatory response C. Complementary
Immune Regulation and Tolerance
Immune Regulation and Tolerance Immunoregulation: A balance between activation and suppression of effector cells to achieve an efficient immune response without damaging the host. Activation (immunity)