TNF-α (pg/ml) IL-6 (ng/ml)
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1 Xio, et l., Supplementry Figure 1 IL-6 (ng/ml) TNF-α (pg/ml) ,4 1,2 1, med Cl / Pm3CSK4 zymosn curdln Poly (I:C) LPS flgelin MALP-2 imiquimod R848 CpG TNF-α (pg/ml) IL-6 (ng/ml) Cl / Supplementry Figure 1. CBLB inhiits signling vi the dectin-1. (,) ELISA of TNF-α nd IL-6 production y nd Cl / BMDMs nd BMDCs were stimulted with TLR lignds 1 to 9, zymosn, nd curdln for 48 h. For ll ELISA experiments dt re representtive of three independent experiments (iologicl replictes). Error rs re men ± s.d. P <.5, P <.1; unpired two-tiled Student s t test. n = 3 per group, ech with three repeted wells. Nture Medicine: doi:1.138/nm.4141
2 Xio, et l., Supplementry Figure 2 TNF-α (pg/ml) Cl / Time fter infection (h) Time fter infection (h) IL-6 (pg/ml) 45 TNF-α (pg/ml) IL-6 (pg/ml) TNF-α (pg/ml) Cl / IL-6 (pg/ml) Time fter infection (h) IL-6 (pg/ml) Time fter infection (h) 7 Supplementry Figure 2. CBLB inhiits TNF-α nd IL-6 production y dendritic cells ut hs limited role in the production of these cytokines y neutrophils upon infection with C. licns yest or hyphe. () ELISA of TNF-α nd IL-6 production in the superntnts collected from BMDCs of nd Cl / mice infected with C. licns yest nd hyphe forms (MOI = 1:1) for 1, 3, nd 6 h. () ELISA of TNF-α nd IL-6, production in the superntnts collected from BM neutrophils of nd Cl / mice infected with C. licns yest nd hyphe forms (MOI = 1:1) for 1, 3, nd 6 h. The dt re representtive of three independent expendents (iologicl replictes). Error rs re men ± s.d. P <.5, unpired two-tiled Student s t test. n = 3 per group, ech with three repeted wells. Nture Medicine: doi:1.138/nm.4141
3 C c 1. C tr si R l NA C sir l N A si R 1 N A nm 2 nm Xio, et l., Supplementry Figure 3 CBLB.1 d Ctr sirna: + Cl sirna (n M): Yest (h): Hyphe (h): Dectin Supplementry Figure 3. Humn mcrophges lcking CBLB fil to down-regulte dectin-1 nd dectin-2 expression nd produce more pro-inflmmtory cytokines upon infection with C. licns yest nd hyphe. (,) ELISA of TNF-α nd IL-6 production y MDMs with or without Cl gene silencing, infected with yest () or hyphe () of C.licns (MOI = 1:1), or left uninfected. For ll ELISA experiments dt re representtive. of two independent experiments (iologicl replictes). Error rs re men ± s.d. P <.5, P <.1; unpired two-tiled Student s t test. n = 3 per group, ech with three repeted wells. (c,d) Immunolot nlysis of CBLB, dectin-1 nd dectin-2, nd ctin expression in MDM lystes. Dt re representtive of two independent experiments. Nture Medicine: doi:1.138/nm.4141 Dectin-2
4 Anti-Dectin-1 Hyphe (min): IP: (U)nDectin-1 1 Cl / Anti-Dectin-2 Cl / Yest (min): IP: IP: IgG IP: IgG Xio, et l., Supplementry Figure 4 (U)nDectin (K48U)nDectin-1 1 (K48U)nDectin Dectin Anti-SYK Hyphe (min): IP: 25 Cl C373A Anti-SYK d Cl C373A Yest (min): IP: IP: IgG c Dectin-2 IP: IgG (K48U)nSYK 1 (K48U)nSYK 15 1 SYK e Cl / Yest (min): SYK SYK SYK psyk p-p65 Cl / Hyphe (min): psyk p-p Supplementry Figure 4. CBLB deficiency impirs uiquitintion of dectin-1, dectin-2, nd SYK in mcrophges induced y C. licns yest nd hyphl infection. (,) Immunolot nlysis of dectin-1 nd dectin-2 uiquitintion of dectin-1 or dectin-2 immunoprecipittes isolted from BMDMs from nd Cl / mice infected with C. licns yest nd hyphe, respectively, y nti-uiquitin nd nti-k48 uiquitin ntiodies. (c,d) Immunolot nlysis of SYK uiquitintion of SYK immunoprecipittes isolted from BMDMs from nd ClC373A mice infected with C. licns yest nd hyphe, respectively, y nti-k48-specific uiquitin ntiody. (e) Immunolot nlysis of phospho-syk nd NF-κB p65 in BMDMs from nd Cl / mice infected with C. licns yest nd hyphe, respectively, y nti-phospho-syk (Y525,Y526) nd nti-phospho-p65 (S536). Dt re representtive of three independent experiments (iologicl replictes). Nture Medicine: doi:1.138/nm.4141
5 Xio, et l. Suppementry Figur 5 ROS (RLU/1 3 cells) CFU (1 x 1 6 /ml) d Normlized to mode Cl / Cl C373A 25 5 Time (min) Control Cl / ROS (RLU/1 3 cells) % killing Cl / 1,5 Ctr Cl / 1, 5 Cl C373A 25 5 Time (min) Normlized to mode Control Cl / c ROS (RLU/1 3 cells) % killing 3, 2, 1, Cl / Cl C373A 25 5 Time (min) / Cl Cl C373A Alex Fluor Alex Fluor 488 Supplementry Figure 5. Loss of CBLB or CBLB C373A muttion enhnces ROS production nd fungl killing ut does not ffect phgocytosis. () ROS production y, Cl / or Cl C373A BMDMs co-cultured with C. licns t MOI = 5:1 nd 2:1, nd monitored in rel time over the indicted time period using the luminol ssy. Vlues re expressed s reltive light units (RLU) per 1, cells nd represent men vlues. () Killing cpcity of or Cl / BMDMs s ssessed y 24 h co-culture with C. licns. Assys were performed in triplicte. Dt re shown s mens ± s.d. (c) ROS production y, Cl /, or Cl C373A BM neutrophils co-cultured with C. licns t 2:1, nd monitored in rel time over the indicted time period using the luminol ssy. Vlues re expressed s reltive light units (RLU) per 1, cells nd represent men vlues (upper pnel). Killing cpcity of, Cl / or Cl C373A BM neutrophils s ssessed y 24 h co-culture with C. licns (lower pnel). (d) Phgocytosis of C. licns. or Cl / BMDMs co-cultured with Alex Fluor 488 leled C. licns. After 45 min of co-culture, or Cl / BMDMs were nlyzed for C. licns uptke y flow cytometry. P <.5, P <.1, Student s t test. Nture Medicine: doi:1.138/nm.4141
6 Xio, et l. Supplementry Figure 6 Supplementry Figure 6. CBLB C373A muttion significntly reduces fungl urden in kidneys, livers, lungs, nd spleens, nd leds to less myeloid cell recruitment to the kidneys. () Fungl urden in depicted orgns t 48 h fter systemic C. licns infection, shown s colony forming units (CFU)/grm orgn weight. Ech dot represents n individul mouse. () Percentges nd solute numers of hemtopoietic cells in the kidneys from nd Cl C373A mice t 48 h fter infection with C. licns (1 x 1 6 CFU). n = 5 for or Cl C373A mice. Dt re shown s mens ± s.d. nd nlyzed using the Student s t test. P <.5, P <.1. Nture Medicine: doi:1.138/nm.4141
7 Xio et l, Supplementry Figure 7 c d e Supplementry Figure 7. CBLB C373A muttion fcilittes fungl killing y enhncing ROS ctivity in the lood nd within spleens nd kidneys y monocytes/mcrophges. () Fungl urden of nd Cl C373A in the lood t 2 nd 6 h fter systemic C. licns infection, nd killing cpcity of or Cl C373A PBMCs nd neutrophils s ssessed y 24 h co-culture with C. licns. () Killing cpcity of splenic monocytes nd neutrophils of or Cl C373A mice s ssessed y 24 h co-culture with C. licns. (c) ROS stining in splenic monocytes, mcrophges nd neutrophils infected with 1 x 1 6 CFU of C. licns performed t dy 2 fter infection. (d) ROS stining in monocytes, mcrophges nd neutrophils in the kidneys of nd Cl C373A infected with 1 x 1 6 CFU of C. licns performed t dy 2 fter infection. Killing cpcity of CD45-enriched cells isolted from nd Cl C373A kindneys infected with C. licns. (e) ELISA of TNF-α, IL-6, nd IL-1β levels of kidney homogentes of or Cl C373A mice infected with 1 x 1 6 CFU of C. licns t 48 h fter infection. n = 5 mice per group nd re representive dt from three independent experiments. Error rs, men ± s.e.m. Dt were nlyzed using the Student s t test. P <.5, P <.1. Nture Medicine: doi:1.138/nm.4141
8 Xio, et l., Supplementry Figure 8 3, 1,6 h 24 h 48 h h 24 h 48 h TNF-α (pg/ml) 2, 1, IL-6 (pg/ml) 1,2 8 4 Fungl urden (CFU/g) 4,5, 3,5, 2,5, 1,5, 5, Cl / Clec7 / Clec7 / Cl / Clec7 / Cl / Cl / Clec7 / Cl / Clec7 / Clec4n / Cl / Clec7 / Cl / Clec7 / Clec7 / Cl / Clec4n / Cl / Clec7 / Clec7 / Cl / Cl / Clec7 / Cl / Clec7 / Supplementry Figure 8. Introducing dectin-1 or dectin-2 deficiency, or oth into Cl / mice significntly reduces serum TNF-α nd IL-6 which correltes with incresed fungl urden in the kidneys. () ELISA of serum TNF-α nd IL-6 t 24 nd 48 h from, Cl /, Clec7 /, Clec4n /, Cl / Clec7 /, Cl / Clec4n /, Clec7 / Clec4n / nd Cl / Clec7 / Clec4n / mice infected with C. licns (3.5 x 1 5 CFU) y i.v. injection. () Fungl urden in the ove mice mesured t 48 h fter infection. Dt re representtive of two independent experiments. Nture Medicine: doi:1.138/nm.4141
9 Xio, et l., Supplementry Figure 9 c d Supplementry Figure 9. Autontiody, IgG, nd IgE titers in the ser nd IL-17/IFN-γ in the ser nd kidneys of, Cl /, nd Cl C373A mice efore nd fter C. licns infection. (-c) Serum titers of nti-dsdna nd nti-ssdna ntiodies, IgG, IgE, IL-17, nd IFN-γ in, Cl /, nd Cl C373A mice efore or 48 h fter C. licns infection (1 x 1 6 CFU). (d) IL-17 nd IFN-γ in the kidneys of, Cl /, nd Cl C373A mice efore or 48 h fter C. licns infection. n = 5 mice per group nd re representive dt from three independent experiments. Error rs, men ± s.e.m. Dt were nlyzed using the Student s t test. Nture Medicine: doi:1.138/nm.4141
10 Xio, et l., Supplementry Figure 1 C. licns Cl / Hyphe (min): Hyphe (h): Cl / Dectin-3 MR Mincle DC-SIGN Supplementry Figure 1. Loss of CBLB stilizes dectin-3, ut not MR, Mincle nd DC-SIGN. Immunolot nlysis of lystes of nd Cl / BMDMs infected with C. licns hyphe for the times indicted with ntiodies ginst dectin-3, MR, Mincle, nd DC-SIGN. Results re representive dt from three independent experiments (n = 3). Nture Medicine: doi:1.138/nm.4141
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T cell intrinsic role of Nod in promoting type 1 immunity to Toxoplsm gondii Michel H Shw 1, Thornik Reimer 1, Crmen Sánchez-Vldepeñs, Neil Wrner 1, Yun-Gi Kim 1, Mnuel Fresno & Griel Nuñez 1 Nod elongs
AMPK maintains energy homeostasis and survival in cancer cells via. regulating p38/pgc-1α-mediated mitochondrial biogenesis
SUPPLEMENTARY INFORMATION AMPK mintins energy homeostsis nd survivl in cncer cells vi regulting p38/pgc-1α-medited mitochondril iogenesis Blkrishn Chue 1, Prmnnd Mlvi 1, Shivendr Vikrm Singh 1, Noshd Mohmmd
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doi: 1.138/nature775 4 O.D. (595-655) 3 1 -ζ no antibody isotype ctrl Plated Soluble 1F6 397 7H11 Supplementary Figure 1 Soluble and plated anti- Abs induce -! signalling. B3Z cells stably expressing!
Supplementary Figure 1. Deletion of Smad3 prevents B16F10 melanoma invasion and metastasis in a mouse s.c. tumor model.
A B16F1 s.c. Lung LN Distant lymph nodes Colon B B16F1 s.c. Supplementary Figure 1. Deletion of Smad3 prevents B16F1 melanoma invasion and metastasis in a mouse s.c. tumor model. Highly invasive growth
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doi:.38/nture99 Dy Dy Dy 3 Dy 4 Bleed INDO INDO INDO INDO INDO INDO INDO INDO 3 7 CFU-GM/ml lood 6 4 3 Indomethcin Biclein + Indo + Bcln c WBC PMN LYMPH MONO RBC PLT Ctrl 7.4±.9.4±.8.4±.39.37±.6 8.88±.
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SUPPEMENTARY INFORMATION DOI: 1.138/ncb956 Norml CIS Invsive crcinom 4 months months b Bldder #1 Bldder # Bldder #3 6 months (Invsive crcinom) Supplementry Figure 1 Mouse model of bldder cncer. () Schemtic
Supplementary Materials. Viral delivery of mir-196a ameliorates the SBMA phenotype via the silencing of CELF2
Supplementry Mterils Virl delivery of mir-96 meliortes the SBMA phenotype vi the silencing of CELF2 Yu Miyzki, Hiroki Adchi, Mshis Ktsuno, Mkoto Minmiym, Yue-Mei Jing, Zhe Hung, Hideki Doi, Shinjiro Mtsumoto,
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1
Anti-inflmmtory ctivity of IgG1 medited y Fc glctosyltion nd ssocition of FcγRIIB nd dectin-1 Christin M. Krsten, Mnoj K. Pndey, Juli Figge, Regin Kilchenstein, Philip R. Tylor, Mrcel Ross, Jcqueline U.
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doi:.8/nture98 : hr NEMO :5 hr IKK IKK NF-κB p65 p5 p65/-rel NF-κB p65 p5 p65/-rel Cytoplsm Cytoplsm p65/p5 Nuleus Nuleus NEMO IKK IKK d : hr > : hr p65/-rel NF- p65 p5 Cytoplsm Cytoplsm p65/p5 p65/-rel
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SUPPLEMENTARY INFORMATION doi:.8/nture89 4 4 Ilr -/- Ilr -/- Ilr -/- Cspse- -/- As -/- Nlrp -/- Il8 -/- Ilr -/- Supplementl figure. Inresed severity of NASH in inflmmsome-defiient mie, ut not in Ilr-defiient
Platelet-derived growth factor-a receptor activation is required for human cytomegalovirus infection
Vol 455 18 Septemer 28 doi:1.138/nture729 LETTERS Pltelet-derived growth fctor- receptor ctivtion is required for humn cytomeglovirus infection Lilin Sorocenu 1, Armin Akhvn 1 & Chrles S. Cos 1,2 Humn
Supplementary Figure 1. Characterization of basophils after reconstitution of SCID mice
Supplementary figure legends Supplementary Figure 1. Characterization of after reconstitution of SCID mice with CD4 + CD62L + T cells. (A-C) SCID mice (n = 6 / group) were reconstituted with 2 x 1 6 CD4
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SUPPLEMENTARY INFORMATION doi:10.1038/nture11225 Numer of OTUs sed on 3% distnce Numer of 16s rrna-sed V2-V4 tg sequences LF MF PUFA Supplementry Figure 1. High-ft diets decrese the richness nd diversity
Control vector. HA-Elfn2. HA-Elfn1
Control vector c HA-Elfn2 HA- Control vector HA-Elfn2 HA- nti- nti-ha Hippocmpus (CA3) PV DAPI SOM DAPI Hippocmpus (dentte gyrus) PV DAPI SOM DAPI Supplementry Figure 1. Specificity of the nti- ntiody
Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4 þ effector T cells
Received 4 Jul 15 Accepted 9 Fe 16 Pulished 18 Apr 16 DOI: 1.138/ncomms116 OPEN Ndfip-medited degrdtion of Jk1 tunes cytokine signlling to limit expnsion of CD4 þ effector T cells Clire E. O Lery 1, Christopher
NappHS. rrna. transcript abundance. NappHS relative con W+W 0.8. nicotine [µg mg -1 FM]
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(A) W+OS 3 min 6 min con L S L S RNA loding control NppHS rrna (B) (C) 8 1 k NppHS reltive trnscript undnce 6 4.5 *** *** *** *** 3 k. + + + line 1 line (D) nicotine [µg mg -1 FM] 1..8.4. con W+W Supplementl
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doi:1.138/nature1554 a TNF-α + in CD4 + cells [%] 1 GF SPF 6 b IL-1 + in CD4 + cells [%] 5 4 3 2 1 Supplementary Figure 1. Effect of microbiota on cytokine profiles of T cells in GALT. Frequencies of TNF-α
Supplemental Figure Legends
Supplemental Figure Legends Supplemental Figure 1. SemaB / mice have normal immune cell populations. Cells were prepared from the spleens of WT and SemaB / mice, stained with various antibodies and then
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DOI: 1.138/n358 TLR2 nd MyD88 expression in murine mmmry epithelil supopultions. CD24 min plus MRU Myo-epithelil Luminl progenitor (CD61 pos ) Mture luminl (CD61 neg ) CD49f CD61 Reltive expression Krt5
Cos7 (3TP) (K): TGFβ1(h): (K)
IP#2: IP#1: Totl Lystes luiferse tivity (K): 6-4 - (K): luiferse tivity luiferse tivity (K): 2 1 RL-: - + + + + + Sm4-3F: + - + + + + MYC-Sm3: - - - - + + TβRI-HA(T204D): - - - + - + α-ha Luiferse Ativity
Supplementary Figure S1
Supplementry Figure S Connexin4 TroponinI Merge Plsm memrne Met Intrcellulr Met Supplementry Figure S H9c rt crdiomyolsts cell line. () Immunofluorescence of crdic mrkers: Connexin4 (green) nd TroponinI
fig. S1 Gene silencing of LC3B by sirna enhances IL-1β secretion. Peritoneal
15 Scramble sirna LC3B sirna IL-1β (pg/ml) 1 5 LC3B (kda) - 18 (LC3B I) - 16 (LC3B II) β-actin - 42 ( _ ) LPS LPS ATP fig. S1 Gene silencing of LC3B by sirna enhances IL-1β secretion. Peritoneal macrophages
CD160 inhibits activation of human CD4 + T cells through interaction with herpesvirus entry mediator
CD16 inhiits ctivtion of humn CD4 + T cells through interction with herpesvirus entry meditor Guifng Ci, Anuknth Anumnthn, Juli A Brown, Edwrd A Greenfield, Bogong Zhu & Gordon J Freemn CD16, glycosylphosphtidylinositol-nchored
Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity
Received 1 Oct 215 Accepted 8 Mr 216 Pulished 12 Apr 216 DOI: 1.138/ncomms11273 OPEN Clec4A4 is regultory receptor for dendritic cells tht impirs inflmmtion nd T-cell immunity Tomofumi Uto 1,, Tomohiro
Supplementary Figure 1. Scheme of unilateral pyramidotomy used for detecting compensatory sprouting of intact CST axons.
() BDA 2 weeks fter Py () AAVs Cre or GFP t P1 BDA 2 weeks fter Py CSMN CST () Py t P7 or 2 months () Py t 2 months Supplementry Figure 1. Sheme of unilterl pyrmidotomy used for deteting ompenstory sprouting
Supplemental information
Supplemental information PI(3)K p11δ controls the sucellular compartmentalization of TLR4 signaling and protects from endotoxic shock Ezra Aksoy, Salma Taoui, David Torres, Sandrine Delauve, Aderrahman
Supplementary Information. Title: RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-
Supplementry Informtion Title: RAS-MAPK dependence underlies rtionl polytherpy strtegy in EML4- ALK positive lung cncer Authors: Gorjn Hrustnovic, Victor Olivs, Evngelos Pzrentzos, Asmin Tulpule, Surh
Supplemental Materials
Supplementl Mterils Cellulose deficiency of shv3svl1 is enhnced y hyper ccumultion of exogenous sucrose vi the plsm memrne sucrose/h symporter SUC1 Trevor H. Yets, Hgit Sorek, Dvid E. Wemmer, Chris R.
RESEARCH ARTICLE. Supplemental Figure 5
11.5 2 2 11. RESEARCH ARTICLE RBC ( 1 12 /L) 1.5 1. 9.5 PLT ( 1 9 /L) 1 16 14 HGB (g/l) 19 1 17 16 9. 12 4 4 46 Cellulr & Moleulr Immunology dvne online pulition, PCV (%) 44 MCV (fl) 46 44 ; doi:1.13/mi.214.16
Serum cytokine levels in control and tumor-bearing male and female mice at day 15.
Supplementary Table 1. Serum cytokine levels in control and tumor-bearing male and female mice at day 15. Male Female Cytokine Control C-26 Control C-26 IL-1β 2.0 ± 0.8 9.6 ± 1.5* 1.8 ± 0.2 6.8 ± 1.4*
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SUPPLEMENTARY INFORMATION CD169 + MACROPHAGES PRESENT LIPID ANTIGENS TO MEDIATE EARLY ACTIVATION OF INVARIANT NKT CELLS IN LYMPH NODES Ptrii Brrl, Polo Polzell, Andres Brukuer, Nio vn Rooijen, Gurdyl S.
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doi:0.08/nture0987 SUPPLEMENTARY FIGURE Structure of rbbit Xist gene. Exons re shown in boxes with romn numbers, introns in thin lines. Arrows indicte the locliztion of primers used for mplifiction. WWW.NATURE.COM/NATURE
Supplementary Figures for TSC1 controls macrophage polarization to prevent inflammatory disorder by Linnan Zhu et al
Supplementary Figures for TSC1 controls macrophage polarization to prevent inflammatory disorder by Linnan Zhu et al Suppl. Fig. 1 Tissue DN C Proteins kd TSC1-17 TSC 1 loxp bp -48-285 ctin PEMs Neutrophils
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1 SUPPLEMENARY INFORMAION 13 supplementry figures, 2 supplementry tles, nd supplementry note he leukocyte integrin ntgonist Del-1 inhiits IL-17 medited inflmmtory one loss Mehmet A. Eskn 1,2, Rvi Jotwni
Chow KD CR HFD. Fed Fast Refed
Supplementry Figure 1 Control d/d Chow KD CR Fed Fst Refed Supplementry Figure 1: Liver expression in diet nd disese models. () expression in the livers of ontrol nd d/d mie. () expression in the livers
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{ OI: 1.138/n31 Srifie n nlyze APs on week 1 s of iet 1 4 6 High-ft iet BrU High-ft iet BrU 4 High-ft iet BrU 6 High-ft iet BrU Lin - Lin - : C34 + : C9 + 1 1 3 1 4 1 5 C45 1 C34 1 1 1 1 3 1 4 1 5 S-1
IL-18 induction of IgE: dependence on CD4 + T cells, IL-4 and STAT6
ARTICLES IL-18 induction of IgE: dependence on CD4 + T cells, IL-4 nd STAT6 Tomohiro Yoshimoto 1,2,7, Hitoshi Mizutni 3, Hiroko Tsutsui 1, Nncy Noen-Truth 6, Kei-ichi Ymnk 3, Minoru Tnk 4, Shinzo Izumi
Alternative cross-priming through CCL17-CCR4- mediated attraction of CTLs toward NKT cell licensed DCs
Alterntive cross-priming through CCL17-CCR4- medited ttrction of CTLs towrd NKT cell licensed DCs 21 Nture Americ, Inc. All rights reserved. Veren Semmling 1,1, Veronik Lukcs-Kornek 1,9,1, Christoph A
Supplementary Fig. 1 p38 MAPK negatively regulates DC differentiation. (a) Western blot analysis of p38 isoform expression in BM cells, immature DCs
Supplementary Fig. 1 p38 MAPK negatively regulates DC differentiation. (a) Western blot analysis of p38 isoform expression in BM cells, immature DCs (idcs) and mature DCs (mdcs). A myeloma cell line expressing
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SUPPLEMEARY IFORMAIO doi:./nture correction to Supplementry Informtion Adenom-linked rrier defects nd microil products drive IL-/IL-7-medited tumour growth Sergei I. Grivennikov, Kepeng Wng, Dniel Mucid,
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doi:.38/nture73 Glucose SSP THF Methyl- THF Purines 3- PG PHGDH PSAT PSPH Glycine SHMT GSH Lctte Pyruvte ROS TCA Cycle Glucose p53 p Purines 3- PG PHGDH PSAT PSPH Glycine SHMT GSH Lctte Pyruvte ROS TCA
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
Supplementary Figures 1-8 Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel Marc Schmidt 1,2, Badrinarayanan Raghavan 1,2, Verena Müller 1,2, Thomas Vogl 3, György
Nature Medicine: doi: /nm.3922
Title: Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells Authors: Il-Kyu Kim, Byung-Seok Kim, Choong-Hyun
Expanded View Figures
Gregory T Ellis et al Lung damage by monocyte TRIL allows coinfection EMO reports Expanded View Figures % survival Clinical score Influenza Matrix /HPRT (log ) CFU/L (log ) 3 irway early.7.7 + h Survival
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DOI: 10.1038/nc2824 Hcn4 Tx5 Mlc2 c Hcn4- ISH d Tx5- ISH e Mlc2-ISH Hcn4-ISH f e Tx5-ISH f -ISH Figure S1 Section in situ hyridistion nlysis of crescent stge mouse emryos (E7.5). () More nterior section
Unique roles of the unfolded protein response pathway in fungal. development and differentiation. Kwang Woo Jung, Yee Seul So, & Yong Sun Bahn *
Supplementry Informtion Unique roles of the unfolded protein response pthwy in fungl development nd differentition Kwng Woo Jung, Yee Seul So, & Yong Sun Bhn * Contents Supplementry Figure S1 Supplementry
a surface permeabilized
a surface permeabilized RAW 64.7 P388D1 J774 b CD11b + Ly-6G - Blood Monocytes WT Supplementary Figure 1. Cell surface expression on macrophages and DCs. (a) RAW64.7, P388D1, and J774 cells were subjected