Atopic Dermatitis - Japan Drug Forecast and Market Analysis to 2024

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1 Atopic Dermatitis - Japan Drug Forecast and Market Analysis to 2024

2 Atopic Dermatitis - Japan Drug Forecast and Market Analysis to 2024 BioPortfolio has been marketing business and market research reports from selected publishers for over fifteen years. BioPortfolio offers a personal service to our customers with dedicated research managers who will work with you to source the best report for your needs. Based in the UK, BioPortfolio is well positioned to coordinate our customers' orders sourced from over 50 global report publishers. We are pleased to present details of this report to assist your buying decision and administrative process. You will find easy-to-use How To Buy information on the last page of this document. We look forward to being of service to you. If you have bulk and/or recurring requirements, please get in touch - we can liaise with publishers to obtain sample pages and negotiate discounts on your behalf. Phone: +44 (0) or 2

3 Atopic Dermatitis - Japan Drug Forecast and Market Analysis to 2024 Atopic Dermatitis - Japan Drug Forecast and Market Analysis to 2024 Summary Although the past decade has seen the atopic dermatitis market remain relatively unchanged and a saturated, highly genericized arena, the coming decade could see the launch of the first biologic, which will set a precedent and pave the way for others to follow suit. By the mid-to-late term of GlobalData s 2014 to 2024 forecast, Sanofi/Regeneron s dupilumab is expected to reshape the adult moderate and severe treatment landscape and to slowly enter the market for younger patients with milder forms of the disease. Other events that are expected to invoke change to the previously stagnant atopic dermatitis market include the launch of a non-steroidal topical from Anacor, AN2728, generic erosion of branded topicals Protopic and Elidel in the US. GlobalData values the atopic dermatitis market in Japan at $397.0m in Growth within that market will stem from the positive uptake of systemic agents and the pipeline therapy dupilumab. In terms of branded products, Protopic dominates the topical calcineurin inhibitor class in Japan with estimated sales of $31.5m in Since its key competitor Elidel is not available in Japan, Protopic s strong stance in that market remains relatively unchallenged throughout the 10-year forecast. Scope - Overview of Atopic Dermatitis including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape. - Detailed information on the key drugs in Japan including product Atopic Dermatitiscription, safety and efficacy profiles as well as a SWOT analysis. - Sales forecast for the top drugs in Japan from Analysis of the impact of key events as well the drivers and restraints affecting Japan Atopic Dermatitis market. Reasons to buy - Understand and capitalize by identifying products that are most likely to ensure a robust return - Stay ahead of the competition by understanding the changing competitive landscape for Atopic Dermatitis. - Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential 3

4 - Make more informed business decisions from insightful and in-depth analysis of drug performance - Obtain sales forecast for drugs from in Japan. Additional Details Publisher : Global Data Reference : GDHC302CFR Number of Pages : 143 Report Format : PDF Publisher Information : 4

5 Table Of Contents for Atopic Dermatitis - Japan Drug Forecast and Market Analysis to Table of Contents1 Table of Contents 21.1 List of Tables 51.2 List of Figures 72 Introduction 82.1 Catalyst 82.2 Related Reports 82.3 Upcoming Related Reports 93 Disease Overview Etiology and Pathophysiology Etiology Pathophysiology Symptoms 154 Disease Management Diagnosis and Treatment Overview Diagnosis Treatment Guidelines Leading Prescribed Drugs for the Treatment of Atopic Dermatitis Clinical Practice Japan 245 Competitive Assessment Overview Strategic Competitor Assessment Product Profiles - Major Brands Protopic (tacrolimus) Elidel Cyclosporine (numerous generic names) Other Therapeutic Drug Classes Used in Atopic Dermatitis Product Profiles - Off-Label Therapies Xolair (omalizumab) Actimmune (interferon gamma-1b) 546 Opportunity and Unmet Need Overview A Systemic Drug for Severe Recalcitrant Patients Tests that Stratify Patients and Allow for a Tailored Treatment Approach A Drug that Effectively Controls Patients Pruritus Further Research into the Pathophysiology of Atopic Dermatitis A Drug that Induces Disease Remission Improved Quality of Life for Both Patients and their Carers 737 Pipeline Assessment Overview Clinical Trial Mapping Clinical Trials by Therapy Type Promising Drugs in Clinical Development Dupilumab (SAR231893/ REGN668) AN Other Drugs in Development 1078 Market Outlook Japan Forecast Key Events Drivers and Barriers 1129 Appendix Bibliography Abbreviations Methodology Forecasting Methodology Diagnosed Atopic Dermatitis Patients Percent Drug-treated Patients Drugs Included in Each Therapeutic Class Launch and Patent Expiry Dates General Pricing Assumptions Individual Drug Assumptions Generic Erosion Pricing of Pipeline Agents Physicians and Specialists Included in this Study Primary Research - Prescriber Survey About the Authors Author Reviewer Epidemiologist Global Director of Therapy Analysis and Epidemiology Global Head of Healthcare About GlobalData Disclaimer 142 5

6 List Of Tables in Atopic Dermatitis - Japan Drug Forecast and Market Analysis to List of Tables Table 1: Symptoms of Atopic Dermatitis 16 Table 2: Treatment Guidelines for Atopic Dermatitis 21 Table 3: Most Prescribed Drugs for Atopic Dermatitis by Severity in the Global Markets, Table 4: Country Profile - Japan 26 Table 5: Leading Treatments for Atopic Dermatitis, Table 6: Product Profile - Protopic 31 Table 7: Clinical Response Data of Protopic (0.03% and 0.1%) versus Vehicle Ointment at Week 12 from One Study in Pediatric Patients and Two Combined Studies in Adult Patients 32 Table 8: Protopic SWOT Analysis, Table 9: Global Sales Forecasts ($m) for Protopic, Table 10: Product Profile - Elidel 38 Table 11: Combined Clinical Efficacy Results of Elidel versus Vehicle Cream at Week 6 from Two Phase III Studies 39 Table 12: Elidel SWOT Analysis, Table 13: Global Sales Forecasts ($m) for Elidel, Table 14: Product Profile - Cyclosporine 44 Table 15: Cyclosporine SWOT Analysis, Table 16: Global Sales Forecasts ($m) for Cyclosporine, Table 17: Summary of Other Therapeutic Classes for Atopic Dermatitis, Table 18: Product Profile - Xolair 50 Table 19: Xolair SWOT Analysis, Table 20: Global Sales Forecasts ($m) Xolair, Table 21: Product Profile - Actimmune 55 Table 22: Actimmune SWOT Analysis, Table 23: Global Sales Forecasts ($m) Actimmune, Table 24: Overall Unmet Needs in Atopic Dermatitis - Current Level of Attainment 60 Table 25: Clinical Unmet Needs in Atopic Dermatitis - Gap Analysis, Table 26: Late-Stage Atopic Dermatitis Pipeline,

7 Table 27: Product Profile - Dupilumab 83 Table 28: Ongoing Clinical Trials of Dupilumab in Atopic Dermatitis Patients, as of December Table 29: Dupilumab SWOT Analysis, Table 30: Global Sales Forecasts ($m) for Dupilumab, Table 31: Product Profile - AN Table 32: Efficacy Results for AN2728 in Mild to Moderate Adolescent Atopic Dermatitis Patients (Day 29) 98 Table 33: AN2728 SWOT Analysis, Table 34: Global Sales Forecasts ($m) for AN2728, Table 35: Drugs in Early-stage Clinical Development for Atopic Dermatitis, Table 36: Sales Forecasts ($m) for Atopic Dermatitis in Japan, Table 37: Key Event Impacting Sales for Atopic Dermatitis in Japan, Table 38: Atopic Dermatitis Market in Japan - Drivers and Barriers, Table 39: Key Launch Dates 131 Table 40: Key Patent Expiries 131 Table 41: Physicians Surveyed, By Country 138 7

8 List Of Figures, Charts and Diagrams in Atopic Dermatitis - Japan Drug Forecast and Market Analysis to List of Figures Figure 1: Immunologic Pathway Involved in Healthy, Acute Atopic Dermatitis, and Chronic Atopic Dermatitis Skin 13 Figure 2: Flow Chart of the Diagnosis and Management of Atopic Dermatitis 20 Figure 3: Atopic Dermatitis Therapeutics - Clinical Trials by Therapy Type and Development Stage, October Figure 4: Atopic Dermatitis - Phase III Pipeline, December Figure 5: Competitive Assessment of Late-Stage Pipeline Agents in Atopic Dermatitis, Figure 6: Sales for Atopic Dermatitis in Japan by Drug Class,

9 How to Buy... Atopic Dermatitis - Japan Drug Forecast and Market Analysis to 2024 Option 1 - Online Go to our website and pay online with any major debit or credit card: Option 2 - Request a Proforma Invoice Fill in the details below, and either Scan this page and it to us at or Fax it to us at +44 (0) We will send you a Proforma Invoice and deliver your report on settlement. Your Name: Job Title: Your Your Contact Phone: Company Name: Address: Post/Zip Code: Country: P.O. Number: Any Other Instructions: Pricing Options: (please tick one) $4995 Single User Price $9990 Site License Price $14985 Enterprise License Price Payment Options: (please tick one) Online Credit Card (we will you the invoice with a payment link) Direct Wire Transfer (we will you the invoice with our bank details) Authorising Signature: Option 3 - Phone Us on +44 (0) We will be delighted to give you our personal attention. 9

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