Mannitol - A natural food supplement shown to arrest Parkinson's progression and reverse symptoms

Transcription

1 Mannitol - A natural food supplement shown to arrest Parkinson's progression and reverse symptoms A report

2 This could be a game-changer for many people You just never know what might be the key which unlocks your Parkinson s and restores you to good health. A sweetener, produced by most plants and used in chewable pharmaceutical tablets, has been found by researchers to prevent the alpha-synuclein protein from forming clumps in the brain. These clumps are common events in Parkinson s disease. I first read about the sweetener, Mannitol, in a July 2013 Parkinson s Disease Foundation news release Common Natural Sweetener May Treat Parkinson s Disease. This news release is featured in full in the following pages. It s easy to understand. In three different studies, scientists at Tel Aviv University demonstrated the ability of mannitol to reduce alpha-synuclein accumulation and restore function (at least, in the treated fruit flies). Details of these studies can be found in subsequent pages of this report. Where does this leave Parkinson s people right now? Well, there s no approved treatment using Mannitol for Parkinson s and it will be years before it arrives, if ever. To understand why, see Parkinson s and Drug Development later in this report. However, one enterprising man with Parkinson s has created a supplement, incorporating Mannitol, which he has used to reverse his Parkinson s symptoms. He states that others have achieved similar outcomes. He has patents pending on the compound. This supplement, Syncolein, can be purchased online and a month s supply costs $40 + shipping. Will It Work? There s only one way to find out and that is to try it. Is it Safe? Mannitol is FDA approved as a food for human consumption without a prescription and is on the FDA GRAS inventory (Generally Recognized As Safe). There is no evidence, either way, as to whether Syncolein is safe or harmful in the quantities recommended to treat Parkinson s in humans. Given the harmful nature of Parkinson s, you may consider this an acceptable risk. More Information More detailed information, including how to purchase Syncolein, can be found on subsequent pages of this report.

3 Science News Common Natural Sweetener May Treat Parkinson s Disease Jul The natural sweetener mannitol, a common component of sugar-free gums and candies, may hold potential for Parkinson s disease (PD) according to a study, funded in part by the Parkinson's Disease Foundation, in the June 14 issue of The Journal of Biological Chemistry. In this initial study, the compound not only improved PD-like symptoms in fruit flies, but also reduced harmful levels of alpha- synuclein (the hallmark of PD) in the brains of fruit flies and mice. Researchers took interest in mannitol because, when given as an injection, it has two unique properties. First, it can disrupt the blood brain barrier (meaning the drug can reach the brain). Second, it is able to stop some proteins in the body from clumping together, which is interesting in light of the fact that clumps of the protein alpha-synuclein are a well-known sign of Parkinson s disease. Knowing these properties, Daniel Segal, Ph.D., and Ehud Gazit, Ph.D., at Tel Aviv University, in Israel, wondered whether mannitol might be helpful for Parkinson s disease. So they examined mannitol in the lab and in fruit flies and mice. They studied whether mannitol could improve the motor symptoms of fruit flies with PD-like symptoms, and whether it changed levels of alphasynuclein in all three experiments. Results In the test tube, mannitol injections prevented alpha-synuclein protein from clumping into the Lewy bodies that form in the brains of people with PD. In the fruit fly model of PD, mannitol injections restored the flies normal movements, for example their ability to climb up test tubes. In the same flies,

4 In the mice model of PD, mannitol injections reduced alpha-synuclein clumps in several areas of the brain involved with classic PD and protected dopamine-iproducing neurons, the brain cells affected in PD. What Does It Mean? This initial study demonstrates the potential ability of mannitol to prevent alpha-synuclein clumping that takes place in PD. The results indicate that mannitol should be studied for its potential to treat PD. In the study, mannitol prevented alpha-synuclein from clumping in all three experiments in the test tube and in the brains of fruit flies and mice with a PD-like condition. Scientists suggest that mannitol appears to function as a chemical chaperone, meaning that the sweetener stabilizes proteins like alpha-synuclein and prevents them from inappropriately clumping together. In support of this idea, feeding mannitol to fruit flies improved their PD-like symptoms, allowing the flies to regain their normal movements. Yet there is a long stretch from improving the behavior of flies to treating PD symptoms in people. Researchers need to test the ability of mannitol to improve PD symptoms in other animal models of PD, (e.g., in additional mice models). If the results hold up in mice, then mannitol could be tested in clinical trials for the treatment of PD in people. The US Food and Drug Administration (FDA) has already approved an oral form of mannitol as a diuretic to help flush excess water out of the body, and a mannitol injection to prepare people for chemotherapy. But much research needs to be done before we understand the impact on people with PD, for example, what doses would be needed to be safe and if the drug would be effective. People with PD should not attempt to medicate themselves by eating large amounts of sugar-free candy or chewing gum. Even if they were able to consume enough mannitol to reach the level fed to fruit flies, there is currently no evidence that this will help their Parkinson s.

5 Syncolein - What Don McCammon inventor has to say I am 66 years old and had all the symptoms of Parkinson s disease i.e. tremors, drooling, tiredness, falling down, loss of balance, trouble urinating, handwriting problems, shuffling, not sleeping etc. I used myself as a research subject. I started taking mannitol orally in small doses until I found a therapeutic dose that began to restore my functioning. There were some negative side effects including diarrhea, gas and urinary retention, so I reduced the dose and added alphagalactosidase to offset the side effects. I added vitamin D3 and vitamin K2to feed the mitochondria that power the lysosomes that consume the defective alpha-synuclein. After 30 days I could stand and walk regularly. I had a great deal more energy, had much better balance, slept 8 to 10 hours a night, no longer had problems urinating, could walk up and down stairs without holding the rails and no longer drooled as often. I still had tremors but they were diminished. I have given the compound to others with Parkinson s who have had similar results. I have two patents pending on the compound. The supplement is prepared as a powder and the recommended dosage is one tablespoon daily dissolved in a cup of hot caffeinated coffee or tea. I have been taking the supplement for over seven months as of January, I have had no new Parkinson s symptoms during that period of time. During a one week period I stopped taking it because my left eye swelled and I was fearful it was a side effect. I saw my primary care doctor and was diagnosed with an eye infection which was treated with a topical antibiotic. However, after 7 days off the supplement, I started having an in- crease in Parkinson s symptoms again. The symptoms diminished after 4 days back on the supplement.

6 Syncolein - What Don McCammon inventor has to say (cont.) Based on animal studies, it is believed that the supplement broke up alpha-synuclein clusters in my brain which resulted in stopping the progression of Parkinson s disease and restoring much of my functioning. It is also believed that the supplement rejuvenated the mitochondria in the lysosomes that consume the defective al- pha-synuclein. The only definitive way to verify that is by autopsy. Is this a cure for Parkinson s disease? No, however the daily dosage of the supplement has dramatically restored my functioning and I hope the major symptoms of the disease will stay in remission as long as I take a therapeutic daily dose. I believe the supplement I developed has stopped the progress of the disease and I know that it has greatly improved the quality of my life. Parkinson's and Drug Development Firstly, a nutritional supplement like Syncolein (ie mannitol) is highly unlikely to become and approved treatment for Parkinson's disease and prescribed by doctors. To achieve that status it will have needed to undertake large scale, double-blind, placebo controlled trials. These are only affordable where there is the prospect of a patent and super-profits. That is not going to happen with a nutritional supplement using a commonly available foodstuff. The alternative route is for a pharmaceutical company to develop a drug which uses mannitol in some form, probably in combination with other chemicals. Such a drug will take 10+ years if it's to be developed. There's no sign of anything happening on the drugs front. Where that leaves you The decision lies with you and which you have to make on the available information. You are advised to act only in consultation with your doctor.

7 How to Buy Syncolein To purchase Syncolein, go to Currently, Syncolein costs $80 + shipping for two months' supply. In Conclusion This document neither offers advice nor recommendations. We merely share with you information upon which you may decide to take action. You should consult your doctor before changing your diet or making any changes to your medication. Mannitol has been shown, in small scale studies, to reduce alpha-synuclein accumulation and restore function in fruit flies affected by Parkinson's. No trials have been conducted with humans. There are subjective reports, most notably by Don McCammon, of substantial improvement in Parkinson's symptoms when using his nutritional supplement, Syncolein, which contains mannitol. Mannitol is a foodstuff approved by the FDA and is on the FDA GRAS (Generally Recognized As Safe) inventory. Syncolein has not ben approved as a treatment for Parkinson's disease, and there is no evidence that it is safe to consume the recommended quantities. There is no evidence that it is unsafe, either. As with all nutritional supplements, it's a decision the individual needs to take, weighing up any possible risks presented by Syncolein against the certainties of continued degeneration as Parkinson's progresses.

8 Research Studies To read the research study in full, paste the title into your internet search engine, On alpha-synuclein α-synuclein and Parkinson s disease FASEB Journal, April 2004 Alpha-synuclein: from secretion to dysfunction and death Neuroscience, July 2012 Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease. FASEB Journal, March 2006 Models of α-synuclein aggregation in Parkinson s disease Acta Neuropathologica Communications. Dec 2014 Progressive aggregation of alpha-synuclein and selective degeneration of lewy inclusion-bearing neurons in a mouse model of parkinsonism Cell Reports Mar 2015 On Mannitol A Blood-Brain Barrier (BBB) Disrupter Is Also a Potent α-synuclein (α-syn) Aggregation Inhibitor Journal of Biological Chemistry, June 2013 Medical Food to Stop the Progression of Parkinson s Disease Scientific Research, May 2014

9 Natures Healthworks Ltd Basepoint Business & Innovation Centre Harts Farm Way Havant, Hants PO9 1HS United Kingdom Tel. +44 (0) and Natures Healthworks Limited (owner of share information from other sources, such as research centres, and the personal experiences of others in their struggle to overcome Parkinson s disease and associated symptoms. The information is strictly for informational purposes alone. We do not offer advice and nothing on any website, or any other communication is intended to treat, diagnose, prevent or cure any disease. It is not a substitute for consulting your doctor. You should consult a doctor for diagnosis of conditions, before beginning any diet, exercise or supplementation or if you suspect you have any health issue. You should not stop medication without consulting your doctor. I share information for the benefit of fellow people with Parkinson s and do not receive any personal remuneration, commissions or any other financial consideration, whether directly or indirectly, from any supplier of dietary supplements, service or product that may be mentioned from time to time.