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1 4th edition comprehensive pharmacy review EDITORS Leon Shargel, PhD, RPh, PharmD, FASHP, RPh Paul F. Souney, MS, RPh Larry N. Swanson, PharmD, FASHP, RPh LIPPINCOTT WILLIAMS & WILKINS A Wolters Kluwer Company Philadelphia Baltimore New York London Buenos Aires Hong Kong Sydney Tokyo

2 Contents Contributors ~ ix Preface xv Taking,A Test xvii Introduction to the NAPLEX xxi PART I 1 Drug Product Development in the Pharmaceutical Industry 1 Anton H. Amann, Leon Shargel 2 Pharmaceutical Calculations and Statistics 9 Riccardo Boni, James K. Drennen, III 3 Pharmaceutical Principles and Drug Dosage Forms 28 Lawrence H. Block, Andrew B. C. Yu 4 Biopharmaceutics and Drug Delivery Systems 78 Lawrence H. Block, Charles C. Collins 5 Extemporaneous Prescription Compounding 92 Loyd V. Allen, Jr. 6 Basic Pharmacokinetics 111 Leon Shargel 7 Bioavailability and Bioequivalence 131 Leon Shargel O Organic Chemistry and Biochemistry 141 Edward F. LaSala, John D. Leary 9 Microbiology t 154 Ralph N. Blomster, Carolyn Dabirsiaghi 10 Immunology /, 165 Gail Goodrffan-Snitkoff 11 Biotechnology 199 Godwin W. Fong, Charles Lee 1 2 Principles of Pharmacodynamics and Medicinal Chemistry 213 Marc W. Harrold, Nelson S. Yee, Leon Shargel 1 3 Medicinal Chemistry and Pharmacology: Drugs Affecting the Autonomic Nervous System and Central Nervous System 241 Ashiwel S. Undie, David C. Kosegarten, Edward F. LaSala

3 1 4 Medicinal Chemistry and Pharmacology: Autocoids, Non-Narcotic Analgesic-Antipyretics, and Nonsteroidal Anti-Inflammatory Drugs 279 Scoff F. Long 1 5 Medicinal Chemistry and Pharmacology: Cardiovascular and Diuretic Drugs 298 David C. Kosegarten, Edward F. LaSala, J. Edward Moreton 1 6 Medicinal Chemistry and Pharmacology: Endocrinology and Related Drugs 323 Marc W. Harrold, Pui-Kai Li 1 7 Drug Metabolism and Drug Interactions 345 Marc W. Harrold, Alice C. Engelbrecht, Leon Shargel 1 8 Nuclear Pharmacy 370 Stephen C. Dragotakes, Allegra L. DePietro, Ronald J. Callahan PART II 1 9 Pharmaceutical Care and Disease State Management 393 Peggy C. Yarborough 20 Drug Information Resources 406 Paul F. Souney, Connie Lee Barnes 21 Adverse Drug Reactions and Post Market Surveillance 416 Barbara Szymusiak-Mutnick 22 Clinical Toxicology 424 John J. Ponzillo ^- 23 Federal Pharmacy Law 441 Robert C. Pavlan, Jr. 24 Reviewing and Dispensing Prescriptions and Medication Orders 467 Todd A. Brown ^ 25 Sterile Products and Parenteral Drug Delivery 475 John Fanikos y f 26 Parapharmaceuticals, Home Diagnostics, and Medical Devices 492 Todd A. Brown 27 OTC Otic, Dental, and Ophthalmic Agents 503 Larry N. Swanson, Connie Lee Barnes, Tina M. Harrison 28 OTC Dermatologic Agents 522 Larry N. Swanson VI

4 29 OTC Weight Control, Sleep Aids, and Smoking Cessation 543 Larry N. Swanson, Tina M. Harrison 30 OTC Agents for Fever, Pain, Cough, Cold, and Allergic Rhinitis 556 Gerald E. Schumacher, Larry N. Swanson 31 OTC Agents for Constipation, Diarrhea, Hemorrhoids, and Heartburn 575 Stephen H. Fuller, Michelle A. Long, Steven M. Davis 32 OTC Menstrual, Vaginal, and Contraceptive Agents 597 Larry N. Swanson, Mollie A. Scott, Tina M. Harrison 33 Herbal Medicines and Nutritional Supplements 609 Teresa Klepser 34 Clinical Pharmacokinetics and Therapeutic Drug Monitoring 625 Gerald E. Schumacher 35 Drug Use in Special Patient Populations: Pediatric, Pregnant, Geriatric 638 Mark K. Sorenson, Beth Bryles Phillips, 36 Common Clinical Laboratory Tests 657 D. Byron May, Larry N. Swanson 37 Ischemic Heart Disease 676 Barbara Szymusiak-Mutnick 38 Cardiac Arrhythmias Hypertension Congestive Heart Failure Thromboembolic Disease 754 James B. Groce, III 42 Infectious^Diseases 768 Paul F. Souney, Ron DeBellis, Anthony E. Zimmerman 43 Seizure Disorders 822 Azita Razzaghi-Hedayat 44 Parkinson's Disease 845 Azita Razzaghi-Hedayat 45 Schizophrenia 863 Penny S. Shelton, Faith L. Barnett VII

5 46 Mood Disorders 873 Faith L. Barnett, Penny S. Shelton 47 Asthma and Chronic Obstructive Pulmonary Disease 892 Mona G. Tsoukleris, Brian G. Katona 48 Rheumatoid Arthritis 924 Michelle A. Fritsch, Larry N. Swanson 49 Hyperuricemia and Gout 937 Larry N. Swanson 50 Peptic Ulcer Disease 948 Paul F. Souney, Anthony E. Zimmerman 51 Diabetes Mellitus " 970 Peggy C. Yarborough, Sally T. Johnson 52 Thyroid Disease 993 John E. Janosik 53 Renal Failure 1014 Andrew L. Wilson, Donald F. Brophy 54 Cancer Chemotherapy 1030 Amy J. Becker 55 Pain Management 1043 Alan F. Kaul 56 Nutrition and the Hospitalized Patient 1056 Robert A. Quercia, Kevin P. Keating, Maria Evasovich 57 Immunosuppressive Agents in Organ Transplantation 1071 David I. Min 58 Outcomes Research and Pharmacoeconomics 1079 Peter K. Wong, App. A Prescriptiqn''Dispensing Information and Metrology App. B Common Prescription Drugs and Over-the-Counter Products App. C Reference Charts Useful for Patient Counseling App. D State and National Pharmacy Organizations App. E Budgeting for Drug Information Resources Index

comprehensive pharmacy review

comprehensive pharmacy review 3rd edition comprehensive pharmacy review EDITORS, Ph.D., R.Ph., Pharm.D., R.Ph. Paul F. Souney, M.S., R.Ph., Pharm.D., R.Ph. Lawrence H. Block, Ph.D., R.Ph. Williams &: Wilkins A WAVERLY COMPANY BALTIMORE

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