A review of nonsteroidal anti-inflammatory drugs

Transcription

1 A review of nonsteroidal anti-inflammatory drugs Natalie Schellack, BCur, BPharm, PhD(Pharmacy), Associate Professor Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University Gustav Schellack, BCur, AdvUnivDiplNursSc(HSM), HonsBSc(Pharmacology), Clinical Research Manager Pharmaceutical Industry, Specialising in Clinical Research and Applied Pharmacology Johani Fourie, BPharm, Academic Intern Department of Pharmacy, Faculty of Health Sciences, Sefako Makgatho Health Sciences University Keywords: NSAIDs, coxibs, nonsteroidal anti-inflammatory drugs, cyclo-oxygenase Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) include the nonselective or traditional NSAIDs, as well as the cyclo-oxygenase-2- specific ones. These agents are most often used to manage pain associated with musculoskeletal conditions. The nonselective or traditional agents are still widely used, and are also freely available as over-the-counter analgesics. However, they carry the of serious cardiovascular, and renal adverse effects, such as peptic ulcers and bleeding, especially in patients who have a pre-existing high- profile. It is imperative that physicians are aware of these factors and choose agents that will provide the best benefit-to- profile, while taking into consideration the patient s individual needs and profile. Medpharm S Afr Pharm J 2015;82(3):8-18 Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) are used worldwide to treat pain and inflammation. 1 However, in 2007, the American Heart Association published a warning in a focused update on the use of NSAIDs with respect to patients with established cardiac disease. 2 The cardiovascular side-effects relating to the NSAIDs first became apparent in clinical trials that investigated the effects of selective cyclo-oxygenase-2 (COX- 2) inhibitors. It has also been suggested in subsequent followup studies that there is an increase in cardiovascular in the nonselective NSAID group, e.g. ibuprofen and diclofenac. NSAIDs are still widely used across the globe and many of them can be purchased as over-the-counter (OTC) analgesics, e.g. ibuprofen, diclofenac, naproxen and mefenamic acid. 3 Diclofenac was identified by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency as a high- NSAID in terms of its effects on the heart and circulation when administered systemically, i.e. capsules, tablets or injections. 4 Individual drugs carry differing degrees of within the larger group of NSAIDs. Naproxen and low-dose ibuprofen carry the lowest cardiovascular, while diclofenac, at available OTC doses, carries a higher. The available data for etoricoxib [one of the selective cyclo-oxygenase inhibitors (coxibs) that are still available on the market] is still sparse, but it has a higher relative when compared to naproxen or ibuprofen. There are a range of and central nervous system side-effects with indomethacin, and it has a cardiovascular profile similar to that of diclofenac. 5 It is also well-recognised that there are severe side-effects with NSAIDs, ranging from dyspepsia to gastroduodenal ulceration and bleeding. 6 Cardiovascular effects Physiology involved in the causation of cardiovascular adverse effects Both isoforms of the COX enzyme, namely COX-1 and COX- 2, are found in the blood vessels, stomach and kidneys. 7,8 The normal action of COX-1 includes the physiological production and regulation of the prostanoids that are responsible for the maintenance of the following: 7,8 The mucosa: Production of bicarbonate and mucus from the mucosa, blood flow regulation and epithelial proliferation Platelet aggregation Renal prostaglandin synthesis: The two prostaglandins that are found in the kidneys are prostaglandin E 2 (PGE 2 ) and prostacyclin (PGI 2 ]. PGE 2 is involved in sodium reabsorption in the thick ascending loop of Henle (in the nephron), as well as in the collecting tubules, and also seems to antagonise the antidiuretic effect of vasopressin on the latter. COX-2 is expressed in the adult, mammalian renal cortex, the macula densa, the thick ascending limb of the loop of Henle, the interstitial cells in the inner medulla, and in the papillae and podocytes. 7,8 COX-2 is detected upon stimulation in the monocyte, macrophage, neutrophil and endothelial cells. 7,8 COX- 2-release is triggered by cytokines, mitogens and endotoxins S Afr Pharm J 8

2 in the inflammatory cells, and is responsible for prostaglandin production in inflamed tissue. 7,8 Cardiovascular events Individual factors may contribute to the relative of cardiovascular adverse events; underlying pathology, including pre-existing hypertension and renal impairment; and concomitant therapy, which may exacerbate the cardiovascular toxicity of the NSAIDs Cardiovascular-related toxicity includes (Table I): 9-11 An increase in arterial blood pressure of approximately 4-6 mmhg, especially in susceptible individuals, i.e. those with known hypertension, or patients who are already on antihypertensive treatment New-onset congestive cardiac failure and the recurrence thereof Sodium and water retention that is primarily owing to the effects of COX-2. (COX-2 is produced by the cells of the macula densa. Inhibition can lead to sodium and water retention) Table I: Cardiac effects relating to the use of nonsteroidal antiinflammatory drugs 9-11 An increase in blood pressure Sodium and water retention Congestive cardiac failure Atrial fibrillation Atrial fibrillation or flutter: The use of non-aspirin NSAIDs carries an increased of atrial fibrillation (AF) and flutter, where the highest incidence has been found in new users (The increases in specific relation to COX-2 inhibitors). Mechanisms involved in fluid retention, heart failure and hypertension These events may be owing to the presence of COX-2 in the kidneys and the effects of COX-1 in relation to the maintenance of a normal glomerular filtration rate (GFR) (Figure 1). Inhibition of these enzymes by the nonselective or traditional NSAIDs and selective COX-2 inhibitors results in renal effects, with varying degrees of sodium and water retention, depending on the agent in question. 7 Some prostaglandins are synthesised in the kidneys and the disruption of their synthesis by the NSAIDs can result in acute renal failure, acute nephritis, electrolyte imbalances and reduced renal perfusion. 7,9 The fluid retention might increase peripheral vascular resistance, with deleterious effects to the heart, including hypertension and heart failure. However, only a small proportion of patients who develop fluid retention eventually develop congestive heart failure. 7,9 Within the group, there may be varying degrees of influence by the NSAIDs on blood pressure. Indomethacin is the most potent inhibitor of the prostaglandins, and is also associated with the highest incidence of heart failure. It provides great challenges to (-) COX-1 NSAIDs Coxibs Glucocorticosteroids Constitutive with normal housekeeping functions, i.e. homeostatic functions. (-) (-) COX-2 Inducible and proinflammatory. However, also constitutive (but not normally found most tissues). Constitutive prostaglandins: Cytoprotection of the gastric mucosa Maintenance of normal kidney function and renal perfusion. Able to maintain normal GFR when renal perfusion is decreased, e.g. in patients with hypovolaemia TXA 2 Vasoconstriction Promotes platelet aggregation Normal platelet activity and function to limit blood loss subsequent to a loss of vascular integrity, i.e. blood vessel injury. Housekeeping versus proinflammatory functions (cyclo-oxygenase-1 and cyclo-oxygenase-2) Physiological functions: Maintaining a normal TXA 2 :PGI 2 ratio (COX-2 is a source of vascular prostacyclin, see below) Maintenance of normal kidney function Involvement in normal functioning of the reproductive system Proinflammatory prostaglandins: Mediators of the inflammatory response Uterine smooth muscle contraction PGI 2 : Vasodilation Prevents platelet aggregation (anti-platelet effects) Recognised housekeeping or physiological functions (cyclo-oxygenase-2) Glomerular filtration rate Coxibs: specific cyclo-oxygenase-2 inhibitors, COX-1: cyclo-oxygenase-1, COX-2: cyclo-oxygenase-2, GFR: glomerular filtration rate, NSAIDs: nonsteroidal anti-inflammatory drugs, PGI 2 : prostacyclin, TXA 2 : thromboxane A 2 Figure 1: A comparison of the cyclo-oxygensase-1 and cyclo-oxygensase-2 isozymes 7,9 S Afr Pharm J 10

3 Patients who require frequent or ongoing NSAID therapy Assess: Cardiovascular profile Gastrointestinal profile High cardiovascular Naproxen is preferred High Average Risk factors for a cardiovascular assessment include: Established coronary artery disease Lose-dose, prophylactic aspirin therapy An estimated 10-year cardiovascular of > 20% Risk factors for a assessment include: Age years Prior upper event The concomitant use of aspirin, corticosteroids or anticoagulants Average cardiovascular Any suitable NSAID High Average with a proton-pump inhibitor (PPI), so as to enable ease of use in patients who require NSAID therapy, with the addition of an effective gastroprotective agent. Currently, it is indicated in patients with inflammatory joint conditions, i.e. rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, who need proton-pump inhibition to reduce the incidence of NSAIDassociated gastroduodenal ulceration Naproxen has been established as the only safe traditional, nonselective NSAID, because it does not exhibit an increase in cardiothrombotic at its maximal dose of mg per day. The fixed-dose combination tablet has been designed to contain a non-enteric-coated outer layer of esomeprazole for immediate release in the stomach, and an enteric-coated naproxen core for dissolution in the small intestine. Furthermore, with reference to its safety profile, the fixed-dose combination of naproxen plus esomeprazole has shown significantly improved tolerability when compared to enteric-coated naproxen on its own, with significantly fewer gastric ulcers Avoid the NSAIDs or If unavoidable, use naproxen plus a PPI or misoprostol Naproxen, if the patient is not on aspirin already. If on aspirin, use naproxen plus a PPI or misoprostol A non-selective NSAID plus a PPI or misoprostol or A coxib plus a PPI or misoprostol Coxib: specific cyclo-oxygenase-2 inhibitor, NSAID: nonsteroidal anti-inflammatory drug, PPI: proton-pump inhibitor Figure 2: Management algorithm for frequent or ongoing nonsteroidal anti-inflammatory drug therapy 4,7,9 effective blood pressure control. The NSAIDs (both nonselective and selective) antagonise most of the important agents used to manage arterial hypertension, thus aggravating this condition. 7,9 As stated previously, the cardiovascular profile of the NSAIDs differs among the various drugs, and currently naproxen appears to be the safer choice (Figure 2), particularly when compared to diclofenac, which presently carries a restrictive warning, especially when used in patients with an existing cardiovascular profile, such as high blood pressure, raised blood cholesterol, diabetes mellitus or smoking. 4,7,9 A fixed-dose combination containing 500 mg of naproxen and 20 mg of esomeprazole (Vimovo ) was introduced to the South African market towards the end of This product effectively combines the nonsteroidal, anti-inflammatory action of naproxen Gastrointestinal effects when compared to the latter Erosive gastritis, dyspepsia, gastritis, diarrhoea, Nonselective gastric ulceration, upper abdominal pain NSAID only and nausea were commonly observed adverse reactions that were reported and associated during the conduct of clinical trials on the fixed-dose combination. It remains a recommendation, as for all NSAIDs and coxibs, that the lowest effective dose should be utilised, for the shortest possible duration, based on the patient s individual treatment plan. 14 Pathophysiology of nonsteroidal anti-inflammatory drug-induced gastric damage and related toxicities The NSAIDs, including aspirin, cause gastric mucosal damage in two very specific ways (Figure 3), namely: 16 Systemic inhibition of endogenous mucosal prostaglandin synthesis Direct or topical irritation of the gastric epithelium S Afr Pharm J 12

4 Mechanisms of action Detrimental physiological effects Result X Protection of the mucosa COX-1 inhibition Blood flow is reduced Injury to the gastric mucosa Taking a NSAID Topical irritation Epithelial damage COX-2 inhibition X Adhesion of white blood cells inos NO production, PMN activation and the formation of oxygen radicals Inflammation Prostanoids that promote oedema, fever, pain and healing inos: inducible nitric oxide synthase, NO: nitric oxide, PMN: polymorphonucleocyte, X: inhibition by the nonsteroidal anti-inflammatory drugs, COX-1: cyclo-oxygenase-1, COX-2: cyclooxygenase-2, NSAID: nonsteroidal anti-inflammatory drug Figure 3: Pathogenesis of gastric damage induced by nonsteroidal anti-inflammatory drugs, including aspirin 16 Table II: The regulation and location of the cyclo-oxygenase isoforms 16 Where they are normally found Functions COX-1 COX-1: cyclo-oxygenase-1, COX-2: cyclo-oxygenase-2 Mostly found in body tissue, which includes the stomach, kidney, intestines and platelets Produces protective prostaglandins which regulate physiological processes, such as: Gastrointestinal mucosal integrity Platelet homeostasis Renal function COX-2 Undetectable in most tissues during normal physiological conditions, but is particularly expressed in inflammatory conditions and arthritis Mostly induced unregulated through inflammatory stimuli, such as cytokines, which then produce the prostaglandins responsible for fever and pain Is also expressed under normal physiological circumstances in the brain, kidneys and reproductive tract The systemic inhibition of endogenous, mucosal prostaglandin synthesis is the result of inhibition of the COX enzyme. COX is the rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, and is inhibited by the NSAIDs. Two COX isoforms have been identified, namely COX-1 and COX-2 (Table II). 16 The side-effects associated with the NSAIDs are owing to the nonselective inhibition of COX-1, while their anti-inflammatory properties are because of the inhibition of COX-2. The nonselective or traditional NSAIDs, e.g. ibuprofen and diclofenac, inhibit COX-1 and COX-2, whereas the selective COX-2 inhibitors, e.g. celecoxib, are highly-selective inhibitors of the COX-2 isozyme. 16 So why is COX-2 still associated with adverse outcomes? The original hypothesis was that selective COX-2 inhibitors would spare COX-1-mediated prostaglandins, and only inhibit the production of COX-2-mediated prostaglandins involved in the inflammatory process. 17 However, COX-2 is actually involved in mucosal defence and repair, and it seems that both the COX isoforms are responsible for the physiological processes of tissue injury. It did not seem that the inhibition resulted in significant gastric damage in animal studies when COX-1 was selectively inhibited. 17 In other studies in which selective COX-2 inhibitors were compared to nonselective or traditional NSAIDs for gastric complications, they produced severe complications less frequently than the NSAIDs, but when compared to placebo, clinically significant injuries appeared more frequently than those in the control group. 17 The addition of aspirin to a selective COX-2 regimen further reduces the benefit of the ulcer-sparing abilities and increases the ulcer. 16 The use of clopidogrel and other medicines that impair S Afr Pharm J 13

5 angiogenesis does not cause ulcers, but rather prevents the healing of gastric erosions that may lead to ulceration and bleeding. 16 Angiogenesis is important for the repair of mucosal disruptions. 18 Furthermore, following the administration of NSAIDs, leukocytes (mostly neutrophils) tend to adhere to the vascular endothelium of the gastric microcirculation. This seems to be a critical event in the formation of gastric ulcers. When this step was inhibited in laboratory animals, it seemed as if the gastric ulcers were prevented. 17 However, neutrophil adhesion in the vascular endothelium contributes to NSAID-induced gastropathy in two ways, namely the: Physical obstruction of capillary blood flow Release of tissue-damaging proteases and oxygen-derived free radicals, once the neutrophils have been activated. The inhibition of COX-2 induces neutrophil adherence when NSAIDs are administered. Thus, when a selective COX-2 inhibitor is administered, it may spare much of the total prostaglandin synthesis by the mucosa. 17 It also triggers the key event in the pathogenesis of NSAID-induced gastropathy. 17 When comparing traditional NSAIDs and coxibs, celecoxib is known to cause less harm to the tract because of the mechanism by which this drug selectively inhibits COX Geriatric patients may still experience intolerance (17%), although the occurrence is lower than that when using traditional NSAIDs (21-30%). 19 The topical irritant properties associated with the NSAIDs are mostly linked to the more acidic drugs, such as aspirin (Table III). 16 This is because of their ability to decrease the hydrophobicity of the mucous gel layer in the gastric mucosa. 16 Aspirin is the most damaging of all the NSAIDs, although most of them have topical irritant effects. 16 Other formulations of NSAIDs, e.g. prodrugs, Table III: The minor and major gastroinstestinal adverse effects of the nonsteroidal anti-inflammatory drugs 16 Minor effects Dyspepsia, nausea and heartburn are reported as the most common side-effects of NSAIDs, occurring mostly in the upper tract. Patients notice these side-effects and can be readily diagnosed at the clinic. Various effective gastroduodenal protective approaches to control the sideeffects have been reported NSAIDs: non-steroidal anti-inflammatory drugs Major effects More serious symptoms occur in the distal segment of the tract, for example, diaphragm disease (a rare condition that is associated with the long-term use of NSAIDs). All NSAIDs are known to cause these effects. Minor effects are noted easily by the patients themselves, whereas major effects which occur with respect to the lower part of the tract are not noted as readily. Limited options are available to control such serious effects parenteral formulations, rectal preparations and entericcoated aspirin, may be associated with less acute topical gastric mucosal injury, but may still be involved in varying degrees of toxicity owing to their systemic inhibition of endogenous prostaglandins. 16 Pharmacotherapeutic strategies for the prevention and treatment of nonsteroidal anti-inflammatory drug-related ulcers Identifying a profile for patients using nonsteroidal anti-inflammatory drug-associated adverse events The of a NSAID-induced ulcer may be reduced by substituting the NSAID with a non-nsaid analgesic, such as paracetamol. This may not necessarily be feasible, especially in a patient with a severe, debilitating inflammatory condition, such as arthritis. Figure 2 depicts a possible algorithm for managing vulnerable patients on long-term NSAIDs, and those who also have cardiovascular factors. It illustrates the following basic principles: 6,15 When a patient requires long-term NSAID therapy, the need for the NSAID should be reviewed and alternative approaches to treatment considered If no other alternative exists, the NSAID should be used at the lowest possible effective dose for the shortest possible period If the patient is going to be on long-term NSAID-therapy, a and cardiovascular profile should be completed using the patient s history, physical examination findings and laboratory investigations, as needed The lowest effective dose of aspirin should be initiated in patients with an increased cardiovascular Naproxen may be used in patients with a low and high cardiovascular because it has the lowest cardiovascular profile in the group If a patient needs naproxen and aspirin, the addition of a gastroprotective agent, such as a PPI should be considered Testing for Helicobacter pylori in patients with a high- of NSAID-related bleeding should be considered A COX-2 inhibitor and a PPI may offer good protection in a patient who also has a very high of an upper event. When a patient has both a high and cardiovascular profile, then NSAIDs should be avoided. If this cannot be avoided altogether, then the physician should prioritise the cardiovascular and the s. If the is the primary concern, a COX-2 inhibitor plus a PPI can be used. If the cardiovascular is the primary concern, then naproxen and a PPI should be considered, especially if the patient is already on aspirin. S Afr Pharm J 14

6 Other treatment options Misoprostol Ulcer prophylaxis may be achieved by using misoprostol when the patient has to remain on NSAID therapy. 6,20 As a synthetic PGE 1 analogue, misoprostol replaces the cytoprotective prostaglandins that are depleted by the NSAIDs from the mucosa. 6,20 The efficacy of misoprostol in preventing ulcers in patients using NSAIDs has been demonstrated in various studies, and proven to be above the use of placebo. 6,20 Although the use of misoprostol has been demonstrated to reduce the of events, it has also been proven to have its own spectrum of side-effects. Side-effects associated with the use of misoprostol include abdominal pain, nausea and diarrhoea, and it should be avoided in women of childbearing potential. 6,20 The side-effect profile and the frequent dosing needed with misoprostol makes compliance with therapy increasingly difficult, and comparative studies have shown that the PPIs may be more effective in patients with NSAID-induced gastric ulceration. 6 A significant difference was not found between PPIs and misoprostol in preventing endoscopic ulcers in head-to-head studies that compared the PPIs to either low-dose or high-dose misoprostol. However, PPIs have proven to be superior in the prevention of duodenal ulcers. 20 A less frequent association with endoscopically diagnosed ulcers has been demonstrated with the fixed-dose combination of misoprostol and diclofenac (Arthrotec ). 6 The incidence of sideeffects with misoprostol is dose-dependent. However, reducing the dose reduces both the side-effects and efficacy. 6 Sucralphate Sucralphate is a basic aluminium salt of sucrose octasulphate, which forms an adherent complex at the duodenal ulcer sites. 6,16 It may be beneficial to use when treating NSAID-induced duodenal ulcers provided that the causative NSAID has been stopped. 6,16 Sucralphate has not been shown to be effective in the prevention of NSAID-related gastric ulcers, and thus its routine use for this purpose is not recommended owing to the availability of superior therapeutic options. 6,16 Histamine 2-receptor antagonists (cimetidine, ranitidine, famotidine and nizatidine) These agents act by competitive inhibition of the action of histamine at the histamine-2 (H 2 )-receptor site on the gastric parietal cell, thereby modulating gastric ph. 6 Standard doses of the H 2 -receptor antagonists (H 2 RAs) may be effective in reducing NSAID-induced duodenal ulcers, but not gastric ulcers (the ulcer type most frequently associated with NSAIDs). 16 The use of H 2 RAs at higher doses, e.g. famotidine 20 or 40 mg twice daily, may reduce the incidence of gastric and duodenal ulceration. 6,16 Having stated that, it is not recommended for these agents to be used routinely in asymptomatic patients receiving NSAIDs since this may mask dyspeptic symptoms associated with mucosal injury. 6,16 PPIs have been demonstrated to be superior in healing gastroduodenal ulcers in patients using NSAIDs and are more effective in preventing ulcer recurrence. 6,16 Proton-pump inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole and pantoprazole) PPIs bind irreversibly to the proton pump (H + -K + -ATPase), inhibiting basal and stimulated gastric acid secretion. 6,15,16 They are administered as prodrugs that are activated in the acidic environment of the parietal cells. 6 Lansoprazole has been proven to protect and heal the gastric mucosa following gastric damage induced by the NSAIDs. This is achieved via a novel mechanism of action, which uses an anti-apoptotic action mediated through regulating the factors involved in the mitochondrial and Fasmediated death pathways of apoptosis. 21 In addition to inhibiting acid secretion, lansoprazole also seems to offer gastroprotection through the inhibition of apoptosis and the stimulation of cell survival and proliferation. 21 After 3-4 days of therapy, the degree of acid suppression increases as more of the proton pumps are inhibited. They only act on actively secreting proton pumps. Thus, they should be taken minutes prior to having a meal. The PPIs are available in various dosage forms and formulations, which include delayed-release, enteric-coated doses that have ph-sensitive granules in a gelatine capsule, rapidly disintegrating capsules and delayed-release enteric-coated tablets. Similar healing times are seen in the five commonly available PPIs, i.e omeprazole, lansoprazole, rabeprazole, pantoprazole and esomeprazole, with similar maintenance times for ulcer healing and symptom relief, when used at the recommended dose. 6,16 In conclusion, the PPIs, especially when used as co-therapy to NSAIDs, reduce the of NSAID-induced gastric and duodenal ulcers, and are better tolerated than misoprostol. All of the PPIs are equally effective when used at standard doses, and they reduce the of NSAID-related ulcer bleeding. 6,16,21 Chronic use of PPI therapy may be associated with an increased of infection and nutritional deficiencies as gastric acid plays a role in the defence against bacterial colonisation and nutrient absorption. 6,16 Patients should be carefully monitored when using chronic therapy with the PPIs. 6,16,21 Cyclo-oxygenase-2 inhibitors (celecoxib and etoricoxib) With concerns regarding their cardiovascular safety and the recent information on their related toxicity, the use of COX-2 inhibitors should be evaluated on a case-by-case basis, with the s carefully weighed against the benefits for each patient. Celecoxib is no longer considered to be a truly selective COX-2 inhibitor as the same warnings apply as those for the non-selective NSAIDs. 6,16 There seems to be a dose-dependent correlation in cardiovascular toxicity with celecoxib. 6,16 The increase in cardiovascular toxicity S Afr Pharm J 16

7 appears to relate to the dose and duration of use. 6,16 When using these agents, they should be given at the lowest possible dose, for the shortest possible duration. 6,16 The gastric side-effects of the COX-2 inhibitors appear to be similar to those of the nonselective NSAIDs, namely dyspepsia, abdominal pain, fluid retention, hypertension and renal toxicity. 6,16 Renal effects The pathophysiological role of prostaglandins in the kidney The normal function of COX-1 in the kidney is to control renal haemodynamics and the GFR. The function of COX-2 affects water and salt excretion. 21 NSAIDs can cause both acute and chronic renal failure. Various forms of decreased renal function or renal failure have been observed. 19 A reduced glomerular filtration rate (GFR) The GFR is indicative of damage to the renal system. When a patient presents with either acute renal failure (ARF) or chronic renal failure (CRF), a reduction in the GFR is noted. 19 Acute renal failure (AFR) ARF is a rapid and sustained disruption of the normal kidney function which leads to an accumulation of waste products (urea and creatinine). ARF, as a potential side-effect of NSAID usage, is duration and dose-dependent, and reversible. The mechanism though which the NSAIDs can cause ARF is via their inhibition of the production of prostaglandins, and the resultant decrease in blood flow to the kidneys. Patients with a past history of heart failure, hypertension or diabetes mellitus have a higher of developing ARF, secondary to taking NSAIDs, than patients with normal renal function. The concomitant use of angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, the aminoglycosides and diuretics, pose an increased for the development of ARF. 19 Renal papillary necrosis Renal papillary necrosis (RPN) is a kidney disorder that is characterised by the destruction of parts of, or all of, the renal papillae. NSAID-induced RPN is caused by the resultant lack of blood flow to the renal papillae, with the result that hypoxia occurs in these structures. Several of the NSAIDs, including celecoxib, can cause RPN, and the patient presents with high levels of urea and creatinine in the bloodstream. 19 Nephrotic syndrome with acute interstitial nephritis NSAIDs can cause nephrotic syndrome, owing to their inhibition of COX that would normally increase the production of arachidonic acid cascade products. Patients with nephrotic syndrome can present with oedema, proteinuria, foamy urine, oliguria and haematuria. NSAIDs can also cause acute interstitial nephritis (AIN) owing to inflammation in the interstitial spaces between the kidney tubules, or because of hypersensitivity reactions to these drugs. AIN is a rare disease, is reversible, and may already be present within days of NSAID exposure. 19 Chronic renal failure (CFR) NSAIDs can cause CRF owing to interstitial nephritis or papillary necrosis. Patients are at much greater of developing CRF if they previously suffered from ARF. Any NSAID that is used on a chronic basis can potentially cause CRF in selected patients. 19 Conclusion The use of NSAIDs should be reserved for patients suffering from debilitating musculoskeletal conditions, e.g. osteoarthritis, and only when the benefit outweighs the. NSAIDS (nonselective and selective) should be used with caution in patients with preexisting cardiovascular conditions, and the physician should select the NSAID with the lowest possible to the patient s current condition, i.e. ensure that it is used at the lowest effective dose, and for the shortest possible period. It was once believed that only nonselective or traditional NSAIDs were the causative agents, but selective COX-2 inhibitors have now also been shown to be associated with untoward side-effects. An individualised assessment of a patient s current disease state and medication use is required to prevent NSAID-related ulceration. More importantly, the patient should be assessed for his or her degree of in terms of, cardiovascular and renal toxicities. References 1. Farkouth ME, Greenberg BP. An evidence-based review of the cardiovascular s of nonsteroidal anti-inflammatory drugs. Am J Cardiol. 2009;103(9): Olsen AS, Fosbøl EL, Lindhardsen J, et al. 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