Macrophages: the overlooked target for pulmonary fibrosis and COPD Boorsma, Carian Eline

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1 University of Groningen Macrophages: the overlooked target for pulmonary fibrosis and COPD Boorsma, Carian Eline IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2016 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Boorsma, C. E. (2016). Macrophages: the overlooked target for pulmonary fibrosis and COPD [Groningen]: Rijksuniversiteit Groningen Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:

2 Macrophages: the overlooked target for pulmonary fibrosis and COPD Carian Eline Boorsma

3 Noordelijke Cara Stichting The work described in this thesis was performed at the Department of Pharmacokinetics, Toxicology and Targeting at the University of Groningen, The Netherlands. The research project was financially supported by a grand from the Dutch Northern Cara Foundation (Noordelijke Cara Stichting) and the Pender Foundation (Pender Fonds). Research communication was made possible by financial support from the Dutch Respiratory Society (Nederlandse Respiratory Society) and the lung fund (het Longfonds). Printing this thesis was financially supported by the University of Groningen and Greiner bio-one. Macrophages: the overlooked target for pulmonary fibrosis and COPD copyright 2016 Carian Eline Boorsma All rights reserved No part of this thesis may be reproduced or transmitted in any form or by any means without prior written permission from the author. isbn: isbn electronic version: Cover: Graphical display of the lungs with three windows showing the inside structure of the lungs Cover design: Bert Holtkamp Layout: Bert Holtkamp Illustrations: made possible by lipi, curve, Andrejs Kirma, Katrin Leo Pako, Wes Breazell, David Padrosa and Nut Chanut from the Noun Project. Illustrations design: Nina Boorsma Printing: Ridderprint BV

4 Macrophages: the overlooked target for pulmonary fibrosis and COPD Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op vrijdag 2 december 2016 om uur door Carian Eline Boorsma geboren op 18 maart 1987 te Groningen

5 Promotores Prof. dr. B.N. Melgert Prof. dr. W. Timens Prof. dr. K. Poelstra Beoordelingscommissie Prof. dr. R. Gosens Prof. dr. M.C. Harmsen Prof. dr. J.C. Grutters

6 Paranimfen Fransien van Dijk Nina Eliisa Boorsma

7

8 Er gebeurt meer achter de schermen dan je ziet op het toneel.

9

10 Inhoud Chapter 1 General introduction 11 Chapter 2 The RANK/RANKL/OPG axis has a role in regulating tissue repair processes in lung 43 Chapter 3 A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages 77 Chapter 4 Current smoking is associated with fewer CD16+ monocytes in peripheral blood of male healthy controls and patients with COPD 105 Chapter 5 Characterization of Interstitial Macrophages Around Airways of Current and Ex-smoking COPD Patients and Controls 123 Chapter 6 General discussion 141 Chapter 7 APPENDIX PATENT 155 Chapter 8 Dankwoord 198 Curriculum Vitae 203 List of publications 204

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