Pulmonary deposition of inhaled drugs

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1 Pulmonary deposition of inhaled drugs Federico Lavorini Dept. Experimental and Clinical Medicine Careggi University Hospital Florence - Italy

2 Presenter Disclosures F.L. has received in the last 5 years fees for lectures, advisory boards and reimbursements for attending meetings from the following pharma companies: - AstraZeneca, - Boehringer Ingelheim, - CIPLA, - Chiesi, - Mundipharma, - TEVA. The content of this talk represents the personal opinion of the presenter and does not necessarily represent the views or policy of the A.O.U. Careggi.

3 The efficacy by which inhaled drug particles reach the target site in the lung is determined by: Throat deposition Penetration of the particles into the airways Sedimentation Deposition of the particles on the wall of the airways Exhalation Deposition is the process by which an aerosol particle leaves the airstream and is retained on the epithelium Bisgaard H, O Callaghan C, Smaldone GC. Drug delivery to the Lungs, 2002

4 Factors Influencing the Lung Deposition of Medical Aerosols Aerosol Characteristics Particle size Particle density Particle charge Aerosol plume speed & duration Lipophilicity Hygroscopicity Patient Factors Inhalation technique - Inspired volume - Inspiratory flow - Breath hold pause Airway disease & severity Device acceptance Compliance Labiris & Dolovich, Br J Clin Pharm 2003

5 Factors Influencing the Lung Deposition of Medical Aerosols Aerosol Characteristics Particle size Particle density Particle charge Aerosol plume speed & duration Lipophilicity Hygroscopicity Patient Factors Inhalation technique - Inspired volume - Inspiratory flow - Breath hold pause Airway disease & severity Device acceptance Compliance Labiris & Dolovich, Br J Clin Pharm 2003

6 1: PARTICLE SIZE But before we get started.... Some terms used to describe an aerosol

7 Aerosol particles can be considered small spheres with a diameter and a density. Mass Median Aerodynamic Diameter (MMAD) is defined as the diameter at which 50% of the particles are larger and 50% are smaller. Geometric Standard Deviation (GSD) is a measure of the spread of an aerodynamic particle size distribution. MMAD

8 Monodisperse aerosol: particles with the same size (GSD<1.2).Example: laboratory generated aerosols Polydisperse aerosol: particles include a widerange of sizes (GSD >1.2). Example: therapeutic medications range from 2-3 Fine Particle Fraction (FPF): The proportion of particles within the aerosol with MMAD <5 µm, or fine particle dose if expressed in absolute mass of drug in particle with MMAD<5 µm.

9 MMAD, GSD, FPF are the most frequently used terms to describe an aerosol Andersen Cascade Impaction Aerodynamic Particle Size Distribution A series of 8 stages reflecting the progressive decreasing in size of the airways

10 Inhaled dose

11 Deposition: main mechanisms - Inertial transport (impaction): large particles (6-10 μm); high flow velocity; mainly in the upper and large airways. - Gravitational transport (sedimentation): small particles (0.5-6 μm); low flow velocity; timedependent transport mechanism; mainly in the lung periphery lower generations where the velocity is low and airway is small. - Diffusional transport (diffusion): very small particles (< 0.5 μm); low flow velocity; timedependent transport mechanism; mainly in the alveoli due to long residence time. Courtesy by AH de Boer

12 Sedimentation takes time Sedimentation (under influence of the force of gravity) takes time and the stationary settling velocity decreases with the square of the diameter The time necessary to fall a distance of 0.5 mmm for a particle of: 1 µm is 16.5 s 2 µm is 4.2 s 4 µm is 1,0 s

13 Relationship between the impaction parameter and the oropharyngeal deposition Oropharyngeal deposition becomes higher when the flow rate is increased and the effect is greater for larger particles Recalculated from: Usmani et al., Am J Respir Crit Care Med 2005; 172:

14 Particle size: Summary Inertial impaction in the larger airways depends on particle diameter (D) and particle flow rate ( ), Sedimentation in the smaller airways depends on particle diameter (D) and particle residence time

15 Where do most inhaled aerosols deposit in the healthy human adult male respiratory tract? «Respirable range» Chrystyn, Allergy 1999

16 Patient with cystic fibrosis after inhalation of 7- and 3-μm radiolabelled carbenicillin aerosols

17 Gamma camera images of 99m Tclabelled salbutamol monodisperse aerosols in one asthma patient. 1.5µm 3µm 6µm 1.5µm 3µm 6µm 1,5 μm Posterior thorax 3,0 μm 6,0 μm Smaller Particles = Good Lung & Peripheral Deposition; Low Oropharyngeal Deposition

18 % Regional Lung Deposition Small Particles = High Total Lung Deposition 75 Central (C) + Intermediate (I) Zone Peripheral Zone (P) 50 TLD µm 3µm 6µm 0 Usmani, AJRCCM 2005 Small Particles = Better Peripheral Deposition

19 % Deposition Small Particles = Low Oropharyngeal Deposition * 1.5µm 3µm 6µm * * * Oro-P * * 0 Lung O Lung O Lung O O = Oropharyngeal * p<0.05 Usmani, AJRCCM 2005

20 % Deposition % Deposition Small Particles = Exhaled less vs. in vitro data µm 3µm 6µm 1.5µm 3µm 6µm * * * L O E L O E L O E * L Total Lung Deposition, O Oropharyngeal, E Exhaled * * * p< p<0.05 Usmani, AJRCCM 2005

21 2. Aerosol plume speed & duration

22 Duration [s] Respimat: aerosol characteristics Velocity at 10 cm distance from orifice [m/s] 1,6 1,4 Respimat Duration 10 9 Velocity 1,2 1, HFA-MDI CFC-MDI 0,8 5 0,6 4 0,4 0,2 HFA-MDI CFC-MDI Respimat 0,0 0 Hochrainer Hochrainer et et al al J J Aerosol Aerosol Med Med Respimat may reduce the need of hand-breath coordination!

23 Proportion of emitted dose (%) Particle size distribution for Respimat ~ 45% in the range < < < < < < < < <10.0 ³10.0 Andersen cascade impactor data Fine particle range (µm) Zierenberg B. J Aerosol Med 1999

24 Lung Deposition se (% dose) Lungs Oropharynx Device Exhaled 20 0 Respimat pmdi + spacer

25 Drug delivery to the lungs with Respimat is more efficient than with HFA-pMDI, even in patients with poor inhaler technique.

26 3. Airway disease & severity

27 Total deposition of particles is increased in patients with obstructive airway disease, and correlates with FEV 1.

28 Quiet breathing Flow limitation 6 subjects with induced flow limitation Regional deposition patterns is affected by airway obstruction with a shift of particles deposition from lung periphery towards proximal airways.

29 Particles deposition is less uniform with enhanced focal distribution («hot spots») of deposited particles with increasing dose of metahcoline (MCh).

30 Small Particles (MMAD 1.5µm) Achieve Consistent Lung Deposition in Varying Airflow Obstruction De Backer, JAMPDD 2010 Healthy Asthma COPD FEV 1 112% pred) FEV 1 71% pred) FEV 1 44% pred) 34% 31% 33% Scintigraphic images show consistency in lung deposition in different disease groups

31 4: BREATHING PATTERN & INHALATION MANOUVRE

32 Breathing pattern harldy affects the shape of the deposition curve, but it can shift the curve up and down affecting deposition values across the entire range of particle size.

33 Fixed f (15 breaths/min) Fixed Q (250 ml/s) Particles 3 and 5 μm: total deposition increases by rising VT; Particles 1 μm: total deposition unaffected by VT increases; Particles 1-5 μm: total deposition increases by rising both VT and f;

34 Deposition shifts to larger airways when the flow rate is increased Deposition fraction Airway generation PR Byron: Respiratory Drug Delivery. CRC Boca Raton 1990; 1 38.

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37 Crucial differences between device types

38 Deposition (% emitted dose) Lung deposition of small-particle aerosol under coordinated and dis-coordinated conditions N=7 asthmatics, FEV 1 91% pred. Lung Oropharynx pmdi pmdi pmdi ON TIME EARLY LATE Leach et al J Aerosol Med 2005

39 % Total Lung Deposition (TLD) Small Particles = Less Affected by Inhalation Flow 75 FAST: >60 litres/ min = SLOW: litres/ min 50 * TLD 25 * p< µg dose 1.5µm 3µm 6µm Slow Fast Slow Fast Slow Fast SLOW Inhalation is better Usmani, AJRCCM 2005

40 Δ FEV 1 (ml) Inhalation flow rate can affect clinical outcomes Patients with stable, mild-to-moderate asthma (n=12) Monodispersed salbutamol aerosols of three different diameters 750 p < 0.05 p < 0.05 p < Slow inhalation Fast inhalation μm 3.0 μm 6.0 μm Aerosol diameter Usmani et al. Am J Respir Crit Care Med 2005; 172:

41 Crucial differences between device types

42 Powder formulations are always agglomerated (particles 1 5 m) Adhesive mixtures Soft (spherical) agglomerates/pellets Frijlink & de Boer. Expert Opinion on Drug Delivery 2004; 1(1): 67-86

43 Particle emission from a DPI and the inhalation flow Inhalation flow Dose emission from a reservoir DPI Patient s inhalation flow Profile through a DPI Each inhalation should be as fast as you can from the start and for as long as possible Dose emission from a capsule DPI Time Adapted from Bisgaard et al Eur Respir J 1998

44 DPI OPERATING PRINCIPLE Airflow Generated By Patient s Inspiratory Effort Inspiratory Force Flow & Pressure De-aggregation Fine Particle Mass Drug Lactose Turbulent Energy: P = Q x R Q = Inhalation Flow R = Inhaler resistance..for an inhaler with a low resistance you need a very high inhalation flow whereas for a higher resistance you need a low inhalation flow... Chrystyn et al. Am J Respir Crit Care Med 2001

45 Inspiratory flow resistance (kpa 0.5 L/min -1 ) Inspiratory flow rate (L/min) Inhaler resistance and the corresponding flow to achieve 4 kpa pressure drop

46 Flow rate (L/min) Breezhaler Diskusr Aerolizer ELLIPTA Inhaler resistance + Genuair Turbohaler NEXThaler Twisthaler Q = Easyhaler 1 R inh dp dp = Q X R inh HandiHaler Pressure drop (kpa) Inspiratory flow Pressure drop Inhaler resistance..with a low resistance inhaler you need a higher inhalation flow than with a high resistance inhaler. Modified from Al-Showair et al Resipr Med 2007; P. Krüger et al ERS meeting 2014

47 Fine Particle Dose (%) DPI Lung Dose Alters with Inhalation Flow Turbuhaler Aerolizer Accuhaler 10 THROAT DEPOSITION Inhalation Flow (l/min) In vitro data do not necessarily correlate with clinical effectiveness Palander, Clin Drug Invest 2000; Weuthen, J Aerosol Med 2002

48 Mean delivered ICS fine particle fraction (FPF) as function of kpa (in vitro) DPI Resistanc e Flow rate (4 kpa) (kpa 0.5.min.L - 1 ) (L/min) Turbuhaler NEXThaler Ellipta* 0, ,5 Diskus # # # # * Similar results for 2 -agonist Elpenhaler #, data from 1;*, data from 2 In vitro data do not necessarily correlate with clinical effectiveness Adapted from: 1 De Boer et al. Eur J Pharm Biopharm 2015; 2 Grant A et al JAMPDD 2015.

49 Let s classify DPIs Inhalation flow dependent High - intermediate resistance Turbuhaler Diskus Inhalation flow dependent Low resistance Pulvinal Jethaler Easyhaler Inhalation flow independent High-intermediate resistance Novolizer Cyclohaler Aerolizer Handihaler Inhalation flow independent Low resistance Diskhaler Aerohaler Clickhaler Spinhaler Gyrohaler Pictures from ADMIT homepage

50 Effect of different flows on airway deposition: an invitro study comparing Diskus vs Novolizer With Diskus the central and peripheral deposition decreases when the flow is increased. With Novolizer the central and peripheral deposition remains fairly constant at all flow rates. Courtesy by A.H. De Boer

51 Delivered dose (µg) Delivered dose (µg) 100 Beclomethasone Dipropionate Formoterol L 4L Flow rate (L/min) Flow rate (L/min) 0

52 SUMMARY The advantages of pulmonary delivery of aerosolized therapeutic drugs have resulted in many classes of drugs and inhalers now available for this route of delivery. However, there are many challenges to optimizing delivery of aerosolized drugs by the pulmonary route. Be aware of the effect of particle size on pulmonary aerosol deposition. Understand the needo for specific inhalation maneuvers to optimize pulmonary delivery of therapeutic medications with available devices.

53 THANKS FOR YOUR KIND ATTENTION Questions? That s a great question!! Come to think of it, I m not sure what it is I was trying to tell you

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57 Regional deposition patterns is altered with increasing severity of airway obstruction healthy subject Patients with various degrees of airway obstruction FEV = 25% FEV = 45% FEV 1 = 50% FEV = 60% Laube BL et al Respiratory Care 2005

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