Responsible Respiratory Prescribing

Transcription

1 Responsible Respiratory Prescribing Dr Vincent Mak Consultant Physician in Respiratory Integrated Care Imperial College Healthcare and Central London Community Healthcare NHS Trust NHS England (London) Respiratory Clinical Leadership Group IPCRG Athens May

2 Disclosures for Dr Vincent Mak In compliance with COI policy, IPCRG 2014 requires the following disclosures to the session audience: Research Support/P.I. Employee Consultant Major Stockholder Speakers Bureau Honoraria No relevant conflicts of interest to declare No relevant conflicts of interest to declare Secondary Care consultant working in Primary Care No relevant conflicts of interest to declare No relevant conflicts of interest to declare AZ, GSK, Boehringer Ingelheim, Novartis Scientific Advisory Board No relevant conflicts of interest to declare Presentation includes discussion of the following off-label use of a drug or medical device: Nil

3 Responsible Prescribing should be based on: Evidence- Based Efficacy (Grade A) Safety (primum non nocere) Value (cost effec>veness) clinicians will need to accept that they are responsible for the stewardship of resources and not just their use Sir Muir Gray BMJ Oct

4 Value Framework Health Outcomes Value = Health Outcomes Cost of delivering Outcomes Cost Porter ME; Lee TH NEJM 2010;363: ;

5 RIGHT CARE RIGHT CARE Do the right thing Do the right thing right Doing the right thing right first -me should deliver quality and value

6 ADDING VALUE by RIGHT CARE High Value High Value High Value Low Value Low Value Added value from doing things right (quality improvement) Added value from doing the right things (making the right decisions)

7 COPD London Respiratory Team Value Pyramid - Cost/QALY

8 To understand VALUE you have to know COST

9 Top 5 Costliest drugs in the NHS (June 2013)? 5. Sere-de 125 evohaler - 81 million/yr 4. Sere-de 500 accuhaler - 85 million/yr 3. Symbicort million/yr 2. Tiotropium million/yr 1. Sere>de 250 evohaler million/yr Total for high potency Seretide: 265million Source:

10 Top 5 Costliest drugs in the NHS (Dec 2013)? 5. Sere-de 125 evohaler - 71 million/yr 4. Sere-de 500 accuhaler - 94 million/yr 3. Symbicort million/yr 2. Sere-de million/yr 1. Tiotropium million/yr Thus, the top 5 costliest drugs to the NHS currently, ALL ARE RESPIRATORY INHALERS Total for high potency Seretide: 252million Source: NHSBSA

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13 Are we doing the right thing?

14 COPD London Respiratory Team Value Pyramid - Cost/QALY

15 Doing the right thing? 15 NHS Presentation to [XXXX Company] [Type Date]

16 16 Doing the right thing 2?

17 Evidence Based Prescribing?

18 BTS/SIGN Asthma Guidelines Does this mean majority of asthmatics are at Step 4+ of BTS guidelines?

19 COPD NICE Guidance

20 Evidence of Overuse of Inhaled Cor>costeroids in COPD De la Rosa et al. ERJ 2011: P4627

21 Evidence from UK White P et al. PLoS One Oct 23;8(10):e doi: /journal.pone ecollection 2013.

22 COPD London Respiratory Team Value Pyramid - Cost/QALY

23 The low value pyramid? Representation based on national GP contract data and locally retrieved data

24 Are we doing it right?

25 Doing the Right Things Right Inhaler Technique In some studies, up to 90% of pa-ents may not be able to use an MDI effec-vely 91% of healthcare professionals who teach use of an MDI cannot demonstrate it correctly* Even with effec-ve technique, lung deposi-on from an MDI is at best 12% (excluding newer fine par-cle inhalers)** Large volume spacer may be easier to use and may increase deposi-on to over 20%** If used incorrectly a lot of the drug from MDI is wasted *Thorax 2010;65:A117 ** Newman S. Chest 1985; 88: 152S-160S

26 ] Is it Safe?

27 Risks of high dose ICS HPA suppression D Price et al. Prim Care Respir J 2012;

28 What can we do?

29 Responsible Respiratory Prescribing Key Messages 1. Respiratory medica>ons are expensive Doing the Right Things: 2. When prescribing any new respiratory inhaler, ensure that the pa-ent has undergone NICE- recommended support to stop smoking 3. Pulmonary rehabilita-on is a cost effec-ve alterna-ve to stepping up to triple therapy and should be the preferred op-on if available and the pa-ent is suitable. Doing the Right Things Right: 4. When prescribing any inhaled medica-on, ensure that the pa-ent has undergone pa-ent centred educa-on about the disease and inhaler technique training by a competent trainer 5. When prescribing an MDI (except salbutamol), ensure that a spacer is also prescribed and will be used 6. When prescribing high dose inhaled cor-costeroids (>1000ug BDP equivalent?), ensure that the pa-ent is issued with an inhaled steroid safety card

30 Minimise Risk : Patient Safety Warn about poten>al for adrenal suppression on high doses of ICS Warn about not stopping high dose ICS suddenly

31 Minimise Risk : Minimise waste : Maximise Value Warn about high dose ICS side effects: Pneumonia Diabetes Bone Loss Adrenal Suppression In COPD moderate dose ICS (800µg BDP equivalent) same clinical efficacy as very high dose ICS (2000µg BDP equivalent). In asthma lible evidence for efficacy of ICS above 800µg/day (BTS/SIGN Grade D evidence) Checking inhaler technique, using ICS through a spacer or changing inhaler device may be more effec>ve than increasing the dose or stepping up treatment If dose of ICS has been stepped up in the treatment of asthma and pa>ent is well controlled consider stepping down acer 3 months.

32 Minimise Risk : Increase awareness Traffic light reference card BDP dose equivalence Which inhalers and at what dose may deliver >1000µg BDP equivalent/day Also gives some idea of cost for BDP equivalent doses of different brands of inhaler

33 Inhaled Corticosteroid Safety Card Increase awareness amongst prescribers of: Waste Risk Value Make prescribers aware of alternatives before high dose ICS May change prescribing behaviour as uncomfortable discussion with patient about risk vs benefit

34 It can be done!?

35 Thank You Grainne D Ancona Principal Pharmacist and Honorary Clinical Lecturer St. Thomas' Hospital London, SE1 7EH Colleagues on London Respiratory Team