Targeted Therapeutics for Inflammatory Disease

Size: px
Start display at page:

Download "Targeted Therapeutics for Inflammatory Disease"

Transcription

1 Targeted Therapeutics for Inflammatory Disease Jefferies Global Healthcare Conference June 2015

2 Forward Looking Statements / Safe Harbor This presentation and the accompanying oral commentary contain forward-looking statements that involve substantial risks and uncertainties. All statements other than statements of historical facts contained in this presentation and the accompanying oral commentary, including statements regarding our future financial condition, business strategy and plans and objectives of management for future operations, are forward looking statements. In some cases, you can identify forward-looking statements by terminology such as believe, will, may, estimate, continue, anticipate, intend, should, plan, might, approximately, expect, predict, could, potentially or the negative of these terms or other similar expressions. Forward looking statements appear in a number of places throughout this presentation and the accompanying oral commentary and include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, our ongoing and planned preclinical development and clinical trials, the timing of and our ability to make regulatory filings and obtain and maintain regulatory approvals for AQX-1125 and our future product candidates, our intellectual property position, the degree of clinical utility of AQX-1125 and our future product candidates, particularly in specific patient populations, our ability to develop commercial functions, expectations regarding clinical trial data, our results of operations, cash needs, financial condition, liquidity, prospects, growth and strategies, the industry in which we operate and the trends that may affect the industry or us. Forward-looking statements involve known and unknown risks, uncertainties, assumptions and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. In evaluating these statements, you should specifically consider various factors, including the risks outlined under the caption Risk Factors set forth in our Quarterly Report on Form 10-Q for the quarter ended March 31, 2015, which we filed with the Securities and Exchange Commission ( SEC ) on May 12, 2015 and other reports and filings we will make with the SEC from time to time. Forward-looking statements represent our management s beliefs and assumptions only as of the date of this presentation. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons why actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future. 2

3 A Novel Class of Anti-Inflammatory Therapies AQX-1125, lead SHIP1 activator: Broad anti-inflammatory potential Positive Preclinical and Clinical PoC Ongoing Phase 2 trials: FLAGSHIP (COPD Exacerbations) Top Line Mid-2015 LEADERSHIP (BPS/IC) Top Line Mid-2015 KINSHIP (Atopic Dermatitis) by Q Worldwide rights and patent coverage to 2028 Diverse library of next-generation compounds targeting SHIP1 3

4 Experienced Management David Main, President & CEO INEX Pharmaceuticals, QLT Stephen Shrewsbury, CMO Sarepta, MAP, Chiron, Glaxo Kamran Alam, CFO Angiotech, AnorMED, PwC Lloyd Mackenzie, VP Technical Ops QLT, Inflazyme David Mitchell, VP Global Regulatory Affairs & QA AbbVie, Biogen Idec, Bayer Schering 4

5 Well Capitalized with Large Pharma Investment ~$34.4M cash on hand as at March 31 st, 2015 Cash to mid-2016 and data from all 3 Phase 2 trials. Backed by Large Pharma Investment: Analyst coverage: 5

6 SHIP1 - Nature s Path to Resolve Inflammation Potential Next-Gen Anti-Inflammatory Drugs PI3K All cells PI-4,5-P 2 PIP 3 SHIP1 Immune cells PI-3,4-P 2 PTEN All cells SHIP1 Activators Cancer Cell growth and survival Inflammation Cell activation and function 6

7 Focused Strategy & Broad Opportunities Phase 2 trials supported by preclinical and clinical PoC Mucosal Inflamma-on Unmet Need Short Dura-on Trials Acute Endpoints Exacerba-ons, Flares, Pain Expand into Chronic Endpoints Lung/Airway COPD Exacerbations (Moderate-Severe) Asthma Non-CF Bronchiectasis Churg-Strauss Syndrome Idiopathic Pulmonary Fibrosis Chronic Rhinosinusitis Epidermal Atopic Dermatitis Urinary Tract BPS/IC Glomerulonephritis Gastrointestinal Eosinophilic Esophagitis Crohn's Disease Ulcerative Colitis 7

8 Clinical Development in Large, Underserved Markets Research/Preclinical Phase 1 Phase 2 AQX-1125 SHIP1 Activator Next Gen SHIP1 Activator Completed Ongoing Future SAD / MAD / FE Chronic Obstructive Pulmonary Disease (COPD) PoC Asthma PoC Chronic Obstructive Pulmonary Disease Exacerbations (COPD) Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) Atopic Dermatitis Other Respiratory, Urology, Gastrointestinal Inflammation Immuno-oncology 8

9 AQX-1125 Clinical Program 9

10 Desirable Once Daily, Oral Pharmacokinetics Single Ascending Dose PK Concentration (ng/ml) mg 400 mg 200 mg 100 mg 50 mg 17 mg t 1/2 =~21 h Time (h) 10

11 Phase 2a Proof of Concept Achieved COPD Two different challenge models for multiple inflammatory diseases LPS challenge; model of the inflammatory mechanisms seen in COPD Cross-over trial; 40 volunteers, once daily x 7 Sputum neutrophils, p<0.1; trend analysis other cell counts Asthma Allergen challenge; model of inflammatory mechanisms in allergic response Cross-over trial; 22 mild asthmatics, once daily x 7 Late Asthmatic Response (LAR), p<0.05; trend analysis for sputum cell counts 11

12 COPD PoC: AQX-1125 Inhibits Sputum Neutrophils AQX-1125 met primary endpoint in healthy volunteers CI ( ) CI ( ) 12

13 COPD PoC: AQX-1125 Compares Favorably Robust Inhibition of Inflammation Drug Class % Neutrophil Inhibition AQX-1125 SHIP1 activator 62% Ph p38 MAP kinase Inhibitor 50% Roflumilast (Daxas, Daliresp) PDE4 inhibitor 39% Prednisolone / Fluticasone Corticosteroids No effect 13

14 Current AQX-1125 Phase 2 Development 14

15 COPD Exacerbations Remain Major Problem AQX-1125 s properties and tolerability provide competitive differentiation Approx. 600 million COPD cases globally with million moderate to severe. 25 million affected in the US. Despite numerous therapies, majority of moderate to severe patients still suffer exacerbations High unmet need for effective oral anti-inflammatories that reduce exacerbations, decrease hospitalization and slow/prevent disease progression 15

16 FLAGSHIP: Targeting Exacerbations Objective: Evaluate AQX-1125 in COPD patients post exacerbation ~400 moderate to severe COPD patients from EU, AUS NZ and USA IND Accepted by FDA in June, 2014 Endpoints: Primary: Sized to detect effect of AQX-1125 (200 mg capsule q.d.) vs. placebo on recurrent COPD exacerbations over 12 weeks (reduction of AAC for EXACT-PRO*) utilizing ediaries Secondary: CAT, PFT, safety, PK, healthcare utilization (rescue meds / hospitalization) Key Milestones: First Pa2ent Top- line data Full data Q Mid (Enrollment Complete) At Scien2fic Mee2ng TBD *EXACT- PRO= EXAcerba2ons of Chronic obstruc2ve pulmonary disease Tool Pa2ent Reported Outcome 16

17 EXACT: Comprehensive COPD Symptom Assessment Offers robust and data rich evaluation of response to therapy Developed by Specialists in Outcome Measurement & Pharma Consortium AZ, Almirall, Bayer, BI, Forest, GSK, Merck, Novartis, Ortho-McNeil, Pfizer, Sepracor FDA guidance received January 2014; EMA guidance received April 2015 Designed to standardize the method for evaluating the frequency, severity, and duration of acute exacerbations of COPD Patient reported outcome (PRO) daily questionnaire utilizing ediaries Developed with considerable regulatory consultation (FDA and EMA) 17

18 BPS/IC: Getting to the Source of the Pain AQX-1125 s distribution and anti-inflammatory properties compelling Up to 14 million may be affected in the US Disease driven by chronic inflammation and pain following damage to bladder lining Common treatment approach: direct instillation for short-term relief of symptoms Oral administration of AQX-1125 results in bladder exposure systemically and through urine. 18

19 LEADERSHIP: Potential Once Daily, Oral Pain Relief Objective: Evaluate AQX-1125 in subjects with BPS/IC pain ~70 moderate to severe patients from Canadian and US sites IND Accepted by FDA in May, 2014 Endpoints: Primary: Sized to detect effect of AQX-1125 (200 mg capsule once daily) vs. placebo on reduction of mean pain score (11 point NRS*) at 6 weeks vs. baseline utilizing ediaries Secondary: urinary symptoms, safety, PK, QOL Key Milestones: First Pa2ent Top- line data Full data Q Mid (Enrollment Complete) At Scien2fic Mee2ng TBD *NRS= Numerical Ra2ng Scale 19

20 A Novel Approach to Atopic Dermatitis Link between SHIP1 and dermatitis creates opportunity for AQX-1125 Estimated 17.8 million affected with all forms of AD in the US (2/3 with moderate to severe form). Global prevalence of AD varies between 1%-20%. Disease characterized by excessive dermal immune cell activation and mobilization. Severe AD (11% of AD population) treated with corticosteroids, cytotoxics and immunosuppressants not suitable for long term treatment. Large market and limited competition for oral, well tolerated treatment. 20

21 KINSHIP: Potential Oral Relief of AD Symptoms Objective: Evaluate AQX-1125 in subjects with mild to moderate AD ~50 mild to moderate patients from Canadian sites Endpoints: Primary: Sized to detect effect of AQX-1125 (200 mg capsule once daily) vs. placebo on change from baseline in Total Lesion Symptom Score (TLSS) after 12 weeks of treatment Secondary: AD symptoms, safety, PK Key Milestones: First Pa2ent Top- line data Full data Q Q (Enrollment Complete) At Scien2fic Mee2ng TBD 21

22 Key Milestones: Near-term data, expanded market opportunities and pipeline advancement COPD Exacerbations First patient: Q (Enrollment Complete) Top-line Data: Mid-2015 Scientific Meeting: TBD Atopic Dermatitis: First patient: Q (Enrollment Complete) Top-line Data: Q Scientific Meeting: TBD BPS/IC First patient: Q (Enrollment Complete) Top-line Data: Mid-2015 Scientific Meeting: TBD Additional AQX-1125 Trials: CRS Trial Initiated: 2015 Next Generation Compounds: Lead Selection: H

23 Targeted Therapeutics for Inflammatory Disease

Targeted Therapeutics for Inflammatory Disease

Targeted Therapeutics for Inflammatory Disease Targeted Therapeutics for Inflammatory Disease Forward Looking Statements / Safe Harbor This presentation and the accompanying oral commentary contain forward-looking statements that involve substantial

More information

Targeted Therapeutics for Inflammatory Disease. Investor Presentation April 2014

Targeted Therapeutics for Inflammatory Disease. Investor Presentation April 2014 Targeted Therapeutics for Inflammatory Disease Investor Presentation April 2014 Forward Looking Statements / Safe Harbor This presentation and the accompanying oral commentary contain forward-looking statements

More information

Aquinox Q2 /2015 Conference Call: LEADERSHIP Secondary Endpoint Update - AQX-1125 in BPS/IC. August 6, 2015

Aquinox Q2 /2015 Conference Call: LEADERSHIP Secondary Endpoint Update - AQX-1125 in BPS/IC. August 6, 2015 Aquinox Q2 /2015 Conference Call: LEADERSHIP Secondary Endpoint Update - AQX-1125 in BPS/IC August 6, 2015 Forward Looking Statements / Safe Harbor This presentation and the accompanying oral commentary

More information

Targeted Therapeutics for Inflammatory Disease Jefferies Healthcare Conference

Targeted Therapeutics for Inflammatory Disease Jefferies Healthcare Conference Targeted Therapeutics for Inflammatory Disease 2016 Jefferies Healthcare Conference Forward Looking Statements / Safe Harbor This presentation and the accompanying oral commentary contain forward-looking

More information

Breathtaking science. Developing respiratory drugs to improve health and quality of life. H.C. Wainwright Global Life Sciences Conference April 2018

Breathtaking science. Developing respiratory drugs to improve health and quality of life. H.C. Wainwright Global Life Sciences Conference April 2018 Breathtaking science Developing respiratory drugs to improve health and quality of life H.C. Wainwright Global Life Sciences Conference April 2018 www.veronapharma.com Forward-Looking Statements This presentation

More information

Anti-IL-33 (ANB020) Program

Anti-IL-33 (ANB020) Program Anti-IL-33 (ANB020) Program Phase 2a Peanut Allergy Clinical Trial Interim Data Update March 26 th 2018 NASDAQ: ANAB Safe Harbor Statement This presentation and the accompanying oral presentation contain

More information

PROMISE 1 Top-Line Data Results. June 27, 2017

PROMISE 1 Top-Line Data Results. June 27, 2017 PROMISE 1 Top-Line Data Results dd June 27, 2017 Forward Looking Statements This presentation and the accompanying commentary contains certain forward-looking statements within the meaning of Section 27A

More information

Jefferies Healthcare Conference. June 6, 2018

Jefferies Healthcare Conference. June 6, 2018 Jefferies Healthcare Conference June 6, 2018 Forward-Looking Statements and Non-GAAP Financial Information Some statements in this presentation may be forward-looking statements for purposes of the Private

More information

Committed to Transforming the Treatment Paradigm for Migraine Prevention

Committed to Transforming the Treatment Paradigm for Migraine Prevention June 14, 2018 Committed to Transforming the Treatment Paradigm for Migraine Prevention September 6, 2018 Forward-Looking Statements This presentation and the accompanying commentary contains certain forward-looking

More information

Corporate Presentation May Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers

Corporate Presentation May Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers Corporate Presentation May 2016 Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers Forward-looking statements / safe harbor This presentation and the accompanying oral commentary contain

More information

Corporate Overview June 2014 Jefferies Healthcare Conference NASDAQ: GLYC

Corporate Overview June 2014 Jefferies Healthcare Conference NASDAQ: GLYC Corporate Overview June 2014 Jefferies Healthcare Conference NASDAQ: GLYC Forward-Looking Statements To the extent that statements contained in this presentation are not descriptions of historical facts

More information

AM-125 : Intranasal Betahistine

AM-125 : Intranasal Betahistine AM-125 : Intranasal Betahistine February 3, 2017 NASDAQ: EARS Forward-looking Statements This presentation and the accompanying oral commentary contain forward-looking statements that involve substantial

More information

Q1 Results 2018 Webcast presentation 26 April 2018

Q1 Results 2018 Webcast presentation 26 April 2018 Q1 Results 2018 Webcast presentation 26 April 2018 Disclaimer This presentation contains forward-looking statements, including (without limitation) statements concerning the progress of our clinical pipeline,

More information

Keyzilen TM Program Update

Keyzilen TM Program Update Keyzilen TM Program Update October 11, 2016 Forward-looking Statements This presentation and the accompanying oral commentary contain forward-looking statements that involve substantial risks and uncertainties.

More information

Committed to Transforming the Treatment Paradigm for Migraine Prevention

Committed to Transforming the Treatment Paradigm for Migraine Prevention Committed to Transforming the Treatment Paradigm for Migraine Prevention 36th Annual J.P. Morgan Healthcare Conference January 8, 2018 Forward-Looking Statements This presentation and the accompanying

More information

Breathtaking science. Developing respiratory drugs to improve health and quality of life

Breathtaking science. Developing respiratory drugs to improve health and quality of life Breathtaking science Developing respiratory drugs to improve health and quality of life June 2017 Forward-Looking Statements This presentation contains forward looking statements that are based on the

More information

PATENCY-1 Top-Line Results

PATENCY-1 Top-Line Results PATENCY-1 Top-Line Results December 13, 2016 2016 Proteon Therapeutics, Inc. Cautionary Note Regarding Forward-Looking Statements This presentation contains statements that are, or may be deemed to be,

More information

November 2, Q Financial Results

November 2, Q Financial Results November 2, 2017 Q3 2017 Financial Results Agenda Today s Speakers Paul Cox, Senior Director, Investor Relations Jeff Jonas, M.D., Chief Executive Officer Steve Kanes, M.D., Ph.D., Chief Medical Officer

More information

Pierre Legault CEO June 2, 2014

Pierre Legault CEO June 2, 2014 April 2012 Pierre Legault CEO June 2, 2014 Forward Looking Statements This presentation includes statements that are, or may be deemed, forward-looking statements. In some cases, these forward-looking

More information

PROMISE 2 Top-Line Data Results January 8, 2018

PROMISE 2 Top-Line Data Results January 8, 2018 PROMISE 2 Top-Line Data Results January 8, 2018 Forward-Looking Statements This presentation and the accompanying commentary contains certain forward-looking statements within the meaning of Section 27A

More information

February 23, Q4 and Year-End 2016 Financial Results

February 23, Q4 and Year-End 2016 Financial Results February 23, 2017 Q4 and Year-End 2016 Financial Results 2 RETHINKING CNS Agenda Today s Speakers Paul Cox, Senior Director, Investor Relations Jeff Jonas, M.D., Chief Executive Officer Jim Doherty, Ph.D.,

More information

Combining HS-110 and anti-pd-1 in NSCLC. September 1, 2015

Combining HS-110 and anti-pd-1 in NSCLC. September 1, 2015 Combining HS-110 and anti-pd-1 in NSCLC September 1, 2015 Forward Looking Statements This presentation includes statements that are, or may be deemed, forward-looking statements. In some cases, these forward-looking

More information

ADAPTIMMUNE INVESTOR PRESENTATION. August 2016

ADAPTIMMUNE INVESTOR PRESENTATION. August 2016 ADAPTIMMUNE INVESTOR PRESENTATION August 2016 DISCLAIMER This presentation contains forward-looking statements, as that term is defined under the Private Securities Litigation Reform Act of 1995 (PSLRA),

More information

SER-287 Phase 1b topline study results in patients with mild-to-moderate Ulcerative Colitis October 2, 2017

SER-287 Phase 1b topline study results in patients with mild-to-moderate Ulcerative Colitis October 2, 2017 SER-287 Phase 1b topline study results in patients with mild-to-moderate Ulcerative Colitis October 2, 2017 Leading the Microbiome Revolution Forward Looking Statements Some of the statements in this presentation

More information

Jefferies Healthcare Conference. June 25, 2008

Jefferies Healthcare Conference. June 25, 2008 Jefferies Healthcare Conference June 25, 2008 Safe Harbor Statement Except for the historical information set forth herein, the matters set forth in this presentation,including without limitation statements

More information

34 th Annual J.P. Morgan Healthcare Conference

34 th Annual J.P. Morgan Healthcare Conference JANUARY 2016 34 th Annual J.P. Morgan Healthcare Conference [ 1 ] Forward Looking Statements SPECIAL NOTE REGARDING FORWARD LOOKING STATEMENTS In addition to historical information, this presentation contains

More information

Transforming Treatment for Migraine. 16 th Annual Needham Healthcare Conference April 4, 2017

Transforming Treatment for Migraine. 16 th Annual Needham Healthcare Conference April 4, 2017 Transforming Treatment for Migraine 16 th Annual Needham Healthcare Conference April 4, 2017 Forward Looking Statements This presentation and the accompanying commentary contain certain forward-looking

More information

New Ideas. Better Medicines. Third Quarter Financial Results Conference Call

New Ideas. Better Medicines. Third Quarter Financial Results Conference Call New Ideas. Better Medicines. Third Quarter 2018 Financial Results Conference Call Forward-Looking Statements 2 This presentation contains forward-looking statements that involve substantial risks and uncertainties.

More information

Determined to realize a future in which people with cancer live longer and better than ever before

Determined to realize a future in which people with cancer live longer and better than ever before Determined to realize a future in which people with cancer live longer and better than ever before 4Q 2016 EARNINGS PRESENTATION MARCH 2017 1 Forward-looking statements disclosure This presentation contains

More information

Breathtaking science. Developing respiratory drugs to improve health and quality of life

Breathtaking science. Developing respiratory drugs to improve health and quality of life Breathtaking science Developing respiratory drugs to improve health and quality of life Wedbush PacGrow Healthcare Conference New York City, August 2018 NASDAQ VRNA www.veronapharma.com Forward-Looking

More information

Creating a Leading Global HBV Therapeutics Company. ARB-1467 Update Call December 12, 2016

Creating a Leading Global HBV Therapeutics Company. ARB-1467 Update Call December 12, 2016 Creating a Leading Global HBV Therapeutics Company ARB-1467 Update Call December 12, 2016 NASDAQ: ABUS www.arbutusbio.com Forward Looking Statements This presentation contains forward-looking statements

More information

JP Morgan Healthcare Conference. January 8, 2007

JP Morgan Healthcare Conference. January 8, 2007 JP Morgan Healthcare Conference January 8, 2007 Safe Harbor Statement Except for the historical information set forth herein, the matters set forth in this presentation,including without limitation statements

More information

Calliditas Therapeutics Q2 Report Webcast August 16, 2018, 10:00 Presenters: Renée Aguiar-Lucander, CEO Fredrik Johansson, CFO

Calliditas Therapeutics Q2 Report Webcast August 16, 2018, 10:00 Presenters: Renée Aguiar-Lucander, CEO Fredrik Johansson, CFO Calliditas Therapeutics Q2 Report 2018 Webcast August 16, 2018, 10:00 Presenters: Renée Aguiar-Lucander, CEO Fredrik Johansson, CFO Disclaimer Important information This presentation may contain certain

More information

Diagnostics for the early detection and prevention of colon cancer. Fourth-Quarter 2014 Earnings Call February 24, 2015

Diagnostics for the early detection and prevention of colon cancer. Fourth-Quarter 2014 Earnings Call February 24, 2015 Diagnostics for the early detection and prevention of colon cancer Fourth-Quarter 2014 Earnings Call February 24, 2015 Safe Harbor Statement Certain statements made in this presentation contain forward-looking

More information

FOURTH QUARTER AND FULL YEAR 2018 FINANCIAL RESULTS AND BUSINESS UPDATE. Thursday, February 7, 2019

FOURTH QUARTER AND FULL YEAR 2018 FINANCIAL RESULTS AND BUSINESS UPDATE. Thursday, February 7, 2019 FOURTH QUARTER AND FULL YEAR 2018 FINANCIAL RESULTS AND BUSINESS UPDATE Thursday, February 7, 2019 Today s Speakers Overview and Key Highlights Clay Siegall, President & CEO Financial Results and Guidance

More information

AGM Presentation For the year to 30 September February 2016

AGM Presentation For the year to 30 September February 2016 AGM Presentation For the year to 30 September 2015 25 February 2016 11 Forward Looking Statements This presentation includes forward-looking statements. These forward-looking statements involve known and

More information

Santhera Pharmaceuticals Company Presentation. September 2018

Santhera Pharmaceuticals Company Presentation. September 2018 Santhera Pharmaceuticals Company Presentation September 2018 Disclaimer This presentation is not and under no circumstances to be construed as a solicitation, offer, or recommendation, to buy or sell securities

More information

Revolutionizing the Treatment of Cancer

Revolutionizing the Treatment of Cancer Revolutionizing the Treatment of Cancer March 2014 Safe Harbor Statement The statements that follow (including projections and business trends) are forward-looking statements. Rexahn's actual results may

More information

Revolutionizing the Treatment of Cancer

Revolutionizing the Treatment of Cancer Revolutionizing the Treatment of Cancer January 2014 Safe Harbor Statement The statements that follow (including projections and business trends) are forward looking statements. Rexahn's actual results

More information

Building a Premier Oncology Biotech

Building a Premier Oncology Biotech Corporate Deck Building a Premier Oncology Biotech Dr. Helen Torley, President and CEO November 2018 Forward-Looking Statements All of the statements in this presentation that are not statements of historical

More information

Idenix Pharmaceuticals Building a Leading Antiviral Franchise. Cowen & Company 27 th Annual Healthcare Conference March 13, 2007 Boston

Idenix Pharmaceuticals Building a Leading Antiviral Franchise. Cowen & Company 27 th Annual Healthcare Conference March 13, 2007 Boston Idenix Pharmaceuticals Building a Leading Antiviral Franchise Cowen & Company 27 th Annual Healthcare Conference March 13, 2007 Boston Safe Harbor This presentation includes forward-looking statements

More information

MANIFEST Phase 2 Enhancement / Expansion

MANIFEST Phase 2 Enhancement / Expansion MANIFEST Phase 2 Enhancement / Expansion Investor Conference Call Stellar Science, Breakthrough Medicine October 11, 2018 Forward-Looking Statements This presentation contains forward-looking statements

More information

GW Pharmaceuticals plc. Investor Presentation August 2014

GW Pharmaceuticals plc. Investor Presentation August 2014 GW Pharmaceuticals plc Investor Presentation August 2014 Forward Looking Statements and Disclaimer This presentation contains forward-looking statements. Some of the matters discussed concerning our operations

More information

Verona Pharma Announces Positive Top-Line Data from Phase 2a Clinical Trial in COPD with RPL554 Dosed in Addition to Tiotropium (Spiriva )

Verona Pharma Announces Positive Top-Line Data from Phase 2a Clinical Trial in COPD with RPL554 Dosed in Addition to Tiotropium (Spiriva ) Press release 7 September 2017 Verona Pharma Announces Positive Top-Line Data from Phase 2a Clinical Trial in COPD with RPL554 Dosed in Addition to Tiotropium (Spiriva ) Achieved significant and clinically

More information

DUPIXENT FDA Approval Call March 28, 2017

DUPIXENT FDA Approval Call March 28, 2017 DUPIXENT FDA Approval Call March 28, 2017 1 Sanofi Forward Looking Statements This presentation contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as

More information

Corporate Update. NASDAQ: GALT April 9, 2018

Corporate Update. NASDAQ: GALT  April 9, 2018 Corporate Update April 9, 2018 NASDAQ: GALT www.galectintherapeutics.com Forward-Looking Statements This presentation contains, in addition to historical information, forward-looking statements within

More information

ArQule Jefferies Global Healthcare Conference June 2015

ArQule Jefferies Global Healthcare Conference June 2015 ArQule Jefferies Global Healthcare Conference June 2015 1 ArQule Corporate Update Safe Harbor This presentation and other statements by ArQule may contain forward-looking statements within the meaning

More information

REPROS THERAPEUTICS. Dedicated to Treating Male and Female Reproductive Disorders. Corporate Presentation. August 2017

REPROS THERAPEUTICS. Dedicated to Treating Male and Female Reproductive Disorders. Corporate Presentation. August 2017 REPROS THERAPEUTICS Dedicated to Treating Male and Female Reproductive Disorders Corporate Presentation August 2017 Safe Harbor Any statements made by the Company that are not historical facts contained

More information

34 th Annual JP Morgan Healthcare Conference. January 13, 2016

34 th Annual JP Morgan Healthcare Conference. January 13, 2016 34 th Annual JP Morgan Healthcare Conference January 13, 2016 SAFE HARBOR Forward Looking Statements These slides and the accompanying oral presentation contain forward-looking statements and information.

More information

Building a Stroke Portfolio. June 28, 2018

Building a Stroke Portfolio. June 28, 2018 Building a Stroke Portfolio June 28, 2018 1 Forward-Looking Statements This presentation contains forward-looking statements, including statements relating to: the potential benefits, safety and efficacy

More information

Acorda Acquisition of Civitas Therapeutics. September 24, 2014

Acorda Acquisition of Civitas Therapeutics. September 24, 2014 Acorda Acquisition of Civitas Therapeutics September 24, 2014 Forward Looking Statement This presentation includes forward-looking statements within the meaning of the Private Securities Litigation Reform

More information

First self-administered antibody therapy for HIV in late-stage clinical trials. CytoDyn Annual Meeting of Stockholders August 24, 2017

First self-administered antibody therapy for HIV in late-stage clinical trials. CytoDyn Annual Meeting of Stockholders August 24, 2017 First self-administered antibody therapy for HIV in late-stage clinical trials CytoDyn Annual Meeting of Stockholders August 24, 2017 (OTCQB: CYDY) www.cytodyn.com Forward-Looking Statements This presentation

More information

Utrophin Modulation: A Universal Treatment Approach to DMD. End Duchenne Tour April 2018

Utrophin Modulation: A Universal Treatment Approach to DMD. End Duchenne Tour April 2018 Utrophin Modulation: A Universal Treatment Approach to DMD April 2018 Legal Disclaimer Statements in this presentation, other than statements of historical fact, constitute forward-looking statements within

More information

Revolutionizing the Treatment of Cancer

Revolutionizing the Treatment of Cancer Revolutionizing the Treatment of Cancer September 2013 Safe Harbor Statement The statements that follow (including projections and business trends) are forward looking statements. Rexahn's actual results

More information

REPROS THERAPEUTICS. Dedicated to Treating Male and Female Reproductive Disorders. Corporate Presentation. September 2017

REPROS THERAPEUTICS. Dedicated to Treating Male and Female Reproductive Disorders. Corporate Presentation. September 2017 REPROS THERAPEUTICS Dedicated to Treating Male and Female Reproductive Disorders Corporate Presentation September 2017 Safe Harbor Any statements made by the Company that are not historical facts contained

More information

Press Release. RedHill Biopharma Announces Enrollment of Last Patient in the BEKINDA Phase II Study for IBS-D

Press Release. RedHill Biopharma Announces Enrollment of Last Patient in the BEKINDA Phase II Study for IBS-D Press Release RedHill Biopharma Announces Enrollment of Last Patient in the BEKINDA Phase II Study for IBS-D Top-line results are expected in the third quarter of 2017 The randomized, double-blind, placebo-controlled

More information

Bank of America Merrill Lynch 2016 Health Care Conference

Bank of America Merrill Lynch 2016 Health Care Conference Bank of America Merrill Lynch 2016 Health Care Conference Dr. Steven Stein Chief Medical Officer David Gryska Chief Financial Officer May 11, 2016 Forward Looking Statements Except for the historical information

More information

LION. Corporate Presentation June 2016 BIOTECHNOLOGIES. Leadership & Innovation in Oncology

LION. Corporate Presentation June 2016 BIOTECHNOLOGIES. Leadership & Innovation in Oncology LION BIOTECHNOLOGIES Leadership & Innovation in Oncology Corporate Presentation June 2016 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private

More information

Merrill Lynch Pharmaceutical, Biotechnology & Medical Device Conference New York, February 4, 2004

Merrill Lynch Pharmaceutical, Biotechnology & Medical Device Conference New York, February 4, 2004 Merrill Lynch Pharmaceutical, Biotechnology & Medical Device Conference New York, February 4, 2004 Disclaimer 2 This presentation contains forward-looking statements, i.e., current estimates or expectations

More information

Phase 1 and 2 Data for Triple Combination Regimens Demonstrate Improvements in Lung Function and Other Measures in CF Patients

Phase 1 and 2 Data for Triple Combination Regimens Demonstrate Improvements in Lung Function and Other Measures in CF Patients Phase 1 and 2 Data for Triple Combination Regimens Demonstrate Improvements in Lung Function and Other Measures in CF Patients July 18, 2017 Agenda Introduction Michael Partridge, VP Investor Relations

More information

Inarigivir ACHIEVE Trial Results and HBV Clinical Program Update. August 2, 2018

Inarigivir ACHIEVE Trial Results and HBV Clinical Program Update. August 2, 2018 Inarigivir ACHIEVE Trial Results and HBV Clinical Program Update August 2, 2018 FORWARD LOOKING STATEMENT This presentation includes forward-looking statements within the meaning of the Private Securities

More information

Memory Pharmaceuticals Establishes Plans for Clinical Program for MEM 3454 in Schizophrenia. -Broadens Roche Nicotinic Alpha-7 Alliance-

Memory Pharmaceuticals Establishes Plans for Clinical Program for MEM 3454 in Schizophrenia. -Broadens Roche Nicotinic Alpha-7 Alliance- Memory Pharmaceuticals Establishes Plans for Clinical Program for MEM 3454 in Schizophrenia -Broadens Roche Nicotinic Alpha-7 Alliance- -Secures Additional $5M Debt Financing to Support Phase 2a Trial-

More information

Targeted Therapeutics for Inflammatory Disease. June 2017

Targeted Therapeutics for Inflammatory Disease. June 2017 Targeted Therapeutics for Inflammatory Disease June 2017 1 Forward Looking Statements/ Safe Harbor This presentation and the accompanying oral commentary contain forward-looking statements that involve

More information

Bobby W. Sandage, Jr., PhD President & Chief Executive Officer. Lazard Capital Markets 8 th Annual Healthcare Conference

Bobby W. Sandage, Jr., PhD President & Chief Executive Officer. Lazard Capital Markets 8 th Annual Healthcare Conference Bobby W. Sandage, Jr., PhD President & Chief Executive Officer Lazard Capital Markets 8 th Annual Healthcare Conference Statements in this presentation that are not descriptions of historical facts are

More information

Prosensa Corporate Overview Jefferies Healthcare Conference London, UK November 19, Hans Schikan, CEO

Prosensa Corporate Overview Jefferies Healthcare Conference London, UK November 19, Hans Schikan, CEO Prosensa Corporate Overview Jefferies Healthcare Conference London, UK November 19, 2014 Hans Schikan, CEO Forward-Looking Statements This presentation may contain statements that constitute forward-looking

More information

Conference Call for Investment Community. Nov 19, 2018

Conference Call for Investment Community. Nov 19, 2018 Conference Call for Investment Community Nov 19, 2018 Agenda for Today s Call Topic Safe Harbor Statement Opening Remarks AR101 for Peanut Allergy Speaker Laura Hansen, PhD, VP, Investor Relations Jayson

More information

Aviragen Therapeutics, Inc. and Vaxart Inc. Joint Conference Call UNLOCKING THE FULL POTENTIAL OF ORAL VACCINES

Aviragen Therapeutics, Inc. and Vaxart Inc. Joint Conference Call UNLOCKING THE FULL POTENTIAL OF ORAL VACCINES Aviragen Therapeutics, Inc. and Vaxart Inc. Joint Conference Call UNLOCKING THE FULL POTENTIAL OF ORAL VACCINES October 30, 2017 Safe Harbor This presentation contains forward-looking statements about

More information

Third Quarter 2018 Financial Results. November 1, 2018

Third Quarter 2018 Financial Results. November 1, 2018 Third Quarter 2018 Financial Results November 1, 2018 Agios Conference Call Participants Prepared Remarks Introduction RENEE LECK, Associate Director, Investor Relations Business Highlights & 2018 Key

More information

February 20, 2019 MANAGEMENT CALL TO DISCUSS PHASE 2 PHOENIX RESULTS AND CKD PROGRAM UPDATES

February 20, 2019 MANAGEMENT CALL TO DISCUSS PHASE 2 PHOENIX RESULTS AND CKD PROGRAM UPDATES February 20, 209 MANAGEMENT CALL TO DISCUSS PHASE 2 PHOENIX RESULTS AND CKD PROGRAM UPDATES Forward-Looking Statements This presentation contains certain forward-looking statements that are made pursuant

More information

Calithera Biosciences. January 2019

Calithera Biosciences. January 2019 Calithera Biosciences January 2019 Forward-Looking Statements This presentation and the accompanying oral commentary contain forward looking statements for purposes of the safe harbor provisions of the

More information

Building a Premier Oncology Biotech

Building a Premier Oncology Biotech Wells Fargo Securities Healthcare Conference Building a Premier Oncology Biotech Dr. Helen Torley, President and CEO September 2018 Forward-Looking Statements All of the statements in this presentation

More information

Theravance Biopharma, Inc. (NASDAQ: TBPH)

Theravance Biopharma, Inc. (NASDAQ: TBPH) Theravance Biopharma, Inc. (NASDAQ: TBPH) FDA Approval of YUPELRI TM (revefenacin) Inhalation Solution November 9, 2018 THERAVANCE and the Cross/Star logo are registered trademarks of the Theravance Biopharma

More information

Jefferies 2016 Healthcare Conference. Reid Huber, PhD Chief Scientific Officer

Jefferies 2016 Healthcare Conference. Reid Huber, PhD Chief Scientific Officer Jefferies 2016 Healthcare Conference Reid Huber, PhD Chief Scientific Officer June 8, 2016 Forward-looking Statements Except for the historical information set forth herein, the matters set forth in this

More information

Determined to realize a future in which people with cancer live longer and better than ever before

Determined to realize a future in which people with cancer live longer and better than ever before Determined to realize a future in which people with cancer live longer and better than ever before 3Q 2018 EARNINGS PRESENTATION NOVEMBER 2018 1 Forward-looking statements disclosure This presentation

More information

Credit Suisse 27 th Annual Healthcare Conference

Credit Suisse 27 th Annual Healthcare Conference CHANGING THE COURSE OF HUMAN HEALTH THROUGH BOLD PURSUITS IN SCIENCE Credit Suisse 27 th Annual Healthcare Conference November 14, 2018 Forward-Looking Statements and Adjusted Financial Information This

More information

Oncology Therapeutics without Compromise APRIL 2011

Oncology Therapeutics without Compromise APRIL 2011 Oncology Therapeutics without Compromise APRIL 2011 Forward Looking Statements This presentation contains forward-looking statements that involve substantial risks and uncertainties, including among other

More information

Prothena Corporation plc

Prothena Corporation plc Prothena Corporation plc PRX003 Investor Update: Phase 2 Development Strategy September 29, 2016 Agenda Dr. Gene Kinney, Chief Operating Officer Introduction Dr. Ken Flanagan, Senior Scientist Th17 and

More information

Genomic Health. Kim Popovits, Chairman, CEO and President

Genomic Health. Kim Popovits, Chairman, CEO and President Genomic Health Kim Popovits, Chairman, CEO and President Safe Harbor Statement Various remarks that we make in this presentation that are not historical, including those about our future financial and

More information

Edasalonexent (CAT-1004) Program

Edasalonexent (CAT-1004) Program Edasalonexent (CAT-1004) Program Oral small molecule designed to inhibit NF-κB for the treatment of Duchenne muscular dystrophy Joanne M. Donovan, MD, PhD Chief Medical Officer, Catabasis Pharmaceuticals

More information

Cavosonstat Phase 2 Trial Results. November 28 th, 2016

Cavosonstat Phase 2 Trial Results. November 28 th, 2016 Phase 2 Trial Results November 28 th, 2016 Nivalis Therapeutics 2016 Agenda Introduction Mike Carruthers, Chief Financial Officer Initial Remarks Jon Congleton, President and CEO Data Highlights David

More information

ESTABLISH 2 Top Line Data Release

ESTABLISH 2 Top Line Data Release The Future of Anti-Infectives ESTABLISH 2 Top Line Data Release March 25, 2013 1 Forward Looking Statements Statements contained in this data release regarding matters that are not historical facts are

More information

Jefferies Healthcare Conference June 8, 2017

Jefferies Healthcare Conference June 8, 2017 Jefferies Healthcare Conference June 8, 2017 1 Forward-Looking Statements and Non-GAAP Financial Information Some statements in this presentation may be forward-looking statements for purposes of the Private

More information

Capricor Therapeutics

Capricor Therapeutics Therapeutics Conference Call to Discuss the HOPE-2 Clinical Trial NASDAQ: CAPR November 29, 2017 Forward-Looking Statements Statements in this presentation regarding the efficacy, safety, and intended

More information

Building a Fully Integrated Biopharmaceutical Company. June 2014

Building a Fully Integrated Biopharmaceutical Company. June 2014 Building a Fully Integrated Biopharmaceutical Company June 2014 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of The Private Securities Litigation

More information

Determined to realize a future in which people with cancer live longer and better than ever before Q Conference Call

Determined to realize a future in which people with cancer live longer and better than ever before Q Conference Call Reimagining Cancer Treatment Determined to realize a future in which people with cancer live longer and better than ever before Q1 2016 Conference Call 1 Forward-Looking Statements Disclosure This presentation

More information

SAVARA CORPORATE PRESENTATION (NASDAQ: SVRA) NOVEMBER 2018

SAVARA CORPORATE PRESENTATION (NASDAQ: SVRA) NOVEMBER 2018 SAVARA CORPORATE PRESENTATION (NASDAQ: SVRA) NOVEMBER 2018 SAFE HARBOR STATEMENT Savara Inc. ( Savara or the Company ) cautions you that statements in this presentation that are not a description of historical

More information

March Corporate Presentation

March Corporate Presentation March 2017 Corporate Presentation Disclaimer This presentation contains forward-looking statements, as that term is defined under the Private Securities Litigation Reform Act of 1995 (PSLRA), which statements

More information

Vicore Pharma AB. Audiocast, October 2, Presentation by Per Jansson, CEO and Ulrike Muscha Steckelings, CSO

Vicore Pharma AB. Audiocast, October 2, Presentation by Per Jansson, CEO and Ulrike Muscha Steckelings, CSO Vicore Pharma AB Audiocast, October 2, 2017 1 Presentation by Per Jansson, CEO and Ulrike Muscha Steckelings, CSO FORWARD-LOOKING STATEMENTS This presentation may contain certain forward-looking statements

More information

Innovation In Ophthalmics

Innovation In Ophthalmics Innovation In Ophthalmics Ophthalmic Innovation Summit @ AAO 2018 October 25, 2018 Mark Iwicki Chairman & CEO, Kala Pharmaceuticals Disclaimers and Notices This presentation contains forward-looking statements

More information

Revolutionizing the Treatment of Cancer

Revolutionizing the Treatment of Cancer Revolutionizing the Treatment of Cancer June 2014 Safe Harbor Statement The statements that follow (including projections and business trends) are forward looking statements. Rexahn's actual results may

More information

PRO 140. First self-administered antibody therapy for HIV in late-stage clinical development. March

PRO 140. First self-administered antibody therapy for HIV in late-stage clinical development. March PRO 140 First self-administered antibody therapy for HIV in late-stage clinical development March 2018 Forward-Looking Statements This presentation includes forward-looking statements and forward-looking

More information

Oragenics Shareholder Update

Oragenics Shareholder Update January 4, 2017 Oragenics Shareholder Update Advances Drug Development Programs Focused on Conditions with Significant Unmet Medical Needs TAMPA, Fla.--(BUSINESS WIRE)-- Oragenics, Inc. (NYSE MKT:OGEN.BC),

More information

37 th Annual J.P. Morgan Healthcare Conference. January 9, 2019

37 th Annual J.P. Morgan Healthcare Conference. January 9, 2019 37 th Annual J.P. Morgan Healthcare Conference January 9, 2019 Forward Looking Statement This presentation includes forward-looking statements. All statements, other than statements of historical facts,

More information

Engineering the Future for Inhaled Therapeutics. July 2016 NASDAQ: PULM

Engineering the Future for Inhaled Therapeutics. July 2016 NASDAQ: PULM Engineering the Future for Inhaled Therapeutics July 2016 NASDAQ: PULM Disclaimers & Forward Looking Statements This presentation contains forward-looking statements. Forward-looking statements may be

More information

Translating Science. Transforming Lives. ACT DMD Clinical Trial Results

Translating Science. Transforming Lives. ACT DMD Clinical Trial Results Translating Science. Transforming Lives ACT DMD Clinical Trial Results FORWARD LOOKING STATEMENTS This presentation contains forward-looking statements within the meaning of The Private Securities Litigation

More information

Investor Presentation

Investor Presentation Investor Presentation June 2017 Joe Turgeon President and Chief Operating Officer Safe Harbor Statement This presentation contains forward-looking statements regarding future events and the future performance

More information

Corporate Presentation November Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers

Corporate Presentation November Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers Corporate Presentation November 2015 Transforming Immuno-Oncology Using Next-Generation Immune Cell Engagers Forward-looking statements / safe harbor This presentation and the accompanying oral commentary

More information

IMMUNOMEDICS, INC. Advanced Antibody-Based Therapeutics. Jefferies 2014 Global Healthcare Conference Cynthia L. Sullivan, President and CEO

IMMUNOMEDICS, INC. Advanced Antibody-Based Therapeutics. Jefferies 2014 Global Healthcare Conference Cynthia L. Sullivan, President and CEO IMMUNOMEDICS, INC. Advanced Antibody-Based Therapeutics Oncology Autoimmune Diseases Jefferies 2014 Global Healthcare Conference Cynthia L. Sullivan, President and CEO Forward-Looking Statements This presentation,

More information

SWISS BIOTECH DAY 2018

SWISS BIOTECH DAY 2018 SWISS BIOTECH DAY 2018 Basel, 3 May 2018 Thomas Meier, CEO Disclaimer This presentation is not and under no circumstances to be construed as a solicitation, offer, or recommendation, to buy or sell securities

More information