The Medical Letter. on Drugs and Therapeutics

Transcription

1 The Medical Letter publications are protected by US and international copyright laws. Forwarding, copying or any other distribution of this material is strictly prohibited. For further information call: Last updated: April 27, 2017 Comparison Table: Some Topical Corticosteroids The Medical Letter on Drugs and Therapeutics Comparison Table: Some Topical Corticosteroids 1,2 Super-High Potency Betamethasone dipropionate augmented generic Apply once/d or bid Should only be used short-term $ (15 g x 2) Diprolene (Merck) Clobetasol propionate generic Clobex (Galderma) gel foam spray shampoo Apply once/d Should not be used under occlusion Ointments are generally the most effective formulations Foams and sprays can be applied to large areas, but the alcohol base used in many of them may cause burning Foam: dispense small amount onto a saucer or other cool surface; will melt immediately if dispensed onto hands (15 g x 2) (30 g) (30 g) (30 g) (50 ml) (60 ml) (50 g) (59 ml) (118 ml) (60 ml) spray (59 ml) shampoo Apply once/d (118mL) Olux (Prestium/Mylan) foam (50 g) Olux-E (Mylan) foam (50 g) Temovate (Fougera) (30 g) (30 g) Cormax (Hi Tech) (50 ml) Fluocinonide generic 0.1% Apply once/d (30 g) Vanos (Valeant) (30 g) Halobetasol propionate generic Apply once/d or bid (50 g) (50 g) Ultravate (Ranbaxy) (50 g) (50 g) (60 ml) e91

2 High Potency Amcinonide generic 0.1% or tid Should only be used short-term Betamethasone dipropionate augmented Apply once/d or bid generic $ (60 g) (15 g x 2) Diprolene AF (Merck) Betamethasone dipropionate generic Desoximetasone generic Topicort (Taro) 0.25% Apply once/d or bid (15 g x 2) (45 g) (60 g) (60 g) (60 g) (60 g) Desoximetasone generic gel (15 g x 2) Diflorasone diacetate generic Apply 1-3 times/d (30 g) Fluocinonide generic Apply 2-4 times/d (30 g) gel (30 g) (30 g) (60 ml) Halcinonide Halog (Ranbaxy) 0.1% -tid (30 g) (30 g) Mometasone furoate generic 0.1% Apply once/d (15 g x 2) Elocon (MSD) (15 g x 2) Medium-High Potency Amcinonide generic 0.1% or tid (30 g) Betamethasone dipropionate generic Betamethasone valerate generic Desoximetasone generic 0.1% Apply once/d or bid Apply 1-3 times/d (60 ml) (15 g x 2) (15 g x 2) (15 g x 2) (15 g x 2) Diflorasone diacetate generic Apply 1-3 times/d (30 g) Fluocinonide emollient generic Apply 2-4 times/d (30 g) Fluticasone propionate generic 0.005% (30 g) Triamcinolone acetonide generic 0.5% Apply 2-4 times/d (15 g x 2) or tid (15 g x 2) e92

3 Medium Potency Betamethasone dipropionate spray Sernivo: shake well before use Sernivo (Promius) Luxiq: dispense small amount onto a saucer or other cool surface; foam $ (120 ml) Betamethasone valerate generic 0.12% foam will melt immediately if dispensed onto hands (50 g) Luxiq (Prestium/Mylan) (50 g) Fluocinolone acetonide generic 0.025% Apply 3-4 times/d (15 g x 2) Synalar (Medimetriks) Apply 2-4 times/d (120 g) Flurandrenolide generic or tid (60 g) Cordran (Aqua) (60 g) Hydrocortisone valerate generic 0.2% or tid (15 g x 2 ) Mometasone furoate generic 0.1% Apply once/d (15 g x 2) Elocon (MSD) (15 g x 2) Triamcinolone acetonide generic 0.1% or tid 6.00 (30 g) 6.20 (30 g) Triderm (Crown) (30 g) Triamcinolone acetonide Trianex (Promius) Apply 2-4 times/d (430 g) Medium-Low Potency Betamethasone dipropionate generic (60 ml) Betamethasone valerate generic 0.1% Apply 1-3 times/d (15 g x 2) Desonide generic Apply 2-4 times/d (15 g x 2) Fluocinolone acetonide generic 0.025% Apply 2-4 times/d (15 g x 2) Synalar (Medimetriks) (120 g) Flurandrenolide generic or tid (120 g) (120 ml) Cordran (Aqua) (120 g) (120 ml) Fluticasone propionate generic Apply once/d or bid (30 g) Apply once/d (120 ml) Cutivate (PharmaDerm) Apply once/d or bid (30 g) Apply once/d (120 ml) e93

4 Medium-Low Potency (continued) Hydrocortisone butyrate generic 0.1% or tid $ (15 g x 2) (15 g x 2) (60 ml) Locoid (Onset) (15 g x 2) (15 g x 2) (60 ml) Locoid Lipo (15 g x 2) Hydrocortisone probutate Pandel (Sandoz) 0.1% Apply once/d or bid (80 g) Hydrocortisone valerate generic 0.2% or tid (15 g x 2) Prednicarbate generic 0.1% (60 g) (60 g) Dermatop (Valeant) (60 g) (60 g) Triamcinolone acetonide generic 0.025% Apply 2-4 times/d (15 g x 2) Triamcinolone acetonide generic 0.1% Apply 3-4 times/d (60 ml) Low Potency Alclometasone dipropionate generic -tid (60 g) (60 g) Betamethasone valerate generic 0.1% Verdeso should be dispensed by inverting can; upright actuation may cause incorrect dosage delivery (60 ml) Clocortolone pivalate generic 0.1% Apply tid (45 g) Cloderm (Promius) (45 g) Desonide generic (30 g) (60 ml) Desowen (Galderma) (60 g) (60 ml) Desonate (Bayer) gel (60 g) Verdeso (Stiefel) foam (100 g) Fluocinolone acetonide generic 0.01% Apply 2-4 times/d (60 g) (60 ml) Triamcinolone acetonide generic 0.025% Apply 2-4 times/d 7.20 (30 g) (60 ml) e94

5 Lowest Potency Hydrocortisone generic Hydrocortisone generic 2.5% 1.0% -qid Apply up to tid-qid Hydrocortisone 2.5% is available by prescription only Hydrocortisone 1% and 0.5% are available without a prescription Individual retailers may have their own OTC generic products May be ineffective for some indications $2.70 (20 g) 3.00 (30 g) (60 ml) 6.80 (30 g) 4 Safe for use on the face and intertriginous areas 6.80 (30 g) 4 Aquanil-HC (Person & Covey) 8.00 (120 ml) 4 Hydrocortisone generic 0.5% Apply up to tid-qid 3.30 (30 g) 5.00 (30 g) 4 Nu-Derm Tolereen (Obagi) 0.5% (57 g) 1. Drugs for psoriasis. Med Lett Drugs Ther 2015; 57: Drugs for allergic disorders. Med Lett Drugs Ther 2017; 59: Approximate WAC for smallest available package size. WAC = wholesaler acquisition cost or manufacturer s published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource Monthly. April 5, Reprinted with permission by First Databank, Inc. All rights reserved Price according to walgreens.com. Accessed April 27, 2017.