PUBLICATIONS. cells. J. Physiol. (London) 517P:91P (Manchester, England, UK).
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1 277 PUBLICATIONS Abstracts Haddad JJ, Land SC (1999). Differential activation of oxygen-responsive transcription factors over fetal-to-neonatal alveolar oxygen tensions in rat fetal distal lung epithelial cells. J. Physiol. (London) 517P:91P (Manchester, England, UK). Haddad JJ (1999). Antioxidant and redox regulation of gene transcription in vitro over fetal-to-neonatal oxygen tensions: Intracellular HIF-1α and NF-κB differential activation. The 8 th Postgraduate Research Symposium 8:12P-13P (Dundee, Scotland, UK). Haddad JJ, Safieh-Garabedian BH, Saadé NE, Land SC (2000). Reactive oxygen species-dependent induction of IL-1β, IL-6 and TNF-α in the alveolar epithelium. FASEB J. 14:A358 (San Diego, California, USA). Haddad JJ, Olver RE, Murphie HM, Land SC (2000). Redox-mediated differential expression of signaling factors involved in apoptosis in the perinatal lung. FASEB J. 14:A582 (San Diego, California, USA). Haddad JJ, Olver RE, Land SC (2000). Antioxidant/pro-oxidant equilibrium modulates the redox sensitivity of the alveolar epithelium: Kinematics of glutathione oxidation-mediated inhibition of HIF-1α and NF-κB. FASEB J. 14:A585 (San Diego, California, USA).
2 278 Haddad JJ (2000). Immunopharmacological properties of glutathione revealed: Redox disequilibrium and chemioxyexcitation ( po 2 /ROS) regulation of cytokines in the alveolar epithelium. The 9 th Postgraduate Research Symposium 9:43P (Dundee, Scotland, UK). Haddad JJ, Land SC, Olver RE, Safieh-Garabedian B, Saadé NE (2000). Redox disequilibrium and chemioxyexcitation ( po 2 /ROS) mediated regulation of the cytokine network in the alveolar epithelium. Acta Physiol. Scand. 170:A (Stockholm, Sweden). Haddad JJ, Saadé NE, Safieh-Garabedian B, Land SC (2001). The immunoregulatory potential of thymulin-zn 2+ is camp-sensitive and mediated by selective targeting of the redox-sensitive transcription factor NF-κB in the alveolar epithelium. J. Physiol. (London) 531P:177P (London, England, UK). Haddad JJ, Olver RE, Land SC (2001). The ex vivo differential expression of apoptosis signaling co-factors in the developing perinatal lung. FASEB J. 15:A82 (Orlando, Florida, USA). Haddad JJ, Saadé NE, Safieh-Garabedian B, Land SC (2001). Thiol regulation of proinflammatory cytokines in lipopolysaccharide-induced alveolar epithelial cells. FASEB J. 15:A162 (Orlando, Florida, USA).
3 279 Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC (2001). The involvement of a NF-κB-dependent pathway in regulating pro-inflammatory cytokine biosynthesis in the alveolar epithelium. FASEB J. 15:A162 (Orlando, Florida, USA). Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC (2001). Exogenous rmtnf-α and redox-sensitive transcription factors HIF-1α and NF-κB: Up-regulation of endogenous pro- and anti-inflammatory cytokine biosynthesis and involvement of an IκB-α dependent pathway. FASEB J. 15:A162 (Orlando, Florida, USA). Haddad JJ, Land SC (2001). Mitogen-activated protein kinase selective regulation of pro-inflammatory cytokines in the alveolar epithelium. Biochem. Soc. Transac. In press (Bristol, England, UK). Haddad JJ, Land SC (2001). N-[1-(4-{[4-(pyrimidin-2-yl)piperazin-1- yl]methyl}phenyl)cyclopropyl] acetamide, (Y-40138), is a novel dual regulator of proand anti-inflammatory cytokines. 1, Involvement of an interleukin (IL)-10 sensitive pathway. Genes Immun. In submission, 2001 (Berlin, Germany). Haddad JJ, Land SC (2001). Y is a novel dual regulator of pro- and antiinflammatory cytokines. 2, Requirement for an IκB-α/NF-κB signal transduction sensitive pathway. Genes Immun. In submission, 2001 (Berlin, Germany). Haddad JJ, Land SC (2001). The potential immunoregulatory role of mitogenactivated protein kinase (MAPK; p38) in modulating pro-inflammatory cytokine biosynthesis in the alveolar epithelium. J. Physiol. (London) In submission (Sheffield, England, UK).
4 280 Peer-Reviewed Full Papers Haddad JJ, Land SC (2000). O 2 -evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 278:L492-L503. Haddad JJ, Land SC (2000). The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-κB (RelA)-selective targeting. Biochem. Biophys. Res. Commun. 271: Haddad JJ, Olver RE, Land SC (2000). Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity: Evidence for inhibition by glutathione oxidation in alveolar epithelial cells. J. Biol. Chem. 275: Haddad JJ, Land SC, Saadé NE, Safieh-Garabedian B (2000). Immunomodulatory potential of thymulin-zn 2+ in the alveolar epithelium: Amelioration of endotoxininduced cytokine release and partial amplification of a cytoprotective IL-10-sensitive pathway. Biochem. Biophys. Res. Commun. 274: Haddad JJ, Safieh-Garabedian B, Saadé NE, Kanaan SA, Land SC (2001). Chemioxyexcitation ( po 2 /ROS) dependent release of IL-1β, IL-6 and TNF-α: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium. Cytokine 13,
5 281 Haddad JJ, Choudhary KK, Land SC (2001). The ex vivo differential expression of apoptosis signaling cofactors in the developing lung: Essential role of oxygenation during the transition from placental to pulmonary-based respiration. Biochem. Biophys. Res. Commun. 281: Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC (2001). Thiol regulation of proinflammatory cytokines reveals a novel immunopharmacological potential of glutathione in the alveolar epithelium. J. Pharmacol. Exp. Therap. 296: Haddad JJ, Lauterbach R, Saadé NE, Safieh-Garabedian B, Land SC (2001). α-melanocyte-related tripeptide, Lys- D -Pro-Val, ameliorates endotoxin-induced NF-κB translocation and activation: Evidence for involvement of an interleukin-1β receptor antagonism in the alveolar epithelium. Biochem. J. (London) 355: Haddad JJ, Collett A, Land SC, Olver RE, Wilson SM (2001). NF-κB blockade reduces the O 2 -evoked rise in Na + conductance in fetal alveolar cells. Biochem. Biophys. Res. Commun. 281: Baines DL, Ramminger SJ, Collet A, Haddad JJ, Best OG, Olver RE, Land SC, Wilson SM (2001). Oxygen-evoked Na + transport in rat fetal distal lung epithelial cells. J. Physiol. (London) 532: Haddad JJ, Safieh-Garabedian B, Saadé NE, Land SC (2001). The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium. Br. J. Pharmacol. 133:49-60.
6 282 Haddad JJ, Land SC (2001). The inhibitory- κb/nuclear factor-κb pathway is not indispensable for redox-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells. J. Mol. Biol. (In submission). Haddad JJ (2001). Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transpiration factors in development and pathophysiology. Cytokines Cell. Mol. Therap. (In submission). Haddad JJ (2001). Glutathione depletion is associated with augmenting a proinflammatory signal: Evidence for an antioxidant/pro-oxidant mechanism regulating cytokines in the alveolar epithelium Cytokines Cell. Mol. Therap. (In submission). Haddad JJ, Land SC (2001). Oxygen homeostasis, thiol equilibrium and redox regulation of HIF-1α and NF-κB in the alveolar epithelium. Physiol. Genomics (In preparation). Haddad JJ, Land SC (2001). Redox regulation of lipopolysaccharide-induced p38/rk MAP kinase-mediated pro-inflammatory TNF-α biosynthesis in the alveolar epithelium. Br. J. Pharmacol. (In preparation). Haddad JJ, Olver RE, Land SC (2001). Thiol regulation of pro-inflammatory cytokines is mediated by redox-sensitive transcription factors HIF-1α and NF-κB: Involvement of selective protein kinases in the alveolar epithelium. J. Biol. Chem. (In preparation).
7 283 Haddad JJ, Olver RE, Land SC (2001). Recombinant tumor necrosis factor (TNF)-α regulates the stabilization, nuclear localization and activation of hypoxia-inducible factor-1 (HIF-1α): Involvement of an antioxidant/redox mechanism in the alveolar epithelium. FEBS Lett. (In preparation). Haddad JJ, Land SC (2001). Amiloride blockades lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IκB-α/NF-κB-dependent mechanism: Evidence for the amplification of an anti-inflammatory pathway in the alveolar epithelium. Am. J. Respir. Cell Mol. Biol. (In preparation). Haddad JJ, Tarnow-Mordi W, Lauterbach R, Zembala M, Land SC (2001). Selective phosphodiesterase inhibition ameliorates endotoxin-induced release of proinflammatory cytokines in the alveolar epithelium. J. Clin. Invest. (In preparation).
John J. Haddad. doi: /cyto , available online at on
doi:10.1006/cyto.2002.1017, available online at http://www.idealibrary.com on RECOMBINANT TNF-α MEDIATED REGULATION OF THE IκB-α/NF-κB SIGNALING PATHWAY: EVIDENCE FOR THE ENHANCEMENT OF PRO- AND ANTI-INFLAMMATORY
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